Molluscan herpesviruses cause disease in species of major importance to aquaculture and are the only known herpesviruses to infect invertebrates, which lack an adaptive immune system. Understanding the evolution of malacoherpesviruses in relation to their hosts will likely require comparative genomic studies on multiple phylogenetic scales. Currently, only two malacoherpesvirus species have genomes that have been fully assembled, which limits the ability to perform comparative genomic studies on this family of viruses. In the present study, we fully assemble a herpesvirus from Illumina and Nanopore sequence data that were previously used to assemble the genome of the gastropod Babylonia areolata. We tentatively assign this novel herpesvirus to the genus Aurivirus within the family Malacoherpesviridae based on a phylogenetic analysis of DNA polymerase. While structurally similar to other malacoherpesvirus genomes, a synteny analysis of the novel herpesvirus with another Aurivirus species indicates that genomic rearrangements might be an important process in the evolution of this genus. We anticipate that future complete assemblies of malacoherpesviruses will be a valuable resource in comparative herpesvirus research.

中文翻译：

---

来自腹足动物 Babylonia areolata 的新型无脊椎动物疱疹病毒的全基因组组装

软体动物疱疹病毒会在对水产养殖至关重要的物种中引起疾病​​，并且是唯一已知的感染缺乏适应性免疫系统的无脊椎动物的疱疹病毒。了解软疱疹病毒与其宿主相关的进化可能需要在多个系统发育尺度上进行比较基因组研究。目前，只有两种软疱疹病毒物种的基因组已完全组装，这限制了对该病毒家族进行比较基因组研究的能力。在本研究中，我们根据 Illumina 和 Nanopore 序列数据完全组装了疱疹病毒，这些数据先前用于组装腹足动物Babylonia areolata的基因组。基于 DNA 聚合酶的系统发育分析，我们暂时将这种新型疱疹病毒归属于软疱疹病毒科的Aurivirus属。虽然结构上与其他软疱疹病毒基因组相似，但新型疱疹病毒与另一种耳病毒属的同线性分析表明，基因组重排可能是该属进化的重要过程。我们预计未来软疱疹病毒的完整组装将成为比较疱疹病毒研究的宝贵资源。