ScopeTolypocladium sinense is a fungus isolated from Cordyceps. Cordyceps has some medicinal value and is also a daily health care product. This study explores the preventive effects of T. sinense mycelium polysaccharide (TSMP) on high‐fat diet‐induced obesity and chronic inflammation in mice.Methods and resultsHere, the study establishes an obese mouse model induced by high‐fat diet. In this study, the mice are administered TSMP daily basis to evaluate its effect on alleviating obesity. The results show that TSMP can significantly inhibit obesity and alleviate dyslipidemia by regulating the expression of lipid metabolism‐related genes such as liver kinase B1 (LKB1), phosphorylated AMP‐activated protein kinase (pAMPK), peroxisome proliferator activated receptor α (PPARα), fatty acid synthase (FAS), and hydroxymethylglutaryl‐CoA reductase (HMGCR) in the liver. TSMP can increase the protein expression of zona occludens‐1 (ZO‐1), Occludin, and Claudin‐1 in the colon, improve the intestinal barrier dysfunction, and reduce the level of serum LPS, thereby reducing the inflammatory response. 16S rDNA sequencing shows that TSMP alters the intestinal microbiota by increasing the relative abundance of Akkermansia, Lactobacillus, and Prevotellaceae_NK3B31_group, while decreasing the relative abundance of Faecalibaculum.ConclusionThe findings show that TSMP can inhibit obesity and alleviates obesity‐related lipid metabolism disorders, inflammatory responses, and oxidative stress by modulating the gut microbiota and improving intestinal barrier.

中文翻译：

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中华毛衣菌菌丝体多糖通过改善肠道屏障和调节肠道菌群，缓解高脂饮食引起的肥胖、脂质代谢紊乱和炎症

范围中华松枝藻是从冬虫夏草中分离出来的真菌。虫草具有一定的药用价值，也是日常保健品。本研究探讨了预防效果中华木犀菌丝体多糖（TSMP）对高脂饮食诱导的小鼠肥胖和慢性炎症的影响。方法和结果本研究建立了高脂饮食诱导的肥胖小鼠模型。在这项研究中，小鼠每天服用 TSMP，以评估其减轻肥胖的效果。结果表明，TSMP通过调节肝激酶B1（LKB1）、磷酸化AMP激活蛋白激酶（pAMPK）、过氧化物酶体增殖物激活受体α（PPARα）、肝脏中的脂肪酸合酶（FAS）和羟甲基戊二酰辅酶A还原酶（HMGCR）。 TSMP可增加结肠中闭合带-1（ZO-1）、Occludin、Claudin-1蛋白表达，改善肠道屏障功能障碍，降低血清LPS水平，从而减轻炎症反应。 16S rDNA 测序表明 TSMP 通过增加相对丰度来改变肠道微生物群阿克曼氏菌,乳酸菌， 和普雷沃特拉科_NK3B31_group，同时降低相对丰度粪菌属结论研究结果表明，TSMP可以通过调节肠道菌群、改善肠道屏障来抑制肥胖，缓解肥胖相关的脂质代谢紊乱、炎症反应和氧化应激。