ObjectiveTo investigate the relationship between serum 25‐hydroxyvitamin D (25(OH)D) level with novel inflammatory markers in hemodialysis‐treated patients.MethodsA total of 167 maintenance hemodialysis‐treated patients were enrolled in this cross‐sectional study. The patients were divided into vitamin D deficiency (a serum 25(OH)D level <20 ng/mL) and nondeficiency (a serum 25(OH)D level ≥20 ng/mL) groups. The neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and monocyte to lymphocyte ratio (MLR) were calculated by the complete blood cell count. The relationship between 25(OH)D level with other parameters was assessed by bivariate correlation analysis and linear regression analysis.ResultsThere were significant differences between the two groups in terms of age, diabetes, levels of albumin, creatinine, high‐density lipoprotein cholesterol (HDL‐C) and low‐density lipoprotein cholesterol (LDL‐C) as well as NLR and MLR (p = .004, p = .031, p < .001, p = .043, p = .008, p = .006, p = .002, and p < .001, respectively). There exist negative correlations between serum 25(OH)D level with age, diabetes, alkaline phosphatase level, NLR, PLR, and MLR (p = .002, p = .002, p = .037, p = .001, p = .041, and p < .001, respectively) and positive correlations between serum 25(OH)D level with albumin level, creatinine level, phosphorus level, HDL‐C, and LDL‐C (p < .001, p < .001, p = .013, p = .02, p = .002, respectively). Multiple analysis results showed that sex, diabetes, albumin level and NLR were independently associated with serum 25(OH)D level (p = .021, p = .015, p = .033, and p = .041, respectively). High values of NLR and MLR were associated with patients with serum 25(OH)D deficiency. There were negative interplays between serum 25(OH) D level with NLR, PLR, and MLR and also an independent association between serum 25(OH) D level with NLR.ConclusionCollectively, serum 25(OH)D level has a negative correlation with inflammatory markers.

中文翻译：

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血液透析治疗患者血清 25-羟基维生素 D 水平与炎症标志物之间的关联

目的探讨血液透析患者血清25羟基维生素D（25(OH)D）水平与新型炎症标志物的关系。方法本次横断面研究共纳入167例维持性血液透析患者。将患者分为维生素 D 缺乏症组（血清 25(OH)D 水平 <20 ng/mL）和非缺乏症组（血清 25(OH)D 水平≥20 ng/mL）。通过全血细胞计数计算中性粒细胞与淋巴细胞比（NLR）、血小板与淋巴细胞比（PLR）和单核细胞与淋巴细胞比（MLR）。采用双变量相关分析和线性回归分析评估25(OH)D水平与其他参数的关系。结果两组在年龄、糖尿病、白蛋白、肌酐、高密度脂蛋白胆固醇水平方面差异有统计学意义( HDL-C）和低密度脂蛋白胆固醇（LDL-C）以及 NLR 和 MLR（p= .004,p= .031,p< .001,p= .043,p= .008,p= .006,p= .002，并且p< .001，分别）。血清25(OH)D水平与年龄、糖尿病、碱性磷酸酶水平、NLR、PLR和MLR之间存在负相关。p= .002,p= .002,p= .037,p= .001,p= .041，并且p< .001，分别）以及血清 25(OH)D 水平与白蛋白水平、肌酐水平、磷水平、HDL-C 和 LDL-C 之间的正相关性（p< .001,p< .001,p= .013,p= .02,p= .002，分别）。多重分析结果显示性别、糖尿病、白蛋白水平和NLR与血清25(OH)D水平独立相关(p= .021,p= .015,p= .033，并且p= .041，分别）。高 NLR 和 MLR 值与血清 25(OH)D 缺乏症患者相关。血清25(OH)D水平与NLR、PLR、MLR呈负相关，且血清25(OH)D水平与NLR呈独立相关。结论：血清25(OH)D水平与炎症反应呈负相关。标记。