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Dual-role transcription factors stabilize intermediate expression levels Cell (IF 64.5) Pub Date : 2024-04-16 Jinnan He, Xiangru Huo, Gaofeng Pei, Zeran Jia, Yiming Yan, Jiawei Yu, Haozhi Qu, Yunxin Xie, Junsong Yuan, Yuan Zheng, Yanyan Hu, Minglei Shi, Kaiqiang You, Tingting Li, Tianhua Ma, Michael Q. Zhang, Sheng Ding, Pilong Li, Yinqing Li
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Global, site-resolved analysis of ubiquitylation occupancy and turnover rate reveals systems properties Cell (IF 64.5) Pub Date : 2024-04-15 Gabriela Prus, Shankha Satpathy, Brian T. Weinert, Takeo Narita, Chunaram Choudhary
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Direct observation of a condensate effect on super-enhancer controlled gene bursting Cell (IF 64.5) Pub Date : 2024-04-12 Manyu Du, Simon Hendrik Stitzinger, Jan-Hendrik Spille, Won-Ki Cho, Choongman Lee, Mohammed Hijaz, Andrea Quintana, Ibrahim I. Cissé
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RNA genome packaging and capsid assembly of bluetongue virus visualized in host cells Cell (IF 64.5) Pub Date : 2024-04-12 Xian Xia, Po-Yu Sung, Michael W. Martynowycz, Tamir Gonen, Polly Roy, Z. Hong Zhou
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ITPRIPL1 binds CD3ε to impede T cell activation and enable tumor immune evasion Cell (IF 64.5) Pub Date : 2024-04-12 Shouyan Deng, Yibo Zhang, Huanbin Wang, Wenhua Liang, Lu Xie, Ning Li, Yuan Fang, Yiting Wang, Jiayang Liu, Hao Chi, Yufan Sun, Rui Ye, Lishen Shan, Jiawei Shi, Zan Shen, Yonggang Wang, Shuhang Wang, Jean-Philippe Brosseau, Feng Wang, Grace Liu, Yingfei Quan, Jie Xu
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NINJ1 mediates plasma membrane rupture by cutting and releasing membrane disks Cell (IF 64.5) Pub Date : 2024-04-12 Liron David, Jazlyn P. Borges, L. Robert Hollingsworth, Allen Volchuk, Isabelle Jansen, Evelyn Garlick, Benjamin E. Steinberg, Hao Wu
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Ending “domestic helicopter research” Cell (IF 64.5) Pub Date : 2024-04-11 W. Marcus Lambert, Marlene Camacho-Rivera, Carla Boutin-Foster, Moro Salifu, Wayne J. Riley
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Problem choice and decision trees in science and engineering Cell (IF 64.5) Pub Date : 2024-04-11 Michael A. Fischbach
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Self-amplifying RNA COVID-19 vaccine Cell (IF 64.5) Pub Date : 2024-04-11 Christopher J. Wayne, Anna K. Blakney
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Elliott Dan Kieff, MD, PhD (1943–2024) Cell (IF 64.5) Pub Date : 2024-04-11 Nancy Raab-Traub, Benjamin E. Gewurz
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Chromatin context-dependent regulation and epigenetic manipulation of prime editing Cell (IF 64.5) Pub Date : 2024-04-11 Xiaoyi Li, Wei Chen, Beth K. Martin, Diego Calderon, Choli Lee, Junhong Choi, Florence M. Chardon, Troy A. McDiarmid, Riza M. Daza, Haedong Kim, Jean-Benoît Lalanne, Jenny F. Nathans, David S. Lee, Jay Shendure
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A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 Cell (IF 64.5) Pub Date : 2024-04-11 Li Ren Kong, Komal Gupta, Andy Jialun Wu, David Perera, Roland Ivanyi-Nagy, Syed Moiz Ahmed, Tuan Zea Tan, Shawn Lu-Wen Tan, Alessandra Fuddin, Elayanambi Sundaramoorthy, Grace Shiqing Goh, Regina Tong Xin Wong, Ana S.H. Costa, Callum Oddy, Hannan Wong, C. Pawan K. Patro, Yun Suen Kho, Xiao Zi Huang, Joan Choo, Mona Shehata, Soo Chin Lee, Boon Cher Goh, Christian Frezza, Jason J. Pitt, Ashok R. Venkitaraman
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Time-series reconstruction of the molecular architecture of human centriole assembly Cell (IF 64.5) Pub Date : 2024-04-10 Marine H. Laporte, Davide Gambarotto, Éloïse Bertiaux, Lorène Bournonville, Vincent Louvel, José M. Nunes, Susanne Borgers, Virginie Hamel, Paul Guichard
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A pan-cancer analysis of the microbiome in metastatic cancer Cell (IF 64.5) Pub Date : 2024-04-09 Thomas W. Battaglia, Iris L. Mimpen, Joleen J.H. Traets, Arne van Hoeck, Laurien J. Zeverijn, Birgit S. Geurts, Gijs F. de Wit, Michaël Noë, Ingrid Hofland, Joris L. Vos, Sten Cornelissen, Maartje Alkemade, Annegien Broeks, Charlotte L. Zuur, Edwin Cuppen, Lodewyk Wessels, Joris van de Haar, Emile Voest
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A genome-wide spectrum of tandem repeat expansions in 338,963 humans Cell (IF 64.5) Pub Date : 2024-04-05 Ya Cui, Wenbin Ye, Jason Sheng Li, Jingyi Jessica Li, Eric Vilain, Tamer Sallam, Wei Li
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Human iPSC 4R tauopathy model uncovers modifiers of tau propagation Cell (IF 64.5) Pub Date : 2024-04-05 Celeste Parra Bravo, Alice Maria Giani, Jesus Madero Perez, Zeping Zhao, Yuansong Wan, Avi J. Samelson, Man Ying Wong, Alessandro Evangelisti, Ethan Cordes, Li Fan, Pearly Ye, Daphne Zhu, Tatyana Pozner, Maria Mercedes, Tark Patel, Allan Yarahmady, Gillian K. Carling, Fredrik H. Sterky, Virginia M.Y. Lee, Edward B. Lee, Michael DeTure, Dennis W. Dickson, Manu Sharma, Sue-Ann Mok, Wenjie Luo, Mingrui
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Tracing the origin of alveolar stem cells in lung repair and regeneration Cell (IF 64.5) Pub Date : 2024-04-04 Kuo Liu, Xinfeng Meng, Zixin Liu, Muxue Tang, Zan Lv, Xiuzhen Huang, Hengwei Jin, Ximeng Han, Xiuxiu Liu, Wenjuan Pu, Huan Zhu, Bin Zhou
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Infant microbes and metabolites point to childhood neurodevelopmental disorders Cell (IF 64.5) Pub Date : 2024-04-03 Angelica P. Ahrens, Tuulia Hyötyläinen, Joseph R. Petrone, Kajsa Igelström, Christian D. George, Timothy J. Garrett, Matej Orešič, Eric W. Triplett, Johnny Ludvigsson
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Gut microbiome and metabolome profiling in Framingham heart study reveals cholesterol-metabolizing bacteria Cell (IF 64.5) Pub Date : 2024-04-02 Chenhao Li, Martin Stražar, Ahmed M.T. Mohamed, Julian A. Pacheco, Rebecca L. Walker, Tina Lebar, Shijie Zhao, Julia Lockart, Andrea Dame, Kumar Thurimella, Sarah Jeanfavre, Eric M. Brown, Qi Yan Ang, Brittany Berdy, Dallis Sergio, Rachele Invernizzi, Antonio Tinoco, Gleb Pishchany, Ramachandran S. Vasan, Emily Balskus, Curtis Huttenhower, Hera Vlamakis, Clary Clish, Stanley Y. Shaw, Damian R. Plichta
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Charting the cellular biogeography in colitis reveals fibroblast trajectories and coordinated spatial remodeling Cell (IF 64.5) Pub Date : 2024-04-02 Paolo Cadinu, Kisha N. Sivanathan, Aditya Misra, Rosalind J. Xu, Davide Mangani, Evan Yang, Joseph M. Rone, Katherine Tooley, Yoon-Chul Kye, Lloyd Bod, Ludwig Geistlinger, Tyrone Lee, Randall T. Mertens, Noriaki Ono, Gang Wang, Liliana Sanmarco, Francisco J. Quintana, Ana C. Anderson, Vijay K. Kuchroo, Jeffrey R. Moffitt, Roni Nowarski
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Cancer SLC6A6-mediated taurine uptake transactivates immune checkpoint genes and induces exhaustion in CD8+ T cells Cell (IF 64.5) Pub Date : 2024-04-01 Tianyu Cao, Wenyao Zhang, Qi Wang, Chen Wang, Wanqi Ma, Cangang Zhang, Minghui Ge, Miaomiao Tian, Jia Yu, Anjun Jiao, Liang Wang, Manjiao Liu, Pei Wang, Zhiyu Guo, Yun Zhou, Shuyi Chen, Wen Yin, Jing Yi, Hao Guo, Hua Han, Baojun Zhang, Kaichun Wu, Daiming Fan, Xin Wang, Yongzhan Nie, Yuanyuan Lu, Xiaodi Zhao
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Barcoding of episodic memories in the hippocampus of a food-caching bird Cell (IF 64.5) Pub Date : 2024-03-29 Selmaan N. Chettih, Emily L. Mackevicius, Stephanie Hale, Dmitriy Aronov
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The SPATA5-SPATA5L1 ATPase complex directs replisome proteostasis to ensure genome integrity Cell (IF 64.5) Pub Date : 2024-03-29 Vidhya Krishnamoorthy, Martina Foglizzo, Robert L. Dilley, Angela Wu, Arindam Datta, Parul Dutta, Lisa J. Campbell, Oksana Degtjarik, Laura J. Musgrove, Antonio N. Calabrese, Elton Zeqiraj, Roger A. Greenberg
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Embracing cancer complexity: Hallmarks of systemic disease Cell (IF 64.5) Pub Date : 2024-03-28 Charles Swanton, Elsa Bernard, Chris Abbosh, Fabrice André, Johan Auwerx, Allan Balmain, Dafna Bar-Sagi, René Bernards, Susan Bullman, James DeGregori, Catherine Elliott, Ayelet Erez, Gerard Evan, Mark A. Febbraio, Andrés Hidalgo, Mariam Jamal-Hanjani, Johanna A. Joyce, Matthew Kaiser, Katja Lamia, Jason W. Locasale, Sherene Loi, Ilaria Malanchi, Miriam Merad, Kathryn Musgrave, Ketan J. Patel, Sergio
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Mastigoneme structure reveals insights into the O-linked glycosylation code of native hydroxyproline-rich helices Cell (IF 64.5) Pub Date : 2024-03-28 Jin Dai, Meisheng Ma, Qingwei Niu, Robyn J. Eisert, Xiangli Wang, Poulomi Das, Karl F. Lechtreck, Susan K. Dutcher, Rui Zhang, Alan Brown
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Challenges and opportunities in oncology drug development and clinical research in China Cell (IF 64.5) Pub Date : 2024-03-28 Feng Wang, Dan-Yun Ruan, Rui-Hua Xu
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Unraveling cellular complexity with transient adapters in highly multiplexed super-resolution imaging Cell (IF 64.5) Pub Date : 2024-03-28 Florian Schueder, Felix Rivera-Molina, Maohan Su, Zach Marin, Phylicia Kidd, James E. Rothman, Derek Toomre, Joerg Bewersdorf
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Structure-guided discovery of protein and glycan components in native mastigonemes Cell (IF 64.5) Pub Date : 2024-03-28 Junhao Huang, Hui Tao, Jikun Chen, Yang Shen, Jianlin Lei, Junmin Pan, Chuangye Yan, Nieng Yan
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Spatial proteomics in neurons at single-protein resolution Cell (IF 64.5) Pub Date : 2024-03-28 Eduard M. Unterauer, Sayedali Shetab Boushehri, Kristina Jevdokimenko, Luciano A. Masullo, Mahipal Ganji, Shama Sograte-Idrissi, Rafal Kowalewski, Sebastian Strauss, Susanne C.M. Reinhardt, Ana Perovic, Carsten Marr, Felipe Opazo, Eugenio F. Fornasiero, Ralf Jungmann
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Only the beginning: 50 years of progress toward curing childhood cancer Cell (IF 64.5) Pub Date : 2024-03-28 Lia Gore, Maureen M. O’Brien
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Cancer biomarkers: Emerging trends and clinical implications for personalized treatment Cell (IF 64.5) Pub Date : 2024-03-28 Antonio Passaro, Maise Al Bakir, Emily G. Hamilton, Maximilian Diehn, Fabrice André, Sinchita Roy-Chowdhuri, Giannis Mountzios, Ignacio I. Wistuba, Charles Swanton, Solange Peters
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It took a long, long time: Ras and the race to cure cancer Cell (IF 64.5) Pub Date : 2024-03-28 Robert A. Weinberg
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Flexible scaffold-based cheminformatics approach for polypharmacological drug design Cell (IF 64.5) Pub Date : 2024-03-28 Zhangcheng Chen, Jing Yu, Huan Wang, Peiyu Xu, Luyu Fan, Fengxiu Sun, Sijie Huang, Pei Zhang, He Huang, Shuo Gu, Bowen Zhang, Yue Zhou, Xiaobo Wan, Gang Pei, H. Eric Xu, Jianjun Cheng, Sheng Wang
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Generating and using real-world data: A worthwhile uphill battle Cell (IF 64.5) Pub Date : 2024-03-28 K. Verkerk, E.E. Voest
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Short-distance vesicle transport via phase separation Cell (IF 64.5) Pub Date : 2024-03-28 Hua Qiu, Xiandeng Wu, Xiaoli Ma, Shulin Li, Qixu Cai, Marcelo Ganzella, Liang Ge, Hong Zhang, Mingjie Zhang
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Single-cell dissection of the human motor and prefrontal cortices in ALS and FTLD Cell (IF 64.5) Pub Date : 2024-03-22 S. Sebastian Pineda, Hyeseung Lee, Maria J. Ulloa-Navas, Raleigh M. Linville, Francisco J. Garcia, Kyriakitsa Galani, Erica Engelberg-Cook, Monica C. Castanedes, Brent E. Fitzwalter, Luc J. Pregent, Mahammad E. Gardashli, Michael DeTure, Diana V. Vera-Garcia, Andre T.S. Hucke, Bjorn E. Oskarsson, Melissa E. Murray, Dennis W. Dickson, Myriam Heiman, Veronique V. Belzil, Manolis Kellis
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Task-driven neural network models predict neural dynamics of proprioception Cell (IF 64.5) Pub Date : 2024-03-21 Alessandro Marin Vargas, Axel Bisi, Alberto S. Chiappa, Chris Versteeg, Lee E. Miller, Alexander Mathis
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Biofilm exopolysaccharides alter sensory-neuron-mediated sickness during lung infection Cell (IF 64.5) Pub Date : 2024-03-21 Elise Granton, Luke Brown, Manon Defaye, Parisa Moazen, Henrik Almblad, Trevor E. Randall, Jacquelyn D. Rich, Andrew Geppert, Nasser S. Abdullah, Mortaza F. Hassanabad, Carlos H. Hiroki, Raquel Farias, Angela P. Nguyen, Courtney Schubert, Yuefei Lou, Graciela Andonegui, Mircea Iftinca, Deepa Raju, Mario A. Vargas, P. Lynne Howell, Tamás Füzesi, Jaideep Bains, Deborah Kurrasch, Joe Jonathan Harrison
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Transport mechanism and pharmacology of the human GlyT1 Cell (IF 64.5) Pub Date : 2024-03-20 Yiqing Wei, Renjie Li, Yufei Meng, Tuo Hu, Jun Zhao, Yiwei Gao, Qinru Bai, Na Li, Yan Zhao
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Cellular architecture of evolving neuroinflammatory lesions and multiple sclerosis pathology Cell (IF 64.5) Pub Date : 2024-03-20 Petra Kukanja, Christoffer M. Langseth, Leslie A. Rubio Rodríguez-Kirby, Eneritz Agirre, Chao Zheng, Amitha Raman, Chika Yokota, Christophe Avenel, Katarina Tiklová, André O. Guerreiro-Cacais, Tomas Olsson, Markus M. Hilscher, Mats Nilsson, Gonçalo Castelo-Branco
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Macromolecular condensation organizes nucleolar sub-phases to set up a pH gradient Cell (IF 64.5) Pub Date : 2024-03-18 Matthew R. King, Kiersten M. Ruff, Andrew Z. Lin, Avnika Pant, Mina Farag, Jared M. Lalmansingh, Tingting Wu, Martin J. Fossat, Wei Ouyang, Matthew D. Lew, Emma Lundberg, Michael D. Vahey, Rohit V. Pappu
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RNA damage compartmentalization by DHX9 stress granules Cell (IF 64.5) Pub Date : 2024-03-18 Yilong Zhou, Amol Panhale, Maria Shvedunova, Mirela Balan, Alejandro Gomez-Auli, Herbert Holz, Janine Seyfferth, Martin Helmstädter, Séverine Kayser, Yuling Zhao, Niyazi Umut Erdogdu, Iga Grzadzielewska, Gerhard Mittler, Thomas Manke, Asifa Akhtar
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Contrasting somatic mutation patterns in aging human neurons and oligodendrocytes Cell (IF 64.5) Pub Date : 2024-03-18 Javier Ganz, Lovelace J. Luquette, Sara Bizzotto, Michael B. Miller, Zinan Zhou, Craig L. Bohrson, Hu Jin, Antuan V. Tran, Vinayak V. Viswanadham, Gannon McDonough, Katherine Brown, Yasmine Chahine, Brian Chhouk, Alon Galor, Peter J. Park, Christopher A. Walsh
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A gut-derived hormone regulates cholesterol metabolism Cell (IF 64.5) Pub Date : 2024-03-18 Xiaoli Hu, Fengyi Chen, Liangjie Jia, Aijun Long, Ying Peng, Xu Li, Junfeng Huang, Xueyun Wei, Xinlei Fang, Zihua Gao, Mengxian Zhang, Xiao Liu, Ye-Guang Chen, Yan Wang, Huijie Zhang, Yiguo Wang
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First-in-class MKK4 inhibitors enhance liver regeneration and prevent liver failure Cell (IF 64.5) Pub Date : 2024-03-14 Stefan Zwirner, Anan A. Abu Rmilah, Sabrina Klotz, Bent Pfaffenroth, Philip Kloevekorn, Athina A. Moschopoulou, Svenja Schuette, Mathias Haag, Roland Selig, Kewei Li, Wei Zhou, Erek Nelson, Antti Poso, Harvey Chen, Bruce Amiot, Yao Jia, Anna Minshew, Gregory Michalak, Wei Cui, Elke Rist, Thomas Longerich, Birgit Jung, Philipp Felgendreff, Omelyan Trompak, Prem K. Premsrirut, Katharina Gries, Thomas
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Microbial metabolite enhances immunotherapy efficacy by modulating T cell stemness in pan-cancer Cell (IF 64.5) Pub Date : 2024-03-14 Dingjiacheng Jia, Qiwen Wang, Yadong Qi, Yao Jiang, Jiamin He, Yifeng Lin, Yong Sun, Jilei Xu, Wenwen Chen, Lina Fan, Ruochen Yan, Wang Zhang, Guohong Ren, Chaochao Xu, Qiwei Ge, Lan Wang, Wei Liu, Fei Xu, Pin Wu, Yuhao Wang, Shujie Chen, Liangjing Wang
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Type-I-interferon-responsive microglia shape cortical development and behavior Cell (IF 64.5) Pub Date : 2024-03-14 Caroline C. Escoubas, Leah C. Dorman, Phi T. Nguyen, Christian Lagares-Linares, Haruna Nakajo, Sarah R. Anderson, Jerika J. Barron, Sarah D. Wade, Beatriz Cuevas, Ilia D. Vainchtein, Nicholas J. Silva, Ricardo Guajardo, Yinghong Xiao, Peter V. Lidsky, Ellen Y. Wang, Brianna M. Rivera, Sunrae E. Taloma, Dong Kyu Kim, Elizaveta Kaminskaya, Hiromi Nakao-Inoue, Bjoern Schwer, Thomas D. Arnold, Ari B. Molofsky
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Rigorous science demands support of transgender scientists Cell (IF 64.5) Pub Date : 2024-03-14 Krisha Aghi, Brendan M. Anderson, Bria M. Castellano, Avery Cunningham, Maggie Delano, Evyn S. Dickinson, Lexy von Diezmann, Sofia Kirke Forslund-Startceva, Dori M. Grijseels, Sebastian S. Groh, Eartha Mae Guthman, Izzy Jayasinghe, Juliet Johnston, Sam Long, Jess F. McLaughlin, Maeve McLaughlin, Miriam Miyagi, Bittu Rajaraman, Fátima Sancheznieto, Ayden I. Scheim, Simón(e) D. Sun, F. Dylan Titmuss
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Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic Cell (IF 64.5) Pub Date : 2024-03-14 Todd Logan, Matthew J. Simon, Anil Rana, Gerald M. Cherf, Ankita Srivastava, Sonnet S. Davis, Ray Lieh Yoon Low, Chi-Lu Chiu, Meng Fang, Fen Huang, Akhil Bhalla, Ceyda Llapashtica, Rachel Prorok, Michelle E. Pizzo, Meredith E.K. Calvert, Elizabeth W. Sun, Jennifer Hsiao-Nakamoto, Yashas Rajendra, Katrina W. Lexa, Devendra B. Srivastava, Bettina van Lengerich, Junhua Wang, Yaneth Robles-Colmenares,
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ZP2 cleavage blocks polyspermy by modulating the architecture of the egg coat Cell (IF 64.5) Pub Date : 2024-03-14 Shunsuke Nishio, Chihiro Emori, Benjamin Wiseman, Dirk Fahrenkamp, Elisa Dioguardi, Sara Zamora-Caballero, Marcel Bokhove, Ling Han, Alena Stsiapanava, Blanca Algarra, Yonggang Lu, Mayo Kodani, Rachel E. Bainbridge, Kayla M. Komondor, Anne E. Carlson, Michael Landreh, Daniele de Sanctis, Shigeki Yasumasu, Masahito Ikawa, Luca Jovine
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mRNA-based monkeypox virus vaccine prevents disease in non-human primates Cell (IF 64.5) Pub Date : 2024-03-14 Adam N. Nitido, Alejandro B. Balazs
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The future of sex and gender in research Cell (IF 64.5) Pub Date : 2024-03-14 Brian A. Aguado, Daniel.L. Jeffries, Rebecca Jordan-Young, Sabra L. Klein, Elle Lett, Nina Stachenfeld, Jessica Tollkuhn, Xiaohong Xu
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Sex contextualism in laboratory research: Enhancing rigor and precision in the study of sex-related variables Cell (IF 64.5) Pub Date : 2024-03-14 Madeleine Pape, Miriam Miyagi, Stacey A. Ritz, Marion Boulicault, Sarah S. Richardson, Donna L. Maney
Understanding sex-related variation in health and illness requires rigorous and precise approaches to revealing underlying mechanisms. A first step is to recognize that sex is not in and of itself a causal mechanism; rather, it is a classification system comprising a set of categories, usually assigned according to a range of varying traits. Moving beyond sex as a system of classification to working
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Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling Cell (IF 64.5) Pub Date : 2024-03-14 Fa-Xing Yu, Bin Zhao, Nattapon Panupinthu, Jenna L. Jewell, Ian Lian, Lloyd H. Wang, Jiagang Zhao, Haixin Yuan, Karen Tumaneng, Hairi Li, Xiang-Dong Fu, Gordon B. Mills, Kun-Liang Guan
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The history of sex research: Is “sex” a useful category? Cell (IF 64.5) Pub Date : 2024-03-14 Beans Velocci