Sedentary behavior, falls, and fear of falling (FoF) are specific concerns for people with MS (pwMS). Considering the relatively high incidence and potential linkage, it is surprising that this triple relationship has as yet not been extensively investigated in pwMS. Thus, the present study aimed to examine the correlates of sedentary behavior with FoF and falls in pwMS. Fifty pwMS, 30 women, were admitted to this cross-sectional study. Primary outcome measures included physical activity and sedentary behavior metrics measured by accelerometry, fall status, and FoF. Additional measures included mobility clinical tests, cognition, perceived fatigue, depression, and anxiety. The sample was divided into two subgroups according to the daily Metabolic Equivalent of Task (MET) rate scores; <1.5 was defined as sedentary, ≥1.5 were defined as non-sedentary. Multivariate analysis of variance and linear regression analyses assessed the relationships by using an alpha of 0.05. Sixty-four percent of the sample were classified as sedentary. The sedentary subgroup reported more FoF than the non-sedentary subgroup (32.5 (S·D. = 11.3) vs. 29.9 (S.D. = 9.5); however, no differences were found in fall status between the subgroups. No differences were found for depression, anxiety, cognition, and perceived fatigue between the subgroups. Furthermore, according to the linear regression analysis, FoF explained 23.9% of the variance pertaining to the daily MET rate when controlling for age, gender, disease duration, and disability. Clinicians are encouraged to incorporate the issue of FoF during standard management, which may represent an opportunity to improve care and reduce sedentary behavior in pwMS.

中文翻译：

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多发性硬化症患者对跌倒的恐惧以及跌倒与久坐行为的关联

久坐行为、跌倒和害怕跌倒 (FoF) 是多发性硬化症 (pwMS) 患者特别关心的问题。考虑到相对较高的发生率和潜在的联系，令人惊讶的是这种三重关系尚未在 pwMS 中得到广泛研究。因此，本研究旨在探讨久坐行为与 FoF 和跌倒 pwMS 的相关性。 50 名 pwMS（30 名女性）被纳入这项横断面研究。主要结果指标包括通过加速度测量、跌倒状态和 FoF 测量的体力活动和久坐行为指标。其他指标包括活动能力临床测试、认知、疲劳感、抑郁和焦虑。根据每日任务代谢当量（MET）率评分将样本分为两个亚组； <1.5被定义为久坐，≥1.5被定义为非久坐。多元方差分析和线性回归分析使用 0.05 的 alpha 来评估关系。百分之六十四的样本被归类为久坐不动的人。久坐亚组报告的 FoF 高于非久坐亚组（32.5 (S·D. = 11.3) vs. 29.9 (SD = 9.5)；然而，亚组之间的跌倒状况没有发现差异。抑郁症没有发现差异此外，根据线性回归分析，在控制年龄、性别、病程和残疾情况时，FoF 解释了与每日 MET 率相关的 23.9% 的差异。在标准管理中纳入 FoF 问题，这可能是改善 pwMS 护理和减少久坐行为的机会。