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Transfer and fates of damaged mitochondria: role in health and disease FEBS J. (IF 5.4) Pub Date : 2024-03-28 Hanbing Li, Weiyun Sun, Wenwen Gong, Yubing Han
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An efficient peptide ligase engineered from a bamboo asparaginyl endopeptidase FEBS J. (IF 5.4) Pub Date : 2024-03-25 Xin-Bo Wang, Cong-Hui Zhang, Teng Zhang, Hao-Zheng Li, Ya-Li Liu, Zeng-Guang Xu, Gang Lei, Chun-Ju Cai, Zhan-Yun Guo
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Unraveling the peculiarities and development of novel inhibitors of leishmanial arginyl-tRNA synthetase FEBS J. (IF 5.4) Pub Date : 2024-03-25 Fouzia Nasim, Muppidi Shravan Kumar, Mallika Alvala, Insaf Ahmed Qureshi
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A novel pathological mutant reveals the role of torsional flexibility in the serpin breach in adoption of an aggregation-prone intermediate FEBS J. (IF 5.4) Pub Date : 2024-03-24 Kamila Kamuda, Riccardo Ronzoni, Avik Majumdar, Fiona H. X. Guan, James A. Irving, David A. Lomas
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Fusion–fission–mitophagy cycling and metabolic reprogramming coordinate nerve growth factor (NGF)-dependent neuronal differentiation FEBS J. (IF 5.4) Pub Date : 2024-02-16 Ilaria Goglia, Ewelina Węglarz-Tomczak, Claudio Gioia, Yanhua Liu, Assunta Virtuoso, Marcella Bonanomi, Daniela Gaglio, Noemi Salmistraro, Ciro De Luca, Michele Papa, Lilia Alberghina, Hans V. Westerhoff, Anna Maria Colangelo
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Structure, cooperativity and inhibition of the inosine 5′-monophosphate-specific phosphatase from Saccharomyces cerevisiae FEBS J. (IF 5.4) Pub Date : 2024-02-16 Sujeong Byun, Changkon Park, Jeong-Yong Suh, Claus-Peter Witte, Sangkee Rhee
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Non-canonical amino acids uncover the significant impact of Tyr671 on Taq DNA polymerase catalytic activity FEBS J. (IF 5.4) Pub Date : 2024-02-16 Wanyi Chen, Binbin Chen, Xinjia Li, Gang Xu, Lirong Yang, Jianping Wu, Haoran Yu
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Myosin heavy chain-perinatal regulates skeletal muscle differentiation, oxidative phenotype and regeneration FEBS J. (IF 5.4) Pub Date : 2024-02-15 Akashi Sharma, Aatifa Zehra, Sam J. Mathew
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Mitochondrial dysfunction and cisplatin sensitivity in gastric cancer: GDF15 as a master player FEBS J. (IF 5.4) Pub Date : 2024-02-13 Maria Cavinato
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Calcium-induced structural transitions are central to the folding, function, and processing of serratiopeptidase zymogen into mature form FEBS J. (IF 5.4) Pub Date : 2024-02-13 Vishal Srivastava, Sheetal Bandhu, Shivam Mishra, Tapan K. Chaudhuri
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Intrinsically disordered Pseudomonas chaperone FapA slows down the fibrillation of major biofilm-forming functional amyloid FapC FEBS J. (IF 5.4) Pub Date : 2024-02-13 Chang-Hyeock Byeon, Kasper Holst Hansen, Jasper Jeffrey, Hakan Saricayir, Maria Andreasen, Ümit Akbey
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PHGDH knockdown increases sensitivity to SR1, an aryl hydrocarbon receptor antagonist, in colorectal cancer by activating the autophagy pathway FEBS J. (IF 5.4) Pub Date : 2024-02-05 Hong-Ming Li, Xiang Li, Ran Xia, Xing Zhang, Tong-Zhao Jin, Hong-Sheng Zhang
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Enhanced translocation of TRIM32 to mitochondria sensitizes dopaminergic neuronal cells to apoptosis during stress conditions in Parkinson's disease FEBS J. (IF 5.4) Pub Date : 2024-02-05 Shanikumar Goyani, Anjali Shinde, Shatakshi Shukla, M. V. Saranga, Fatema Currim, Minal Mane, Jyoti Singh, Milton Roy, Dhruv Gohel, Nisha Chandak, Hitesh Vasiyani, Rajesh Singh
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Translation regulation in response to stress FEBS J. (IF 5.4) Pub Date : 2024-02-03 Thomas D. Williams, Adrien Rousseau
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Anchoring of hyaluronan glycocalyx to CD44 reduces sensitivity of HER2-positive gastric cancer cells to trastuzumab FEBS J. (IF 5.4) Pub Date : 2024-01-26 Si Chen, Guoliang Zhang, Yiwen Liu, Cuixia Yang, Yiqing He, Qian Guo, Yan Du, Feng Gao
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Trypsin-induced aggregation of transthyretin Valine 30 variants associated with hereditary amyloidosis FEBS J. (IF 5.4) Pub Date : 2024-01-25 Mineyuki Mizuguchi, Takayuki Obita, Seiya Yamada, Yuko Nabeshima
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Crosstalk between inflammasome sensors and DNA damage response pathways FEBS J. (IF 5.4) Pub Date : 2024-01-25 Delphine Burlet, Anne-Laure Huber, Agnès Tissier, Virginie Petrilli
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Loop 6 and the β-hairpin flap are structural hotspots that determine cofactor specificity in the FMN-dependent family of ene-reductases FEBS J. (IF 5.4) Pub Date : 2024-01-24 Bianca Kerschbaumer, Massimo G. Totaro, Michael Friess, Rolf Breinbauer, Aleksandar Bijelic, Peter Macheroux
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Citric acid promotes SPARC release in pancreatic cancer cells and inhibits the progression of pancreatic tumors in mice on a high-fat diet FEBS J. (IF 5.4) Pub Date : 2024-01-20 Guohui Xiao, Yan Wei, Rongli Xie, Yiusing Tsang, Jianhua Gu, Dongjie Shen, Min Ding, Jianming Yuan, Dan Xu, Jian Fei
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Ophthalmic acid is a glutathione regulating tripeptide FEBS J. (IF 5.4) Pub Date : 2024-01-20 Bauke V. Schomakers, Sonia L. Jillings, Michel van Weeghel, Frédéric M. Vaz, Gajja S. Salomons, Georges E. Janssens, Riekelt H. Houtkooper
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FTO protein regulates the TGF-β signalling pathway through RNA N6-methyladenosine modification to induce unexplained recurrent spontaneous abortion FEBS J. (IF 5.4) Pub Date : 2024-01-20 Jun Zhang, Xinqiong Liu, Yali Gao
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Site 1 protease aggravates acute kidney injury by promoting tubular epithelial cell ferroptosis through SIRT3-SOD2-mtROS signaling FEBS J. (IF 5.4) Pub Date : 2024-01-19 Shiying Xie, Wei Zou, Sirui Liu, Qinglan Yang, Tiantian Hu, Wei-ping Zhu, Hua Tang, Cheng Wang
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Responses of animals and plants to physiological doses of ethanol: a molecular messenger of hypoxia? FEBS J. (IF 5.4) Pub Date : 2024-01-17 Alice Diot, Georg Groth, Simon Blanchet, Christian Chervin
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CREB3L1/OASIS: cell cycle regulator and tumor suppressor FEBS J. (IF 5.4) Pub Date : 2024-01-12 Atsushi Saito, Issei Omura, Kazunori Imaizumi
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CD74–ROS1 L2026M mutant enhances autophagy through the MEK/ERK pathway to promote invasion, metastasis and crizotinib resistance in non-small cell lung cancer cells FEBS J. (IF 5.4) Pub Date : 2023-12-26 Xiaobo Xu, Ye Li, Rui Xu, Yuting Meng, Zengqiang Li, Daiying Zuo, Yingliang Wu
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A guide to single-cell RNA sequencing analysis using web-based tools for non-bioinformatician FEBS J. (IF 5.4) Pub Date : 2023-12-26 Sagnik Yarlagadda, Todd D. Giorgio
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Mutations at proximal cysteine residues in PML impair ATO binding by destabilizing the RBCC domain FEBS J. (IF 5.4) Pub Date : 2023-12-21 Suchita Dubey, Neha Mishra, Rohan Shelke, Ashok K. Varma
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Characterization and structural study of a novel β-N-acetylgalactosaminidase from Niabella aurantiaca FEBS J. (IF 5.4) Pub Date : 2023-12-21 Eduardo Sebastian Moreno Prieto, Sune Fjermedal, Suzana Siebenhaar, Marlène Vuillemin, Jesper Holck, Renaud Vincentelli, Garry P. Gippert, Casper Wilkens, Jens Preben Morth, Bernard Henrissat
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The flavodiiron protein from Syntrophomonas wolfei has five domains and acts both as an NADH:O2 or an NADH:H2O2 oxidoreductase FEBS J. (IF 5.4) Pub Date : 2023-12-21 Maria C. Martins, Catarina M. Alves, Miguel Teixeira, Filipe Folgosa
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Ser38-His93-Asn91 triad confers resistance of JFH1 HCV NS5A-Y93H variant to NS5A inhibitors FEBS J. (IF 5.4) Pub Date : 2023-12-20 Wei-Ping Lee, Keng-Chang Tsai, Shi-Xian Liao, Yi-Hsiang Huang, Ming-Chih Hou, Keng-Hsin Lan
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Alpha-synuclein promotes PRMT5-mediated H4R3me2s histone methylation by interacting with the BAF complex FEBS J. (IF 5.4) Pub Date : 2023-12-17 Takaaki Nakamura, Naoto Sugeno, Takafumi Hasegawa, Kensho Ikeda, Shun Yoshida, Shun Ishiyama, Kazuki Sato, Atsushi Takeda, Masashi Aoki
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Circular RNA-circLRP6 protects cardiomyocyte from hypoxia-induced apoptosis by facilitating hnRNPM-mediated expression of FGF-9 FEBS J. (IF 5.4) Pub Date : 2023-12-17 Wei Ding, Lin Ding, Yijian Lu, Weihan Sun, Yu Wang, Jianxun Wang, Yufang Gao, Mengyang Li
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Atypical activation of the RNA sensor MDA5 by hepatitis C virus FEBS J. (IF 5.4) Pub Date : 2023-12-15 Surajit Chakraborty, Junji Zhu, Michaela U. Gack
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Chimeric and mutant CARD9 constructs enable analyses of conserved and diverged autoinhibition mechanisms in the CARD-CC protein family FEBS J. (IF 5.4) Pub Date : 2023-12-14 Jens Staal, Yasmine Driege, Femke Van Gaever, Jill Steels, Rudi Beyaert
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Trypanosoma cruzi heme responsive gene (TcHRG) plays a central role in orchestrating heme uptake in epimastigotes FEBS J. (IF 5.4) Pub Date : 2023-12-13 Evelyn Tevere, Cecilia Beatriz Di Capua, Nathan Michael Chasen, Ronald Drew Etheridge, Julia Alejandra Cricco
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HB-EGF promotes progenitor cell proliferation and sensory neuron regeneration in the zebrafish olfactory epithelium FEBS J. (IF 5.4) Pub Date : 2023-12-13 Siran Sireci, Yigit Kocagöz, Aysu Sevval Alkiraz, Kardelen Güler, Zeynep Dokuzluoglu, Ecem Balcioglu, Sinem Meydanli, Mehmet Can Demirler, Nuray Sögünmez Erdogan, Stefan Herbert Fuss
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Sequence differences between BAX and BAK core domains manifest as differences in their interactions with lipids FEBS J. (IF 5.4) Pub Date : 2023-12-13 Michelle S. Miller, Angus D. Cowan, Jason M. Brouwer, Sean T. Smyth, Liuyu Peng, Ahmad Z. Wardak, Rachel T. Uren, Cindy Luo, Michael J. Roy, Sayali Shah, Ziwen Tan, Gavin E. Reid, Peter M. Colman, Peter E. Czabotar
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The crystal structure of RsSymEG1 reveals a unique form of smaller GH7 endoglucanases alongside GH7 cellobiohydrolases in protist symbionts of termites FEBS J. (IF 5.4) Pub Date : 2023-12-10 Topi Haataja, Henrik Hansson, Shigeharu Moriya, Mats Sandgren, Jerry Ståhlberg
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Fibrillation of α-synuclein triggered by bacterial endotoxin and lipid vesicles is modulated by N-terminal acetylation and familial Parkinson's disease mutations FEBS J. (IF 5.4) Pub Date : 2023-12-08 José Raphael Monteiro Neto, Vanderlei de Araújo Lima, Cristian Follmer
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Store-operated calcium entry inhibits primary ciliogenesis via the activation of Aurora A FEBS J. (IF 5.4) Pub Date : 2023-12-04 Yi-Shyun Lai, Ta-Wei Chan, Thi My Hang Nguyen, Tzu-Chien Lin, Yu-Ying Chao, Chia-Yih Wang, Liang-Yi Hung, Shaw-Jenq Tsai, Wen-Tai Chiu
The primary cilium is an antenna-like organelle protruding from the cell surface that can detect physical and chemical stimuli in the extracellular space to activate specific signaling pathways and downstream gene expressions. Calcium ion (Ca2+) signaling regulates a wide spectrum of cellular processes, including fertilization, proliferation, differentiation, muscle contraction, migration and death
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miR-93 and synaptotagmin-7: two novel players in the regulation of autophagy during cardiac hypertrophy FEBS J. (IF 5.4) Pub Date : 2023-12-01 Maurizio Forte, Gianmarco Sarto, Sebastiano Sciarretta
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Deciphering the structure and mechanism-of-action of computer-designed mastoparan peptides FEBS J. (IF 5.4) Pub Date : 2023-11-24 Karen G. N. Oshiro, Carlos D. P. Freitas, Samilla B. Rezende, Raquel M. Q. Orozco, Lai Y. Chan, Nicole Lawrence, Luciano M. Lião, Maria L. R. Macedo, David J. Craik, Marlon H. Cardoso, Octávio L. Franco
Mastoparans are cationic peptides with multifunctional pharmacological properties. Mastoparans-R1 and R4 were computationally designed based on native mastoparan-L from wasps and have improved therapeutic potential for the control of bacterial infections. Here, we evaluated whether these peptides maintain their activity against Escherichia coli strains under a range of salt concentrations. We found
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Hydrolytic activity of yeast oligosaccharyltransferase is enhanced when misfolded proteins accumulate in the endoplasmic reticulum FEBS J. (IF 5.4) Pub Date : 2023-11-24 Sheng-Tao Li, Hiroto Hirayama, Chengcheng Huang, Tsugiyo Matsuda, Ritsuko Oka, Takahiro Yamasaki, Daisuke Kohda, Tadashi Suzuki
It is known that oligosaccharyltransferase (OST) has hydrolytic activity towards dolichol-linked oligosaccharides, which results in the formation of free N-glycans (FNGs), i.e. unconjugated oligosaccharides with structural features similar to N-glycans. The functional importance of this hydrolytic reaction, however, remains unknown. In this study, the hydrolytic activity of OST was characterized in
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Gasdermin-B (GSDMB) takes center stage in antibacterial defense, inflammatory diseases, and cancer FEBS J. (IF 5.4) Pub Date : 2023-11-23 David Sarrio, Sara Colomo, Gema Moreno-Bueno
One of the hottest topics in biomedical research is to decipher the functional implications of the Gasdermin (GSDM) protein family in human pathologies. These proteins are the key effectors of a lytic and pro-inflammatory cell death type termed pyroptosis (also known as “Gasdermin-mediated programmed cell death”). However, ever-growing evidence showed that GSDMs can play multiple and complex roles
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Molecular characterization of the craniosynostosis-associated interleukin-11 receptor variants p.T306_S308dup and p.E364_V368del FEBS J. (IF 5.4) Pub Date : 2023-11-22 Birte Kespohl, Anna-Lena Hegele, Stefan Düsterhöft, Hans Bakker, Falk F. R. Buettner, Roland Hartig, Juliane Lokau, Christoph Garbers
Interleukin-11 (IL-11) is a member of the IL-6 family of cytokines and is an important factor for bone homeostasis. IL-11 binds to and signals via the membrane-bound IL-11 receptor (IL-11R, classic signaling) or soluble forms of the IL-11R (sIL-11R, trans-signaling). Mutations in the IL11RA gene, which encodes the IL-11R, are associated with craniosynostosis, a human condition in which one or several
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The Crosstalk between ILC3s and Adaptive Immunity in Diseases FEBS J. (IF 5.4) Pub Date : 2023-11-22 Wenyan Wang, Na Li, Xiaohuan Guo
RORγt+ group 3 innate lymphoid cells (ILC3s), the innate counterpart of Th17 cells, are enriched in the mucosal area and lymphoid tissues. ILC3s interact with a variety of cells through their effector molecules and play an important role in the host defense against a spectrum of infections. Recent studies suggest that the extensive crosstalk between ILC3s and adaptive immune cells, especially T cells
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RRM1 and PAB domains of translation initiation factor eIF4G (Tif4631p), play a crucial role in the nuclear degradation of export-defective mRNAs in Saccharomyces cerevisiae FEBS J. (IF 5.4) Pub Date : 2023-11-22 Upasana Saha, Rajlaxmi Gaine, Sunirmal Paira, Satarupa Das, Biswadip Das
In Saccharomyces cerevisiae, the CTEXT complex consisting of Cbc1/2p, Tif4631p, and Upf3p promotes the exosomal degradation of aberrantly long 3′-extended, export-defective transcripts and a small group of normal (dubbed ‘special’) mRNAs. We carried out a systematic analysis of all previously characterized functional domains of the major CTEXT component Tif4631p by deleting each of them and interrogating
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Correction FEBS J. (IF 5.4) Pub Date : 2023-11-23
Correction to “Linear ubiquitination improves NFAT1 protein stability and facilitates NFAT1 signalling in Kawasaki disease”. Ying Miao, Guanghui Qian, Renxia Zhang, Yukang Yuan, Yibo Zuo, Yueyue Ding, Xuan Li, Yunjia Tang, Hui Zheng, Haitao Lv (2023) Linear ubiquitination improves NFAT1 protein stability and facilitates NFAT1 signalling in Kawasaki disease. FEBS J 290: 4224–4237. https://doi.org/10
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Expression of Concern: Curcumin upregulates phosphatase and tensin homologue deleted on chromosome 10 through microRNA-mediated control of DNA methylation—a novel mechanism suppressing liver fibrosis FEBS J. (IF 5.4) Pub Date : 2023-11-21
This Expression of Concern relates to Ref. [1], published online on 21 October 2013, in Wiley Online Library (wileyonlinelibrary.com), and has been published by agreement between the journal's Editor-in-Chief, Seamus Martin, and John Wiley & Sons Ltd. The Expression of Concern relates to unusual similarities between some of the western blot data contained in the manuscript (DNMT3b probes within Fig
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Gasdermin-B (GSDMB) takes center stage in antibacterial defense, inflammatory diseases, and cancer FEBS J. (IF 5.4) Pub Date : 2023-11-23 David Sarrio, Sara Colomo, Gema Moreno-Bueno
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The chemokines CCL5 and CXCL12 exhibit high-affinity binding to N-terminal peptides of the non-cognate receptors CXCR4 and CCR5, respectively FEBS J. (IF 5.4) Pub Date : 2023-11-23 Naama Kessler, Sabine R. Akabayov, Leah S. Cohen, Tali Scherf, Fred Naider, Jacob Anglister
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Genetic mechanisms of multiciliated cell development: from fate choice to differentiation in zebrafish and other models FEBS J. (IF 5.4) Pub Date : 2023-11-23 Hannah M. Wesselman, Liana Arceri, Thanh Khoa Nguyen, Caroline M. Lara, Rebecca A. Wingert
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The chemokines CCL5 and CXCL12 exhibit high-affinity binding to N-terminal peptides of the non-cognate receptors CXCR4 and CCR5, respectively FEBS J. (IF 5.4) Pub Date : 2023-11-23 Naama Kessler, Sabine R. Akabayov, Leah S. Cohen, Tali Scherf, Fred Naider, Jacob Anglister
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Molecular characterization of the craniosynostosis-associated interleukin-11 receptor variants p.T306_S308dup and p.E364_V368del FEBS J. (IF 5.4) Pub Date : 2023-11-22 Birte Kespohl, Anna-Lena Hegele, Stefan Düsterhöft, Hans Bakker, Falk F. R. Buettner, Roland Hartig, Juliane Lokau, Christoph Garbers
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The crosstalk between ILC3s and adaptive immunity in diseases FEBS J. (IF 5.4) Pub Date : 2023-11-22 Wenyan Wang, Na Li, Xiaohuan Guo
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The biophysical and compositional properties of human basement membranes FEBS J. (IF 5.4) Pub Date : 2023-11-20 Monica S. Schoenenberger, Willi Halfter, Alexia Ferrand, Kathrin Halfter, Alexandar Tzankov, Hendrik P. N. Scholl, Paul Bernhard Henrich, Christophe A. Monnier
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Butyrate functions as a histone deacetylase inhibitor to protect pancreatic beta cells from IL-1β-induced dysfunction FEBS J. (IF 5.4) Pub Date : 2023-11-20 Signe Schultz Pedersen, Lars Roed Ingerslev, Mathias Olsen, Michala Prause, Nils Billestrup
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OPTN gene therapy increases autophagy and protects mitochondria in SOD1-G93A-expressing transgenic mice and cells FEBS J. (IF 5.4) Pub Date : 2023-11-20 Di Wen, Yingxiao Ji, Yuanyuan Li, Weisong Duan, Yanyan Wang, Zhongyao Li, Meichun Tao, Yakun Liu
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Too big not to fail: emerging evidence for size-induced senescence FEBS J. (IF 5.4) Pub Date : 2023-11-20 Sandhya Manohar, Gabriel E. Neurohr