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Longitudinal microstructural changes in 18 amygdala nuclei resonate with cortical circuits and phenomics Commun. Biol. (IF 5.9) Pub Date : 2024-04-18 Karam Ghanem, Karin Saltoun, Aparna Suvrathan, Bogdan Draganski, Danilo Bzdok
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A chromosome-level genome assembly for the amphibious plant Rorippa aquatica reveals its allotetraploid origin and mechanisms of heterophylly upon submergence Commun. Biol. (IF 5.9) Pub Date : 2024-04-18 Tomoaki Sakamoto, Shuka Ikematsu, Hokuto Nakayama, Terezie Mandáková, Gholamreza Gohari, Takuya Sakamoto, Gaojie Li, Hongwei Hou, Sachihiro Matsunaga, Martin A. Lysak, Seisuke Kimura
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Multiple factors and features dictate the selective production of ct-siRNA in Arabidopsis Commun. Biol. (IF 5.9) Pub Date : 2024-04-18 Feng Li, Wei Yan, Xianli Tang, Huihui Wu, Yajie Pan, Dongdong Lu, Qianyan Ling-hu, Yuelin Liu, Yongqi Liu, Xiehai Song, Muhammad Ali, Liang Fang, Hongwei Guo, Bosheng Li
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Highly pathogenic avian influenza A(H5N1) virus in a common bottlenose dolphin (Tursiops truncatus) in Florida Commun. Biol. (IF 5.9) Pub Date : 2024-04-18 Allison Murawski, Thomas Fabrizio, Robert Ossiboff, Christina Kackos, Trushar Jeevan, Jeremy C. Jones, Ahmed Kandeil, David Walker, Jasmine C. M. Turner, Christopher Patton, Elena A. Govorkova, Helena Hauck, Suzanna Mickey, Brittany Barbeau, Y. Reddy Bommineni, Mia Torchetti, Kristina Lantz, Lisa Kercher, Andrew B. Allison, Peter Vogel, Michael Walsh, Richard J. Webby
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Near-infrared PAINT localization microscopy via chromophore replenishment of phytochrome-derived fluorescent tag Commun. Biol. (IF 5.9) Pub Date : 2024-04-18 Kai Lu, Tetsuichi Wazawa, Tomoki Matsuda, Daria M. Shcherbakova, Vladislav V. Verkhusha, Takeharu Nagai
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Quantifying maternal investment in mammals using allometry Commun. Biol. (IF 5.9) Pub Date : 2024-04-18 Tim E.R.G. Huijsmans, Alexandre Courtiol, Ann Van Soom, Katrien Smits, François Rousset, Jella Wauters, Thomas B. Hildebrandt
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An evolutionary timeline of the oxytocin signaling pathway Commun. Biol. (IF 5.9) Pub Date : 2024-04-17 Alina M. Sartorius, Jaroslav Rokicki, Siri Birkeland, Francesco Bettella, Claudia Barth, Ann-Marie G. de Lange, Marit Haram, Alexey Shadrin, Adriano Winterton, Nils Eiel Steen, Emanuel Schwarz, Dan J. Stein, Ole A. Andreassen, Dennis van der Meer, Lars T. Westlye, Constantina Theofanopoulou, Daniel S. Quintana
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SPADE: spatial deconvolution for domain specific cell-type estimation Commun. Biol. (IF 5.9) Pub Date : 2024-04-17 Yingying Lu, Qin M. Chen, Lingling An
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Cellular geometry and epithelial-mesenchymal plasticity intersect with PIEZO1 in breast cancer cells Commun. Biol. (IF 5.9) Pub Date : 2024-04-17 Choon Leng So, Mélanie Robitaille, Francisco Sadras, Michael H. McCullough, Michael J. G. Milevskiy, Geoffrey J. Goodhill, Sarah J. Roberts-Thomson, Gregory R. Monteith
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The CBS/H2S signalling pathway regulated by the carbon repressor CreA promotes cellulose utilization in Ganoderma lucidum Commun. Biol. (IF 5.9) Pub Date : 2024-04-17 Jiaolei Shangguan, Jinjin Qiao, He Liu, Lei Zhu, Xiaofei Han, Liang Shi, Jing Zhu, Rui Liu, Ang Ren, Mingwen Zhao
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High temperature and humidity in the environment disrupt bile acid metabolism, the gut microbiome, and GLP-1 secretion in mice Commun. Biol. (IF 5.9) Pub Date : 2024-04-17 Song Chen, Zongren Hu, Jianbang Tang, Haipeng Zhu, Yuhua Zheng, Jiedong Xiao, Youhua Xu, Yao Wang, Yi Luo, Xiaoying Mo, Yalan Wu, Jianwen Guo, Yongliang Zhang, Huanhuan Luo
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Genetic barriers more than environmental associations explain Serratia marcescens population structure Commun. Biol. (IF 5.9) Pub Date : 2024-04-17 Lodovico Sterzi, Riccardo Nodari, Federico Di Marco, Maria Laura Ferrando, Francesca Saluzzo, Andrea Spitaleri, Hamed Allahverdi, Stella Papaleo, Simona Panelli, Sara Giordana Rimoldi, Gherard Batisti Biffignandi, Marta Corbella, Annalisa Cavallero, Paola Prati, Claudio Farina, Daniela Maria Cirillo, Gianvincenzo Zuccotti, Claudio Bandi, Francesco Comandatore
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Structural dynamics of Na+ and Ca2+ interactions with full-size mammalian NCX Commun. Biol. (IF 5.9) Pub Date : 2024-04-16 Moshe Giladi, Lukáš Fojtík, Tali Strauss, Benny Da’adoosh, Reuben Hiller, Petr Man, Daniel Khananshvili
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Post-click labeling enables highly accurate single cell analyses of glucose uptake ex vivo and in vivo Commun. Biol. (IF 5.9) Pub Date : 2024-04-16 Masaki Tsuchiya, Nobuhiko Tachibana, Itaru Hamachi
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Co-clustering of EphB6 and ephrinB1 in trans restrains cancer cell invasion Commun. Biol. (IF 5.9) Pub Date : 2024-04-16 Lung-Yu Liang, Niall D. Geoghegan, Michael Mlodzianoski, Andrew Leis, Lachlan W. Whitehead, Minglyanna G. Surudoi, Samuel N. Young, Peter Janes, Doulin Shepherd, Debnath Ghosal, Kelly L. Rogers, James M. Murphy, Isabelle S. Lucet
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The VP53 protein encoded by RNA2 of a fabavirus, broad bean wilt virus 2, is essential for viral systemic infection Commun. Biol. (IF 5.9) Pub Date : 2024-04-16 Myung-Hwi Kim, Boram Choi, Seok-Yeong Jang, Ji-Soo Choi, Sora Kim, Yubin Lee, Suejin Park, Sun-Jung Kwon, Jin-Ho Kang, Jang-Kyun Seo
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Label-free Brillouin endo-microscopy for the quantitative 3D imaging of sub-micrometre biology Commun. Biol. (IF 5.9) Pub Date : 2024-04-15 Salvatore La Cavera, Veeren M. Chauhan, William Hardiman, Mengting Yao, Rafael Fuentes-Domínguez, Kerry Setchfield, Sidahmed A. Abayzeed, Fernando Pérez-Cota, Richard J. Smith, Matt Clark
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Cytoskeletal rearrangement precedes nucleolar remodeling during adipogenesis Commun. Biol. (IF 5.9) Pub Date : 2024-04-15 Evdokiia Potolitsyna, Sarah Hazell Pickering, Aurélie Bellanger, Thomas Germier, Philippe Collas, Nolwenn Briand
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Neural circuits regulating visceral pain Commun. Biol. (IF 5.9) Pub Date : 2024-04-13 Xiaoli Chang, Haiyan Zhang, Shaozong Chen
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Nimble vs. torpid responders to hydration pulse duration among soil microbes Commun. Biol. (IF 5.9) Pub Date : 2024-04-12 Patrick Kut, Ferran Garcia-Pichel
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RORγt inverse agonist TF-S14 inhibits Th17 cytokines and prolongs skin allograft survival in sensitized mice Commun. Biol. (IF 5.9) Pub Date : 2024-04-12 Ahmed Fouda, Mohamed Taoubane Maallah, Araz Kouyoumdjian, Sarita Negi, Steven Paraskevas, Jean Tchervenkov
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New insights into pterosaur cranial anatomy: X-ray imaging reveals palatal structure and evolutionary trends Commun. Biol. (IF 5.9) Pub Date : 2024-04-12 He Chen, Shunxing Jiang, Alexander W. A. Kellner, Xiaolin Wang
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Pseudomonas putida as saviour for troubled Synechococcus elongatus in a synthetic co-culture – interaction studies based on a multi-OMICs approach Commun. Biol. (IF 5.9) Pub Date : 2024-04-12 Franziska Kratzl, Marlene Urban, Jagroop Pandhal, Mengxun Shi, Chen Meng, Karin Kleigrewe, Andreas Kremling, Katharina Pflüger-Grau
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Epidermal retinol dehydrogenases cyclically regulate stem cell markers and clock genes and influence hair composition Commun. Biol. (IF 5.9) Pub Date : 2024-04-12 Kelli R. Goggans, Olga V. Belyaeva, Alla V. Klyuyeva, Jacob Studdard, Aja Slay, Regina B. Newman, Christine A. VanBuren, Helen B. Everts, Natalia Y. Kedishvili
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Life strategy of Antarctic silverfish promote large carbon export in Terra Nova Bay, Ross Sea Commun. Biol. (IF 5.9) Pub Date : 2024-04-11 Clara Manno, Erica Carlig, Pier Paolo Falco, Pasquale Castagno, Giorgio Budillon
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Glutamate production from aerial nitrogen using the nitrogen-fixing bacterium Klebsiella oxytoca Commun. Biol. (IF 5.9) Pub Date : 2024-04-11 Daisuke Yoshidome, Makoto Hidaka, Toka Miyanaga, Yusuke Ito, Saori Kosono, Makoto Nishiyama
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A unified analysis of evolutionary and population constraint in protein domains highlights structural features and pathogenic sites Commun. Biol. (IF 5.9) Pub Date : 2024-04-11 Stuart A. MacGowan, Fábio Madeira, Thiago Britto-Borges, Geoffrey J. Barton
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An abundant bacterial phylum with nitrite-oxidizing potential in oligotrophic marine sediments Commun. Biol. (IF 5.9) Pub Date : 2024-04-11 Rui Zhao, Steffen L. Jørgensen, Andrew R. Babbin
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Zyxin is important for the stability and function of podocytes, especially during mechanical stretch Commun. Biol. (IF 5.9) Pub Date : 2024-04-11 Felix Kliewe, Florian Siegerist, Elke Hammer, Jaafar Al-Hasani, Theodor Rolf Jakob Amling, Jonas Zeno Eddy Hollemann, Maximilian Schindler, Vedran Drenic, Stefan Simm, Kerstin Amann, Christoph Daniel, Maja Lindenmeyer, Markus Hecker, Uwe Völker, Nicole Endlich
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Insights into the molecular mechanism of yellow cuticle coloration by a chitin-binding carotenoprotein in gregarious locusts Commun. Biol. (IF 5.9) Pub Date : 2024-04-11 Nikita A. Egorkin, Eva E. Dominnik, Eugene G. Maksimov, Nikolai N. Sluchanko
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An in vitro CRISPR screen of cell-free DNA identifies apoptosis as the primary mediator of cell-free DNA release Commun. Biol. (IF 5.9) Pub Date : 2024-04-10 Brad. A. Davidson, Adam X. Miranda, Sarah C. Reed, Riley E. Bergman, Justin D. J. Kemp, Anvith P. Reddy, Morgan V. Pantone, Ethan K. Fox, R. Dixon Dorand, Paula J. Hurley, Sarah Croessmann, Ben Ho Park
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Microtubule polarity determines the lineage of embryonic neural precursor in zebrafish spinal cord Commun. Biol. (IF 5.9) Pub Date : 2024-04-10 Clément-Alexis Richard, Carole Seum, Marcos Gonzalez-Gaitan
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Bioluminescence imaging of Cyp1a1-luciferase reporter mice demonstrates prolonged activation of the aryl hydrocarbon receptor in the lung Commun. Biol. (IF 5.9) Pub Date : 2024-04-10 Nicolas Veland, Hannah J. Gleneadie, Karen E. Brown, Alessandro Sardini, Joaquim Pombo, Andrew Dimond, Vanessa Burns, Karen Sarkisyan, Chris Schiering, Zoe Webster, Matthias Merkenschlager, Amanda G. Fisher
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Revealing myopathy spectrum: integrating transcriptional and clinical features of human skeletal muscles with varying health conditions Commun. Biol. (IF 5.9) Pub Date : 2024-04-10 Huahua Zhong, Veronica Sian, Mridul Johari, Shintaro Katayama, Ali Oghabian, Per Harald Jonson, Peter Hackman, Marco Savarese, Bjarne Udd
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Contribution of host species and pathogen clade to snake fungal disease hotspots in Europe Commun. Biol. (IF 5.9) Pub Date : 2024-04-10 Gaëlle Blanvillain, Jeffrey M. Lorch, Nicolas Joudrier, Stanislaw Bury, Thibault Cuenot, Michael Franzen, Fernando Martínez-Freiría, Gaëtan Guiller, Bálint Halpern, Aleksandra Kolanek, Katarzyna Kurek, Olivier Lourdais, Alix Michon, Radka Musilová, Silke Schweiger, Barbara Szulc, Sylvain Ursenbacher, Oleksandr Zinenko, Joseph R. Hoyt
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Genetic associations of risk behaviours and educational achievement Commun. Biol. (IF 5.9) Pub Date : 2024-04-10 Michelle Arellano Spano, Tim T. Morris, Neil M. Davies, Amanda Hughes
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Cranial functional specialisation for strength precedes morphological evolution in Oviraptorosauria Commun. Biol. (IF 5.9) Pub Date : 2024-04-10 Luke E. Meade, Michael Pittman, Amy Balanoff, Stephan Lautenschlager
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State-dependent binding of cholesterol and an anionic lipid to the muscle-type Torpedo nicotinic acetylcholine receptor Commun. Biol. (IF 5.9) Pub Date : 2024-04-10 Anna Ananchenko, Rui Yan Gao, François Dehez, John E. Baenziger
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Probiotics reshape the coral microbiome in situ without detectable off-target effects in the surrounding environment Commun. Biol. (IF 5.9) Pub Date : 2024-04-09 Nathalia Delgadillo-Ordoñez, Neus Garcias-Bonet, Inês Raimundo, Francisca C. García, Helena Villela, Eslam O. Osman, Erika P. Santoro, Joao Curdia, Joao G. D. Rosado, Pedro Cardoso, Ahmed Alsaggaf, Adam Barno, Chakkiath Paul Antony, Carolina Bocanegra, Michael L. Berumen, Christian R. Voolstra, Francesca Benzoni, Susana Carvalho, Raquel S. Peixoto
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Vaccine-elicited IL-1R signaling results in Th17 TRM-mediated immunity Commun. Biol. (IF 5.9) Pub Date : 2024-04-09 Joseph P. Hoffmann, Akhilesh Srivastava, Haoran Yang, Naoki Iwanaga, T. Parks Remcho, Jenny L. Hewes, Rayshma Sharoff, Kejing Song, Elizabeth B. Norton, Jay K. Kolls, Janet E. McCombs
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PPARγ alleviates preeclampsia development by regulating lipid metabolism and ferroptosis Commun. Biol. (IF 5.9) Pub Date : 2024-04-09 Weisi Lai, Ling Yu, Yali Deng
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Pancreatic cancer-associated fibroblasts modulate macrophage differentiation via sialic acid-Siglec interactions Commun. Biol. (IF 5.9) Pub Date : 2024-04-09 Kelly Boelaars, Ernesto Rodriguez, Zowi R. Huinen, Chang Liu, Di Wang, Babet O. Springer, Katarzyna Olesek, Laura Goossens-Kruijssen, Thomas van Ee, Dimitri Lindijer, Willemijn Tak, Aram de Haas, Laetitia Wehry, Joline P. Nugteren-Boogaard, Aleksandra Mikula, Charlotte M. de Winde, Reina E. Mebius, David A. Tuveson, Elisa Giovannetti, Maarten F. Bijlsma, Manfred Wuhrer, Sandra J. van Vliet, Yvette
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A genome-wide association study provides insights into the genetic etiology of 57 essential and non-essential trace elements in humans Commun. Biol. (IF 5.9) Pub Date : 2024-04-09 Marta R. Moksnes, Ailin F. Hansen, Brooke N. Wolford, Laurent F. Thomas, Humaira Rasheed, Anica Simić, Laxmi Bhatta, Anne Lise Brantsæter, Ida Surakka, Wei Zhou, Per Magnus, Pål R. Njølstad, Ole A. Andreassen, Tore Syversen, Jie Zheng, Lars G. Fritsche, David M. Evans, Nicole M. Warrington, Therese H. Nøst, Bjørn Olav Åsvold, Trond Peder Flaten, Cristen J. Willer, Kristian Hveem, Ben M. Brumpton
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Visualizing subcellular changes in the NAD(H) pool size versus redox state using fluorescence lifetime imaging microscopy of NADH Commun. Biol. (IF 5.9) Pub Date : 2024-04-09 Angela Song, Nicole Zhao, Diana C. Hilpert, Caroline Perry, Joseph A. Baur, Douglas C. Wallace, Patrick M. Schaefer
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Hot springs viruses at Yellowstone National Park have ancient origins and are adapted to thermophilic hosts Commun. Biol. (IF 5.9) Pub Date : 2024-04-09 L. Felipe Benites, Timothy G. Stephens, Julia Van Etten, Timeeka James, William C. Christian, Kerrie Barry, Igor V. Grigoriev, Timothy R. McDermott, Debashish Bhattacharya
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Dynamic molecular network analysis of iPSC-Purkinje cells differentiation delineates roles of ISG15 in SCA1 at the earliest stage Commun. Biol. (IF 5.9) Pub Date : 2024-04-09 Hidenori Homma, Yuki Yoshioka, Kyota Fujita, Shinichi Shirai, Yuka Hama, Hajime Komano, Yuko Saito, Ichiro Yabe, Hideyuki Okano, Hidenao Sasaki, Hikari Tanaka, Hitoshi Okazawa
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Targeting TRIP13 in favorable histology Wilms tumor with nuclear export inhibitors synergizes with doxorubicin Commun. Biol. (IF 5.9) Pub Date : 2024-04-08 Karuna Mittal, Garrett W. Cooper, Benjamin P. Lee, Yongdong Su, Katie T. Skinner, Jenny Shim, Hunter C. Jonus, Won Jun Kim, Mihir Doshi, Diego Almanza, Bryan D. Kynnap, Amanda L. Christie, Xiaoping Yang, Glenn S. Cowley, Brittaney A. Leeper, Christopher L. Morton, Bhakti Dwivedi, Taylor Lawrence, Manali Rupji, Paula Keskula, Stephanie Meyer, Catherine M. Clinton, Manoj Bhasin, Brian D. Crompton, Yuen-Yi
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A single-cell atlas of lung homeostasis reveals dynamic changes during development and aging Commun. Biol. (IF 5.9) Pub Date : 2024-04-08 Hao Jia, Yuan Chang, Yulin Chen, Xiao Chen, Hang Zhang, Xiumeng Hua, Mengda Xu, Yixuan Sheng, Ningning Zhang, Hao Cui, Lei Han, Jian Zhang, Xiaodong Fu, Jiangping Song
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Klebsiella pneumoniae peptide hijacks a Streptococcus pneumoniae permease to subvert pneumococcal growth and colonization Commun. Biol. (IF 5.9) Pub Date : 2024-04-08 Janine Lux, Hannah Portmann, Lucía Sánchez García, Maria Erhardt, Lalaina Holivololona, Laura Laloli, Manon F. Licheri, Clement Gallay, Robert Hoepner, Nicholas J. Croucher, Daniel Straume, Jan-Willem Veening, Ronald Dijkman, Manfred Heller, Denis Grandgirard, Stephen L. Leib, Lucy J. Hathaway
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A cyclical switch of gametogenic pathways in hybrids depends on the ploidy level Commun. Biol. (IF 5.9) Pub Date : 2024-04-08 Dmitrij Dedukh, Anatolie Marta, Ra-Yeon Myung, Myeong-Hun Ko, Da-Song Choi, Yong-Jin Won, Karel Janko
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High microbiome and metabolome diversification in coexisting sponges with different bio-ecological traits Commun. Biol. (IF 5.9) Pub Date : 2024-04-08 Valerio Mazzella, Antonio Dell’Anno, Néstor Etxebarría, Belén González-Gaya, Genoveffa Nuzzo, Angelo Fontana, Laura Núñez-Pons
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Functional and structural reorganization in brain tumors: a machine learning approach using desynchronized functional oscillations Commun. Biol. (IF 5.9) Pub Date : 2024-04-06 Joan Falcó-Roget, Alberto Cacciola, Fabio Sambataro, Alessandro Crimi
Neuroimaging studies have allowed for non-invasive mapping of brain networks in brain tumors. Although tumor core and edema are easily identifiable using standard MRI acquisitions, imaging studies often neglect signals, structures, and functions within their presence. Therefore, both functional and diffusion signals, as well as their relationship with global patterns of connectivity reorganization
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Synaptic ribbon dynamics after noise exposure in the hearing cochlea Commun. Biol. (IF 5.9) Pub Date : 2024-04-06 Noura Ismail Mohamad, Peu Santra, Yesai Park, Ian R. Matthews, Emily Taketa, Dylan K. Chan
Moderate noise exposure induces cochlear synaptopathy, the loss of afferent ribbon synapses between cochlear hair cells and spiral ganglion neurons, which is associated with functional hearing decline. Prior studies have demonstrated noise-induced changes in the distribution and number of synaptic components, but the dynamic changes that occur after noise exposure have not been directly visualized
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A multi-ancestry GWAS of Fuchs corneal dystrophy highlights the contributions of laminins, collagen, and endothelial cell regulation Commun. Biol. (IF 5.9) Pub Date : 2024-04-06 Bryan R. Gorman, Michael Francis, Cari L. Nealon, Christopher W. Halladay, Nalvi Duro, Kyriacos Markianos, Giulio Genovese, Pirro G. Hysi, Hélène Choquet, Natalie A. Afshari, Yi-Ju Li, J. Michael Gaziano, Adriana M. Hung, Wen-Chih Wu, Paul B. Greenberg, Saiju Pyarajan, Jonathan H. Lass, Neal S. Peachey, Sudha K. Iyengar
Fuchs endothelial corneal dystrophy (FECD) is a leading indication for corneal transplantation, but its molecular etiology remains poorly understood. We performed genome-wide association studies (GWAS) of FECD in the Million Veteran Program followed by multi-ancestry meta-analysis with the previous largest FECD GWAS, for a total of 3970 cases and 333,794 controls. We confirm the previous four loci
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Distinct forms of structural plasticity of adult-born interneuron spines in the mouse olfactory bulb induced by different odor learning paradigms Commun. Biol. (IF 5.9) Pub Date : 2024-04-06 Aymeric Ferreira, Vlad-Stefan Constantinescu, Sarah Malvaut, Armen Saghatelyan, Simon V. Hardy
The morpho-functional properties of neural networks constantly adapt in response to environmental stimuli. The olfactory bulb is particularly prone to constant reshaping of neural networks because of ongoing neurogenesis. It remains unclear whether the complexity of distinct odor-induced learning paradigms and sensory stimulation induces different forms of structural plasticity. In the present study
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Elevated glucocorticoid alters the developmental dynamics of hypothalamic neurogenesis in zebrafish Commun. Biol. (IF 5.9) Pub Date : 2024-04-05 Helen Eachus, Min-Kyeung Choi, Anna Tochwin, Johanna Kaspareit, May Ho, Soojin Ryu
Exposure to excess glucocorticoid (GC) during early development is implicated in adult dysfunctions. Reduced adult hippocampal neurogenesis is a well-known consequence of exposure to early life stress or elevated GC, however the effects on neurogenesis during development and effects on other brain regions are not well understood. Using an optogenetic zebrafish model, here we analyse the effects of
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Catalytic-dependent and -independent roles of TET3 in the regulation of specific genetic programs during neuroectoderm specification Commun. Biol. (IF 5.9) Pub Date : 2024-04-05 Harmony C. Ketchum, Masako Suzuki, Meelad M. Dawlaty
The ten-eleven-translocation family of proteins (TET1/2/3) are epigenetic regulators of gene expression. They regulate genes by promoting DNA demethylation (i.e., catalytic activity) and by partnering with regulatory proteins (i.e., non-catalytic functions). Unlike Tet1 and Tet2, Tet3 is not expressed in mouse embryonic stem cells (ESCs) but is induced upon ESC differentiation. However, the significance
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Mechano-sensitivity of β2-adrenoceptors enhances constitutive activation of cAMP generation that is inhibited by inverse agonists Commun. Biol. (IF 5.9) Pub Date : 2024-04-05 Sean A. Cullum, Simon Platt, Natasha Dale, Oliver C. Isaac, Edward S. Wragg, Mark Soave, Dmitry B. Veprintsev, Jeanette Woolard, Laura E. Kilpatrick, Stephen J. Hill
The concept of agonist-independent signalling that can be attenuated by inverse agonists is a fundamental element of the cubic ternary complex model of G protein-coupled receptor (GPCR) activation. This model shows how a GPCR can exist in two conformational states in the absence of ligands; an inactive R state and an active R* state that differ in their affinities for agonists, inverse agonists, and
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Unsupervised deep representation learning enables phenotype discovery for genetic association studies of brain imaging Commun. Biol. (IF 5.9) Pub Date : 2024-04-05 Khush Patel, Ziqian Xie, Hao Yuan, Sheikh Muhammad Saiful Islam, Yaochen Xie, Wei He, Wanheng Zhang, Assaf Gottlieb, Han Chen, Luca Giancardo, Alexander Knaack, Evan Fletcher, Myriam Fornage, Shuiwang Ji, Degui Zhi
Understanding the genetic architecture of brain structure is challenging, partly due to difficulties in designing robust, non-biased descriptors of brain morphology. Until recently, brain measures for genome-wide association studies (GWAS) consisted of traditionally expert-defined or software-derived image-derived phenotypes (IDPs) that are often based on theoretical preconceptions or computed from
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Resilience to periodic disturbances and the long-term genetic stability in Acropora coral Commun. Biol. (IF 5.9) Pub Date : 2024-04-04 L. Thomas, D. Şahin, A. S. Adam, C. M. Grimaldi, N. M. Ryan, S. L. Duffy, J. N. Underwood, W. J. Kennington, J. P. Gilmour
Climate change is restructuring natural ecosystems. The direct impacts of these events on biodiversity and community structure are widely documented, but the impacts on the genetic variation of populations remains largely unknown. We monitored populations of Acropora coral on a remote coral reef system in northwest Australia for two decades and through multiple cycles of impact and recovery. We combined