Proteins are one of the most prevalent components of the extracellular matrix, which are used in bone tissue engineering for construction of scaffolds. Due to their biocompatibility, biodegradability, non-immunogenicity and having cell motifs (cell recognition sites), they are capable of providing cell adhesion and favorable scaffold-cell interactions. However, proteins have crucial disadvantages, including lack of mechanical strength required for bone regeneration, as well as rapid degradation rate, which have restricted their implementation as a sole component in the construction of scaffolds. To overcome such disadvantages and at the same time, benefit from their properties, proteins are combined with other materials, such as carbohydrates and synthetic polymers and glass-ceramides. This review summarizes different types of protein hybrid scaffolds for bone tissue engineering and also discusses the function and significance of proteins in bone regeneration.

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基于蛋白质的混合支架：在骨组织工程中的应用

蛋白质是细胞外基质最普遍的成分之一，用于骨组织工程中构建支架。由于它们的生物相容性、生物可降解性、非免疫原性和具有细胞基序（细胞识别位点），它们能够提供细胞粘附和有利的支架-细胞相互作用。然而，蛋白质具有严重的缺点，包括缺乏骨再生所需的机械强度以及快速降解速度，这限制了它们作为支架构建中的唯一成分的应用。为了克服这些缺点，同时利用其特性，将蛋白质与其他材料（例如碳水化合物、合成聚合物和玻璃神经酰胺）相结合。本文总结了用于骨组织工程的不同类型的蛋白质混合支架，并讨论了蛋白质在骨再生中的功能和意义。

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