Venoarterial extracorporeal membrane oxygenation (VA ECMO) has become a standard of care for severe cardiogenic shock, refractory cardiac arrest and related impending multiorgan failure. The widespread clinical use of this complex temporary circulatory support modality is still contrasted by a lack of formal scientific evidence in the current literature. This might at least in part be attributable to VA ECMO related complications, which may significantly impact on clinical outcome. In order to limit adverse effects of VA ECMO as much as possible an indepth understanding of the complex physiology during extracorporeally supported cardiogenic shock states is critically important. This review covers all relevant physiological aspects of VA ECMO interacting with the human body in detail. This, to provide a solid basis for health care professionals involved in the daily management of patients supported with VA ECMO and suffering from cardiogenic shock or cardiac arrest and impending multiorgan failure for the best possible care.

中文翻译：

---

静脉动脉体外膜氧合的生理学 - 全面的临床视角

静脉动脉体外膜肺氧合 (VA ECMO) 已成为严重心源性休克、难治性心脏骤停和相关的即将发生的多器官衰竭的护理标准。这种复杂的临时循环支持方式在临床上的广泛使用仍然与当前文献中缺乏正式的科学证据形成鲜明对比。这可能至少部分归因于 VA ECMO 相关并发症，这可能对临床结果产生重大影响。为了尽可能限制 VA ECMO 的不良影响，深入了解体外支持的心源性休克状态期间的复杂生理学至关重要。本综述详细涵盖了 VA ECMO 与人体相互作用的所有相关生理方面。这为参与 VA ECMO 支持的、患有心源性休克或心脏骤停以及即将发生的多器官衰竭的患者的日常管理的医疗保健专业人员提供了坚实的基础，以获得最佳的护理。