Emerging data support associations between the depletion of the healthy gut microbiome and aging-related physiological decline and disease. In humans, fecal microbiota transplantation (FMT) has been used successfully to restore gut microbiome structure and function and to treat C. difficile infections, but its application to healthy aging has been scarcely investigated. The marmoset is an excellent model for evaluating microbiome-mediated changes with age and interventional treatments due to their relatively shorter lifespan and many social, behavioral, and physiological functions that mimic human aging. Prior work indicates that FMT is safe in marmosets and may successfully mediate gut microbiome function and host health. This narrative review (1) provides an overview of the rationale for FMT to support healthy aging using the marmoset as a translational geroscience model, (2) summarizes the prior use of FMT in marmosets, (3) outlines a protocol synthesized from prior literature for studying FMT in aging marmosets, and (4) describes limitations, knowledge gaps, and future research needs in this field.

中文翻译：

---

开发普通狨猴作为转化老年科学模型来研究微生物组和健康衰老

新数据支持健康肠道微生物组的消耗与衰老相关的生理衰退和疾病之间的关联。在人类中，粪便微生物群移植（FMT）已成功用于恢复肠道微生物组结构和功能以及治疗艰难梭菌感染，但其在健康老龄化方面的应用却很少被研究。狨猴是评估微生物组介导的随年龄和介入治疗变化的优秀模型，因为它们的寿命相对较短，并且具有许多模仿人类衰老的社会、行为和生理功能。先前的研究表明，FMT 对于狨猴来说是安全的，并且可以成功调节肠道微生物组功能和宿主健康。这篇叙述性综述 (1) 概述了使用狨猴作为转化老年科学模型的 FMT 支持健康老龄化的基本原理，(2) 总结了 FMT 在狨猴中的先前使用，(3) 概述了根据先前文献综合的方案研究衰老狨猴的 FMT，(4) 描述了该领域的局限性、知识差距和未来的研究需求。