Accurate assessment of physical activity and motor function in children with cerebral palsy is crucial for determining the effectiveness of interventions. This study aimed to investigate the correlation between real-world activity monitoring outcomes and in-laboratory standardized hand function assessments in children with unilateral cerebral palsy. Actigraphy data were collected over 3 days from children aged 4–12 years with unilateral cerebral palsy before in-laboratory assessments. To tackle the high dimensionality and collinearity of actigraphy variables, we first applied hierarchical clustering using the Pearson correlation coefficient as the distance metric and then performed a principal component analysis (PCA) to reduce the dimensionality of our data. Both hierarchical clustering and PCAs revealed a consistent pattern in which magnitude ratio variables (ln[affected side magnitude/less-affected side magnitude]) were more strongly associated with standardized assessments of hand function than with activity time and distance domain variables. Hierarchical clustering analysis identified two distinct clusters of actigraphy variables, with the second cluster primarily consisting of magnitude ratio variables that exhibited the strongest correlation with Melbourne Assessment 2, Pediatric Motor Activity Log, Assisting Hand Assessment, and Manual Ability Classification System level. Principal component 2, primarily representing the magnitude ratio domain, was positively associated with a meaningful portion of subcategories of standardized measures, whereas principal component 1, representing the activity time and distance component, showed limited associations. The magnitude ratio of actigraphy can provide additional objective information that complements in-laboratory hand function assessment outcomes in future studies of children with unilateral cerebral palsy. NCT04904796 (registered prospectively; date of registration: 23/05/2021).

中文翻译：

---

确定反映标准化手部功能评估的最具代表性的体动记录变量，用于单侧脑瘫儿童的远程监测

准确评估脑瘫儿童的身体活动和运动功能对于确定干预措施的有效性至关重要。本研究旨在调查单侧脑瘫儿童的真实活动监测结果与实验室标准化手功能评估之间的相关性。在进行实验室评估之前，我们在 3 天内收集了 4-12 岁单侧脑瘫儿童的体动记录数据。为了解决体动记录变量的高维性和共线性问题，我们首先使用皮尔逊相关系数作为距离度量来应用层次聚类，然后进行主成分分析（PCA）以降低数据的维数。层次聚类和 PCA 都揭示了一种一致的模式，其中幅度比变量（ln[受影响侧幅度/受影响较小侧幅度]）与手部功能标准化评估的相关性比与活动时间和距离域变量的相关性更强。分层聚类分析确定了两个不同的体动记录变量簇，第二个簇主要由幅度比变量组成，这些变量与墨尔本评估 2、儿科运动活动日志、辅助手评估和手动能力分类系统水平具有最强的相关性。主成分 2 主要代表幅度比域，与标准化测量子类别的有意义部分呈正相关，而主成分 1 代表活动时间和距离成分，显示出有限的关联。体动记录仪的幅度比可以提供额外的客观信息，补充单侧脑瘫儿童未来研究中的实验室手功能评估结果。 NCT04904796（前瞻性注册；注册日期：23/05/2021）。