Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system resulting from loss of immune tolerance. Many disease-modifying therapies for MS have broad immunosuppressive effects on peripheral immune cells, but this can increase risks of infection and attenuate vaccine-elicited immunity. A more targeted approach is to re-establish immune tolerance in an autoantigen-specific manner. This review discusses methods to achieve this, focusing on tolerogenic dendritic cells. Clinical trials in other autoimmune diseases also provide learnings with regards to clinical translation of this approach, including identification of autoantigen(s), selection of appropriate patients and administration route and frequency.

中文翻译：

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通过递送耐受性树突状细胞来治疗多发性硬化症的抗原特异性免疫疗法

多发性硬化症（MS）是一种因免疫耐受丧失而导致的中枢神经系统慢性炎症性脱髓鞘疾病。许多针对多发性硬化症的疾病缓解疗法对外周免疫细胞具有广泛的免疫抑制作用，但这可能会增加感染风险并削弱疫苗引起的免疫力。更有针对性的方法是以自身抗原特异性的方式重新建立免疫耐受。这篇综述讨论了实现这一目标的方法，重点关注耐受性树突状细胞。其他自身免疫性疾病的临床试验也提供了有关该方法临床转化的经验，包括识别自身抗原、选择合适的患者以及给药途径和频率。