An AIE-based fluorescent probe was designed to evaluate peroxynitrite levels in complex biological samples. The newly synthesized hydrazone-conjugated probe fluoresces strongly in the presence of peroxynitrite. Clinically, the peroxynitrite levels can be measured in human serum and cellular mitochondria with an LOD of 6.5 nM by fluorescence imaging in vitro.

中文翻译：

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基于AIE的荧光探针检测人血清中过氧亚硝酸盐水平及其细胞成像

基于 AIE 的荧光探针旨在评估复杂生物样品中的过氧亚硝酸盐水平。新合成的腙结合探针在过氧亚硝酸盐存在下会发出强烈的荧光。临床上，可以通过体外荧光成像测量人血清和细胞线粒体中的过氧亚硝酸盐水平，LOD 为 6.5 nM 。