When chemical pollutants enter the environment, they can undergo diverse transformation processes, forming a wide range of transformation products (TPs), some of them benign and others more harmful than their precursors. To date, the majority of TPs remain largely unrecognized and unregulated, particularly as TPs are generally not part of routine chemical risk or hazard assessment. Since many TPs formed from oxidative processes are more polar than their precursors, they may be especially relevant in the context of persistent, mobile, and toxic (PMT) and very persistent and very mobile (vPvM) substances, which are two new hazard classes that have recently been established on a European level. We highlight herein that as a result, TPs deserve more attention in research, chemicals regulation, and chemicals management. This perspective summarizes the main challenges preventing a better integration of TPs in these areas: (1) the lack of reliable high-throughput TP identification methods, (2) uncertainties in TP prediction, (3) inadequately considered TP formation during (advanced) water treatment, and (4) insufficient integration and harmonization of TPs in most regulatory frameworks. A way forward to tackle these challenges and integrate TPs into chemical management is proposed.

中文翻译：

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转型产品是否应该改变我们管理化学品的方式？

当化学污染物进入环境时，它们可以经历不同的转化过程，形成各种各样的转化产物（TP），其中一些是良性的，另一些比其前体更有害。迄今为止，大多数TP在很大程度上仍未得到认可和监管，特别是因为TP通常不属于常规化学品风险或危害评估的一部分。由于氧化过程形成的许多 TP 比其前体更具极性，因此它们可能与持久性、移动性和毒性 (PMT) 以及非常持久和非常移动 (vPvM) 物质特别相关，这是两种新的危险类别，最近在欧洲层面上建立了。我们在此强调，因此，TP 在研究、化学品监管和化学品管理方面值得更多关注。这一观点总结了阻碍这些领域更好地整合TP的主要挑战：（1）缺乏可靠的高通量TP识别方法，（2）TP预测的不确定性，（3）在（高级）水期间没有充分考虑TP的形成(4) 大多数监管框架中的转让定价整合和协调不够。提出了应对这些挑战并将TP纳入化学品管理的前进方向。