This study addresses a crucial necessity in the field of noninvasive liver fibrosis diagnosis by introducing the concept of continuous shear wave elastography (C-SWE), utilizing an external vibration source and color Doppler imaging. However, an application of C-SWE to assess liver elasticity, a deep region within the human body, arises an issue of signal instability in the obtained data. To tackle this challenge, this work proposes a method involving the acquisition of multiple frames of datasets, which are subsequently compressed. Furthermore, the proposed frame-to-frame equalization method compensates discrepancies in the initial phase that might exist among multiple-frame datasets, thereby significantly enhancing signal stability. The experimental validation of this approach encompasses both phantom tests and in vivo experiments. In the phantom tests, the proposed technique is validated through a comparison with the established shear wave elastography (SWE) technique. The results demonstrate a remarkable agreement, with an error in shear wave velocity of less than 4.2%. Additionally, the efficacy of the proposed method is confirmed through in vivo tests. As a result, the stabilization of observed shear waves using the frame-to-frame equalization technique exhibits promising potential for accurately assessing human liver elasticity. These findings collectively underscore the viability of C-SWE as a potential diagnostic instrument for liver fibrosis.

中文翻译：

---

使用复振幅帧间均衡的肝脏连续剪切波弹性成像

这项研究通过引入连续剪切波弹性成像（C-SWE）的概念，利用外部振动源和彩色多普勒成像，解决了无创肝纤维化诊断领域的关键需求。然而，应用 C-SWE 评估人体深层区域肝脏弹性时，会出现所获得数据信号不稳定的问题。为了应对这一挑战，这项工作提出了一种涉及获取多帧数据集并随后进行压缩的方法。此外，所提出的帧到帧均衡方法补偿了多帧数据集之间可能存在的初始相位差异，从而显着增强了信号稳定性。该方法的实验验证包括模型测试和体内实验。在体模测试中，通过与已建立的剪切波弹性成像（SWE）技术进行比较来验证所提出的技术。结果显示出显着的一致性，剪切波速度的误差小于 4.2%。此外，所提出方法的功效通过体内测试得到证实。因此，使用帧到帧均衡技术稳定观察到的剪切波在准确评估人类肝脏弹性方面表现出良好的潜力。这些发现共同强调了 C-SWE 作为肝纤维化潜在诊断工具的可行性。