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The role of photobiomodulation in accelerating bone repair Prog. Biophys. Mol. Biol. (IF 3.8) Pub Date : 2024-03-16 Ping Lu, Jinfeng Peng, Jie Liu, Lili Chen
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Electromagnetic fields regulate iron metabolism in living organisms: A review of effects and mechanism Prog. Biophys. Mol. Biol. (IF 3.8) Pub Date : 2024-03-04 Chenxiao Zhen, Gejing Zhang, Shenghang Wang, Jianping Wang, Yanwen Fang, Peng Shang
The emergence, evolution, and spread of life on Earth have all occurred in the geomagnetic field, and its extensive biological effects on living organisms have been documented. The charged characteristics of metal ions in biological fluids determine that they are affected by electromagnetic field forces, thus affecting life activities. Iron metabolism, as one of the important metal metabolic pathways
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The synchronic, diachronic cell as the holism of consciousness Prog. Biophys. Mol. Biol. (IF 3.8) Pub Date : 2024-02-24 John S. Torday
The cell is both synchronic and diachronic, based on ontogeny and phylogeny, respectively. As experimental evidence for this holism, absent gravitational force, differentiated lung and bone cells devolve, losing their phenotypes, losing their evolutionary status, reverting to their nonlocal status. Thus, when evolution is seen as serial homeostasis, it is homologous with Quantum Entanglement as the
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The quantum cell Prog. Biophys. Mol. Biol. (IF 3.8) Pub Date : 2024-02-22 John S. Torday
There is a consensus that we are conscious of something greater than ourselves, as if we are derived from some other primordial set of principles. Classical or Newtonian physics is based on the Laws of Nature. Conversely, in a recent series of articles, it has been hypothesized that the cell was formed from lipid molecules submerged in the primordial ocean that covered the earth 100 million years after
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Research progress on the role of reactive oxygen species in the initiation, development and treatment of breast cancer Prog. Biophys. Mol. Biol. (IF 3.8) Pub Date : 2024-02-20 Jing Zhong, Yan Tang
According to international cancer data, breast cancer (BC) is the leading type of cancer in women. Although significant progress has been made in treating BC, metastasis and drug resistance continue to be the primary causes of mortality for many patients. Reactive oxygen species (ROS) play a dual role in vivo: normal levels can maintain the body's normal physiological function; however, high levels
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The therapeutic effect of MSCs and their extracellular vesicles on neuroblastoma Prog. Biophys. Mol. Biol. (IF 3.8) Pub Date : 2024-02-17 Mohsen Karami Fath, Samaneh Mohammad Bagherzadeh Torbati, Vahid Saqagandomabadi, Omid Yousefi Afshar, Mohammad Khalilzad, Sara Abedi, Afshin Moliani, Danyal Daneshdoust, Ghasem Barati
Neuroblastoma is a common inflammatory-related cancer during infancy. Standard treatment modalities including surgical interventions, high-dose chemotherapy, radiotherapy, and immunotherapy are not able to increase survival rate and reduce tumor relapse in high-risk patients. Mesenchymal stem cells (MSCs) are known for their tumor-targeting and immunomodulating properties. MSCs could be engineered
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Responses to commentaries on “The gene: An appraisal” Prog. Biophys. Mol. Biol. (IF 3.8) Pub Date : 2024-02-14 Keith Baverstock
The central conclusions of “The Gene: An Appraisal” are that genetic variance does not underpin biological evolution, and, therefore, that genes are not Mendel's units of inheritance. In this response, I will address the criticisms I have received via commentaries on that paper by defending the following statements:
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Why death and aging ? All memories are imperfect Prog. Biophys. Mol. Biol. (IF 3.8) Pub Date : 2024-02-03 William B. Miller Jr, František Baluška, Arthur S. Reber, Predrag Slijepčević
Recent papers have emphasized the primary role of cellular information management in biological and evolutionary development. In this framework, intelligent cells collectively measure environmental cues to improve informational validity to support natural cellular engineering as collaborative decision-making and problem-solving in confrontation with environmental stresses. These collective actions
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The holism of evolution as consciousness Prog. Biophys. Mol. Biol. (IF 3.8) Pub Date : 2024-01-29 John S. Torday
Quantum Entanglement has been hypothesized to mediate non-local consciousness, underlying which, empirically, is the force of gravity. Upon further reflection, the case can be made for ‘the breath’ as the physiologic trait that binds all of these properties together, offering further opportunity for hypothesis testing experimentation. Humans have inexplicably made extraordinary intellectual and technical
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Promising application of pulsed electromagnetic fields on tissue repair and regeneration Prog. Biophys. Mol. Biol. (IF 3.8) Pub Date : 2024-01-26 Dan-bo Su, Zi-xu Zhao, Da-chuan Yin, Ya-jing Ye
Tissue repair and regeneration is a vital biological process in organisms, which is influenced by various internal mechanisms and microenvironments. Pulsed electromagnetic fields (PEMFs) are becoming a potential medical technology due to its advantages of effectiveness and non-invasiveness. Numerous studies have demonstrated that PEMFs can stimulate stem cell proliferation and differentiation, regulate
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A Landscape of Consciousness: Toward a Taxonomy of Explanations and Implications Prog. Biophys. Mol. Biol. (IF 3.8) Pub Date : 2024-01-26 Robert Lawrence Kuhn
Diverse explanations or theories of consciousness are arrayed on a roughly physicalist-to-nonphysicalist landscape of essences and mechanisms. Categories: Materialism Theories (philosophical, neurobiological, electromagnetic field, computational and informational, homeostatic and affective, embodied and enactive, relational, representational, language, phylogenetic evolution); Non-Reductive Physicalism;
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Amyloid oligomers and their membrane toxicity - A perspective study Prog. Biophys. Mol. Biol. (IF 3.8) Pub Date : 2024-01-10 Alessandro Nutini
Amyloidosis is a condition involving a disparate group of pathologies characterized by the extracellular deposition of insoluble fibrils composed of broken-down proteins. These proteins can accumulate locally, causing peculiar symptoms, or in a widespread way, involving many organs and.
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Editorial for online collection — The gene: An appraisal Prog. Biophys. Mol. Biol. (IF 3.8) Pub Date : 2024-01-03 Denis Noble
Abstract not available
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The mobius strip, the cell, and soft logic mathematics Prog. Biophys. Mol. Biol. (IF 3.8) Pub Date : 2023-12-29 John S. Torday, Moshe Klein, Oded Maimon
The cell-cell signaling mechanisms that are the basis for all of physiology have been used to trace evolution back to the unicellular state, and beyond, to the “First Principles of Physiology”. And since our physiology derives from the Cosmos based on Symbiogenesis, it has been hypothesized that the cell behaves like a functional Mobius Strip, having no ‘inside or outside’ cell membrane surface - it
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Darwinian evolution has become dogma; AI can rescue what is salvageable Prog. Biophys. Mol. Biol. (IF 3.8) Pub Date : 2023-12-23 Olen R. Brown, David A. Hullender
Artificial Intelligence (AI), as an academic discipline, is traceable to the mid-1950s but it is currently exploding in applications with successes and concerns. AI can be defined as intelligence demonstrated by computers, with intelligence difficult to define but it must include concepts of ability to learn, reason, and generalize from a vast amount of information and, we propose, to infer meaning
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Music, cells and the dimensionality of nature Prog. Biophys. Mol. Biol. (IF 3.8) Pub Date : 2023-12-14 Mark William Johnson
One of the foundational principles of recent developments in evolutionary biology has been the acknowledgement of homeostasis as an organising principle of cellular development from unicellular origins. Fundamentally, this concerns the balance between the inside of a biological entity and its environment. Given that the organ of balance is the ear, and that the evolutionary provenance of the vestibular
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The Gene: An appraisal Prog. Biophys. Mol. Biol. (IF 3.8) Pub Date : 2023-12-02 Keith Baverstock
The gene can be described as the foundational concept of modern biology. As such, it has spilled over into daily discourse, yet it is acknowledged among biologists to be ill-defined. Here, following a short history of the gene, I analyse critically its role in inheritance, evolution, development, and morphogenesis. Wilhelm Johannsen's genotype-conception, formulated in 1910, has been adopted as the
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Family Constellation therapy: A nascent approach for working with non-local consciousness in a therapeutic container Prog. Biophys. Mol. Biol. (IF 3.8) Pub Date : 2023-12-03 Dan Cohen
Family Constellations are an emerging therapeutic approach for working with local and non-local consciousness. First developed by German psychoanalyst Bert Hellinger, and now practiced by thousands of licensed and un-licensed facilitators globally, Family Constellations are a transpersonal and systemically oriented therapeutic process. Their aim is to address a focus client's emotional, behavioral
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An insight to the recent advancements in detection of Mycobacterium tuberculosis using biosensors: A systematic review Prog. Biophys. Mol. Biol. (IF 3.8) Pub Date : 2023-12-03 Mansi Chaturvedi, Monika Patel, Archana Tiwari, Neeraj Dwivedi, D.P. Mondal, Avanish Kumar Srivastava, Chetna Dhand
Since ancient times, Tuberculosis (TB) has been a severe invasive illness that has been prevalent for thousands of years and is also known as “consumption” or phthisis. TB is the most common chronic lung bacterial illness in the world, killing over 2 million people each year, caused by Mycobacterium tuberculosis (MTB). As per the reports of WHO, in spite of technology advancements, the average rate
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Cold snapshots of DNA repair: Cryo-EM structures of DNA-PKcs and NHEJ machinery Prog. Biophys. Mol. Biol. (IF 3.8) Pub Date : 2023-11-28 Himani Amin, Sayma Zahid, Chloe Hall, Amanda K. Chaplin
The proteins and protein assemblies involved in DNA repair have been the focus of a multitude of structural studies for the past few decades. Historically, the structures of these protein complexes have been resolved by X-ray crystallography. However, more recently with the advancements in cryo-electron microscopy (cryo-EM) ranging from optimising the methodology for sample preparation to the development
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How can Phycobilisome, the unique light harvesting system in certain algae working highly efficiently: The connection in between structures and functions Prog. Biophys. Mol. Biol. (IF 3.8) Pub Date : 2023-11-28 Runze Liu, Zhang-He Zhen, Wenjun Li, Baosheng Ge, Song Qin
Algae, which are ubiquitous in ecosystems, have evolved a variety of light-harvesting complexes to better adapt to diverse habitats. Phycobilisomes/phycobiliproteins, unique to cyanobacteria, red algae, and certain cryptomonads, compensate for the lack of chlorophyll absorption, allowing algae to capture and efficiently transfer light energy in aquatic environments. With the advancement of microscopy
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Corrigendum to “The gene: An appraisal” [Prog. Biophys. Mol. Biol. (2021) 46–62] Prog. Biophys. Mol. Biol. (IF 3.8) Pub Date : 2023-11-23 Keith Baverstock
Abstract not available
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Cells and sounds Prog. Biophys. Mol. Biol. (IF 3.8) Pub Date : 2023-11-23 Michael Spitzer
Abstract not available
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Shannon's (informational) dissipation as the major engine leading to living dynamic and the origin of self. Prog. Biophys. Mol. Biol. (IF 3.8) Pub Date : 2023-11-13 Salvatore Chirumbolo, Antonio Vella
Abstract not available
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Growth or death? Control of cell destiny by mTOR and autophagy pathways Prog. Biophys. Mol. Biol. (IF 3.8) Pub Date : 2023-11-08 Mahmoud I. Khalil, Mohamad M. Ali, Jasmine Holail, Marwa Houssein
One of the central regulators of cell growth, proliferation, and metabolism is the mammalian target of rapamycin, mTOR, which exists in two structurally and functionally different complexes: mTORC1 and mTORC2; unlike m TORC2, mTORC1 is activated in response to the sufficiency of nutrients and is inhibited by rapamycin. mTOR complexes have critical roles not only in protein synthesis, gene transcription
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How an emergent cosmology of a nonlocally unified, meaningfully in-formed and holographically manifested Universe can underpin and frame the biological embodiment of quantum entanglement Prog. Biophys. Mol. Biol. (IF 3.8) Pub Date : 2023-10-21 Jude Currivan
With a Nobel Prize for Physics widely viewed as only given for ‘settled’ science, the award then essentially accepts the validity of universal nonlocality. Other key discoveries and insights in recent years are also progressively pointing to the appearance of our Universe, its energy-matter and space-time, as not being foundational but emerging from deeper, discarnate realms of causation. as digitized
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Computational approaches for modeling and structural design of biological systems: A comprehensive review Prog. Biophys. Mol. Biol. (IF 3.8) Pub Date : 2023-10-09 Ekambaram Gayathiri, Palanisamy Prakash, Priya Kumaravel, Jayanthi Jayaprakash, Manikkavalli Gurunathan Ragunathan, Sharmila Sankar, Saravanan Pandiaraj, Natesan Thirumalaivasan, Muthu Thiruvengadam, Rajakumar Govindasamy
The convergence of biology and computational science has ushered in a revolutionary era, revolutionizing our understanding of biological systems and providing novel solutions to global problems. The field of genetic engineering has facilitated the manipulation of genetic codes, thus providing opportunities for the advancement of innovative disease therapies and environmental enhancements. The emergence
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Recent progress of mechanosensitive mechanism on breast cancer Prog. Biophys. Mol. Biol. (IF 3.8) Pub Date : 2023-10-02 Xiao-Xia Chai, Jie Liu, Tong-Yao Yu, Ge Zhang, Wen-Jun Sun, Yan Zhou, Li Ren, Hui-Ling Cao, Da-Chuan Yin, Chen-Yan Zhang
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HIF-1α and periodontitis: Novel insights linking host-environment interplay to periodontal phenotypes Prog. Biophys. Mol. Biol. (IF 3.8) Pub Date : 2023-09-26 Chao Shan, YuNing Xia, Zeyu Wu, Jin Zhao
Periodontitis, the sixth most prevalent epidemic disease globally, profoundly impacts oral aesthetics and masticatory functionality. Hypoxia-inducible factor-1α (HIF-1α), an oxygen-dependent transcriptional activator, has emerged as a pivotal regulator in periodontal tissue and alveolar bone metabolism, exerts critical functions in angiogenesis, erythropoiesis, energy metabolism, and cell fate determination
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Piezo1:the potential new therapeutic target for fibrotic diseases Prog. Biophys. Mol. Biol. (IF 3.8) Pub Date : 2023-09-16 Xin Liu, Weipin Niu, Shuqing Zhao, Wenjuan Zhang, Ying Zhao, Jing Li
Fibrosis is a pathological process that occurs in various organs, characterized by excessive deposition of extracellular matrix (ECM), leading to structural damage and, in severe cases, organ failure. Within the fibrotic microenvironment, mechanical forces play a crucial role in shaping cell behavior and function, yet the precise molecular mechanisms underlying how cells sense and transmit these mechanical
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An overview of polymer surface coated synthetic quantum dots as therapeutics and sensors applications Prog. Biophys. Mol. Biol. (IF 3.8) Pub Date : 2023-08-29 Ancha Kishore Babu, M. K. Mohan Maruga Raja, Mehrukh Zehravi, Badrud Duza Mohammad, Mohammed Imran Anees, Cheepurupalli Prasad, Barrawaz Aateka Yahya, Rokeya Sultana, Rohit Sharma, Jay Singh, Khalid Ali Khan, Falak A. Siddiqui, Sharuk L. Khan, Talha Bin Emran
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Application of nanomaterials as potential quorum quenchers for disease: Recent advances and challenges Prog. Biophys. Mol. Biol. (IF 3.8) Pub Date : 2023-09-02 Saad Alghamdi, Krisha Khandelwal, Soumya Pandit, Arpita Roy, Subhasree Ray, Ahad Amer Alsaiari, Abdulelah Aljuaid, Mazen Almehmadi, Mamdouh Allahyani, Rohit Sharma, Jigisha Anand, Ahmad Adnan Alshareef
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Advances in surface-enhanced Raman spectroscopy-based sensors for detection of various biomarkers Prog. Biophys. Mol. Biol. (IF 3.8) Pub Date : 2023-08-28 Nidhi Chauhan, Kirti Saxena, Rachna Rawal, Lalit Yadav, Utkarsh Jain
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Commentary on “A systematic review on machine learning and deep learning techniques in cancer survival prediction”: Validation of survival methods Prog. Biophys. Mol. Biol. (IF 3.8) Pub Date : 2023-08-12 J. Sidorova, J.J. Lozano
Abstract not available
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A systematic review on intracranial aneurysm and hemorrhage detection using machine learning and deep learning techniques Prog. Biophys. Mol. Biol. (IF 3.8) Pub Date : 2023-07-25 S. Nafees Ahmed, P. Prakasam
The risk of discovering an intracranial aneurysm during the initial screening and follow-up screening are reported as around 11%, and 7% respectively (Zuurbie et al., 2023) to these mass effects, unruptured aneurysms frequently generate symptoms, however, the real hazard occurs when an aneurysm ruptures and results in a cerebral hemorrhage known as a subarachnoid hemorrhage. The objective is to study
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Method versatility in RNA extraction-free PCR detection of SARS-CoV-2 in saliva samples Prog. Biophys. Mol. Biol. (IF 3.8) Pub Date : 2023-06-25 Orchid M. Allicock, Devyn Yolda-Carr, Rebecca Earnest, Mallery I. Breban, Noel Vega, Isabel M. Ott, Chaney Kalinich, Tara Alpert, Mary E Petrone, Anne L. Wyllie
Early in the pandemic, a simple, open-source, RNA extraction-free RT-qPCR protocol for SARS-CoV-2 detection in saliva was developed and made widely available. This simplified approach (SalivaDirect) requires only sample treatment with proteinase K prior to PCR testing. However, feedback from clinical laboratories highlighted a need for a flexible workflow that can be seamlessly integrated into their
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Biological evolution requires an emergent, self-organizing principle Prog. Biophys. Mol. Biol. (IF 3.8) Pub Date : 2023-06-19 Olen R. Brown, David A. Hullender
In this perspective review, we assess fundamental flaws in Darwinian evolution, including its modern versions. Fixed mutations ‘explain’ microevolution but not macroevolution including speciation events and the origination of all the major body plans of the Cambrian explosion. Complex, multifactorial change is required for speciation events and inevitably requires self-organization beyond what is accomplished
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A review: Exploring the metabolic and structural characterisation of beta pleated amyloid fibril in human tissue using Raman spectrometry and SAXS Prog. Biophys. Mol. Biol. (IF 3.8) Pub Date : 2023-06-10 N.S. Mohd Nor Ihsan, S.F. Abdul Sani, L.M. Looi, P.L. Cheah, S.F. Chiew, Dharini Pathmanathan, D.A. Bradley
Amyloidosis is a deleterious condition caused by abnormal amyloid fibril build-up in living tissues. To date, 42 proteins that are linked to amyloid fibrils have been discovered. Amyloid fibril structure variation can affect the severity, progression rate, or clinical symptoms of amyloidosis. Since amyloid fibril build-up is the primary pathological basis for various neurodegenerative illnesses, characterization
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Cross-talk between non-ionizing electromagnetic fields and metastasis; EMT and hybrid E/M may explain the anticancer role of EMFs Prog. Biophys. Mol. Biol. (IF 3.8) Pub Date : 2023-06-10 Romina Mehdizadeh, Alireza Madjid Ansari, Flora Forouzesh, Reyhane Ghadirian, Fatemeh Shahriari, Seyed Peyman Shariatpanahi, Mohammad Amin Javidi
Recent studies have shown that non-ionizing electromagnetic fields (NIEMFs) in a specific frequency, intensity, and exposure time can have anti-cancer effects on various cancer cells; however, the underlying precise mechanism of action is not transparent. Most cancer deaths are due to metastasis. This important phenomenon plays an inevitable role in different steps of cancer including progression and
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A critical appraisal of the relative contribution of tissue architecture, genetics, epigenetics and cell metabolism to carcinogenesis Prog. Biophys. Mol. Biol. (IF 3.8) Pub Date : 2023-06-01 Thomas W. Grunt, Gerwin Heller
Here we contrast several carcinogenesis models. The somatic-mutation-theory posits mutations as main causes of malignancy. However, inconsistencies led to alternative explanations. For example, the tissue-organization-field-theory considers disrupted tissue-architecture as main cause. Both models can be reconciled using systems-biology-approaches, according to which tumors hover in states of self-organized
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A revised central dogma for the 21st century:all biology is cognitive information processing Prog. Biophys. Mol. Biol. (IF 3.8) Pub Date : 2023-06-01 William B. Miller, František Baluška, Arthur S. Reber
Crick's Central Dogma has been a foundational aspect of 20th century biology, describing an implicit relationship governing the flow of information in biological systems in biomolecular terms. Accumulating scientific discoveries support the need for a revised Central Dogma to buttress evolutionary biology's still-fledgling migration from a Neodarwinian canon. A reformulated Central Dogma to meet contemporary
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Towards solving the mystery of spiral phyllotaxis Prog. Biophys. Mol. Biol. (IF 3.8) Pub Date : 2023-05-19 Boris Rozin
The mystery of the morphogenesis of phyllotaxis has been of concern for several generations of botanists and mathematicians. Of particular interest is the fact that the number of visible spirals is equal to the number from the Fibonacci series. The article proposes an analytical solution to two fundamental questions of phyllotaxis: what is the morphogenesis of patterns of spiral phyllotaxis? and why
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Identification and diagnosis of long COVID-19: A scoping review Prog. Biophys. Mol. Biol. (IF 3.8) Pub Date : 2023-05-12 Sujata Srikanth, Jessica R. Boulos, Tristan Dover, Luigi Boccuto, Delphine Dean
Long COVID-19 (LC-19) is a condition that has affected a high percentage of the population that recovered from the initial disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). LC-19 diagnosis is currently poorly defined because of its variable, multisystem, episodic symptoms, and lack of uniformity in the critical time points associated with the disease. Considering the number
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Investigation of thermal stability characteristic in family A DNA polymerase - A theoretical study Prog. Biophys. Mol. Biol. (IF 3.8) Pub Date : 2023-05-13 Seddigheh Borhani, Seyed Shahriar Arab
DNA polymerases create complementary DNA strands in living cells and are crucial to genome transmission and maintenance. These enzymes possess similar human right-handed folds which contain thumb, fingers, and palm subdomains and contribute to polymerization activities. These enzymes are classified into seven evolutionary families, A, B, C, D, X, Y, and RT, based on amino acid sequence analysis and
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Smartphone-based diagnostics for biosensing infectious human pathogens Prog. Biophys. Mol. Biol. (IF 3.8) Pub Date : 2023-05-08 Aditya Amrut Pawar, Sanchita Bipin Patwardhan, Sagar Barage, Rajesh Raut, Jaya Lakkakula, Arpita Roy, Rohit Sharma, Jigisha Anand
The widespread usage of smartphones has made accessing vast troves of data easier for everyone. Smartphones are powerful, handy, and easy to operate, making them a valuable tool for improving public health through diagnostics. When combined with other devices and sensors, smartphones have shown potential for detecting, visualizing, collecting, and transferring data, enabling rapid disease diagnosis
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The flexible and iterative steps within the NHEJ pathway Prog. Biophys. Mol. Biol. (IF 3.8) Pub Date : 2023-05-05 Go Watanabe, Michael R. Lieber
Cellular and biochemical studies of nonhomologous DNA end joining (NHEJ) have long established that nuclease and polymerase action are necessary for the repair of a very large fraction of naturally-arising double-strand breaks (DSBs). This conclusion is derived from NHEJ studies ranging from yeast to humans and all genetically-tractable model organisms. Biochemical models derived from recent real-time
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Quantum noise may limit the mechanosensory sensitivity of cilia in the left–right organizer of the vertebrate bodyplan Prog. Biophys. Mol. Biol. (IF 3.8) Pub Date : 2023-05-01 Julyan H.E. Cartwright
Could nature be harnessing quantum mechanics in cilia to optimize the sensitivity of the mechanism of left–right symmetry breaking during development in vertebrates? I evaluate whether mechanosensing — i.e., the detection of a left-right asymmetric signal through mechanical stimulation of sensory cilia, as opposed to biochemical signalling — might be functioning in the embryonic left–right organizer
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The role of quantum mechanics in cognition-based evolution Prog. Biophys. Mol. Biol. (IF 3.8) Pub Date : 2023-05-02 Perry Marshall
In 2021 I noted that in all information-based systems we understand, Cognition creates Code, which controls Chemical reactions. Known agents write software which controls hardware, and not the other way around. I proposed the same is true in all of biology. Though the textbook description of cause and effect in biology proposes the reverse, that Chemical reactions produce Code from which Cognition
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An update on ATP synthase inhibitors: A unique target for drug development in M. tuberculosis Prog. Biophys. Mol. Biol. (IF 3.8) Pub Date : 2023-04-25 Lakshmi Mounika Kelam, Mushtaq Ahmad Wani, Devendra K. Dhaked
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From traditional medicine to modern oncology: Scutellarin, a promising natural compound in cancer treatment Prog. Biophys. Mol. Biol. (IF 3.8) Pub Date : 2023-04-18 Shadi Vesaghhamedani, Seyedeh Shabnam Mazloumi Kiapey, Arezoo Gowhari Shabgah, Sedigheh Amiresmaili, Abbas Jahanara, Maziar Oveisee, Aliakbar Shekarchi, Seyed Mohammad Gheibihayat, Farhad Jadidi-Niaragh, Jamshid Gholizadeh Navashenaq
Natural substances are increasingly being used as cancer treatments. Scutellarin, as a flavonoid, recently has been identified in a Chinese herbal extract called Erigeron breviscapus (Vant.). Scutellarin is being researched for its potential benefits due to the discovery that it possesses a variety of biological effects, such as neuroprotective, anti-bacterial, and anti-viral properties. In addition
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Origin of life: Drawing the big picture Prog. Biophys. Mol. Biol. (IF 3.8) Pub Date : 2023-04-18 Francisco Prosdocimi, Sávio Torres de Farias
Trying to provide a broad overview about the origin of life in Earth, the most significant transitions of life before cells are listed and discussed. The current approach emphasizes the symbiotic relationships that emerged with life. We propose a rational, stepwise scenario for the origin of life that starts with the origin of the first biomolecules and steps forward until the origins of the first
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Constrained disorder principle-based variability is fundamental for biological processes: Beyond biological relativity and physiological regulatory networks Prog. Biophys. Mol. Biol. (IF 3.8) Pub Date : 2023-04-15 Yaron Ilan
The constrained disorder principle (CDP) defines systems based on their degree of disorder bounded by dynamic boundaries. The principle explains stochasticity in living and non-living systems. Denis Noble described the importance of stochasticity in biology, emphasizing stochastic processes at molecular, cellular, and higher levels in organisms as having a role beyond simple noise. The CDP and Noble's
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Colon cancer transcriptome Prog. Biophys. Mol. Biol. (IF 3.8) Pub Date : 2023-04-13 Khatere Mokhtari, Maryam Peymani, Mohsen Rashidi, Kiavash Hushmandi, Kamran Ghaedi, Afshin Taheriazam, Mehrdad Hashemi
Over the last four decades, methodological innovations have continuously changed transcriptome profiling. It is now feasible to sequence and quantify the transcriptional outputs of individual cells or thousands of samples using RNA sequencing (RNA-seq). These transcriptomes serve as a connection between cellular behaviors and their underlying molecular mechanisms, such as mutations. This relationship
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A systematic review and repeatability study on the use of deep learning for classifying and detecting tuberculosis bacilli in microscopic images Prog. Biophys. Mol. Biol. (IF 3.8) Pub Date : 2023-04-05 Thales Francisco Mota Carvalho, Vívian Ludimila Aguiar Santos, Jose Cleydson Ferreira Silva, Lida Jouca de Assis Figueredo, Silvana Spíndola de Miranda, Ricardo de Oliveira Duarte, Frederico Gadelha Guimarães
Tuberculosis (TB) is among the leading causes of death worldwide from a single infectious agent. This disease usually affects the lungs (pulmonary TB) and can be cured in most cases with a quick diagnosis and proper treatment. Microscopic sputum smear is widely used to diagnose and manage pulmonary TB. Despite being relatively fast and low cost, it can be exhausting because it depends on manually counting
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The effect of magnetic fields on tumor occurrence and progression: Recent advances Prog. Biophys. Mol. Biol. (IF 3.8) Pub Date : 2023-04-03 Ge Zhang, Xinli Liu, Yali Liu, Shilong Zhang, Tongyao Yu, Xiaoxia Chai, Jinliang He, Dachuan Yin, Chenyan Zhang
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Glycometabolism reprogramming: Implications for cardiovascular diseases Prog. Biophys. Mol. Biol. (IF 3.8) Pub Date : 2023-03-23 Guolong Peng, Jialong Yan, Linxi Chen, Lanfang Li
Glycometabolism is well known for its roles as the main source of energy, which mainly includes three metabolic pathways: oxidative phosphorylation, glycolysis and pentose phosphate pathway. The orderly progress of glycometabolism is the basis for the maintenance of cardiovascular function. However, upon exposure to harmful stimuli, the intracellular glycometabolism changes or tends to shift toward