Primate lateral intraparietal area (LIP) is critical for cognitive processing. Its contribution to categorization and decision-making has been causally linked to neurons' spatial sensorimotor selectivity. We reveal the intrinsic anatomical circuits and neuronal responses within LIP that provide the substrate for this flexible generation of motor responses to sensory targets. Retrograde tracers delineate a loop between two distinct operational compartments, with a sensory-like, point-to-point projection from ventral to dorsal LIP and an asymmetric, more widespread projection in reverse. Neurophysiological recordings demonstrate that especially more ventral LIP neurons exhibit motor response fields that are spatially distinct from its sensory receptive field. The different associations of response and receptive fields in single neurons tile visual space. These anatomical circuits and neuronal responses provide the basis for the flexible allocation of attention and motor responses to salient or instructive visual input across the visual field.

中文翻译：

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后顶叶皮层单个神经元灵活空间映射的解剖电路

灵长类动物顶内外侧区（LIP）对于认知处理至关重要。它对分类和决策的贡献与神经元的空间感觉运动选择性存在因果关系。我们揭示了 LIP 内的内在解剖回路和神经元反应，为这种对感觉目标的运动反应的灵活产生提供了基础。逆行示踪剂在两个不同的操作区之间描绘出一个环路，具有从腹侧到背侧唇的类似感觉的点对点投影，以及反向的不对称、更广泛的投影。神经生理学记录表明，尤其是更多的腹侧唇神经元表现出与其感觉感受野在空间上不同的运动反应场。单个神经元中反应和感受野的不同关联平铺视觉空间。这些解剖回路和神经元反应为灵活分配注意力和运动反应到整个视野中的显着或指导性视觉输入提供了基础。