Arthritis causes inflammatory damage to joints and connective tissues. In the treatment of arthritis, precise and controlled drug delivery to the target site is among the frontline research approaches. In the present research work, celecoxib drug and bioactive glass incorporated chitosan hydrogels were fabricated by the freeze gelation method. Fourier transform infrared spectroscopy, scanning electron microscopy, and thermogravimetric analysis/differential scanning calorimetry techniques were used to characterize the hydrogels. Different kinetic models were applied to study the drug release kinetics. The celecoxib release was mainly controlled by a Fickian diffusion process followed by the Higuchi model. Maximum 86.2% drug entrapment was observed in 20 mg drug-loaded hydrogel and its swelling ratio was 115.5% in 28 d. Good hydrophilicity, good drug entrapment efficiency, and moderate drug release patterns of hydrogels can make them suitable for sustained drug release. The cytocompatibility of hydrogels was established by performing an MTT assay on the BHK-21 fibroblast cell line. The promising results have proved that hydrogels can be considered potential material for the slow release of anti-inflammatory drug at the target site in arthritis.

中文翻译：

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塞来昔布负载生物活性玻璃壳聚糖复合水凝胶的制备：非甾体抗炎药治疗递送的简单方法

关节炎会对​​关节和结缔组织造成炎症损伤。在关节炎的治疗中，精确且受控的药物递送至目标部位是前沿研究方法之一。在目前的研究工作中，通过冷冻凝胶法制备了塞来昔布药物和生物活性玻璃掺入壳聚糖水凝胶。使用傅里叶变换红外光谱、扫描电子显微镜和热重分析/差示扫描量热技术来表征水凝胶。应用不同的动力学模型来研究药物释放动力学。塞来昔布的释放主要由 Fickian 扩散过程和 Higuchi 模型控制。 20 mg载药水凝胶中观察到最大86.2%的药物截留，28 d时其溶胀率为115.5%。水凝胶良好的亲水性、良好的药物包封率和适度的药物释放模式使其适合药物持续释放。通过对 BHK-21 成纤维细胞系进行 MTT 测定来确定水凝胶的细胞相容性。这一令人鼓舞的结果证明，水凝胶可以被认为是在关节炎靶点缓慢释放抗炎药物的潜在材料。