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All-Rounder Liposomes in Cancer Immunotherapy: Strategies and Design Applications of Engineered Liposomal Nanomaterials Biochip J. (IF 4.3) Pub Date : 2024-04-03 Gahyun Lee, Yonghyun Choi, Joohye Hong, Jiwon Kim, Jayoung Chae, Suyeon Ahn, Heejin Ha, Eunseo Jeong, Hee-Young Lee, Jonghoon Choi
Cancer is a major health problem worldwide, which is responsible for more than 10 million deaths annually. Cancer treatment has traditionally been based on chemotherapy and surgery; however, owing to cytotoxicity, drug resistance, and non-specificity, cancer immunotherapy, which involves using the patient’s own immune system in treatment, has recently gained prominence as a new cancer treatment strategy
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One-Step Immunoassay for the Detection of SARS-CoV-2 Nucleocapsid Protein Using Screened Fv-Antibodies Biochip J. (IF 4.3) Pub Date : 2024-04-02 Jaeyong Jung, Jeong Soo Sung, Tae-Hun Kim, Min-Jung Kang, Joachim Jose, Hyun-Jin Shin, Jae-Chul Pyun
Fv-antibodies against the nucleocapsid protein (NP) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were screened from an Fv-antibody library, and a one-step immunoassay was performed to detect SARS-CoV-2 using real viral samples. The Fv-antibody library was prepared using site-directed mutagenesis of the CDR3 region, which was composed of 11 amino acids. To screen the target Escherichia
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Acoustofluidic Microbioreactor Using Surface Acoustic Wave-induced Acoustic Streaming Flow Biochip J. (IF 4.3) Pub Date : 2024-04-02
Abstract Microbioreactors have been widely utilized as an alternative to conventional benchtop reactors, since the miniaturized platforms offer advantages including reduced sample volume and homogeneous microenvironments. Here, we proposed an acoustofluidic microbioreactor based on surface acoustic wave (SAW)-induced acoustic streaming flow (ASF). The SAW-induced ASF, which originates from the wave
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Rapid and Cost-Effective On-site Detection of Plant Viruses Using Personal Glucose Meters Integrated with LAMP and Cascade Enzymatic Reactions Biochip J. (IF 4.3) Pub Date : 2024-03-26 Hyogu Han, Yang Chan Park, Kwang-Kyu Kim, Hak Ju Kim, Han Kyu Seo, Jeanho Park, Jae Sun Moon, Jun Ki Ahn
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Fabrication of Highly Ordered Nanopillar Array Electrode for High-Performance Humidity Sensors Biochip J. (IF 4.3) Pub Date : 2024-03-26 Sung Tae Jang, Seo Jin Kim, Jueun Kim, Eun Seop Yoon, Oh Seok Kwon, Kyoung G. Lee, Bong Gill Choi
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Non-invasive Thermohydrodynamic Approach for Fast Cell Manipulation at the Microscale Biochip J. (IF 4.3) Pub Date : 2024-03-25 Víctor de la Asunción-Nadal, Marta Pacheco, Beatriz Jurado-Sánchez, Estela Lapeira, Maialen Aginagalde, M. Mounir Bou-Ali, Alberto Escarpa
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Recent Progress in High-Throughput Enzymatic DNA Synthesis for Data Storage Biochip J. (IF 4.3) Pub Date : 2024-03-18 David Baek, Sung-Yune Joe, Haewon Shin, Chaewon Park, Seokwoo Jo, Honggu Chun
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A Recycled-Material-Based Electrochemical Eco-sensor for Sensitive Detection of Antischistosomal Drug Residues in Bovine-Derived Food Samples Biochip J. (IF 4.3) Pub Date : 2024-03-08 Khalid A. M. Attia, Ahmed E. F. Abbas, Ahmed El-Olemy, Nahla A. Abdelshafi, Sherif M. Eid
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Microfluidic Capture Device for Simple, Cell Surface Marker-Based Quantification of Senescent CD8+ T Cells Biochip J. (IF 4.3) Pub Date : 2024-03-08 Yo-han Choi, Woo-Joong Kim, Dongwoo Lee, Bum-Joon Jung, Eui-Cheol Shin, Wonhee Lee
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Recent Advances in Electrochemical and Nanophotonic Biosensors for SARS-CoV-2 Detection Biochip J. (IF 4.3) Pub Date : 2024-03-08
Abstract The contagious respiratory illness coronavirus disease 2019 (COVID-19) has had an unprecedented impact on both global health and society, causing a global pandemic due to its rapid transmission. The emergence of numerous variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) underscores the critical importance of accurately diagnosing variants of concern (VOCs). Viruses have
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Simultaneous Triplex Detection in a Single-Test-Line Lateral Flow Immunoassay Utilizing Distinct Nanoparticle Colorimetry Biochip J. (IF 4.3) Pub Date : 2024-03-08 Youngkwang Moon, Hui Hun Cho, Hyeokgyun Moon, Hyewon Song, Jae Chul Ro, Jung Heon Lee, Jinkee Lee
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Passive-Flow-Based MPS: Emerging Physiological Flow-Mimetic Platforms for Studying Effects of Flow on Single Tissues and Inter-tissue Interactions Biochip J. (IF 4.3) Pub Date : 2024-03-08 Geonho Jin, Dohyung Kim, Seonghun Mun, Seokyoung Bang
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Optimization of Tumor Spheroid Preparation and Morphological Analysis for Drug Evaluation Biochip J. (IF 4.3) Pub Date : 2024-02-21
Abstract Due to its similarity to in vivo conditions, tumor spheroids are actively used in research areas, such as drug screening and cell–cell interactions. A substantial quantity of spheroids is crucial for obtaining dependable results in high-throughput screening. Conventional fabrication methods of spheroid have limitations in low yield and morphological variation. Droplet-based microfluidic system
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Surface Plasmon Resonance (SPR) Biosensor for the Detection of SARS-CoV-2 Using Autodisplyaed FV-antibodies on Outer Membrane of E. coli Biochip J. (IF 4.3) Pub Date : 2024-02-21 Ji-Hong Bong, Soo Jeong Lee, Jaeyong Jung, Jeong Soo Sung, Min-Jung Kang, Misu Lee, Joachim Jose, Jae-Chul Pyun
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Functionalized Carbon Quantum Dots Derived from Zelkova serrata Plant Leaves for the Detection of Normetanephrine in Geriatric Plasma Samples and ROS-Induced Antibacterial Applications Using a Plausible Mechanistic Approach Biochip J. (IF 4.3) Pub Date : 2024-02-12 Yanamala Poojitha, Gayathri Chellasamy, Saravanan Govindaraju, Kyusik Yun
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Advances in Technical Assessment of Spiral Inertial Microfluidic Devices Toward Bioparticle Separation and Profiling: A Critical Review Biochip J. (IF 4.3) Pub Date : 2024-01-22 Mahsa Bagi, Fatemeh Amjad, Seyed Majid Ghoreishian, Somayeh Sohrabi Shahsavari, Yun Suk Huh, Mostafa Keshavarz Moraveji, Sirivatch Shimpalee
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Intensity Histogram-Based Reliable Image Analysis Method for Bead-Based Fluorescence Immunoassay Biochip J. (IF 4.3) Pub Date : 2024-01-15 Sanghyun Lee, Juyeong Kim, Pankee Bae, Sangmin Lee, Hojin Kim
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Numerical-Simulation-Based Buffer Design for Microchip Electrophoresis with Capacitively Coupled Contactless Conductivity Detection Biochip J. (IF 4.3) Pub Date : 2024-01-03
Abstract We present a numerical simulation method for designing a buffer system in microchip electrophoresis (MCE) equipped with capacitively-coupled-contactless-conductivity detection (C4D). One of the key design considerations for MCE-C4D is background electrolyte (BGE). This is because a C4D typically exhibits low sensitivity, and optimizing BGE conditions (e.g., base and acid species, pH, and ionic
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Towards Nanomaterial-Incorporated Soft Actuators: from Inorganic/Organic Material-Based Soft Robot to Biomaterial-Based Biohybrid Robot Biochip J. (IF 4.3) Pub Date : 2023-12-27 Minkyu Shin, Seewoo Kim, Ambrose Ashwin Melvin, Jeong-Woo Choi
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Label-Free and Real-Time Electrical Impedance Monitoring of Macrophage Polarization of THP-1 Monocytes on Indium Tin Oxide Electrode Biochip J. (IF 4.3) Pub Date : 2023-12-27 Duc-Trung Pham, Hoang Lan Pham, Hien T. Ngoc Le, My-Van Tieu, Daesoo Kim, Jae Young Kim, Sungbo Cho
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Synthesis of Truncated DNA Aptamer and Its Application to an Electrochemical Biosensor Consisting of an Aptamer and a MXene Heterolayer for Yellow Fever Virus Biochip J. (IF 4.3) Pub Date : 2023-12-18 Nayeon Kwon, Siyun Lee, Moonbong Jang, Jin-Ho Lee, Chulhwan Park, Taek Lee
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Colorimetric Detection of Staphylococcus aureus Based on Direct Loop-Mediated Isothermal Amplification in Combination with Lateral Flow Assay Biochip J. (IF 4.3) Pub Date : 2023-12-14 Seungjin Lee, Seung Hyeon Reo, Seokjoon Kim, Seokhwan Kim, Eun Sung Lee, Byung Seok Cha, Jiye Shin, Jinjoo Han, So Min Ahn, Han-Seung Shin, Ki Soo Park
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Plasmonic-Multichromatic Sensor for Gallic Acid Assay Utilizing Ag-Coated Au Nanobipyramids Biochip J. (IF 4.3) Pub Date : 2023-12-06 Mohamed H. Mostafa, Samy M. Shaban, Eslam Hafez, Jihoon Shin, Dong-Hwan Kim
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Combining Ultrasound-Mediated Intracellular Delivery with Microfluidics in Various Applications Biochip J. (IF 4.3) Pub Date : 2023-11-28 Guangyong Huang, Lin Lin, Shixiong Wu, Haojie Dang, Xuesong Cheng, Ying Liu, Hui You
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Recent Progress in Rapid Biosensor Fabrication Methods: Focus on Electrical Potential Application Biochip J. (IF 4.3) Pub Date : 2023-11-28 Yejin Yoon, Yein Kwon, Hanbin Park, Siyun Lee, Chulhwan Park, Taek Lee
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Rapid and Ultrasensitive Detection of Staphylococcus aureus Using a Gold-Interdigitated Single-Wave-Shaped Electrode (Au-ISWE) Electrochemical Biosensor Biochip J. (IF 4.3) Pub Date : 2023-11-14 My-Van Tieu, Duc Trung Pham, Hien T. Ngoc Le, Thi Xoan Hoang, Sungbo Cho
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A Controlled Transcription-Driven Light-Up Aptamer Amplification for Nucleoside Triphosphate Detection Biochip J. (IF 4.3) Pub Date : 2023-10-25 Deok-Gyu Lee, Hye-Jin Lim, Ha-Yeong Lee, Dong-Myung Kim, Kyung-Ho Lee, Ju-Young Byun, Yong-Beom Shin
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Enhanced Antitumor Effect of the Combination of Bacille Calmette-Guérin and an Immune Checkpoint Inhibitor in Bladder Cancer-On-a-Chip Biochip J. (IF 4.3) Pub Date : 2023-10-17 Se Young Choi, Mirinae Kim, Su Jeong Kang, Young Wook Choi, Sejung Maeng, Sung-Hwan Kim, In Ho Chang
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Continuous Isolation of Stem-Cell-Derived Extracellular Vesicles (SC-EVs) by Recycled Magnetic Beads in Microfluidic Channels Biochip J. (IF 4.3) Pub Date : 2023-10-04 Haeun Yu, Jaejeung Kim, Jianning Yu, Kyung-A Hyun, Jae-Yol Lim, Yeo-Jun Yoon, Sunyoung Park, Hyo-Il Jung
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Analysis of Thrombosis Formation and Growth Using Microfluidic Chips and Multiphase Computational Fluid Dynamics Biochip J. (IF 4.3) Pub Date : 2023-09-28 Dong-Hwi Ham, Ji-Seob Choi, Pyeong-Ho Jeong, Jung-Hyun Kim, Helem Betsua Flores Marcial, Jin-Ho Choi, Woo-Tae Park
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In Vitro Assays of Neurite Outgrowth and Synapse Formation Using Thermoplasmonic Ablation Technique Biochip J. (IF 4.3) Pub Date : 2023-09-26 Nari Hong, Yoonkey Nam
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Integration of an Aptamer-Based Signal-On Probe and a Paper-Based Origami Preconcentrator for Small Molecule Biomarkers Detection Biochip J. (IF 4.3) Pub Date : 2023-09-21 Na Eun Lee, Ji Hye Hong, Seungmin Lee, Yong Kyoung Yoo, Kang Hyeon Kim, Jeong Soo Park, Cheonjung Kim, Junghyo Yoon, Dae Sung Yoon, Jeong Hoon Lee
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Low-Loaded Polyethylene Glycol (PEG) Resin for High-Purity Peptide Synthesis and Cell Binding Assays Biochip J. (IF 4.3) Pub Date : 2023-09-19 Seongsoo Kim, Jeeyeon Park, Hye-Won Kim, Jinsik Kim, Joonwon Bae, Min Hee Lee, Dong-Sik Shin
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Inflammatory Bowel Disease: Pathophysiology, Treatment, and Disease Modeling Biochip J. (IF 4.3) Pub Date : 2023-08-29 Jiryeon Jang, Sehoon Jeong
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Laser-Assisted Recovery of On-Chip Phage Viral DNA for Phage Fluorescence Immunoassay Microchip Biochip J. (IF 4.3) Pub Date : 2023-08-29 Seohee Chang, Soohyun Kim, Daewon Lee, Seung Ah Lee, Junho Chung, Sunghoon Kwon, Junhoi Kim
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Microfluidic Device to Maximize Capillary Force Driven Flows for Quantitative Single-Molecule DNA Analysis Biochip J. (IF 4.3) Pub Date : 2023-08-11 Taesoo Kim, Kyubong Jo
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Real-Time Detection of SARS-CoV-2 Nucleocapsid Antigen Using Data Analysis Software and IoT-Based Portable Reader with Single-Walled Carbon Nanotube Field Effect Transistor Biochip J. (IF 4.3) Pub Date : 2023-08-07 Da Eun Oh, Ji Sun Kim, In Kyoung Hwang, Hong-Seog Park, Chang-Seuk Lee, Tae Hyun Kim
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Machine Learning-Aided Three-Dimensional Morphological Quantification of Angiogenic Vasculature in the Multiculture Microfluidic Platform Biochip J. (IF 4.3) Pub Date : 2023-07-31 Wonjun Lee, Byoungkwon Yoon, Jungseub Lee, Sangmin Jung, Young Sun Oh, Jihoon Ko, Noo Li Jeon
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Nanomaterials-Based Exosomes for the Diagnostics and Drug Deliveries of Central Nervous System Diseases Biochip J. (IF 4.3) Pub Date : 2023-07-04 Izzati Haizan, Dong Hyeok Park, Min Yu Choi, Hyerim Lee, Jin-Ha Choi
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Optical-Switch Raman Spectroscopy for High Throughput Screening Biochip J. (IF 4.3) Pub Date : 2023-07-04 Seung-Jin Lee, Kwan Hee Lee, Young-Wan Choi, Jun Ki Kim, Woo June Choi
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Fabrication of Hydrogel Microchannels Using Aqueous Two-Phase Printing for 3D Blood Brain Barrier Biochip J. (IF 4.3) Pub Date : 2023-07-04 Hyunjik Oh, Minjin Kang, Eunji Bae, Yonghun Jung, Jinhui Cho, Joscillyn Poirier, Jong Sung Kim, John P. Frampton, Nakwon Choi, Seok Chung
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Low-Powered pH-Stable Nano-electrokinetically Enhanced Lateral Flow Assay for COVID-19 Antigen Test Biochip J. (IF 4.3) Pub Date : 2023-07-04 Kang Hyeon Kim, Yong Kyoung Yoo, Na Eun Lee, Junwoo Lee, Cheonjung Kim, Seungmin Lee, Jinhwan Kim, Seong Jun Park, Dongtak Lee, Sang Won Lee, Hyungseok Kim, Don Hur, Dae Sung Yoon, Jeong Hoon Lee
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Development of an Extracellular Matrix Plate for Drug Screening Using Patient-Derived Tumor Organoids Biochip J. (IF 4.3) Pub Date : 2023-06-19 Yong Hun Jung, Kyungwon Park, Minseop Kim, Hyunjik Oh, Dong-Hee Choi, Jinchul Ahn, Sat-byol Lee, Kyuhwan Na, Byung Soh Min, Jin-A. Kim, Seok Chung
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Nanoscale Diesel-Exhaust Particulate Matter (DPM) Impairs Synaptic Plasticity of Human iPSCs-Derived Cerebral Organoids Biochip J. (IF 4.3) Pub Date : 2023-06-19 Soo-jeong Park, Jeong-Woo Choi
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The Detection of Urinary Exosomal miRNAs for Cancer Diagnostics and Prognostics Biochip J. (IF 4.3) Pub Date : 2023-06-19 Junbeom Kim, Mina Kim, Ji Yoon Kang, Ki Wan Bong, Nakwon Choi
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Immunogenicity Monitoring Cell Chip Incorporating Finger-Actuated Microfluidic and Colorimetric Paper-Based Analytical Functions Biochip J. (IF 4.3) Pub Date : 2023-06-19 Kyung Won Lee, Eun Kyeong Yang, Yujeong Oh, Eunhye Park, Kwan Young Jeong, Hyun C. Yoon
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Recent Advances in Photoelectrochemical Sensing of Alzheimer’s Biomarkers Biochip J. (IF 4.3) Pub Date : 2023-06-12 Kayoung Kim
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Surface Modification Strategies for Biomedical Applications: Enhancing Cell–Biomaterial Interfaces and Biochip Performances Biochip J. (IF 4.3) Pub Date : 2023-06-12 Soonjong Roh, Yerim Jang, Jin Yoo, Hyejeong Seong
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Microtubule WGM Sensor: Applications and Key Technologies Biochip J. (IF 4.3) Pub Date : 2023-06-12 Guoqing Yuan, Hong Li, Xinjian Luo, Lidan Lu, Lianqing Zhu
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Advanced Organotypic In Vitro Model Systems for Host–Microbial Coculture Biochip J. (IF 4.3) Pub Date : 2023-05-22 Raehyun Kim
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Paper-Based Radial Flow Assay Integrated to Portable Isothermal Amplification Chip Platform for Colorimetric Detection of Target DNA Biochip J. (IF 4.3) Pub Date : 2023-04-27 Tai-Yong Kim, Sanha Kim, Jae Hwan Jung, Min-Ah Woo
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Comparison and Analysis of Polymer-Functionalized Carbon Nanotubes for Enhancement of the Quantitative Detection of Procalcitonin Levels in Human Plasma Biochip J. (IF 4.3) Pub Date : 2023-04-27 Ariadna Schuck, Hyo Eun Kim, Minhee Kang, Yong-Sang Kim
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A Laser-Micromachined PCB Electrolytic Micropump Using an Oil-Based Electrolyte Separation Barrier Biochip J. (IF 4.3) Pub Date : 2023-03-30 Seonhyeok Baek, Hakhyun Kim, Heewon Hwang, Abdi Mirgissa Kaba, Hyeonsik Kim, Minsub Chung, Jintae Kim, Dohyun Kim
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From Single- to Multi-organ-on-a-Chip System for Studying Metabolic Diseases Biochip J. (IF 4.3) Pub Date : 2023-02-15 Minjeong Jang, Hong Nam Kim
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Development of Gut-Mucus Chip for Intestinal Absorption Study Biochip J. (IF 4.3) Pub Date : 2023-02-15 Seung Yeon Lee, Yujeong Lee, Nakwon Choi, Hong Nam Kim, Bumsang Kim, Jong Hwan Sung
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Flexible Capillary Microfluidic Devices Based on Surface-Energy Modified Polydimethylsiloxane and Polymethylmethacrylate with Room-Temperature Chemical Bonding Biochip J. (IF 4.3) Pub Date : 2023-01-31 Lai Thi Ngoc Huyen, Seok Ju Hong, Tran Quang Trung, Montri Meeseepong, A Ri Kim, Nae-Eung Lee
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Fluorescent Lateral Flow Assay with Carbon Nanodot Conjugates for Carcinoembryonic Antigen Biochip J. (IF 4.3) Pub Date : 2023-01-17 Jung Min Lim, Mulya Supianto, Tae Yang Kim, Byeong Soo Kim, Jeong Woo Park, Hyun Hee Jang, Hye Jin Lee
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Identification of Potential Allergens of Atractylodes japonica and Addition of Panels for Allergic Diseases Biochip J. (IF 4.3) Pub Date : 2023-01-17 Wona Jee, Hyun Min Ko, Seung Won Kwon, Woo Sang Jung, Hyeung-Jin Jang
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Deep Learning-Assisted Droplet Digital PCR for Quantitative Detection of Human Coronavirus Biochip J. (IF 4.3) Pub Date : 2023-01-17 Young Suh Lee, Ji Wook Choi, Taewook Kang, Bong Geun Chung
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Polydopamine Nanoparticle-Incorporated Fluorescent Hydrogel for Fluorescence Imaging-Guided Photothermal Therapy of Cancers Biochip J. (IF 4.3) Pub Date : 2022-12-06 Kyung Kwan Lee, Sang Cheon Lee, Hongki Kim, Chang-Soo Lee