Environmental antibiotics exposure and childhood obesity: A cross-sectional case-control study,Ecotoxicology and Environmental Safety

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Environmental antibiotics exposure and childhood obesity: A cross-sectional case-control study
Ecotoxicology and Environmental Safety ( IF 6.8 ) Pub Date : 2024-04-25 , DOI: 10.1016/j.ecoenv.2024.116339
Yu-Qing Wang , Yu Zhang , Wei-Feng Tang , Zhong-Cheng Luo , Yun-Ting Zhang , Chong-huai Yan , Jun Zhang , Qian Chen

Children’s exposures to environmental antibiotics are a major public health concern. However, limited data are available on the effects of environmental antibiotic exposures on childhood obesity. Our study aimed to explore this relationship. We conducted a cross-sectional case-control study nested in a population-based survey of primary school students, including 1855 obese and 1875 random selected control children. A total of 10 antibiotics in urine samples were measured by liquid chromatography-tandem mass spectrometry. Multivariable survey logistic regression was used to assess the associations between environmental antibiotics exposures and childhood obesity. After adjusting for potential confounders, increased odds of obesity were observed in children exposed to tetracycline (OR = 1.31, 95% CI: 1.09–1.57) and sulfamonomethoxine (OR = 1.43, 95% CI: 1–2.05). Comparing none (

中文翻译：

环境抗生素暴露与儿童肥胖：横断面病例对照研究

儿童接触环境抗生素是一个主要的公共卫生问题。然而，关于环境抗生素暴露对儿童肥胖的影响的数据有限。我们的研究旨在探索这种关系。我们进行了一项横断面病例对照研究，该研究以基于人口的小学生调查为基础，其中包括 1855 名肥胖儿童和 1875 名随机选择的对照儿童。采用液相色谱-串联质谱法测定尿样中10种抗生素的含量。使用多变量调查逻辑回归来评估环境抗生素暴露与儿童肥胖之间的关联。调整潜在的混杂因素后，观察到接触四环素（OR = 1.31，95% CI：1.09–1.57）和磺胺间甲氧嘧啶（OR = 1.43，95% CI：1–2.05）的儿童肥胖几率增加。没有比较（

更新日期：2024-04-25

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