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Cost-effectiveness analysis of fluticasone furoate/umeclidinium bromide/vilanterol and umeclidinium bromide/vilanterol in the management of moderate and severe COPD in China Resp. Med. (IF 4.3) Pub Date : 2024-04-16 Yuan Zhou, Shujing Duan, Lei Zhang, Fangchen Peng
A study has analyzed the long-term cost-effectiveness of fluticasone furoate/umeclidinium bromide/vilanterol combination therapy (FF/UMEC/VI) versus umeclidinium bromide/vilanterol dual therapy (UMEC/VI) in the treatment of moderate or severe chronic obstructive pulmonary disease (COPD), providing evidence for decision-making in COPD treatment. From the perspective of the whole society, a Markov model
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Can Galectin-3 be a reliable predictive biomarker for post-COVID syndrome development? Resp. Med. (IF 4.3) Pub Date : 2024-04-12 Andrea Portacci, Monica Amendolara, Vitaliano Nicola Quaranta, Ilaria Iorillo, Enrico Buonamico, Fabrizio Diaferia, Sara Quaranta, Cristian Locorotondo, Annalisa Schirinzi, Esterina Boniello, Silvano Dragonieri, Giovanna Elisiana Carpagnano
Reliable biomarkers able to predict post-COVID syndrome development are still lacking. The aim of the study was to evaluate the relationship between Galectin-3 blood concentrations and the development of post-COVID syndrome. We performed a single-center, prospective, observational study, enrolling 437 consecutive patients attending our outpatient clinic for the post-COVID assessment. For each patient
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Beyond Symptoms: Radiologic identification of asymptomatic Mycobacterium avium complex pulmonary infections Resp. Med. (IF 4.3) Pub Date : 2024-04-09 Keiji Fujiwara, Fumiya Watanabe, Fumiko Uesugi, Koji Furuuchi, Masashi Ito, Tatsuya Kodama, Yoshiaki Tanaka, Takashi Yoshiyama, Satoshi Mitarai, Atsuyuki Kurashima, Ken Ohta, Kozo Morimoto
Although international nontuberculous mycobacterial pulmonary disease (NTM-PD) guidelines highlight symptom presence at diagnosis, the clinical characteristics of asymptomatic complex pulmonary infection (MAC-PI) patients remain understudied. We clarified the clinical characteristics and course of asymptomatic MAC-PI patients. We retrospectively analyzed 200 consecutive patients with MAC-PIs and adequate
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Development and validation of a claims-based algorithm to identify moderate exacerbations in patients with asthma treated in the US Resp. Med. (IF 4.3) Pub Date : 2024-04-07 Melissa H. Roberts, Mei Sheng Duh, Kieran J. Rothnie, Shiyuan Zhang, Alexandrosz Czira, David Slade, Wendy Y. Cheng, Philippe Thompson-Leduc, Alexandra Greatsinger, Adina Zhang, Douglas Mapel
Definitions of moderate asthma exacerbation have been inconsistent, making their economic burden difficult to assess. An algorithm to accurately identify moderate exacerbations from claims data is needed. A retrospective cohort study of Reliant Medical Group patients aged ≥18 years, with ≥1 prescription claim for inhaled corticosteroid/long-acting β-agonist, and ≥1 medical claim with a diagnosis code
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Frequency and economic burden of exacerbations in inhaled corticosteroid/long-acting beta-agonist-treated patients with asthma: A retrospective US claims study Resp. Med. (IF 4.3) Pub Date : 2024-04-07 Mei Sheng Duh, Melissa H. Roberts, Kieran J. Rothnie, Wendy Y. Cheng, Philippe Thompson-Leduc, Shiyuan Zhang, Alexandrosz Czira, David Slade, Alexandra Greatsinger, Adina Zhang, Douglas Mapel
Despite adherence to inhaled corticosteroid/long-acting β-agonist (ICS/LABA) therapy, many patients with asthma experience moderate exacerbations. Data on the impact of moderate exacerbations on the healthcare system are limited. This study assessed the frequency and economic burden of moderate exacerbations in patients receiving ICS/LABA. Retrospective, longitudinal study analyzed data from Optum's
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The discrepancy in bronchodilator response between ATS/ERS 2021 and 1991 criteria Resp. Med. (IF 4.3) Pub Date : 2024-04-05 Diana Betancor, Blanca Barroso, Marcela Valverde-Monge, Alicia Gomez-Lopez, Joaquin Sastre, CIBERES ASTHMA GROUP-MEGA STUDY, José María Olaguibel, José Manuel Rodrigo-Muñoz, Maria Jose Alvarez Puebla, Ebymar Arismendi, Irina Bobolea, Blanca Cárdaba, María Jesús Cruz, Elena Curto, Victoria Del Pozo, Javier Domínguez-Orteg, Francisco-Javier González-Barcala, J.A. Luna-Porta, Carlos Martínez-Rivera, Joaquim
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Determining if the prognostic nutritional index can predict outcomes in community acquired bacterial pneumonia Resp. Med. (IF 4.3) Pub Date : 2024-04-05 Lisa De Rose, John Sorge, Brianna Blackwell, Mark Benjamin, Ayman Mohamed, Theodoor Roverts, Susan Szpunar, Louis D. Saravolatz
The Prognostic Nutritional Index (PNI) uses albumin levels and total lymphocyte count to predict the relationship between immune-nutritional state and prognosis in a variety of diseases, however it has not been studied in community acquired bacterial pneumonia (CABP). We conducted a historical cohort study to determine if there was an association between PNI and clinical outcomes in patients with CABP
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Organ involvement in newly diagnosed sarcoidosis patients in the Netherlands: The first large European multicentre prospective study Resp. Med. (IF 4.3) Pub Date : 2024-04-04 Julie Van Woensel, Bart Koopman, Mart Schiefer, Coen van Kan, Marlou T.F.H. Janssen, Sofia Ramiro, César Magro-Checa, Robert BM. Landewé, Martijn D. de Kruif, Paul Bresser, Rémy L.M. Mostard
Clinical presentation and prevalence of organ involvement is highly variable in sarcoidosis and depends on ethnic, genetic and geographical factors. These data are not extensively studied in a Dutch population. To determine the prevalence of organ involvement and the indication for systemic immunosuppressive therapy in newly diagnosed sarcoidosis patients in the Netherlands. Two large Dutch teaching
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Association of inadequate social support and clinical outcomes in patients with chronic obstructive pulmonary disease – A cross-sectional study Resp. Med. (IF 4.3) Pub Date : 2024-04-02 Anna L. Stoustrup, Daisy J.A. Janssen, Nienke Nakken, Emiel F.M. Wouters, Alda Marques, Ulla Møller Weinreich, Martijn A. Spruit
In patients with chronic obstructive pulmonary disease (COPD), loneliness and social isolation are associated with increased morbidity and decreased mobility, self-reliance, and health-related quality of life. Social support has been shown to improve these outcomes. This cross-sectional study aimed to investigate the level of experienced social support and the clinical outcomes associated with inadequate
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Swedish translation and psychometric testing of the Self-Conscious Emotions in COPD Questionnaire Resp. Med. (IF 4.3) Pub Date : 2024-04-01 Sara Lundell, Ulf Isaksson, Anna-Britt Coe, Samantha L. Harrison, Senada Hajdarevic
Assessment of self-conscious emotions is important to develop tailored interventions for people with chronic obstructive pulmonary disease (COPD). Previous instruments have largely been developed for mental health populations. The Self-Conscious Emotions in COPD Questionnaire was the first instrument to assess self-conscious emotions in people with COPD, but it was only available in English.
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A network meta-analysis of the association between patient traits and response to regular dosing with ICS plus short-acting β2-agonist reliever or ICS/formoterol reliever only in mild asthma Resp. Med. (IF 4.3) Pub Date : 2024-03-30 Arzu Yorgancıoğlu, Alvaro A. Cruz, Gabriel Garcia, Kim L. Lavoie, Nicolas Roche, Manish Verma, Anurita Majumdar, Swarnendu Chatterjee
Mild asthma treatment recommendations include intermittent inhaled corticosteroid (ICS)/formoterol dosing or regular ICS dosing with short-acting β-agonist reliever. Due to the heterogeneity of asthma, identification of traits associated with improved outcomes to specific treatments would be clinically beneficial. To assess the impact of patient traits on treatment outcomes of regular ICS dosing compared
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Latent class analysis of chest CT abnormalities to define subphenotypes in patients with MPO-ANCA-positive microscopic polyangiitis Resp. Med. (IF 4.3) Pub Date : 2024-03-26 Yu Gu, Ting Zhang, Min Peng, Yang Han, Weihong Zhang, Juhong Shi
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A comprehensive evaluation of online inhaler use techniques for obstructive airway disease Resp. Med. (IF 4.3) Pub Date : 2024-03-26 Brandon Luu, Anu Chinnadurai, Omer Choudhary, Nikki Breede, Lee M. Fidler, Clodagh M. Ryan, Mohammad Hashim Khan, Ambrose K. Lau, Alina J. Blazer, Kirsten Wentlandt, Dmitry Rozenberg
Pulmonary inhaler therapy is a core treatment modality for >600 million individuals affected by obstructive airways disease globally. Poor inhaler technique is associated with reduced disease control and increased health care utilization; however, many patients rely on the internet as a technical resource. This study assesses the content and quality of online resources describing inhaler techniques
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Comparison of organ involvement clusters in Black and White American sarcoidosis patients from a prospectively collected patient registry Resp. Med. (IF 4.3) Pub Date : 2024-03-26 Logan J. Harper, Anoosha Tauquir, Shuaiqi Huang, Xiaofeng Wang, Jonas C. Schupp, Robert Baughman, Daniel A. Culver
Due to the heterogeneity of sarcoidosis, there is a need to define clinical phenotypes to allow for tailoring of clinical care and identification of more homogenous populations to facilitate research. We utilized data from a prospectively collected registry of sarcoidosis patients seen at a single quaternary referral center between January 2019 and February 2021. We used multiple correspondence analysis
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National survey conducted among Italian pediatricians examining the therapeutic management of croup Resp. Med. (IF 4.3) Pub Date : 2024-03-24 Luca Pierantoni, Laura Andreozzi, Giacomo Stera, Gaia Toschi Vespasiani, Carlotta Biagi, Daniele Zama, Elena Balduini, Lawrence Matthew Scheier, Marcello Lanari
Practice-to-recommendations gaps exist in croup management and have not been critically investigated. This study examined the therapeutic management of croup among a national sample of Italian pediatric providers. A survey was administered online to a sample of primary care and hospital-based pediatricians. Demographic data, perception regarding disease severity, treatment and knowledge of croup, choices
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Prevalence and disparities in influenza vaccination among patients with COPD: A French nationwide population study Resp. Med. (IF 4.3) Pub Date : 2024-03-22 Maéva Zysman, Anaëlle Coquelin, Nelly Le Guen, Agnès Solomiac, Marina Guecamburu, Marie Erbault, Elodie Blanchard, Nicolas Roche, Sandrine Morin
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Predictive factors for dose reduction and discontinuation of nintedanib in fibrotic interstitial lung diseases: Real life data Resp. Med. (IF 4.3) Pub Date : 2024-03-19 Emanuel Costa, Ana Rita Pedroso, Rita Matos, Márcio Cunha Rodrigues, Eva Padrão, Joana Sousa-Neves, Rui Rolo
Nintedanib, an intracellular inhibitor targeting multiple tyrosine kinases, has emerged as a standard treatment for various fibrotic lung diseases. Despite its efficacy, side effects such as nausea, diarrhea, and hepatotoxicity often lead to dose reduction or discontinuation. In this retrospective analysis at an university hospital's interstitial lung disease clinic, we aimed to identify baseline characteristics
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Diagnosis of extra pulmonary tuberculosis: An update on novel diagnostic approaches Resp. Med. (IF 4.3) Pub Date : 2024-03-19 Rashi Jain, Gopika Gupta, D.K. Mitra, Randeep Guleria
Tuberculosis (TB) remains a major global public health problem worldwide. Though Pulmonary TB (PTB) is mostly discussed, one in five cases of TB present are extrapulmonary TB (EPTB) that manifests conspicuous diagnostic and management challenges with respect to the site of infection. The diagnosis of EPTB is often delayed or even missed due to insidious clinical presentation, pauci-bacillary nature
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Revisiting the use of high flow nasal cannula in acute exacerbation of COPD and conclusion of trial Resp. Med. (IF 4.3) Pub Date : 2024-03-18 Toshiro Goto, Masahiro Banno, Ryota Kimura
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Airway stenting for liberation from positive pressure ventilation in patients with central airway obstruction presenting with acute respiratory failure Resp. Med. (IF 4.3) Pub Date : 2024-03-16 Bertin D. Salguero, Abhinav Agrawal, Viren Kaul, Christian M. Lo Cascio, Greta Joy, Matsuo So, Rohit Munagala, Timothy Harkin, Udit Chaddha
Central airway obstruction (CAO) can lead to acute respiratory failure (RF) necessitating positive pressure ventilation (PPV). The efficacy of airway stenting to aid liberation from PPV in patients with severe acute RF has been scarcely published. We present a systematic review and our recent experience. A systematic review of PubMed was performed, and a retrospective review of cases performed at our
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Relationship of computed tomography-based measurements with symptom perception and quality of life in patients with severe asthma Resp. Med. (IF 4.3) Pub Date : 2024-03-16 Jinyoung Jeong, Young-Hee Nam, Da Woon Sim, Byung-Keun Kim, Youngsoo Lee, Ji-Su Shim, Suh-Young Lee, Min-Suk Yang, Min-Hye Kim, So Ri Kim, Sanghun Choi, Sang-Heon Kim, Young-Il Koh, Heung-Woo Park, KoSAR investigators
Symptom perception and quality of life (QOL) are important domains for properly managing severe asthma. This study aimed to assess the relationship between airway structural and parenchymal variables measured using chest computed tomography (CT) and subjective symptom perception and QOL in patients with severe asthma enrolled in the Korean Severe Asthma Registry. This study used CT-based objective
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Dynamic hyperinflation is a risk factor for mortality and severe exacerbations in COPD patients Resp. Med. (IF 4.3) Pub Date : 2024-03-16 Isabel Lorenzana, Raúl Galera, Raquel Casitas, Elisabet Martínez-Cerón, María Alejandra Castillo, Enrique Alfaro, Carolina Cubillos-Zapata, Francisco García-Río
To assess if dynamic hyperinflation is an independent risk factor for mortality and severe exacerbations in COPD patients. A cohort of 141 patients with stable COPD and moderate to very severe airflow limitation, treated according to conventional guidelines, was followed for a median of 9 years. Clinical characteristics were recorded and arterial blood gases, pulmonary function tests, 6-min walk and
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Clinical phenotypes of nontuberculous mycobacterial disease by cluster analysis based on pulmonary function Resp. Med. (IF 4.3) Pub Date : 2024-03-13 Nobuyoshi Hamao, Isao Ito, Issei Oi, Masahiro Shirata, Kensuke Nishioka, Yasuyuki Hayashi, Seiichiro Imai, Toyohiro Hirai
Nontuberculous mycobacterial pulmonary disease (NTM-PD) often exhibits pulmonary function impairment, such as obstructive or restrictive pattern, with variation among patients according to the damaged lesions in the lung. Patients with NTM-PD were consecutively enrolled between September 2019 and December 2020 at the Respiratory Infection Clinic of our hospital. Patients’ data were comprehensively
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Advances in co-pathogenesis of the united airway diseases Resp. Med. (IF 4.3) Pub Date : 2024-03-12 Xinjun Xu, Jiali Yin, Yujuan Yang, Huifang Liu, Jingyi Yu, Xianghuang Luo, Yu Zhang, Xicheng Song
According to the concept of “united airway diseases”, the airway is a single organ in which upper and lower airway diseases are commonly comorbid. A range of inflammatory factors have been found to play an important role in the chain reaction of upper and lower airway diseases. However, the amount of research on this concept remains limited. The underlying mechanism of the relationship between typical
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Survival and response to pulmonary vasodilator therapies in patients with chronic obstructive pulmonary disease and pulmonary vascular phenotype Resp. Med. (IF 4.3) Pub Date : 2024-03-11 Mathilde Steger, Matthieu Canuet, Irina Enache, Thibaut Goetsch, Aissam Labani, Léo Meyer, Guillaume Martin, Romain Kessler, David Montani, Marianne Riou
The aim of the study was to describe and investigate the effect of pulmonary arterial hypertension (PAH) therapies in a cohort of patients with severe precapillary pulmonary hypertension (PH) associated with chronic obstructive pulmonary disease (COPD; PH-COPD), and to assess factors predictive of treatment response and mortality. We retrospectively included patients with severe incident PH-COPD who
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Systematic review of tailored dietary advice and dietitian involvement in the treatment of chronic obstructive pulmonary disease (COPD) Resp. Med. (IF 4.3) Pub Date : 2024-03-11 Kylie Bell, Josh Lawson, Erika Penz, Allison Cammer
Chronic obstructive pulmonary disease (COPD) is a leading public health concern globally. Interdisciplinary pulmonary rehabilitation programs exist and should ideally consider nutritional health impacts since the nutritional status of COPD patients is often compromised. However, little is known about the role of dietary counseling in COPD management. Does providing tailored dietary advice to adult
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Implementation of virtual pulmonary rehabilitation during the COVID-19 pandemic: Experiences and perceptions of patients and healthcare providers Resp. Med. (IF 4.3) Pub Date : 2024-03-07 L. Verweel, T. Packham, R. Goldstein, D. Brooks, C. MacKay
Pulmonary rehabilitation (PR) plays an important role in the management of symptomatic patients with chronic respiratory diseases (CRD). While studies have investigated the feasibility and efficacy of virtual PR (VPR), it is important to understand the experiences of patients and healthcare providers (HCPs) during the rapid digital health transformation that occurred in the COVID-19 pandemic. To explore
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Chronic obstructive pulmonary disease and the airway microbiome: A review for clinicians Resp. Med. (IF 4.3) Pub Date : 2024-03-07 Lingxin Luo, Junli Tang, Xianzhi Du, Na Li
Chronic obstructive pulmonary disease (COPD) is a complex heterogeneous disease characterized by progressive airflow limitation and chronic inflammation. The progressive development and long-term repeated acute exacerbation of COPD make many patients still unable to control the deterioration of the disease after active treatment, and even eventually lead to death. An increasing number of studies have
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Exhaled breath analyses for bronchial thermoplasty in severe asthma patients Resp. Med. (IF 4.3) Pub Date : 2024-03-04 Pieta C. Wijsman, Annika W.M. Goorsenberg, Julia N.S. d’Hooghe, Els J.M. Weersink, Dominic W. Fenn, Anke H. Maitland van der Zee, Jouke T. Annema, Paul Brinkman, Peter I. Bonta
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Impact of biologics on lung hyperinflation in patients with severe asthma Resp. Med. (IF 4.3) Pub Date : 2024-03-01 Mauro Maniscalco, Claudio Candia, Cecilia Calabrese, Maria D'Amato, Maria Gabriella Matera, Antonio Molino, Mario Cazzola
In asthma, inflammation affects both the proximal and distal airways and can cause significant hyperinflation, which is thought to be a major cause of dyspnea. This is a retrospective observational study evaluating the effect of three months of treatment with different biologic drugs (benralizumab, dupilumab and omalizumab) on pulmonary hyperinflation in a cohort of patients with severe asthma already
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No remission in 60% of those with childhood-onset asthma - A population-based cohort followed from 8 to 28 years of age Resp. Med. (IF 4.3) Pub Date : 2024-02-28 Linnéa Almqvist, Martin Andersson, Helena Backman, Eva Rönmark, Linnéa Hedman
Although remission occur, childhood-onset asthma may persist until adulthood. Since few longitudinal population-based studies have followed a cohort from childhood until adulthood, the knowledge on predictors of persistence of asthma is sparse. To estimate persistence of asthma from 8 to 28 years and its associated factors. Within the OLIN (Obstructive Lung Disease in Northern Sweden) studies, a cohort
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Validity and reliability of the Swedish version of the Leicester Cough Questionnaire in unexplained chronic cough Resp. Med. (IF 4.3) Pub Date : 2024-02-28 Ewa Ternesten-Hasséus, Ewa-Lena Johansson Corresponding author
Cough is considered chronic when it lasts for >8 weeks. When no medical explanation can be found it is often called unexplained chronic cough (UCC), which may affect health-related quality of life (HRQOL). This study aimed to assesses the validity and reliability of the Swedish version of the Leicester Cough Questionnaire (LCQ-S) in patients with UCC. Seventy-six consecutively selected patients with
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Long-term air pollution exposure and risk of SARS-CoV-2 infection: A UK-wide cohort study Resp. Med. (IF 4.3) Pub Date : 2024-02-27 Hajar Hajmohammadi, Mohammad Talaei, Daniela Fecht, Weiyi Wang, Giulia Vivaldi, Sian E. Faustini, Alex G. Richter, Seif O. Shaheen, Adrian R. Martineau, Aziz Sheikh, Ian S. Mudway, Christopher J. Griffiths
The association between air quality and risk of SARS-CoV-2 infection is poorly understood. We investigated this association using serological individual-level data adjusting for a wide range of confounders, in a large population-based cohort (COVIDENCE UK). We assessed the associations between long-term (2015–19) nitrogen dioxide (NO) and fine particulate matter with an aerodynamic diameter of ≤2.5 μm
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Indwelling tunneled pleural catheter infections and host related factors Resp. Med. (IF 4.3) Pub Date : 2024-02-24 Priyanka Makkar, Jacob Schwartz, Kevin Shayani, Saira Imran, Jessica Flynn, Joanne Chu, Mohit Chawla, Robert Lee
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Radiological and histopathological features and treatment response by subtypes of interstitial pneumonia with autoimmune features: A prospective, multicentre cohort study Resp. Med. (IF 4.3) Pub Date : 2024-02-24 Noriyuki Enomoto, Shusuke Yazawa, Yasutaka Mochizuka, Atsuki Fukada, Yuko Tanaka, Hyogo Naoi, Yuya Aono, Yusuke Inoue, Hideki Yasui, Masato Karayama, Yuzo Suzuki, Hironao Hozumi, Kazuki Furuhashi, Mikio Toyoshima, Masato Kono, Shiro Imokawa, Takehisa Sano, Taisuke Akamatsu, Naoki Koshimizu, Koshi Yokomura, Hiroyuki Matsuda, Yusuke Kaida, Masahiro Shirai, Kazutaka Mori, Masafumi Masuda, Tomoyuki Fujisawa
Patients with idiopathic interstitial pneumonia (IIP) have a favourable prognosis when they have interstitial pneumonia with autoimmune features (IPAF). However, precise IPAF-related findings from high-resolution computed tomography (HRCT) and lung histopathological specimens and the treatment response have not been fully determined. Therefore, this study was conducted to evaluate the relationship
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Comparative study of the inhalation parameters of COPD patients through NEXThaler® and Ellipta® dry powder inhalers Resp. Med. (IF 4.3) Pub Date : 2024-02-23 Árpád Farkas, Alpár Horváth, Izolda Réti, Norbert Ilyés, Botond Havadtői, Tamás Kovács, Balázs Sánta, Gábor Tomisa, Péter Czaun, Gabriella Gálffy
The deposition of dry powder aerosol drugs depends on the inhalation parameters of the patients through the inhaler. These data are not directly measured in clinical practice. Their prediction based on the routinely measured spirometric data could help in choosing the appropriate device and optimizing the therapy. The aim of this study was to perform inhalation experiments to find correlations between
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Treatable traits in advanced emphysema patients eligible for bronchoscopic lung volume reduction with endobronchial valves Resp. Med. (IF 4.3) Pub Date : 2024-02-17 Rein Posthuma, Marieke C. van der Molen, Jorine E. Hartman, Martijn A. Spruit, Dirk-Jan Slebos, Lowie E.G.W. Vanfleteren, Anouk W. Vaes
Patients with advanced emphysema eligible for bronchoscopic lung volume reduction (BLVR) using endobronchial valves (EBV) are characterized by severe static lung hyperinflation, which can be considered a treatable trait. Other treatable traits (TTs), which are assumed to be present in this highly selected patient group, have not been studied in detail nor how they may affect health-related quality
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Corrigendum to “Burden of chronic cough on social participation, healthcare resource utilisation and activities of daily living in the Canadian Longitudinal Study on Aging (CLSA)” [Respir. Med. 219 (2013) 107431] Resp. Med. (IF 4.3) Pub Date : 2024-02-14 Imran Satia, Alexandra J. Mayhew, Nazmul Sohel, Om Kurmi, Kieran J. Killian, Paul M. O'Byrne, Parminder Raina
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Efficacy and safety of the Spiration Valve System™ for the treatment of severe emphysema in patients with Alpha-1 antitrypsin deficiency (EMPROVE) Resp. Med. (IF 4.3) Pub Date : 2024-02-14 Douglas K. Hogarth, Antoine Delage, Michael A. Zgoda, Stephanie Nsiah-Dosu, David Himes, Michael F. Reed
Alpha-1 antitrypsin deficiency (AATD) is a hereditary condition associated with emphysema. This study analyzed the efficacy and safety of Spiration Valve System (SVS) among AATD patients with severe emphysema. This multicenter prospective study included 20 patients demonstrating AATD as assessed by quantitative levels of AAT and genotype containing two ZZ alleles. Most diseased lobe based on high resolution
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Predicting exacerbations in COPD in the Danish general population Resp. Med. (IF 4.3) Pub Date : 2024-02-13 Jacob Louis Marott, Truls Sylvan Ingebrigtsen, Yunus Çolak, Jørgen Vestbo, Børge Grønne Nordestgaard, Peter Lange
Risk of exacerbations in individuals with mild chronic obstructive pulmonary disease (COPD) in the general population is less well described than in more advanced disease. We hypothesized that in addition to history of previous exacerbation also other clinical characteristics predict future moderate exacerbations. In 96,462 individuals in the Copenhagen General Population Study, we identified 3175
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The influence of body mass index on airway resistance in children with sickle cell disease: A longitudinal study based on impulse oscillometry Resp. Med. (IF 4.3) Pub Date : 2024-02-13 Pritish Mondal, Stephanie Padilla Lopez, Arshjot Khokhar, David Snyder, Diane Kitch, Ahmed Veten
Impulse oscillometry (IOS) is an effective tool for assessing airway mechanics and diagnosing obstructive airway disease (OAD) in children with sickle cell disease (C-SCD). Obesity is known to be associated with OAD, and untreated OAD often leads to hypoxia-related complications in C-SCD. Considering the increasing prevalence of obesity in C-SCD, it is important to explore the influence of body mass
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Quantitative evaluation of endobronchial ultrasound elastography in the diagnosis of benign and malignant mediastinal and hilar lymph nodes Resp. Med. (IF 4.3) Pub Date : 2024-02-12 Zhen Wang, Jiayu Bai, Guangyu Jiao, Peng Li
To compare the diagnostic value of different quantitative methods of endobronchial ultrasound elastography in benign and malignant mediastinal and hilar lymph nodes. This retrospective study included patients who underwent endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) for mediastinal and hilar lymph node enlargement in our hospital between January 2019 and August 2022
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Disease Behaviour Classification: A pragmatic model for predicting outcomes in Interstitial Lung Disease Resp. Med. (IF 4.3) Pub Date : 2024-02-12 Megan Harrison, Helen E. Jo, Lauren K. Troy, Benjamin Nguyen, Susanne E. Webster, Monika Geis, Simon Lai, Ellie Mulyadi, Wendy A. Cooper, Annabelle Mahar, Alan Teoh, Adelle Jee, Tamera J. Corte
The interstitial lung diseases (ILD) are a heterogenous group of disorders with similar clinical presentation, but widely varying prognoses. The use of a pragmatic disease behaviour classification (DBC), first proposed in international guidelines in 2013, categorises diseases into five behavioural classes based on their predicted clinical course. This study aimed to determine the prognostic utility
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Analysis of body composition with bioelectrical impedance analysis in patients with severe COPD and pulmonary emphysema Resp. Med. (IF 4.3) Pub Date : 2024-02-11 Christina Rott, Eldridge Limen, Katharina Kriegsmann, Felix Herth, Judith Maria Brock
Patients with chronic obstructive pulmonary disease (COPD) often suffer from cachexia and malnutrition. Less is known about body composition and nutritional behaviour in patients with advanced COPD and pulmonary emphysema. We performed a single-center prospective analysis of patients with COPD GOLD III/IV. Metabolic parameters, dietary and exercise behavior, lung function, exercise capacity and body
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Beyond breathing: Systematic review of global chronic obstructive pulmonary disease guidelines for pain management Resp. Med. (IF 4.3) Pub Date : 2024-02-11 Kaelee Brockway, Shakeel Ahmed
Patients with chronic obstructive pulmonary disease (COPD) experience pain as both symptom and comorbidity. There has been no evaluation of the recommendations for pain management in updated clinical practice guidelines (CPGs). Update the evidence on pain management, determine alignment of pain management recommendations with best-practice, and advocate for optimal pain management in patients with
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Role of screening for uveitis in subjects with sarcoidosis Resp. Med. (IF 4.3) Pub Date : 2024-02-10 L.H.L. Koh, J.L. Sims, F. Pepin, M. Wilsher, R.L. Niederer
Ocular involvement is common in sarcoidosis. Our study aimed to evaluate the role of screening for uveitis in subjects with sarcoidosis. Retrospective case series of 88 subjects with a pre-existing diagnosis of sarcoidosis, with no previous diagnosis of uveitis, reviewed by Ophthalmology at Auckland District Health Board between January 2016 and May 2022. Among those undergoing a screening examination
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Enhanced prothrombotic and proinflammatory activity of circulating extracellular vesicles in acute exacerbations of chronic obstructive pulmonary disease Resp. Med. (IF 4.3) Pub Date : 2024-02-09 Dario Nieri, Camilla Morani, Miriam De Francesco, Roberta Gaeta, Mariapia Niceforo, Mariella De Santis, Ilaria Giusti, Vincenza Dolo, Marta Daniele, Alberto Papi, Alessandro Celi, Tommaso Neri
Acute exacerbations of chronic obstructive pulmonary disease (AE-COPD) are associated with a high rate of cardiovascular events. Thromboinflammation (the interplay between coagulation and inflammation) is probably involved in these events. Extracellular vesicles (EV) increase during AE-COPD, but their role in thromboinflammation in COPD is still unknown. We investigated EV-associated prothrombotic
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Is there still a social gradient in respiratory symptoms? A population-based Nordic EpiLung-study Resp. Med. (IF 4.3) Pub Date : 2024-02-08 Heidi Andersén, Laxmi Bhatta, Muwada Bashir, Bright Nwaru, Arnulf Langhammer, Steinar Krokstad, Päivi Piirilä, Hanna Hisinger-Mölkänen, Helena Backman, Hannu Kankaanranta, Linnea Hedman
Respiratory symptoms are a common public health issue that can partly be attributed to preventable risk factors, such as tobacco smoking and occupational exposure, which are more common in individuals with lower socioeconomic status. Our aim was to evaluate the social gradient in respiratory symptoms in Nordic countries. This study included participants aged 30–65 years from five cross-sectional population-based
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Screening tools for the detection of clinically silent cardiac sarcoidosis Resp. Med. (IF 4.3) Pub Date : 2024-02-08 Alessandro De Bortoli, Kristin A. Dawson, Dalia Hashem, Stewart David Spence, Elena Pena, João R. Inacio, Pablo Nery, Daniel Juneau, Girish Dwivedi, Robert Beanlands, Ian Paterson, David H. Birnie
clinically silent cardiac sarcoidosis (CS) may be associated with adverse outcomes, hence the rationale for screening patients with extracardiac sarcoidosis. The optimal screening strategy has not been clearly defined. patients with extra-cardiac sarcoidosis were prospectively included and underwent screening consisting of symptom history, electrocardiography (ECG), transthoracic echocardiogram, Holter
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Evaluating the safety of intraprocedural chest tube removal during medical thoracoscopy Resp. Med. (IF 4.3) Pub Date : 2024-02-07 Bertin D. Salguero, Sidra Salman, Abhinav Agrawal, Christian M. Lo Cascio, Greta Joy, Udit Chaddha
Medical Thoracoscopy (MT) is a diagnostic procedure during which after accessing the pleural space the patient's negative-pressure inspiratory efforts draw atmospheric air into the pleural cavity, which creates a space to work in. At the end of the procedure this air must be evacuated via a chest tube, which is typically removed in the post-anesthesia care unit (PACU). We hypothesized that its removal
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Neutrophil–lymphocyte ratio being associated with mortality risk in patients receiving antifibrotic therapy Resp. Med. (IF 4.3) Pub Date : 2024-02-07 Sho Takuma, Yuzo Suzuki, Masato Kono, Hirotsugu Hasegawa, Dai Hashimoto, Koshi Yokomura, Kazutaka Mori, Mikihiro Shimizu, Yusuke Inoue, Hideki Yasui, Hironao Hozumi, Masato Karayama, Kazuki Furuhashi, Noriyuki Enomoto, Tomoyuki Fujisawa, Naoki Inui, Takafumi Suda
Antifibrotic therapy is widely used for patients with progressive fibrotic interstitial lung disease (ILD), regardless of etiology. There is an urgent need for a simple, inexpensive, and repeatable biomarker to evaluate disease severity and mortality risk. This retrospective multicohort study assessed the neutrophil–lymphocyte ratios (NLRs) of 416 patients with ILD who received antifibrotic therapy
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Improving asthma control and quality of life via a smartphone self-management app: A randomized controlled trial Resp. Med. (IF 4.3) Pub Date : 2024-02-05 Mehrdad Farzandipour, Marzieh Heidarzadeh Arani, Reihane Sharif, Ehsan Nabovati, Hossein Akbari, Shima Anvari
Mobile phone applications (apps) show promise for enhancing asthma self-management, but their effectiveness varies. This study examined the effect of a smartphone asthma app on asthma control and quality of life. Using block randomization, 60 patients with asthma were allocated to an intervention group (n = 30) or control group (n = 30) for this single-blind randomized controlled trial. At baseline
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Exercise training initiated early during hospitalisation in individuals with chronic obstructive pulmonary disease is safe and improves exercise capacity and physical function at hospital discharge: A systematic review and meta-analysis Resp. Med. (IF 4.3) Pub Date : 2024-02-01 Yuin Lai, Vinicius Cavalheri, Abbey Sawyer, Kylie Hill
Earlier reviews of exercise in people during exacerbation of chronic obstructive pulmonary disease (COPD) included studies where exercise training was initiated late during hospital admission or shortly following hospital discharge. Our question was: in adults hospitalised with an exacerbation of COPD, does initiating exercise training early during an admission not initiating exercise training during
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Severity of bronchiectasis predicts use of and adherence to high frequency chest wall oscillation therapy - Analysis from the United States Bronchiectasis and NTM research registry Resp. Med. (IF 4.3) Pub Date : 2024-02-01 Ashwin Basavaraj, Radmila Choate, Brian C. Becker, Timothy R. Aksamit, Mark L. Metersky
High frequency chest wall oscillation (HFCWO) is a form of airway clearance therapy that has been available since the mid-1990s and is routinely used by patients suffering from retained pulmonary secretions. Patients with cystic fibrosis (CF), neuromuscular disease (NMD), and other disorders, including bronchiectasis (BE) and COPD (without BE), are commonly prescribed this therapy. Limited evidence
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The diagnostic value of bronchial provocation testing combined with fractional exhaled nitric oxide (FeNO) in children with chest tightness-variant asthma (CTVA) Resp. Med. (IF 4.3) Pub Date : 2024-01-28 Tengteng Zhang, Lijuan Xu, Yingqian Zhang, Lina Zhen
Background Chest tightness-variant asthma (CTVA) is a novel atypical asthma characterized by chest tightness as the sole or primary symptom. Objectives To investigate the value of bronchial provocation testing combined with fractional exhaled nitric oxide (FeNO) in the diagnosis of CTVA in children. Methods This study included 95 children aged 6–14 years with chest tightness as the sole symptom, with
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Rapid review of ventilator-induced diaphragm dysfunction Resp. Med. (IF 4.3) Pub Date : 2024-01-28 Huimin Wu, Bobby Chasteen
Ventilator-induced diaphragm dysfunction is gaining increased recognition. Evidence of diaphragm weakness can manifest within 12 h to a few days after the initiation of mechanical ventilation. Various noninvasive and invasive methods have been developed to assess diaphragm function. The implementation of diaphragm-protective ventilation strategies is crucial for preventing diaphragm injuries. Furthermore
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Secondary Analysis of Fluids and Catheters Treatment Trial (FACTT) data reveal poor clinical outcomes in acute respiratory distress syndrome patients with diabetes Resp. Med. (IF 4.3) Pub Date : 2024-01-28 Abdulaziz H. Alanazi, Sultan Almuntashiri, Andrea Sikora, Duo Zhang, Payaningal R. Somanath
Objectives Conflicting reports exist about the link between diabetes mellitus (DM) and acute respiratory distress syndrome (ARDS). Our study examines the impact of pre-existing DM on ARDS patients within the Fluid and Catheter Treatment Trial (FACTT). Design Conducting a secondary analysis of FACTT data, we incorporated 967 participants with identified DM status (173 with DM, 794 without DM) and examined
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Dupilumab sustains lung function improvements in patients with moderate-to-severe asthma Resp. Med. (IF 4.3) Pub Date : 2024-01-23 Alberto Papi, Mario Castro, Jonathan Corren, Ian D. Pavord, Yuji Tohda, Arman Altincatal, Nami Pandit-Abid, Elizabeth Laws, Bolanle Akinlade, Leda P. Mannent, Rebecca Gall, Juby A. Jacob-Nara, Yamo Deniz, Paul J. Rowe, David J. Lederer, Megan Hardin
TRAVERSE (NCT02134028), a phase 3 open-label extension study, assessed dupilumab safety and efficacy in patients with asthma aged ≥12 years who completed a previous dupilumab asthma study. This analysis evaluated changes in multiple lung function parameters in patients with moderate-to-severe asthma with elevated type 2 biomarkers (baseline eosinophils ≥150 cells·μL or fractional exhaled nitric oxide