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Lipid-lowering drug targets and lung related diseases: a Mendelian randomization study Front. Life Sci. (IF 1.333) Pub Date : 2024-03-12 Haifeng Yu, Xiaofei Zhang, Bian Wen, Shuo Hu, Bin Ni
OBJECTIVES This genetics-based study aimed to evaluate the relationships of long-term lipid-lowering agents on lung-related diseases (LRD) outcomes.METHODS We extracted genetic variations of six dr...
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Proteomics study of Mongolian medicine warm acupuncture in the treatment of p-chlorophenylalanine-induced insomnia in rats Front. Life Sci. (IF 1.333) Pub Date : 2024-02-22 Yanan Xu, Jianxun Wen, Wenyan Han, Gula A, Xiulan Su
Mongolian medical warm acupuncture (MMWA) therapy is a traditional external therapy method that has a definite clinical effect in the treatment of insomnia, but research on its underlying neural me...
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Oxidative stress: an overview of past research and future insights Front. Life Sci. (IF 1.333) Pub Date : 2024-02-21 Aaser M. Abdelazim, Mosleh M. Abomughaid
‘Oxidative stress' (OS) refers to the deviations in redox biology inside biological systems. This term has been used to illustrate the imbalance between oxidants and antioxidants, which has been a ...
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Evaluating capability of two halophyte plants for phytoextraction of cadmium from contaminated soils Front. Life Sci. (IF 1.333) Pub Date : 2024-02-20 Mahboubeh Mazhari, Safoora Asadi Kapourchal, Mehdi Homaee
Selecting an appropriate plant is a key factor for the phytoextraction of heavy metals from contaminated soils. The possibility of using two halophytes for the remediation of cadmium (Cd) from cont...
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Comparative transcriptome analysis revealed gene expression differences in fruits between two Actinidia chinensis cultivars Front. Life Sci. (IF 1.333) Pub Date : 2024-02-14 Lina Guo, Kai Yan, Dan Li, Wanxing Li
The kiwifruit JD (Jindun No. 1) and HY (Hongyang) are two species of Actinidia chinensis, a major horticultural crop growing worldwide. Fruity texture and taste of HY are better compared with that ...
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The genomic copy number determination of improved Cre in transgenic mice using standards derived from megaprimer PCR constructed tandem repeats Front. Life Sci. (IF 1.333) Pub Date : 2024-02-12 Ge Diao, Min Tian, Runbo Li, Jie Huang, Jian Han, Jianxin Guo
Determination of the genomic copy number of Cre transgene is critical for the establishment of transgenic animal models. We demonstrate a real-time quantitative polymerase chain reaction (RT-qPCR) ...
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Cardiac regeneration: 20 years of development and update in zebrafish and mouse Front. Life Sci. (IF 1.333) Pub Date : 2024-02-07 Lekun Gui, Lijun Jin, Huangjun Liu
Cardiovascular diseases are one of the leading causes of death globally. The primary pathological mechanism in myocardial infarction and heart failure is irreversible cardiomyocyte loss. The conven...
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16S rRNA gene sequencing of non-lactic acid bacteria cultures from lait caillé in Burkina Faso Front. Life Sci. (IF 1.333) Pub Date : 2024-01-31 Geoffroy Romaric Bayili, Clarisse S. Compaoré, Bréhima Diawara, Lene Jespersen, Hagretou Sawadogo-Lingani
Diverse species of lactic acid bacteria (LAB) are involved in the spontaneous fermentation of lait caillé, a traditional milk product from Burkina Faso. However, there is little information on the ...
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Analysis of differentially expressed genes in hypertension and hypertensive cerebral hemorrhage via RNA-sequencing Front. Life Sci. (IF 1.333) Pub Date : 2024-01-17 Hongwu Qi, Min Qiao, Yansong Liu, Weijun Zeng, Lizhao Zhang, Hongjun Guo
Hypertension (HT) is a major cause of intracerebral hemorrhage (ICH), and hypertensive cerebral hemorrhage (HCH) has a serious impact on life quality of patients and gives society a heavy burden. T...
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Assessment of the yield and yield attributing characters of oat (Avena sativa L.) grown under different tillage methods and NPK fertilizer rates in semi-arid conditions Front. Life Sci. (IF 1.333) Pub Date : 2024-01-16 Marwan Noori Ramadhan
Field experiments were conducted to determine the effect of tillage practices and inorganic sources of different combinations of nitrogen, phosphorus, and potassium fertilizers on some physical pro...
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Plac8 regulates the fibrogenic ability of cardiac fibroblasts in mice with myocardial infarction Front. Life Sci. (IF 1.333) Pub Date : 2024-01-02 Ting Fu, Jianping Gong, Lei Xu, Ningning Ji
Cardiac fibroblasts (CFs) are of vital importance for post-myocardial infarction (MI) remodeling. This study explored the role of Placenta specific 8 (Plac8) in MI on the basis of single-cell RNA-S...
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Outcomes in patients with metastatic gastric cancer: a surveillance, epidemiology, and end results program (SEER) database analysis Front. Life Sci. (IF 1.333) Pub Date : 2023-12-01 Wenhan Li, Yao Tang, Danfang Wang, Jianhui Li
Owing to tumor heterogeneity and individual physiological variations, there remains a necessity to enhance the current prognosis prediction system for metastatic gastric cancer (MGC). This study ai...
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The predictive value of admission serum and urine carboxypeptidase-B activation peptide for the severity of acute pancreatitis: a meta-analysis Front. Life Sci. (IF 1.333) Pub Date : 2023-12-01 Liang Dai, Wei-Yan Guo, Xing-Wei Xuan, Xiao-Dong Meng, Yin-Hua Wang, Hai-Xia Chai, Jian-Li Chen, Jun-Mao Chen, Jian-Yi Pu
This meta-analysis examined the predictive value of admission serum and urine carboxypeptidase-B activation peptide (CAPAP) in patients with severe acute pancreatitis. PubMed, Embase, and the Cochr...
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Phytochemical profile and anti-inflammatory effect of Artemisia annua L. essential oil Front. Life Sci. (IF 1.333) Pub Date : 2023-12-01 Congcong Zhu, Ge Yan, Manqi Hu, Zongguang Tai, Bin Fan, Pei Zhao, Xiao Miao, Quangang Zhu
Plant-derived natural compounds are desired for their anti-inflammatory properties. We investigated the chemical composition and the anti-inflammatory effects of the essential oil obtained from lea...
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Habitat preference and diversity of bryophyte in the Jiulongshan National Forest Park, Eastern China Front. Life Sci. (IF 1.333) Pub Date : 2023-11-01 Pengcheng Ye, Xiaohui Qian, Jianyong Wu, Xiao Zhao
In densely populated, highly urbanized regions such as Zhejiang Province (eastern China), species are under enormous environmental pressures resulting from human activities, land use changes, and h...
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Evaluation of cytotoxic and genotoxic potential of avobenzone and octocrylene on human skin fibroblast cells Front. Life Sci. (IF 1.333) Pub Date : 2023-10-30 Özgür Vatan, Duygu Sevinç, Dilek Yılmaz Çelik, A. Carine Aurelie Allounan, Özgün Teksoy, Neylan Oral, Huzeyfe Huriyet, Tolga Çavaş, Nilüfer Çinkılıç
We investigated the cytotoxic and genotoxic effects of the organic UVA filter avobenzone (AVB), and the UVB filter octocrylene (OCT), found alone or in combination in different sunscreen formulatio...
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Identification of potential hub genes and therapeutic drugs in ovarian cancer via bioinformatics analysis Front. Life Sci. (IF 1.333) Pub Date : 2023-10-30 Xinyue Zhou, Zuofei Song, Jia Chen, Dongxue Wang, Jingli Sun
This study aimed to identify hub genes and drugs for ovarian cancer (OC) using bioinformatics analysis. Gene expression data and clinical information were downloaded from public databases. Differen...
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Clinicopathological relevance of BRAF and SMO mutations in Chinese patients with ameloblastoma Front. Life Sci. (IF 1.333) Pub Date : 2023-10-24 Chen Ruixue, Li Hexiang, Hou Yali, Li Xiangjun, Sun Xu, Wang Jie, Zhang Xudong
Ameloblastomas are benign tumors associated with recurrence and morbidity. Mutations in the V-Raf murine sarcoma viral oncogene homolog B1 (BRAF) and smoothened (SMO) genes have been identified in ...
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Investigation of the content of anabolic steroids in food supplements used in sports practice Front. Life Sci. (IF 1.333) Pub Date : 2023-10-26 Elina Petkova-Gueorguieva, Stanislav Gueorguiev, Hristina Lebanova, Anna Mihaylova, Vasil Madzharov
The goal of this study is to establish the presence or absence of anabolic androgenic steroids in food supplements implemented in sports practice, to assess the health risk from intake of food supp...
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Experimental validation and bioinformatics analysis of hub genes in myocardial infarction Front. Life Sci. (IF 1.333) Pub Date : 2023-09-26 Li-Jun Wang, Bai-Quan Qiu, Hua-Xi Zou, Cheng-Wu Gong, Song-Qing Lai, Jian-Jun Xu, Yong-Bing Wu, Ji-Chun Liu
There is an urgent need to explore and validate novel biomarkers relevant to patients with myocardial infarction (MI), which is the leading cause of death in the world. Dysregulated microRNAs (miRN...
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Key genes of inflammation and Crohn’s disease severity identified via bioinformatics and clinical specimen analysis Front. Life Sci. (IF 1.333) Pub Date : 2023-09-14 Min Lu, Zhirui Zeng, Yongjian Ling, Qinsong Zhong, Zhiliang Mai, Hua Mao, Qian Wang
Crohn’s disease (CD) is a nonspecific inflammatory disease of digestive tract with limited known biomarkers. We aimed to identify potential molecules involved in CD severity. Weighted gene co-expression network and differentially expressed gene analyses were used to explore hub genes associated with inflammation and involved in pathological processes of CD in the GSE83448 cohort. The expression and
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Associations between genetically predicted plasma N-glycans and pancreatic cancer risk Front. Life Sci. (IF 1.333) Pub Date : 2023-08-22 Duo Liu, Tianying Zhao, Jingjing Zhu, Sodbo Sharapov, Evgeny Tiys, Lang Wu
Objectives: Previous studies have suggested a potential link between glycan levels and pancreatic cancer. To better characterize this relationship, we performed a study to evaluate the association between genetically predicted N-glycan levels in plasma and pancreatic cancer risk. Methods: Using genetic variants identified to be associated with plasma N-glycan levels in large genome-wide association
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The mitochondrial genome of Ectropis dentilineata Moore, 1868 (Lepidoptera: Geometridae) from tea plantations in Guizhou province, China Front. Life Sci. (IF 1.333) Pub Date : 2023-08-17 Zhaohe Lu, Ruizhong Yuan, Pu Tang, Zhizhi Wang, Xiaogui Zhou, Xuexin Chen
Ectropis dentilineata Moore, 1868 has a wide geographic distribution while its genome data are largely unknown. In this study, we collected samples of E. dentilineata from a tea plantation in Guizhou province, China. Illumina sequencing showed that the mitochondrial genome of E. dentilineata is 15,356 bp in length, containing the entire set of 37 mitochondrial genes. Several tRNAs show gene arrangements
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IL4 rs34142320 polymorphism is associated with susceptibility to Helicobacter pylori infection in Chinese Han population in northwestern China Front. Life Sci. (IF 1.333) Pub Date : 2023-08-03 Xudong Sun, Shijun Zhao, Fuhua Zhang, Lili He, Jinhua Zhang, Xiaohua Li, Li Wang, Tao Jing, Yongning Zhou, Jian Han
Previous studies revealed that both Helicobacter pylori infection and some cytokine gene polymorphisms are risk factors for gastric diseases. The association between H. pylori and gene polymorphisms is worth exploring. Here we conducted a case–control study and systematically evaluate on association between H. pylori infection and IL4, TNFA, and IL10 polymorphisms in a Chinese Han population in northwestern
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Agro-morphological traits-based genetic diversity assessment on oat (Avena sativa L.) genotypes in the central highlands of Ethiopia Front. Life Sci. (IF 1.333) Pub Date : 2023-07-19 Gezahagn Kebede, Walelign Worku, Fekede Feyissa, Habte Jifar
The study aimed to estimate the extent of genetic variability, heritability, and expected genetic gain attributable to agro-morphological traits and to suggest an effective selection scheme and specify promising genotypes for future oat breeding programs. One hundred twenty oat (Avena sativa L.) genotypes were evaluated at two locations in the central highlands of Ethiopia. The analysis of variance
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Alpha-cyano-4-hydroxycinnamic acid alleviates renal fibrosis and inflammation in chronic kidney disease Front. Life Sci. (IF 1.333) Pub Date : 2023-07-17 Meng Pan, Hua Wang, Weixian Chen, Weisong Jin
Renal fibrosis is a crucial pathological phenomenon of chronic kidney disease (CKD) that contributes to the progressive loss of renal function. Monocarboxylate transporter 1 (MCT1) plays an important role in clear cell renal cell carcinoma; however, the role of the MCT1 inhibitor alpha-cyano-4-hydroxycinnamic acid (α-CHCA) in renal fibrosis remains unclear. In this study, we evaluated the role of α-CHCA
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Characteristics of immune cell infiltration in inflamed mucosa of ulcerative colitis patients, hub gene candidates and key pathways in intestinal macrophage expression Front. Life Sci. (IF 1.333) Pub Date : 2023-07-04 Yiqiu Peng, Zilu Cui, Yingying Li, Yuxi Yang, Ruixia Liu, Yingyi Luan, Chenghong Yin
Background: The ulcerative colitis (UC) associated immune cell network was revealed by analyzing the immune cell composition of inflamed and uninflamed mucosal biopsy samples from the same patients with UC. For differentially expressed macrophages, the differentially expressed genes (DEGs), functional enrichment analyses, and protein–protein interaction (PPI) network was analyzed to understand further
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Drivers of smallholder farmers’ organic farming adoption and the organic share of the total cropland in Northern Ghana Front. Life Sci. (IF 1.333) Pub Date : 2023-06-26 Vivian Fiatusey Boateng, Samuel Arkoh Donkoh, Mensah Tawiah Cobbinah
Organic agriculture (OA) claims to have the potential to address future ecological challenges in food production. However, there is a need to scale up OA in order to meet increasing consumer demand for organic foods. Against this background, this study examined the factors driving farmers to adopt organic vegetable production (OVP) and how much acreage they commit to it. We used structured questionnaires
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Occupational hazards of Indian shrimp farm workers Front. Life Sci. (IF 1.333) Pub Date : 2023-06-26 Arpita Sharma, Suchismita Prusty, Rajiv Rathod, R. Arthi, Andrew Watterson, Lissandra Cavalli
The paper reviews a range of global aquaculture health and safety literature to inform and contribute to the development of a socio-economic profile of Indian shrimp farm workers including the occupational hazards and injuries they face. In addition, 60 shrimp farm workers were interviewed from each of the states of Andhra Pradesh, Maharashtra, Gujarat and Tamil Nadu. The study revealed that all shrimp
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Response of tef (Eragrostis tef [Zucc.] Trotter.) variety to varying seed rates and inter-row spacings for growth, yield and lodging severity in Western Ethiopia Front. Life Sci. (IF 1.333) Pub Date : 2023-06-22 Addisu Takele, B. C. Nandeshwar, Zerihun Jalata, Kinde Lamessa
ABSTRACT Tef is a small-seeded staple crop endemic to Ethiopia. However, its yield is low, constrained partly due to improper agronomic practices and lodging. Thus, during the 2019–2020 cropping season, a field experiment was carried out at Reef Tokko Taanne Hamilee in Hababo Guduru district, Western Ethiopia to examine the effects of seed rate and inter-row spacing on growth, phenology, yield, and
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Digital-palmar dermatoglyphics characteristics of patients living with schizophrenia in Ghana Front. Life Sci. (IF 1.333) Pub Date : 2023-06-18 Niena Samira Majeed, Benjamin Arko-Boham, Delali Kudzo Fiagbe, Kevin Kofi Adutwum-Ofosu, Nii Koney-Kwaku Koney, Bismarck Afedo Hottor, Richard Michael Blay, Mubarak Abdul-Rahman, John Ahenkorah
The World Health Organization has acknowledged the gap in schizophrenia diagnoses and recommended further research to identify tools and biomarkers for the disease’s early detection. Because the skin and brain have a common ectodermal origin, dermatoglyphics are hypothesized to serve as a potential mirror for the identification of risks and characteristics of neuropsychiatric diseases. This study aimed
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Improving photosynthesis and drought tolerance in Nicotiana tabacum L. by foliar application of salicylic acid Front. Life Sci. (IF 1.333) Pub Date : 2023-06-14 Yuqing Feng, Yuanyuan Zhao, Yafei Li, Jun Zhou, Hongzhi Shi
Drought causes a decrease in tobacco yield and quality as well as a reduction in net photosynthetic rate. Salicylic acid (SA) is involved in the regulation of many physiological processes and has been widely used to improve plant drought tolerance. The hydroponic experiment was carried out on flue-cured tobacco variety K326. SA solutions (0.3 mM) were sprayed on the leaves every day for three days
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Analysis of lncRNA and mRNA expression profiles in diabetic peripheral neuropathy based on weighted gene co-expression network analysis Front. Life Sci. (IF 1.333) Pub Date : 2023-06-08 Dongdong Yu, Yongkang Wang, Fangqi Ma, Yuxiang Guan, Shu Ye, Guoming Shen, Liangzhen You
Diabetic peripheral neuropathy (DPN) is a common complication of diabetes mellitus. Recent studies have explored the involvement of long non-coding RNA (lncRNA) in diabetes, but its specific role in DPN development remains unclear. To investigate the association between lncRNAs and DPN, we conducted comprehensive bioinformatics analyses. We obtained gene expression data from the sciatic nerve of 8-week-old
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The complete mitochondrial genome of blue-crowned laughingthrush Pterorhinus courtoisi (Ménégaux, 1923), a critically endangered species endemic to China Front. Life Sci. (IF 1.333) Pub Date : 2023-06-02 Lei Chen, Mengyao Sun, Zenghao Gao, Di Xu, Weiwei Zhang
ABSTRACT The blue-crowned laughingthrush Pterorhinus courtoisi (Ménégaux, 1923) is listed as a critically endangered species on the International Union for Conservation of Nature Red List. This species occupies an extremely small known breeding range in China. In this study, we obtain the complete mitochondrial genome of the blue-crowned laughingthrush by using Illumina NovaSeq sequencing. The total
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New approaches for severity intervention and rapid diagnosis of enterohemorrhagic Escherichia coli: a review Front. Life Sci. (IF 1.333) Pub Date : 2023-06-01 Degisew Yinur Mengistu, Yizengaw Mengesha
Enterohemorrhagic Escherichia coli (EHEC) are important pathogenic E. coli characterized by the production of Shiga toxin, intimin, and enterohemolysin, which are important virulence factors for pathogenesis. These virulence factors are the cause of enterocyte extinction and affect both intestinal cells and various extraintestinal cells such as lymphocytes, granulocytes, erythrocytes, and renal cells
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Influence of coronary artery disease on cardiolocomotor coupling during walking: a preliminary study Front. Life Sci. (IF 1.333) Pub Date : 2023-05-31 Shinta Takeuchi, Yusuke Nishida
The mechanisms involved in the coupling between cardiac and locomotor rhythms in patients with heart disease remain unclear. It was speculated that reduced function of the cardiovascular and/or locomotor systems would increase the coupling of these systems to increase energy efficiency in response to increased energy demand during exercise. We investigated the development of cardiolocomotor coupling
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Correction Front. Life Sci. (IF 1.333) Pub Date : 2023-05-12
Published in All Life (Vol. 16, No. 1, 2023)
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Metabolomics investigation reveals metabolic mediators associated with Ligusticum wallichii-relieving experimental acute pancreatitis Front. Life Sci. (IF 1.333) Pub Date : 2023-05-10 Yan Jin, Hong Wang, Jing Li, Xue Lin
Background: Acute pancreatitis (AP) is a typical destructive inflammation of the pancreas. The direct effect of L. wallichii on AP remains unknown. Methods: AP animal model was constructed by intraperitoneal injection of caerulein in male Sprague–Dawley rats. L. wallichii extracts were used to treat rats with AP. Then, tissue injury was evaluated by hematoxylin and eosin staining. Serum indicators
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Identification of α-isopropylmalate synthase mutants capable of overproducing L-leucine in Corynebacterium glutamicum Front. Life Sci. (IF 1.333) Pub Date : 2023-05-10 Yan-Feng Guo, Yu Lu, Lei Song, Jinghua Liu, Yi-Lei Wang, Guo-Qing Meng
The enzyme α-isopropylmalate synthase (α-IPMS) catalyzes the first step of L-leucine biosynthesis and is regulated via feedback inhibition by L-leucine. The gene of α-IPMS variant from strain ARTP-L04 was cloned and sequenced. Interestingly, amino acid mutations of Gly92Asp, Ile162Val, Arg494His and Gly526Asp occurred in the α-IPMS variant. The enzyme of α-IPMS variant was characterized, and exhibited
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Scope and present status of rearing edible insects for animal feeding in Africa Front. Life Sci. (IF 1.333) Pub Date : 2023-05-05 Sekobane D. Kolobe, Tlou G. Manyelo, Nthabiseng A. Sebola, Mabelebele Monnye
Edible insects have sparked more research interest as a cheap alternative protein source to replace soya bean and fish meal in animal diets due to their good nutritional value. In general, information on various insects has been widely researched globally. In Africa, the available literature focused more on traditional harvesting of edible insects for use as food and feed. The collection of insects
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Keeping your strength up: induced pluripotent stem cell-based approaches for the treatment and investigation of skeletal muscle disorders Front. Life Sci. (IF 1.333) Pub Date : 2023-05-05 Hyun-Jun Kim, Da-Woon Jung, Darren R. Williams
Skeletal muscle comprises the major organ system in our bodies and is the effector tissue for fundamental processes, such as movement, breathing and glucose homeostasis. However, muscle regeneration can be insufficient to repair major injuries or become exhausted by the ongoing fiber damage that occurs in muscular dystrophy. Cell therapy to provide a source of myogenic stem cells that repopulate the
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Salmon mass mortality events and occupational health and safety in Chilean aquaculture Front. Life Sci. (IF 1.333) Pub Date : 2023-05-03 Lissandra Souto Cavalli, Carlos Tapia-Jopia, Cory Ochs, María Andrée López Gómez, Barbara Neis
Mass mortality events (MMEs) threaten the health of fish and are also a potential threat to the health and safety of workers. This paper presents findings from a desktop risk assessment exercise focused on potential aquaculture occupational health and safety (AOHS) hazards and risks associated with MMEs in Chile. The study reviews academic and grey literature, government regulations and MME reports
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Illumina MiSeq sequencing investigation on the contrasting rhizosphere soil bacterial community structures in tea orchard soil under different content of aluminium Front. Life Sci. (IF 1.333) Pub Date : 2023-05-02 Yunfei Hu, Huan Li, Yang Zhou, Shuilian Gao, Rajiv Periakaruppan, Huiling Mei, Jianjie Li, Xiao Yuan, Xiaobing Kou, Xinghui Li, Xuan Chen
The rhizosphere of grown tea (Camellia sinensis (L.) O. Kuntze) becomes acidic, and aluminium (Al) toxicity has been identified as a key constraint on plant development in acidic soils. The current study investigated the composition and functions of rhizosphere bacteria as well as soil enzyme activity under different Al stress conditions. The effect of soil pH, soil enzyme activities, the diversity
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DNA methylation and gene expression in malignant transformation of human bronchial epithelial cells induced by glycidyl methacrylate Front. Life Sci. (IF 1.333) Pub Date : 2023-04-27 Quankai Wang, Boshen Wang, Huanhuan Li, Miao Wang, Xinwei Li, Baoli Zhu, Jianning Xu
The aim of this study was to elucidate the role of DNA methylation-silenced genes in malignant transformation. We screened DNA methylation-silenced genes during methacrylate (GMA)-induced malignant transformation of human bronchial epithelial cells (16HBE) by DNA methylation microarray analysis. The methylation status of some identified genes was assessed by a polymerase chain reaction and compared
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Controlling drug resistance by targeting Plasmodium falciparum heat shock protein 70-1, a chaperone at the centre of protein quality control mechanism: a review Front. Life Sci. (IF 1.333) Pub Date : 2023-04-21 Douglas A. M. Ruhwaya, Brilliant Nyathi, Gadzikano Munyuki, Ryman Shoko, Grace Mugumbate
The survival of the malaria parasite is highly dependent on withstanding physiological stresses, which are a proportional response to parasite invasion within the hostile human host environment. Plasmodium falciparum heat shock protein 70-1 (PfHSP70-1) plays a significant role through its network of interactions with the substrate scanners PfHSP40s, the functional maturation protein PfHSP90, the nucleotide
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Increased papillary microcirculation in inactive uveitis patients by optical coherence tomography angiography Front. Life Sci. (IF 1.333) Pub Date : 2023-04-17 Yao Xu, Xuefei Zhu
Aim: To quantitatively analyze the vascular and structure abnormalities in the papillary areas in eyes with noninfectious uveitis during different periods using optical coherence tomography angiography (OCTA). Methods: Forty eyes of 40 uveitis patients in the acute phase, 12 eyes of 12 patients with inactive uveitis and 21 eyes of 21 healthy controls were included in this study. RPCvd% and pRNFL thickness
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Ocular hypotensive effect of fermented Pentaclethra macrophylla seeds in experimentally-induced glaucoma Front. Life Sci. (IF 1.333) Pub Date : 2023-04-13 Ikechukwu Jacob Okoro, Parker Elijah Joshua, Samuel Kyei, Innocent Uzochukwu Okagu, Christian Chijioke Amah, Vitus Ikenna Nnamani, Victor Nwadiogbu Ogugua
ABSTRACT The study aimed to investigate the effect of fermented n-hexane extract of Pentaclethra macrophylla seeds (FPMSE) in an experimental model of glaucoma. Eighteen rabbits (1-1.8 kg body weight) were allocated into six groups of three rabbits (six eyes per group). Group 1 was the normal control. Ocular hypertension was induced with 1% prednisolone acetate ophthalmic solution in groups 2-6, twice
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Advanced analysis and applications of single-cell transcriptome sequencing Front. Life Sci. (IF 1.333) Pub Date : 2023-04-13 Zhao Ruohan, Bai Yicheng, Zhao Jingying, Hu Mei, Zhang Xinyan, Yang Min, Dou Tengfei, Jia Junjing
Single-cell transcriptome sequencing (scRNA-seq) is an unparalleled technology in the field of transcriptomics, which can study cells in a comprehensive and unbiased manner, thus characterizing complex biological processes at the cellular level. At the same time, scRNA-seq can produce a large amount of experimental data; therefore, the extraction of important information is required. In this review
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Progress on the role and mechanism of ribosome assembly regulator PNO1 in tumor Front. Life Sci. (IF 1.333) Pub Date : 2023-04-11 Wanyi Liu, Guicheng Kuang, Binbin Yang, Hanlin Liu, Yangping Lv, Yang Xiong, Yongqiu Zeng
PNO1 (Dim2 or Rrp2 or YOR145), a highly conserved regulator of ribosome assembly from yeast to mammals, is involved in forming the 90S pre-ribosome and plays an essential role in the late stage of 40S small subunit maturation. Recent studies have found that PNO1 is involved in the progression of a variety of tumors and is highly expressed in colorectal, lung, esophageal, glioma, and breast cancer and
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Alternative splicing regulates autophagy in response to environmental stresses in cucumber (Cucumis sativus) Front. Life Sci. (IF 1.333) Pub Date : 2023-04-04 Pawaree Thanapipatpong, Supachai Vuttipongchaikij, Thitikorn Chomtong, Wilasinee Puangtame, Pondpan Napaumpaipond, Leonardo D. Gomez, Anongpat Suttangkakul
Autophagy is important for cell survival during stress and nutrient recycle. However, the mechanisms involved in regulating autophagy in cucumber have not been determined. Here, we analyzed the transcript abundance of key autophagy genes in the conjugation pathway including ATG3, ATG4, ATG5, ATG7, ATG8, ATG10, ATG12 and ATG16 in response to nitrogen deficiency, pathogen infection and oxidative stress
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Metabolomics-based analysis of plasma in postmenopausal women with normal bone mineral density, postmenopausal osteoporosis, and rheumatoid arthritis osteoporosis Front. Life Sci. (IF 1.333) Pub Date : 2023-03-08 Kun Zhu, Ju Zhang, Changchun Zhang, Shufang Zhao, Jie Gao, Jianzhong Guan
This study aimed to examine metabolites in the plasma derived from postmenopausal women by untargeted metabolomics along with possible diagnostic markers for osteoporosis. From March 2020 through June 2020, 30 postmenopausal women with normal bone mineral density (BMD) were recruited in the N group, 30 postmenopausal women with postmenopausal osteoporosis were recruited in the postmenopausal osteoporosis
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Retraction: Expression and significance of N-MID, PAI-1, and RBM5 in patients with brain metastases of lung cancer Front. Life Sci. (IF 1.333) Pub Date : 2023-02-27
Published in All Life (Vol. 16, No. 1, 2023)
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Molecular identification and high fidelity micropropagation of shell ginger (Alpinia zerumbet) Front. Life Sci. (IF 1.333) Pub Date : 2023-02-09 Shashanka Shekhar Sarker, Kh. Muhim Ahmed, Tanzena Tanny, Shamima Nasrin, A. H. M. Mahbubur Rahman, Keshob Chandra Das, Iftekhar Alam
Alpinia zerumbet is a medicinal and ornamental plant of the Zingiberaceae family cultivated in many parts of the world. The plant is medicinally important and often misidentified with closely related species. The objective of this work was to establish its DNA-based identity and a protocol for high-fidelity micropropagation to support the medicinal plant industry. PCR amplification and subsequent sequencing
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Reviewing the mechanism of propofol addiction Front. Life Sci. (IF 1.333) Pub Date : 2023-02-06 Tianhao Zhong, Yuyan Lin, Ruohuai Zhuge, Yujie Lin, Bingwu Huang, Ruifeng Zeng
Propofol is widely used as a short-acting intravenous anaesthetic for the induction and maintenance of anaesthetic sedation. The application of propofol is expanding due to its advantages and the increasing demand for painless diagnosis and treatment. However, accumulating clinical and experimental evidence has shown that propofol can potentially be abused and is prone to causing addiction. To further
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Biological functions and molecular mechanisms of LINC00961 in human cancer Front. Life Sci. (IF 1.333) Pub Date : 2023-02-06 Kai Li, Yan-Mei Ji, Jia-Long Guo, Qiang Guo
Long non-coding RNAs (lncRNAs) are more than 200 bp in length and do not translate into functional proteins. They are involved in inhibiting cell growth, migration, and invasion, and in promoting apoptosis. It was found that cancer-related LINC00961 is downregulated in a variety of malignant tumors, including lung cancer, renal cell carcinoma, and hepatocellular carcinoma. LINC00961 either inhibits
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Effect of Chinese herbal formulae (BU-SHEN-YI-QI granule) treatment on thrombin expression after ischemia/reperfusion Front. Life Sci. (IF 1.333) Pub Date : 2023-02-06 Aihua Liu, Jing Sun, Sagun Tiwari, John Wong, Honglin Wang, Dongxu Tang, Zhenxiang Han
Bu-Shen-Yi-Qi granule (BSYQG), a Chinese herbal formula, has been used for the treatment of ischemic stroke with proven efficacy. The purpose of this study is to evaluate the therapeutic efficacy of BSYQG in neurovascular unit (NVU) and its mechanism of action on the thrombin expression in the cerebral ischemic/reperfusion (I/R) model. In the study, a rat model of I/R was established using middle cerebral
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Proteomic analysis of fetal skin by iTRAQ reveals molecular signals underlying Inner Mongolia Cashmere goat hair follicle initiation Front. Life Sci. (IF 1.333) Pub Date : 2023-02-02 Lele Wang, Rugang Tian, Gaofeng Wang, Meng Zhao, Yanjun Zhang, Jinquan Li
Cashmere goats produce wool from primary hair follicles (PHF)and cashmere from secondary hair follicles(SHF). Numerous genetic factors have been identified to affect HF formation, but the mechanism that controls the distinct morphogenesis of PHFs and SHFs remains unclear. To better describe goat’s hair follicle proteome, we applied iTRAQ technology to study protein expression profiling from nine skin
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Arsenic and diabetes mellitus: a putative role for the immune system Front. Life Sci. (IF 1.333) Pub Date : 2023-02-01 Jingli Liu, Tonia Hermon, Xiaohua Gao, Darlene Dixon, Hang Xiao
Diabetes mellitus (DM) is an enormous public health issue worldwide. Recent data suggest that chronic arsenic exposure is linked to the risk of developing type 1 and type 2 DM, albeit the underlying mechanisms are unclear. This review discusses the role of the immune system as a link to possibly explain some of the mechanisms of developing T1DM or T2DM associated with arsenic exposure in humans, animal
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Chemical screening and mosquitocidal activity of essential oil derived from Mikania scandens (L.) Willd. against Anopheles gambiae Giles and their non-toxicity on mosquito predators Front. Life Sci. (IF 1.333) Pub Date : 2023-02-01 Narayanaswamy Radhakrishnan, Sengodan Karthi, Pandiyan Raghuraman, Raja Ganesan, Kumaraswamy Srinivasan, Edward-Sam Edwin, Selvaraj Ganesh-Kumar, Norhaizan Mohd Esa, Sengottayan Senthil-Nathan, Prabhakaran Vasantha-Srinivasan, Patcharin Krutmuangh, Mona S. Alwahibi, Mohamed Soliman Elshikh
In-vitro chemical characterization and mosquitocidal screening of essential oil derived from Mikania scandens (L.) Willd. (Asteraceae) (CVO-MS) against the malarial vector Anopheles gambiae was investigated. GC-MS analysis evidenced a total of 12 bio-active compounds, and maximum at α-bisabolol (39.34%) followed by stigmasterol (13.45%) respectively. The larvicidal activity of CVO-MS against the malarial
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Relative risk factors of nerve root sedimentation sign (SedSign) in patients with severe central lumbar spinal stenosis (LSS) Front. Life Sci. (IF 1.333) Pub Date : 2023-01-30 Haiming Yu, Yunfeng Han, Rui Zhang, Chu Sun, Mingda Wang, Bo Yue, Kaiping Chou, Bin Li, Nan Zhang
The incidence of nerve root sedimentation sign (SedSign) was evaluated to explore potential pathogenesis in patients with severe lumbar spinal stenosis (LSS). In a total of 209 patients with severe LSS, 290 intervertebral levels were narrow, among which 248 showed a positive SedSign, giving a prevalence of 85.52%. Those levels with a positive SedSign were further analyzed relative to those with a negative