Psoriasis is a common immune-mediated skin disease characterized by abnormally reactive inflammation and epidermal hyperplasia. Previous studies have shown melatonin (MLT) has powerful anti-inflammatory effects. The mechanisms that MLT regulates psoriasis-associated skin inflammation remain unclear. Here, in imiquimod-induced psoriasis-like mice, MLT supplementation reduced skin inflammation and corrected the Th17/Treg cell imbalance. Network pharmacology and proteome sequencing analyses revealed that MLT attenuates the inflammatory response in the skin of psoriatic mice by inhibiting the PI3K/Akt signaling pathway. Overall, the data suggest that MLT has a protective effect against psoriasis-like inflammation.

牛皮癣是一种常见的免疫介导的皮肤病，其特征是异常反应性炎症和表皮增生。先前的研究表明褪黑激素（MLT）具有强大的抗炎作用。 MLT 调节银屑病相关皮肤炎症的机制仍不清楚。在咪喹莫特诱导的银屑病样小鼠中，补充 MLT 可减少皮肤炎症并纠正 Th17/Treg 细胞失衡。网络药理学和蛋白质组测序分析表明，MLT 通过抑制 PI3K/Akt 信号通路来减轻银屑病小鼠皮肤的炎症反应。总体而言，数据表明 MLT 对银屑病样炎症具有保护作用。