BackgroundGastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor of the digestive tract, with the potential to metastasize. Metastases to bone and soft tissue are more frequent in advanced cases, where targeted therapy is the standard treatment. However, around 10–15% of patients develop disease progression despite treatment. Studies have shown the efficacy of ablation in managing bone and soft tissue metastases (1, 2), but there are no reports of ablation for treating GIST bone or soft tissue metastases.Case presentationIn 2022, a 58-year-old man complaining of left back pain was admitted to Sichuan Cancer Hospital. He had undergone radical resection of the primary gastric GIST and vertebral metastases in 2014 and 2018, respectively. In 2019, rib metastases still occurred despite the use of targeted therapy. During the course of radiotherapy, targeted therapy, and immunotherapy, he experienced persistent chest wall pain. In addition, new lesions occurred in the lungs and chest wall in 2022. After a thorough assessment, microwave ablation (MWA) was recommended in response to his demand for immediate pain relief. The large rib metastasis constricted the spleen, so we completed the ablation in two sessions to reduce the risk of complications. He had 17 months of follow-up until September 2023, during which time his discomfort was considerably reduced.ConclusionFor GIST patients with soft tissue and bone metastases, MWA may offer substantial immediate pain alleviation. When other treatment procedures fail to achieve adequate efficacy, it provides an option.

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微波消融治疗胃肠道间质瘤引起的疼痛性胸壁转移：病例报告

背景胃肠间质瘤（GIST）是消化道最常见的间叶性肿瘤，具有转移的潜力。在晚期病例中，骨和软组织转移更为常见，靶向治疗是标准治疗方法。然而，尽管接受了治疗，仍有约 10-15% 的患者出现疾病进展。研究表明消融在控制骨和软组织转移方面的功效（1,2），但尚无消融治疗 GIST 骨或软组织转移的报道。 病例介绍 2022 年，一名 58 岁男性因左背疼痛入院四川省肿瘤医院。他分别于2014年和2018年接受了原发性胃胃肠道间质瘤和椎体转移瘤的根治性切除术。 2019年，尽管采用了靶向治疗，肋骨转移仍然发生。在放疗、靶向治疗、免疫治疗过程中，他出现持续性胸壁疼痛。此外，2022年，肺部和胸壁出现了新的病变。经过全面评估，针对他立即缓解疼痛的要求，建议进行微波消融（MWA）。由于较大的肋骨转移压迫了脾脏，因此我们分两次完成消融，以降低并发症的风险。直到 2023 年 9 月，他进行了 17 个月的随访，在此期间，他的不适感大大减轻。 结论 对于有软组织和骨转移的 GIST 患者，MWA 可以立即显着缓解疼痛。当其他治疗方法无法达到足够疗效时，它提供了一种选择。