The late-stage fluorescent labeling of structurally complex peptides bears immense potential for molecular imaging. Herein, we report on a manganese(I)-catalyzed peptide C–H alkenylation under exceedingly mild conditions with natural fluorophores as coumarin- and chromone-derivatives. The robustness and efficiency of the manganese(I) catalysis regime was reflected by a broad functional group tolerance and low catalyst loading in a resource- and atom-economical fashion.

中文翻译：

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荧光香豆素-炔烃通过锰 (I) 催化的 C-H 烯基化标记氨基酸和肽

结构复杂的肽的后期荧光标记在分子成像方面具有巨大的潜力。在此，我们报道了在极其温和的条件下，使用天然荧光团作为香豆素和色酮衍生物，锰 ( I ) 催化的肽 C–H 烯基化。锰（I）催化体系的稳健性和效率通过以资源和原子经济的方式广泛的官能团耐受性和低催化剂负载量来体现。