Alkylamines form the backbone of countless nitrogen‐containing small molecules possessing desirable biological properties. Despite advances in amine synthesis through transition metal catalysis and photoredox chemistry, multicomponent reactions that leverage inexpensive materials to transform abundant chemical feedstocks into three‐dimensional α‐substituted alkylamines bearing complex substitution patterns remain scarce. Here, we report the design of a catalyst‐free electroreductive manifold that merges amines, carbonyl compounds and carbon‐based radical acceptors under ambient conditions without rigorous exclusion of air and moisture. Key to this aminative carbofunctionalization process is the chemoselective generation of nucleophilic α‐amino radical intermediates that readily couple with electrophilic partners, providing straightforward access to architecturally intricate alkylamines and drug‐like scaffolds which are inaccessible by conventional means.

中文翻译：

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羰基化合物的氨基碳官能化电化学合成富C(sp3)胺

烷基胺形成了无数具有理想生物特性的含氮小分子的主链。尽管通过过渡金属催化和光氧化还原化学在胺合成方面取得了进展，但利用廉价材料将丰富的化学原料转化为具有复杂取代模式的三维α取代烷基胺的多组分反应仍然很少。在这里，我们报告了一种无催化剂电还原歧管的设计，该歧管在环境条件下合并胺、羰基化合物和碳基自由基受体，而无需严格排除空气和湿气。这种氨基碳功能化过程的关键是化学选择性地生成亲核α-氨基自由基中间体，这些中间体很容易与亲电伙伴偶联，从而可以直接获得结构复杂的烷基胺和传统方法无法获得的药物样支架。