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Accelerating data sharing and reuse in volume electron microscopy Nat. Cell Biol. (IF 21.3) Pub Date : 2024-04-12 Kirk James Czymmek, Ilya Belevich, Johanna Bischof, Aastha Mathur, Lucy Collinson, Eija Jokitalo
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A CRISPRi/a screening platform to study cellular nutrient transport in diverse microenvironments Nat. Cell Biol. (IF 21.3) Pub Date : 2024-04-11 Christopher Chidley, Alicia M. Darnell, Benjamin L. Gaudio, Evan C. Lien, Anna M. Barbeau, Matthew G. Vander Heiden, Peter K. Sorger
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Adding a transcription-coupled repair pathway Nat. Cell Biol. (IF 21.3) Pub Date : 2024-04-10 Marco Saponaro
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Tissue pressure and YAP during organogenesis Nat. Cell Biol. (IF 21.3) Pub Date : 2024-04-10 Qian Xu, Thomas G. H. Diekwisch
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Transcription-coupled DNA–protein crosslink repair by CSB and CRL4CSA-mediated degradation Nat. Cell Biol. (IF 21.3) Pub Date : 2024-04-10 Marjolein van Sluis, Qing Yu, Melanie van der Woude, Camila Gonzalo-Hansen, Shannon C. Dealy, Roel C. Janssens, Hedda B. Somsen, Anisha R. Ramadhin, Dick H. W. Dekkers, Hannah Lena Wienecke, Joris J. P. G. Demmers, Anja Raams, Carlota Davó-Martínez, Diana A. Llerena Schiffmacher, Marvin van Toorn, David Häckes, Karen L. Thijssen, Di Zhou, Judith G. Lammers, Alex Pines, Wim Vermeulen, Joris Pothof,
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Endogenous aldehyde-induced DNA–protein crosslinks are resolved by transcription-coupled repair Nat. Cell Biol. (IF 21.3) Pub Date : 2024-04-10 Yasuyoshi Oka, Yuka Nakazawa, Mayuko Shimada, Tomoo Ogi
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Transcription-coupled repair of DNA–protein cross-links depends on CSA and CSB Nat. Cell Biol. (IF 21.3) Pub Date : 2024-04-10 Christopher J. Carnie, Aleida C. Acampora, Aldo S. Bader, Chimeg Erdenebat, Shubo Zhao, Elnatan Bitensky, Diana van den Heuvel, Avital Parnas, Vipul Gupta, Giuseppina D’Alessandro, Matylda Sczaniecka-Clift, Pedro Weickert, Fatih Aygenli, Maximilian J. Götz, Jacqueline Cordes, Isabel Esain-Garcia, Larry Melidis, Annelotte P. Wondergem, Simon Lam, Maria S. Robles, Shankar Balasubramanian, Sheera Adar
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Fatty acyl-coenzyme A activates mitochondrial division through oligomerization of MiD49 and MiD51 Nat. Cell Biol. (IF 21.3) Pub Date : 2024-04-09 Ao Liu, Frieda Kage, Asan F. Abdulkareem, Mac Pholo Aguirre-Huamani, Gracie Sapp, Halil Aydin, Henry N. Higgs
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CD32 captures committed haemogenic endothelial cells during human embryonic development Nat. Cell Biol. (IF 21.3) Pub Date : 2024-04-09 Rebecca Scarfò, Lauren N. Randolph, Monah Abou Alezz, Mahassen El Khoury, Amélie Gersch, Zhong-Yin Li, Stephanie A. Luff, Andrea Tavosanis, Giulia Ferrari Ramondo, Sara Valsoni, Sara Cascione, Emma Didelon, Laura Passerini, Giada Amodio, Chiara Brandas, Anna Villa, Silvia Gregori, Ivan Merelli, Jean-Noël Freund, Christopher M. Sturgeon, Manuela Tavian, Andrea Ditadi
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Transcriptional bodies manage tight resources Nat. Cell Biol. (IF 21.3) Pub Date : 2024-04-08 Natalia Stec, Adam Klosin
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Lipidomes define immune cell identity Nat. Cell Biol. (IF 21.3) Pub Date : 2024-04-08 Kandice R. Levental, Whitney S. Henry
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A lipid atlas of human and mouse immune cells provides insights into ferroptosis susceptibility Nat. Cell Biol. (IF 21.3) Pub Date : 2024-04-08 Pooranee K. Morgan, Gerard Pernes, Kevin Huynh, Corey Giles, Sudip Paul, Adam Alexander T. Smith, Natalie A. Mellett, Amy Liang, Tilly van Buuren-Milne, Camilla Bertuzzo Veiga, Thomas J. C. Collins, Yangsong Xu, Man K. S. Lee, T. Michael De Silva, Peter J. Meikle, Graeme I. Lancaster, Andrew J. Murphy
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Transcription bodies regulate gene expression by sequestering CDK9 Nat. Cell Biol. (IF 21.3) Pub Date : 2024-04-08 Martino Ugolini, Maciej A. Kerlin, Ksenia Kuznetsova, Haruka Oda, Hiroshi Kimura, Nadine L. Vastenhouw
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Proliferation-driven mechanical compression induces signalling centre formation during mammalian organ development Nat. Cell Biol. (IF 21.3) Pub Date : 2024-04-03 Neha Pincha Shroff, Pengfei Xu, Sangwoo Kim, Elijah R. Shelton, Ben J. Gross, Yucen Liu, Carlos O. Gomez, Qianlin Ye, Tingsheng Yu Drennon, Jimmy K. Hu, Jeremy B. A. Green, Otger Campàs, Ophir D. Klein
Localized sources of morphogens, called signalling centres, play a fundamental role in coordinating tissue growth and cell fate specification during organogenesis. However, how these signalling centres are established in tissues during embryonic development is still unclear. Here we show that the main signalling centre orchestrating development of rodent incisors, the enamel knot (EK), is specified
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Glucose controls lipolysis through Golgi PtdIns4P-mediated regulation of ATGL Nat. Cell Biol. (IF 21.3) Pub Date : 2024-04-01 Lianggong Ding, Florian Huwyler, Fen Long, Wu Yang, Jonas Binz, Kendra Wernlé, Matthias Pfister, Manuel Klug, Miroslav Balaz, Barbara Ukropcova, Jozef Ukropec, Chunyan Wu, Tongtong Wang, Min Gao, Pierre-Alain Clavien, Philipp Dutkowski, Mark W. Tibbitt, Christian Wolfrum
Metabolic crosstalk of the major nutrients glucose, amino acids and fatty acids (FAs) ensures systemic metabolic homeostasis. The coordination between the supply of glucose and FAs to meet various physiological demands is especially important as improper nutrient levels lead to metabolic disorders, such as diabetes and metabolic dysfunction-associated steatohepatitis (MASH). In response to the oscillations
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Disordered C-terminal domain drives spatiotemporal confinement of RNAPII to enhance search for chromatin targets Nat. Cell Biol. (IF 21.3) Pub Date : 2024-03-28 Yick Hin Ling, Ziyang Ye, Chloe Liang, Chuofan Yu, Giho Park, Jeffry L. Corden, Carl Wu
Efficient gene expression requires RNA polymerase II (RNAPII) to find chromatin targets precisely in space and time. How RNAPII manages this complex diffusive search in three-dimensional nuclear space remains largely unknown. The disordered carboxy-terminal domain (CTD) of RNAPII, which is essential for recruiting transcription-associated proteins, forms phase-separated droplets in vitro, hinting at
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Cyclophilin A supports translation of intrinsically disordered proteins and affects haematopoietic stem cell ageing Nat. Cell Biol. (IF 21.3) Pub Date : 2024-03-29 Laure Maneix, Polina Iakova, Charles G. Lee, Shannon E. Moree, Xuan Lu, Gandhar K. Datar, Cedric T. Hill, Eric Spooner, Jordon C. K. King, David B. Sykes, Borja Saez, Bruno Di Stefano, Xi Chen, Daniela S. Krause, Ergun Sahin, Francis T. F. Tsai, Margaret A. Goodell, Bradford C. Berk, David T. Scadden, André Catic
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A cell fate decision map reveals abundant direct neurogenesis bypassing intermediate progenitors in the human developing neocortex Nat. Cell Biol. (IF 21.3) Pub Date : 2024-03-28 Laure Coquand, Clarisse Brunet Avalos, Anne-Sophie Macé, Sarah Farcy, Amandine Di Cicco, Marusa Lampic, Ryszard Wimmer, Betina Bessières, Tania Attie-Bitach, Vincent Fraisier, Pierre Sens, Fabien Guimiot, Jean-Baptiste Brault, Alexandre D. Baffet
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RIPK1 and necroptosis role in premature ageing Nat. Cell Biol. (IF 21.3) Pub Date : 2024-03-27 Panxue Wang, John Silke
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Reconstituting the dynamic steady states of actin networks in vitro Nat. Cell Biol. (IF 21.3) Pub Date : 2024-03-27 Manuel Théry, Laurent Blanchoin
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A palmitoylation–depalmitoylation relay spatiotemporally controls GSDMD activation in pyroptosis Nat. Cell Biol. (IF 21.3) Pub Date : 2024-03-27 Na Zhang, Jian Zhang, Yuanxin Yang, Hengyue Shan, Shouqiao Hou, Hongwen Fang, Min Ma, Zhongwen Chen, Li Tan, Daichao Xu
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Defective prelamin A processing promotes unconventional necroptosis driven by nuclear RIPK1 Nat. Cell Biol. (IF 21.3) Pub Date : 2024-03-27 Yuanxin Yang, Jian Zhang, Mingming lv, Na Cui, Bing Shan, Qi Sun, Lingjie Yan, Mengmeng Zhang, Chengyu Zou, Junying Yuan, Daichao Xu
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ACE2-dependent and -independent SARS-CoV-2 entries dictate viral replication and inflammatory response during infection Nat. Cell Biol. (IF 21.3) Pub Date : 2024-03-21 Tianhao Duan, Changsheng Xing, Junjun Chu, Xiangxue Deng, Yang Du, Xin Liu, Yuzhou Hu, Chen Qian, Bingnan Yin, Helen Y. Wang, Rong-Fu Wang
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Competence for neural crest induction is controlled by hydrostatic pressure through Yap Nat. Cell Biol. (IF 21.3) Pub Date : 2024-03-18 Delan N. Alasaadi, Lucas Alvizi, Jonas Hartmann, Namid Stillman, Prachiti Moghe, Takashi Hiiragi, Roberto Mayor
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WIPI4 loss linked to ferroptosis Nat. Cell Biol. (IF 21.3) Pub Date : 2024-03-07 Yang Liu, Hongyuan Yang
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Loss of WIPI4 in neurodegeneration causes autophagy-independent ferroptosis Nat. Cell Biol. (IF 21.3) Pub Date : 2024-03-07 Ye Zhu, Motoki Fujimaki, Louisa Snape, Ana Lopez, Angeleen Fleming, David C. Rubinsztein
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Lipid droplets and cellular lipid flux Nat. Cell Biol. (IF 21.3) Pub Date : 2024-03-07 Alyssa J. Mathiowetz, James A. Olzmann
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Author Correction: Subclonal cooperation drives metastasis by modulating local and systemic immune microenvironments Nat. Cell Biol. (IF 21.3) Pub Date : 2024-03-05 Michalina Janiszewska, Doris P. Tabassum, Zafira Castaño, Simona Cristea, Kimiyo N. Yamamoto, Natalie L. Kingston, Katherine C. Murphy, Shaokun Shu, Nicholas W. Harper, Carlos Gil Del Alcazar, Maša Alečković, Muhammad B. Ekram, Ofir Cohen, Minsuk Kwak, Yuanbo Qin, Tyler Laszewski, Adrienne Luoma, Andriy Marusyk, Kai W. Wucherpfennig, Nikhil Wagle, Rong Fan, Franziska Michor, Sandra S. McAllister, Kornelia
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Distinct pathways drive anterior hypoblast specification in the implanting human embryo Nat. Cell Biol. (IF 21.3) Pub Date : 2024-03-05 Bailey A. T. Weatherbee, Antonia Weberling, Carlos W. Gantner, Lisa K. Iwamoto-Stohl, Zoe Barnikel, Amy Barrie, Alison Campbell, Paula Cunningham, Cath Drezet, Panagiota Efstathiou, Simon Fishel, Sandra Gutiérrez Vindel, Megan Lockwood, Rebecca Oakley, Catherine Pretty, Nabiha Chowdhury, Lucy Richardson, Anastasia Mania, Lauren Weavers, Leila Christie, Kay Elder, Phillip Snell, Magdalena Zernicka-Goetz
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ER remodelling by ER-phagy in neurogenesis Nat. Cell Biol. (IF 21.3) Pub Date : 2024-03-01 Maurizio Molinari
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Targeting stromal metabolism in pancreatic ductal adenocarcinoma Nat. Cell Biol. (IF 21.3) Pub Date : 2024-03-01 Miao Yin, Qun-Ying Lei
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Ironing out the details of ferroptosis Nat. Cell Biol. (IF 21.3) Pub Date : 2024-03-01 Donna D. Zhang
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Cancer-associated fibroblast-derived acetate promotes pancreatic cancer development by altering polyamine metabolism via the ACSS2–SP1–SAT1 axis Nat. Cell Biol. (IF 21.3) Pub Date : 2024-03-01 Divya Murthy, Kuldeep S. Attri, Surendra K. Shukla, Ravi Thakur, Nina V. Chaika, Chunbo He, Dezhen Wang, Kanupriya Jha, Aneesha Dasgupta, Ryan J. King, Scott E. Mulder, Joshua Souchek, Teklab Gebregiworgis, Vikant Rai, Rohit Patel, Tuo Hu, Sandeep Rana, Sai Sundeep Kollala, Camila Pacheco, Paul M. Grandgenett, Fang Yu, Vikas Kumar, Audrey J. Lazenby, Adrian R. Black, Susanna Ulhannan, Ajay Jain, Barish
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Combinatorial selective ER-phagy remodels the ER during neurogenesis Nat. Cell Biol. (IF 21.3) Pub Date : 2024-03-01 Melissa J. Hoyer, Cristina Capitanio, Ian R. Smith, Julia C. Paoli, Anna Bieber, Yizhi Jiang, Joao A. Paulo, Miguel A. Gonzalez-Lozano, Wolfgang Baumeister, Florian Wilfling, Brenda A. Schulman, J. Wade Harper
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A guideline on the molecular ecosystem regulating ferroptosis Nat. Cell Biol. (IF 21.3) Pub Date : 2024-02-29 Enyong Dai, Xin Chen, Andreas Linkermann, Xuejun Jiang, Rui Kang, Valerian E. Kagan, Hülya Bayir, Wan Seok Yang, Ana J. Garcia-Saez, Maria S. Ioannou, Tobias Janowitz, Qitao Ran, Wei Gu, Boyi Gan, Dmitri V. Krysko, Xiaofeng Zhu, Jiayi Wang, Stefan Krautwald, Shinya Toyokuni, Yangchun Xie, Florian R. Greten, Qing Yi, Joel Schick, Jiao Liu, Dmitry I. Gabrilovich, Jinbao Liu, Herbert J. Zeh, Donna D.
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Mesoscale condensates organize the cytoplasm Nat. Cell Biol. (IF 21.3) Pub Date : 2024-02-29 Leshani Ahangama Liyanage, Jonathon A. Ditlev
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Evidence for widespread cytoplasmic structuring into mesoscale condensates Nat. Cell Biol. (IF 21.3) Pub Date : 2024-02-29 Felix C. Keber, Thao Nguyen, Andrea Mariossi, Clifford P. Brangwynne, Martin Wühr
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CAMSAPs and nucleation-promoting factors control microtubule release from γ-TuRC Nat. Cell Biol. (IF 21.3) Pub Date : 2024-02-29 Dipti Rai, Yinlong Song, Shasha Hua, Kelly Stecker, Jooske L. Monster, Victor Yin, Riccardo Stucchi, Yixin Xu, Yaqian Zhang, Fangrui Chen, Eugene A. Katrukha, Maarten Altelaar, Albert J. R. Heck, Michal Wieczorek, Kai Jiang, Anna Akhmanova
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METTL3 restrains autoimmunity in β-cells Nat. Cell Biol. (IF 21.3) Pub Date : 2024-02-26 Balasubramanian Krishnamurthy, Helen E. Thomas
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Redox regulation of m6A methyltransferase METTL3 in β-cells controls the innate immune response in type 1 diabetes Nat. Cell Biol. (IF 21.3) Pub Date : 2024-02-26 Dario F. De Jesus, Zijie Zhang, Natalie K. Brown, Xiaolu Li, Ling Xiao, Jiang Hu, Matthew J. Gaffrey, Garrett Fogarty, Sevim Kahraman, Jiangbo Wei, Giorgio Basile, Tariq M. Rana, Clayton Mathews, Alvin C. Powers, Audrey V. Parent, Mark A. Atkinson, Sirano Dhe-Paganon, Decio L. Eizirik, Wei-Jun Qian, Chuan He, Rohit N. Kulkarni
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Contractility drives the spatio-temporal coordination of morphogenesis and cell fate in hair follicles Nat. Cell Biol. (IF 21.3) Pub Date : 2024-02-23
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Lessons from infrastructure and research advocacy in India Nat. Cell Biol. (IF 21.3) Pub Date : 2024-02-23 Arun K. Shukla
Scientists must actively advocate for infrastructure development and funding of emerging research directions through collective efforts. In India, this has been crucial to help reverse the brain drain and enable equitable contributions to research and development at the global level.
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Metabolic regulation of chemoresistance and immuno-surveillance in AML by SHP-1 Nat. Cell Biol. (IF 21.3) Pub Date : 2024-02-23
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Lysosomal channels sensing forces Nat. Cell Biol. (IF 21.3) Pub Date : 2024-02-22 Erika Riederer, Dejian Ren
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Drosophila TMEM63 and mouse TMEM63A are lysosomal mechanosensory ion channels Nat. Cell Biol. (IF 21.3) Pub Date : 2024-02-22 Kai Li, Yanmeng Guo, Yayu Wang, Ruijun Zhu, Wei Chen, Tong Cheng, Xiaofan Zhang, Yinjun Jia, Ting Liu, Wei Zhang, Lily Yeh Jan, Yuh Nung Jan
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Mapping T cell landscapes in B cell lymphomas Nat. Cell Biol. (IF 21.3) Pub Date : 2024-02-20 Ralf Küppers
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Multimodal and spatially resolved profiling identifies distinct patterns of T cell infiltration in nodal B cell lymphoma entities Nat. Cell Biol. (IF 21.3) Pub Date : 2024-02-20 Tobias Roider, Marc A. Baertsch, Donnacha Fitzgerald, Harald Vöhringer, Berit J. Brinkmann, Felix Czernilofsky, Mareike Knoll, Laura Llaó-Cid, Anna Mathioudaki, Bianca Faßbender, Maxime Herbon, Tobias Lautwein, Peter-Martin Bruch, Nora Liebers, Christian M. Schürch, Verena Passerini, Marc Seifert, Alexander Brobeil, Gunhild Mechtersheimer, Carsten Müller-Tidow, Oliver Weigert, Martina Seiffert, Garry
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Author Correction: Stiff matrix induces exosome secretion to promote tumour growth Nat. Cell Biol. (IF 21.3) Pub Date : 2024-02-12 Bin Wu, Di-Ao Liu, Lei Guan, Phyoe Kyawe Myint, LiKang Chin, Hien Dang, Ye Xu, Jinqi Ren, Ting Li, Ziyan Yu, Sophie Jabban, Gordon B. Mills, Jonathan Nukpezah, Youhai H. Chen, Emma E. Furth, Phyllis A. Gimotty, Rebecca G. Wells, Valerie M. Weaver, Ravi Radhakrishnan, Xin Wei Wang, Wei Guo
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Biomolecular condensation orchestrates clathrin-mediated endocytosis in plants Nat. Cell Biol. (IF 21.3) Pub Date : 2024-02-12 Jonathan Michael Dragwidge, Yanning Wang, Lysiane Brocard, Andreas De Meyer, Roman Hudeček, Dominique Eeckhout, Peter Grones, Matthieu Buridan, Clément Chambaud, Přemysl Pejchar, Martin Potocký, Joanna Winkler, Michaël Vandorpe, Nelson Serre, Matyáš Fendrych, Amelie Bernard, Geert De Jaeger, Roman Pleskot, Xiaofeng Fang, Daniël Van Damme
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mtDNA caught in the act again Nat. Cell Biol. (IF 21.3) Pub Date : 2024-02-08 Kate McArthur, Benjamin T. Kile
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Mitochondrial DNA replication stress triggers a pro-inflammatory endosomal pathway of nucleoid disposal Nat. Cell Biol. (IF 21.3) Pub Date : 2024-02-08 Laura E. Newman, Sammy Weiser Novak, Gladys R. Rojas, Nimesha Tadepalle, Cara R. Schiavon, Danielle A. Grotjahn, Christina G. Towers, Marie-Ève Tremblay, Matthew P. Donnelly, Sagnika Ghosh, Michaela Medina, Sienna Rocha, Ricardo Rodriguez-Enriquez, Joshua A. Chevez, Ian Lemersal, Uri Manor, Gerald S. Shadel
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Author Correction: Denervation-activated STAT3–IL-6 signalling in fibro-adipogenic progenitors promotes myofibres atrophy and fibrosis Nat. Cell Biol. (IF 21.3) Pub Date : 2024-02-07 Luca Madaro, Magda Passafaro, David Sala, Usue Etxaniz, Francesca Lugarini, Daisy Proietti, Maria Vittoria Alfonsi, Chiara Nicoletti, Sole Gatto, Marco De Bardi, Ricardo Rojas-García, Lorenzo Giordani, Sara Marinelli, Vittoria Pagliarini, Claudio Sette, Alessandra Sacco, Pier Lorenzo Puri
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Conference accessibility should be a universal concern Nat. Cell Biol. (IF 21.3) Pub Date : 2024-02-07 Urszula Lucja McClurg
In this piece, I share a personal encounter that underscores the glaring gaps in conference accessibility and challenges faced by disabled academics. I reveal historical biases and resistance to change and propose ways to transform conferences into more inclusive spaces, ensuring that all scientists can fully participate in the scientific discourse.
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ECSIT facilitates memory CD8+ T cell development by mediating fumarate synthesis during viral infection and tumorigenesis Nat. Cell Biol. (IF 21.3) Pub Date : 2024-02-07 Yongbing Yang, Yanan Wang, Zhongcheng Wang, Huanyu Yan, Yi Gong, Yingchao Hu, Yuying Jiang, Shuang Wen, Feifei Xu, Bingwei Wang, Fiachra Humphries, Yun Chen, Xi Wang, Shuo Yang
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Epithelial zonation along the mouse and human small intestine defines five discrete metabolic domains Nat. Cell Biol. (IF 21.3) Pub Date : 2024-02-06 Rachel K. Zwick, Petr Kasparek, Brisa Palikuqi, Sara Viragova, Laura Weichselbaum, Christopher S. McGinnis, Kara L. McKinley, Asoka Rathnayake, Dedeepya Vaka, Vinh Nguyen, Coralie Trentesaux, Efren Reyes, Alexander R. Gupta, Zev J. Gartner, Richard M. Locksley, James M. Gardner, Shalev Itzkovitz, Dario Boffelli, Ophir D. Klein
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SHP-1 inhibition targets leukaemia stem cells to restore immunosurveillance and enhance chemosensitivity by metabolic reprogramming Nat. Cell Biol. (IF 21.3) Pub Date : 2024-02-06 Xi Xu, Yanhui Yu, Wenwen Zhang, Weiwei Ma, Chong He, Guo Qiu, Xinyi Wang, Qiong Liu, Minyi Zhao, Jiayi Xie, Fang Tao, John M. Perry, Qifa Liu, Shuan Rao, Xunlei Kang, Meng Zhao, Linjia Jiang
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Compositional plasticity of the Atg1 complex Nat. Cell Biol. (IF 21.3) Pub Date : 2024-02-05 Xiaoli Ma, Hong Zhang
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A metabolite sensor subunit of the Atg1/ULK complex regulates selective autophagy Nat. Cell Biol. (IF 21.3) Pub Date : 2024-02-05 A. S. Gross, R. Ghillebert, M. Schuetter, E. Reinartz, A. Rowland, B. C. Bishop, M. Stumpe, J. Dengjel, M. Graef
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Orphan nuclear receptors joining the reprogramming club Nat. Cell Biol. (IF 21.3) Pub Date : 2024-02-02
Huck-Hui Ng is a senior group leader at the Genome Institute of Singapore of A*STAR. In this article, Ng revisits the 2009 Nature Cell Biology study in which he and his team described the role of Esrrb in somatic cell reprogramming.