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Patterns and treatment outcomes of primary bone tumors in children treated at tertiary referral hospital, Ethiopia BMC Cancer (IF 3.8) Pub Date : 2024-03-28 Temesgen Lingerih, Sewagegn Yeshiwas, Abdulkadir Mohamedsaid, Gashaw Arega
Bone tumors account for approximately 6% of all cancers in children. Malignant bone tumors, commonly occurring in children and adolescents, are associated with high mortality and morbidity. The overall survival of children with primary malignant bone tumors is affected by the stage of disease, time of diagnosis, and treatment response. Despite advanced treatment modalities with chemotherapy, surgery
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Immune checkpoint inhibitor plus chemotherapy as first-line treatment for non-small cell lung cancer with malignant pleural effusion: a retrospective multicenter study BMC Cancer (IF 3.8) Pub Date : 2024-03-28 Qi Wei, Taibing Deng, Junhua Wu, Hao Zeng, Chang Qi, Sihan Tan, Yuanyuan Zhang, Qin Huang, Xin Pu, Weiguo Xu, Weimin Li, Panwen Tian, Yalun Li
Immune checkpoint inhibitors (ICI) combined with chemotherapy are efficacious for treating advanced non-small cell lung cancer (NSCLC); however, the effectiveness of this approach in the malignant pleural effusion (MPE) population is unclear. This study evaluated ICI plus chemotherapy in NSCLC patients with MPE. Patients from 3 centers in China with NSCLC and MPE who received ICI plus chemotherapy
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Retraction Note: KRAS activation in gastric cancer stem-like cells promotes tumor angiogenesis and metastasis BMC Cancer (IF 3.8) Pub Date : 2024-03-28 Changhwan Yoon, Jun Lu, Yukyung Jun, Yun-Suhk Suh, Bang-Jin Kim, Jacob E. Till, Jong Hyun Kim, Sara H. Keshavjee, Sandra Ryeom, Sam S. Yoon
Retraction Note: BMC Cancer (2023) 23:690 https://doi.org/10.1186/s12885-023-11170-0 The Editors have retracted this article. After publication, concerns were raised regarding highly similar images in Fig. 5d (VEGF-A sh.KRAS-/sh.VEGF-A + and sh.KRAS+/sh.VEGF-A+). The authors have provided the original data to address these concerns; however, further checks by the publisher have found that a number
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The effectiveness of couple-based interventions on the marital outcomes of women with genital and breast cancer and their partners: a systematic review and meta-analysis BMC Cancer (IF 3.8) Pub Date : 2024-03-27 Hamideh Zahedi, Zohreh Alizadeh-Dibazari, Mojgan Mirghafourvand, Mohammad Hasan Sahebihagh, Mina Hosseinzadeh
Breast cancer and genital cancer are known as cancers that affect people’s relationships with their partners. Women with such cancers are emotionally vulnerable and need more support from their partners. The present systematic review and meta-analysis evaluated the effectiveness of couple-based interventions on the marital outcomes of patients with these cancers and their intimate partners. To perform
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Attitudes of oncology patients’ towards biospecimen donation for biobank research BMC Cancer (IF 3.8) Pub Date : 2024-03-27 Jan Domaradzki, Justyna Czekajewska, Dariusz Walkowiak
Since the biological material that remains after diagnostic and therapeutic procedures plays crucial role in biobank research, this study aims to explore cancer patients’ views on the donation of biospecimens for research purposes. 548 oncology patients from two hospitals with oncology treatment units in Poznan, Poland, completed an anonymous, self-administered pen-and-paper questionnaire. Although
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Assessing the use of anti-PD1 monotherapy as adjuvant therapy and determinants of treatment choice in stage III cutaneous melanoma in the US BMC Cancer (IF 3.8) Pub Date : 2024-03-27 Eric D. Whitman, Todor I. Totev, Shan Jiang, Wilson L. da Costa, Dmitri Grebennik, Hongjue Wang, Andra-Ecaterina Boca, Rajeev Ayyagari
The objective of this study was to describe real-world adjuvant therapy (AT) use by disease substage and assess determinants of treatment choice among patients with stage III melanoma. This non-interventional retrospective study included survey responses and data from patient records provided by US medical oncologists. Survey responses, patient demographic/clinical characteristics, treatment utilization
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Association of hormone receptors and human epidermal growth factor receptor-2/neu expressions with clinicopathologic factors of breast carcinoma: a cross-sectional study in a tertiary care hospital, Kabul, Afghanistan BMC Cancer (IF 3.8) Pub Date : 2024-03-27 Esmatullah Esmat, Ahmed Maseh Haidary, Ramin Saadaat, Syeda Naghma Rizvi, Syeda Aleena, Mujtaba Haidari, Sayed Murtaza Sadat Hofiani, Nasrin Hussaini, Ahmadullah Hakimi, Abdullatif Khairy, Jamshid Abdul-Ghafar
Breast cancer (BC) is one of the major causes of death worldwide. It is the most common cause of death before the age of 70 years. The incidence and mortality of BC are rapidly increasing, posing great challenges to the health system and economy of every nation. A cross-sectional analytical study was conducted at the Department of Pathology and Clinical Laboratory of the French Medical Institute for
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Transarterial chemoembolization with molecular targeted therapies plus camrelizumab for recurrent hepatocellular carcinoma BMC Cancer (IF 3.8) Pub Date : 2024-03-27 Changlong Hou, Baizhu Xiong, Lei Zhou, Yipeng Fei, Changgao Shi, Xianhai Zhu, Tao Xie, Yulin Wu
The safety and efficacy of transarterial chemoembolization plus molecular targeted therapy (MTT) combined with immune checkpoint inhibitors (ICIs) in primary liver cancer have been demonstrated. However, the evidence for TACE plus MTT combined with ICIs in the treatment of recurrent hepatocellular carcinoma (RHCC) is limited. Given the excellent performance of this combination regimen in primary liver
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SIRT5 promote malignant advancement of chordoma by regulating the desuccinylation of c-myc BMC Cancer (IF 3.8) Pub Date : 2024-03-26 Minghui Jiang, Zheng Huang, Li Chen, Ting Deng, Junpeng Liu, Yue Wu
Chordoma is a relatively rare and locally aggressive malignant tumor. Sirtuin (SIRT)5 plays pivotal roles in various tumors, but the role of SIRT5 in chordoma has not been found. This study was performed to investigate the regulatory effects of SIRT5 on cell proliferation, migration, and invasion and the underlying mechanism in chordoma. A xenograft tumor mouse model was established to assess tumor
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High expression of RTEL1 predicates worse progression in gliomas and promotes tumorigenesis through JNK/ELK1 cascade BMC Cancer (IF 3.8) Pub Date : 2024-03-26 Guanjie Wang, Xiaojuan Ren, Jianying Li, Rongrong Cui, Xumin Zhao, Fang Sui, Juan Liu, Pu Chen, Qi Yang, Meiju Ji, Peng Hou, Ke Gao, Yiping Qu
Gliomas are the most common primary intracranial tumor worldwide. The maintenance of telomeres serves as an important biomarker of some subtypes of glioma. In order to investigate the biological role of RTEL1 in glioma. Relative telomere length (RTL) and RTEL1 mRNA was explored and regression analysis was performed to further examine the relationship of the RTL and the expression of RTEL1 with clinicopathological
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Reproductive factors and risk of lung cancer among 300,000 Chinese female never-smokers: evidence from the China Kadoorie Biobank study BMC Cancer (IF 3.8) Pub Date : 2024-03-26 Marwa M. A. Elbasheer, Bastian Bohrmann, Yiping Chen, Jun Lv, Dianjianyi Sun, Xia Wu, Xiaoming Yang, Daniel Avery, Liming Li, Zhengming Chen, Christiana Kartsonaki, Ka Hung Chan, Ling Yang
Lung cancer is the leading cause of cancer mortality among Chinese females despite the low smoking prevalence among this population. This study assessed the roles of reproductive factors in lung cancer development among Chinese female never-smokers. The prospective China Kadoorie Biobank (CKB) recruited over 0.5 million Chinese adults (0.3 million females) from 10 geographical areas in China in 2004–2008
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Carbon-ion radiotherapy for hepatocellular carcinoma with major vascular invasion: a retrospective cohort study BMC Cancer (IF 3.8) Pub Date : 2024-03-26 Takashi Kaneko, Hirokazu Makishima, Masaru Wakatsuki, Yuichi Hiroshima, Toshiaki Matsui, Shigeo Yasuda, Naomi Nagatake Okada, Kenji Nemoto, Hiroshi Tsuji, Shigeru Yamada, Masaru Miyazaki
Macroscopic vascular invasion (MVI) significantly impacts survival in patients with hepatocellular carcinoma (HCC), warranting systemic therapy over locoregional therapy. Despite novel approaches, HCC with MVI has a poor prognosis compared to early-to intermediate-stage HCC. This study aimed to evaluate the safety and efficacy of carbon-ion radiotherapy (C-ion RT) for HCC characterized by MVI. This
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Reductive prodrug and AIE copolymer nanoparticle for monitoring and chemotherapy BMC Cancer (IF 3.8) Pub Date : 2024-03-26 Zigui Wang, Guilin Li, Qiaohui Zhao, Guangyu Fu, Zengli Yang, Guojun Zhang
Polymeric micelle systems for drug delivery, monitor and chemotherapy have gained significant attention, and reductive polymeric micelle systems have become particularly attractive due to their controlled release behavior without additional assistance. However, there are challenges in accurately controlling drug and probe release from the nanoparticles and determining the loading content of drug and
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Evaluation of the diagnostic performance of colposcopy in the detection of cervical high-grade squamous intraepithelial lesions among women with transformation zone type 3 BMC Cancer (IF 3.8) Pub Date : 2024-03-26 Xiaoxiao Li, Yunzhi Zhao, Fenfen Xiang, Xinpei Zhang, Zixi Chen, Mengzhe Zhang, Xiangdong Kang, Rong Wu
Inaccurate colposcopy diagnosis may lead to inappropriate management and increase the incidence of cervical cancer. This study aimed to evaluate the diagnostic accuracy of colposcopy in the detection of histologic cervical intraepithelial neoplasia grade 2 or worse (CIN2+) in women with transformation zone type 3 (TZ3). Records from 764 patients with TZ3 who underwent colposcopy-directed biopsy and/or
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Accuracy of endometrial sampling in the diagnosis of endometrial cancer: a multicenter retrospective analysis of the JAGO-NOGGO BMC Cancer (IF 3.8) Pub Date : 2024-03-25 Zaher Alwafai, Maximilian Heinz Beck, Sepideh Fazeli, Kathleen Gürtler, Christine KunzYoung Academy of Gynecologic Oncology, Juliane Singhartinger, Dominika Trojnarska, Dario Zocholl, David Johannes Krankenberg, Jens-Uwe Blohmer, Jalid Sehouli, Klaus Pietzner
Accurate preoperative molecular and histological risk stratification is essential for effective treatment planning in endometrial cancer. However, inconsistencies between pre- and postoperative tumor histology have been reported in previous studies. To address this issue and identify risk factors related to inaccurate histologic diagnosis after preoperative endometrial evaluation, we conducted this
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A lack of association between BMI and chemoimmunotherapy efficacy in advanced non-small cell lung cancer: Secondary analysis of the IMpower150 and IMpower130 clinical trials BMC Cancer (IF 3.8) Pub Date : 2024-03-25 Lee X. Li, Mark A. Socinski, Ganessan Kichenadasse, Christos S. Karapetis, Adel Shahnam, Ross A. McKinnon, Andrew Rowland, Ashley M. Hopkins, Michael J. Sorich
Multiple studies have indicated that patients with high body mass index (BMI) may have favourable survival outcomes following treatment with an immune checkpoint inhibitor (ICI). However, this evidence is limited by several factors, notably the minimal evidence from randomised controlled trials (RCTs), the use of categorised BMI with inconsistent cut point definitions, and minimal investigation of
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Correction: A real-world study of the effectiveness and safety of apatinib-based regimens in metastatic triple-negative breast cancer BMC Cancer (IF 3.8) Pub Date : 2024-03-25 Weiwei Huang, Chenxi Wang, Yangkun Shen, Qi Chen, Zhijian Huang, Jian Liu, Xiaoyan Lin, Lili Wang, Fan Wu, Xinhua Chen, Nani Li, Yi Hong, Mulan Chen, Jieyu Li, Chuanzhong Huang
Correction: BMC Cancer 24, 39 (2024) https://doi.org/10.1186/s12885-023-11790-6 Following publication of the original article [1], a typesetting error was noticed in the equal contributions statement. The equal contributions should read as follows: † Weiwei Huang and Chenxi Wang contributed equally to this work. The original article [1] has been corrected. Huang W, Wang C, Shen Y, et al. A real-world
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Comment on “A novel super-enhancer-related gene signature predicts prognosis and immune microenvironment for breast cancer” BMC Cancer (IF 3.8) Pub Date : 2024-03-25 Matin Chehelgerdi, Milad Khorramian-Ghahfarokhi, Fereshteh Behdarvand Dehkordi, Mohammad Chehelgerdi
The primary aim of this study is to critically evaluate and comment on the research presented in the article titled “A Novel Super-Enhancer-Related Gene Signature Predicts Prognosis and Immune Microenvironment for Breast Cancer” by Wu et al. Our specific objectives include assessing the methodology employed by the authors, particularly in regard to the utilization of a super-enhancer-related gene signature
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Correction: Effect of educational intervention on the knowledge, attitude and practice of breast self-examination among female students at a private university in Southern Nigeria BMC Cancer (IF 3.8) Pub Date : 2024-03-25 Rejoice Oritsemoyowa Uruntie, Chime Helen Oputa, Esegbue Peters, Agofure Otovwe
Correction: BMC Cancer 24, 355 (2024) https://doi.org/10.1186/s12885-024-12116-w Following publication of the original article [1], the authors noticed a typesetting error, whereby the first author, Rejoice Oritsemoyowa Uruntie, was erroneously omitted from the author group. The publishers apologise for this error and any inconvenience caused. The original article [1] has been corrected. Uruntie RO
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Positivity rates, trends and experiences of health workers on human papillomavirus screened using genexpert in Uganda: a three-year retrospective cohort study BMC Cancer (IF 3.8) Pub Date : 2024-03-25 Harriet Nakigozi, Paul Mukama Ategyeka, Susan Nabadda, Rawlance Ndejjo
Cervical cancer is a major public health issue in Uganda, with high incidence due to limited screening especially in rural areas. In 2019, HPV DNA testing using GeneXpert was rolled out to improve screening access. Assessing progress and challenges since its introduction is important. To determine genotype distribution and explore health worker experiences with HPV screening using GeneXpert in Uganda
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ROAR-A: re-optimization based Online Adaptive Radiotherapy of anal cancer, a prospective phase II trial protocol BMC Cancer (IF 3.8) Pub Date : 2024-03-25 Katrine Smedegaard Storm, Lina M Åström, Patrik Sibolt, Claus P Behrens, Gitte F Persson, Eva Serup-Hansen
Chemo-radiotherapy with curative intent for anal cancer has high complete remission rates, but acute treatment-related gastrointestinal (GI) toxicity is significant. Toxicity occurs due to irradiation of surrounding normal tissue. Current radiotherapy requires the addition of large planning margins to the radiation field to ensure target coverage regardless of the considerable organ motion in the pelvic
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Decision-making and autonomy among participants in early-phase cancer immunotherapy trials: a qualitative study BMC Cancer (IF 3.8) Pub Date : 2024-03-25 Jonathan Avery, Jennifer A.H. Bell, Khotira Baryolay, Gary Rodin, Rinat Nissim, Lynda G. Balneaves
Participants considering early-phase cancer clinical trials (CTs) need to understand the unique risks and benefits prior to providing informed consent. This qualitative study explored the factors that influence patients’ decisions about participating in early-phase cancer immunotherapy CTs through the ethical lens of relational autonomy. Using an interpretive descriptive design, interviews were conducted
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The radiological characteristics, tertiary lymphoid structures, and survival status associated with EGFR mutation in patients with subsolid nodules like stage I-II LUAD. BMC Cancer (IF 3.8) Pub Date : 2024-03-25 Mei Xie, Jie Gao, Xidong Ma, Jialin Song, Chongchong Wu, Yangyu Zhou, Tianjiao Jiang, Yiran Liang, Chen Yang, Xinyu Bao, Xin Zhang, Jie Yao, Ying Jing, Jianlin Wu, Jianxin Wang, Xinying Xue
Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) recommended for the patients with subsolid nodule in early lung cancer stage is not routinely. The clinical value and impact in patients with EGFR mutation on survival outcomes is further needed to be elucidated to decide whether the application of EGFR-TKIs was appropriate in early lung adenocarcinoma (LUAD) stage appearing as
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Single-cell transcriptional signature-based drug repurposing and in vitro evaluation in colorectal cancer BMC Cancer (IF 3.8) Pub Date : 2024-03-25 Roohallah Mahdi-Esferizi, Zahra Shiasi, Razieh Heidari, Ali Najafi, Issa Mahmoudi, Fatemeh Elahian, Shahram Tahmasebian
The need for intelligent and effective treatment of diseases and the increase in drug design costs have raised drug repurposing as one of the effective strategies in biomedicine. There are various computational methods for drug repurposing, one of which is using transcription signatures, especially single-cell RNA sequencing (scRNA-seq) data, which show us a clear and comprehensive view of the inside
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Investigator choice of standard therapy versus sequential novel therapy arms in the treatment of relapsed follicular lymphoma (REFRACT): study protocol for a multi-centre, open-label, randomised, phase II platform trial BMC Cancer (IF 3.8) Pub Date : 2024-03-25 Graham McIlroy, Siân Lax, Charlotte Gaskell, Aimee Jackson, Malcolm Rhodes, Tania Seale, Sonia Fox, Lousie Hopkins, Jessica Okosun, Sally F. Barrington, Ingo Ringshausen, Alan G. Ramsay, Maria Calaminici, Kim Linton, Mark Bishton
Relapsed or refractory follicular lymphoma (rrFL) is an incurable disease associated with shorter remissions and survival after each line of standard therapy. Many promising novel, chemotherapy-free therapies are in development, but few are licensed as their role in current treatment pathways is poorly defined. The REFRACT trial is an investigator-initiated, UK National Cancer Research Institute, open-label
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CD13 expression affects glioma patient survival and influences key functions of human glioblastoma cell lines in vitro BMC Cancer (IF 3.8) Pub Date : 2024-03-22 Wenying Zhang, Anne Blank, Irina Kremenetskaia, Anja Nitzsche, Güliz Acker, Peter Vajkoczy, Susan Brandenburg
CD13 (APN) is an Alanyl-Aminopeptidase with diverse functions. The role of CD13 for gliomas is still unknown. In this study, data of glioma patients obtained by TCGA and CGGA databases were used to evaluate the survival rate and prognostic value of CD13 expression level. Protein expression of CD13 was confirmed by immunofluorescence staining of fresh patient tissues. Eight human glioblastoma cell lines
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Development and validation of a Radiopathomics model based on CT scans and whole slide images for discriminating between Stage I-II and Stage III gastric cancer BMC Cancer (IF 3.8) Pub Date : 2024-03-22 Yang Tan, Li-juan Feng, Ying-he Huang, Jia-wen Xue, Zhen-Bo Feng, Li-ling Long
This study aimed to develop and validate an artificial intelligence radiopathological model using preoperative CT scans and postoperative hematoxylin and eosin (HE) stained slides to predict the pathological staging of gastric cancer (stage I-II and stage III). This study included a total of 202 gastric cancer patients with confirmed pathological staging (training cohort: n = 141; validation cohort:
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Clinical significance of low expression of CADM3 in breast cancer and preliminary exploration of related mechanisms BMC Cancer (IF 3.8) Pub Date : 2024-03-21 Huiyang Ren, Zhen Wang, Lei Zhang, Guolian Zhu, Feng Li, Bo Chen
Cell adhesion molecule 3 (CADM3), a transmembrane glycoprotein on cell membranes, plays a role in the way of ligand and receptor interaction. However, there are few studies on CADM3 in tumors, and how it works in breast cancer (BC) remains unclear. The Cancer Genome Atlas (TCGA) database and clinical samples were used to analyze CADM3 expression and its correlation with clinicopathological factors
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Retraction Note: Haplotype analysis on correlation between transcription factor 7-like 2 gene polymorphism and breast cancer risk BMC Cancer (IF 3.8) Pub Date : 2024-03-21 Yang Wang, Xiaojuan Men, Yongxue Gu, Huidong Wang, Zhicai Xu
Retraction Note: BMC Cancer 21, 885 (2021) https://doi.org/10.1186/s12885-021-08571-4 The Editor has retracted this article because of substantial overlaps with article [1] by different authors that was under submission at the same time. The authors did not respond to a request to explain the overlaps and to provide evidence that an ethics approval had been obtained before the commencement of the study
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The association between organised colorectal cancer screening strategies and reduction of its related mortality: a systematic review and meta-analysis BMC Cancer (IF 3.8) Pub Date : 2024-03-21 Hanyue Ding, Jiaye Lin, Zijun Xu, Harry H. X. Wang, Liwen Huang, Junjie Huang, Martin C. S. Wong
To assess the long-term association between organised colorectal cancer (CRC) screening strategies and CRC-relate mortality. We systematically reviewed studies on organised CRC screening through PubMed, Ovid Medline, Embase and Cochrane from the inception. We retrieved characteristics of organised CRC screening from included literature and matched mortality (over 50 years) of those areas from the International
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APOC1 is a prognostic biomarker associated with M2 macrophages in ovarian cancer BMC Cancer (IF 3.8) Pub Date : 2024-03-21 Shimin Yang, Jingxiao Du, Wei Wang, Dongmei Zhou, Xiaowei Xi
Recent studies have demonstrated that APOC1 is associated with cancer progression, exerting cancer-promoting and immune infiltration-promoting effects. Nevertheless, there is currently no report on the presence of APOC1 in ovarian cancer (OV). In this study, we conducted data analysis using the GEO and TCGA databases. We conducted a thorough bioinformatics analysis to investigate the function of APOC1
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Research on multi-model imaging machine learning for distinguishing early hepatocellular carcinoma BMC Cancer (IF 3.8) Pub Date : 2024-03-21 Ya Ma, Yue Gong, QingTao Qiu, Changsheng Ma, Shuang Yu
To investigate the value of differential diagnosis of hepatocellular carcinoma (HCC) and non-hepatocellular carcinoma (non-HCC) based on CT and MR multiphase radiomics combined with different machine learning models and compare the diagnostic efficacy between different radiomics models. Primary liver cancer is one of the most common clinical malignancies, hepatocellular carcinoma (HCC) is the most
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Clinical characteristics and MRI based radiomics nomograms can predict iPFS and short-term efficacy of third-generation EGFR-TKI in EGFR-mutated lung adenocarcinoma with brain metastases BMC Cancer (IF 3.8) Pub Date : 2024-03-21 Haoran Qi, Yichen Hou, Zhonghang Zheng, Mei Zheng, Qiang Qiao, Zihao Wang, Xiaorong Sun, Ligang Xing
Predicting short-term efficacy and intracranial progression-free survival (iPFS) in epidermal growth factor receptor gene mutated (EGFR-mutated) lung adenocarcinoma patients with brain metastases who receive third-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) therapy was of great significance for individualized treatment. We aimed to construct and validate nomograms
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Comparing the efficacy of a multi-dimensional breast cancer rehabilitation programme versus a home-based exercise programme during adjuvant cancer treatment BMC Cancer (IF 3.8) Pub Date : 2024-03-21 Gobinathan Chandran, Ning Tang, Ednajoy Lay Poh Ngo, Serene Huang, Shuk In Tong, Jie Xin Ong, Effie Chew
Breast cancer is the most common female malignancy worldwide and a major cause of morbidity and mortality. Exercise during adjuvant treatment improves function and relieves symptoms in breast cancer survivors. However, it is unclear if an unsupervised exercise programme may be as effective as a supervised multimodal group. We investigated the feasibility and efficacy of a centre-based multidimensional
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Clinical characteristics and radiation therapy modality of younger patients with early-stage endometrial cancer, a multicenter study in China’s real world BMC Cancer (IF 3.8) Pub Date : 2024-03-20 Kun Zhang, Tiejun Wang, Zi Liu, Jianli He, Xiaoge Sun, Wei Zhong, Fengjv Zhao, Xiaomei Li, Sha Li, Hong Zhu, Zhanshu Ma, Ke Hu, Fuquan Zhang, Xiaorong Hou, Lichun Wei, Lijuan Zou
Endometrial cancer is a prevalent gynecologic malignancy found in postmenopausal women. However, in the last two decades, the incidence of early-stage has doubled in women under 40 years old. This study aimed to investigate the clinical and pathological characteristics and adjuvant therapeutic modalities of both young and not -young patients with early-stage endometrial cancer in China’s real world
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Imprinted gene detection effectively improves the diagnostic accuracy for papillary thyroid carcinoma BMC Cancer (IF 3.8) Pub Date : 2024-03-20 Yanwei Chen, Ming Yin, Yifeng Zhang, Ning Zhou, Shuangshuang Zhao, Hongqing Yin, Jun Shao, Xin Min, Baoding Chen
Papillary thyroid carcinoma (PTC) is the most frequent histological type of thyroid carcinoma. Although an increasing number of diagnostic methods have recently been developed, the diagnosis of a few nodules is still unsatisfactory. Therefore, the present study aimed to develop and validate a comprehensive prediction model to optimize the diagnosis of PTC. A total of 152 thyroid nodules that were evaluated
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Tumor burden score and carcinoembryonic antigen predict outcomes in patients with intrahepatic cholangiocarcinoma following liver resection: a multi‑institutional analysis BMC Cancer (IF 3.8) Pub Date : 2024-03-20 Jun Fu, Lifang Zheng, Shicuan Tang, Kongying Lin, Shuguo Zheng, Xinyu Bi, Jianming Wang, Wei Guo, Fuyu Li, Jian Wang, Kui Wang, Haitao Li, Yongyi Zeng
The prognostic significance of tumor burden score (TBS) in relation to carcinoembryonic antigen (CEA) has not been investigated among patients undergoing hepatectomy for intrahepatic cholangiocarcinoma (ICC). This study aimed to develop and validate a simplified model, a combination of TBS and CEA (CTC grade), for predicting the long-term outcomes of postoperative ICC patients. Patients who underwent
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Transgelin-2, a novel cancer stem cell-related biomarker, is a diagnostic and therapeutic target for biliary tract cancer BMC Cancer (IF 3.8) Pub Date : 2024-03-20 Jung Hyun Jo, Soo Been Park, Joowon Chung, Taeyun Oh, Hee Seung Lee, Moon Jae Chung, Jeong Youp Park, Seungmin Bang, Seung Woo Park, Dawoon E. Jung, Si Young Song
Biliary tract cancer (BTC) is a relatively rare but aggressive gastrointestinal cancer with a high mortality rate. Cancer stem cell (CSC) populations play crucial roles in tumor biology and are responsible for the low response to anti-cancer treatment and the high recurrence rate. This study investigated the role of Transgelin-2 (TAGLN2), overexpressed in CSC in BTC cells, and analyzed its expression
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Factors associated with recurrence in patients with oral cancer in Mongolia BMC Cancer (IF 3.8) Pub Date : 2024-03-20 Oyuntsetseg Davaatsend, Munkhdul Altannamar, Mandukhai Ganbat, Urjinlkham Jagdagsuren
In Mongolia, there has been limited research on the posttreatment survival rate, recurrence, and occurrence of oral cancer. The goal of this study is to investigate the risk factors that contribute to the recurrence of oral cancer to increase survival rates, facilitate early detection, and improve treatment accuracy. A retrospective cohort method was used, with medical records from 173 patients diagnosed
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Effect of educational intervention on the knowledge, attitude and practice of breast self-examination among female students at a private university in Southern Nigeria BMC Cancer (IF 3.8) Pub Date : 2024-03-19 Chime Helen Oputa, Esegbue Peters, Agofure Otovwe
In Nigeria, breast cancer (BC), a disorder marked by the unchecked growth of breast cells, has been the commonest cancer among women in Nigeria. Breast self-examination (BSE) is one of the suggested methods for screening for the early diagnosis of breast cancer. However, studies have reported inadequate knowledge, negative attitudes and poor practices of BSE among undergraduate female students. The
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ART1 knockdown decreases the IL-6-induced proliferation of colorectal cancer cells BMC Cancer (IF 3.8) Pub Date : 2024-03-19 Ting Lin, Shuxian Zhang, Yi Tang, Ming Xiao, Ming Li, Hanjuan Gong, Hailun Xie, Yalan Wang
Colorectal cancer (CRC) is a worldwide health concern. Chronic inflammation is a risk factor for CRC, and interleukin-6 (IL-6) plays a pivotal role in this process. Arginine-specific mono-ADP-ribosyltransferase-1 (ART1) positively regulates inflammatory cytokines. ART1 knockdown reduces the level of glycoprotein 130 (gp130), a key transducer in the IL-6 signalling pathway. However, the relationship
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Pan-cancer analysis of NUP155 and validation of its role in breast cancer cell proliferation, migration, and apoptosis BMC Cancer (IF 3.8) Pub Date : 2024-03-19 Zi-qiong Wang, Zhi-xuan Wu, Zong-pan Wang, Jing-xia Bao, Hao-dong Wu, Di-yan Xu, Hong-feng Li, Yi-Yin Xu, Rong-xing Wu, Xuan-xuan Dai
NUP155 is reported to be correlated with tumor development. However, the role of NUP155 in tumor physiology and the tumor immune microenvironment (TIME) has not been previously examined. This study comprehensively investigated the expression, immunological function, and prognostic significance of NUP155 in different cancer types. Bioinformatics analysis revealed that NUP155 was upregulated in 26 types
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Prognostic marker CD27 and its micro-environmental in multiple myeloma BMC Cancer (IF 3.8) Pub Date : 2024-03-19 Xinya Wang, Keyang Luo, Qiuting Xu, Liqun Chi, Yiwei Guo, Chuiming Jia, Lina Quan
The Cluster of Differentiation 27 (CD27) is aberrantly expressed in multiple myeloma (MM) -derived. This expression facilitates the interaction between tumor and immune cells within TME via the CD27-CD70 pathway, resulting in immune evasion and subsequent tumor progression. The objective of this study is to investigate the correlation between CD27 expression and the prognosis of MM, and to elucidate
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Prediction of cervical cancer screening: application of the information-motivation-behavioral skills model BMC Cancer (IF 3.8) Pub Date : 2024-03-19 Marzieh Ghasemi, Mitra Savabi-Esfahani, Mahnaz Noroozi, Mohammad Satari
Screening is an effective method for preventing cervical cancer. The present study aimed to determine the predictability of cervical cancer screening using the information-motivation-behavioral skills (IMB) model, as this model can help understand the factors that influence health-related behaviors. The present cross-sectional study examined 310 women aged 20 to 60 in Isfahan, Iran, between 2020 and
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Convolutional neural network-based magnetic resonance image differentiation of filum terminale ependymomas from schwannomas BMC Cancer (IF 3.8) Pub Date : 2024-03-19 Zhaowen Gu, Wenli Dai, Jiarui Chen, Qixuan Jiang, Weiwei Lin, Qiangwei Wang, Jingyin Chen, Chi Gu, Jia Li, Guangyu Ying, Yongjian Zhu
Preoperative diagnosis of filum terminale ependymomas (FTEs) versus schwannomas is difficult but essential for surgical planning and prognostic assessment. With the advancement of deep-learning approaches based on convolutional neural networks (CNNs), the aim of this study was to determine whether CNN-based interpretation of magnetic resonance (MR) images of these two tumours could be achieved. Contrast-enhanced
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Assessing colposcopy competencies in medically underserved communities: a multi-center study in China BMC Cancer (IF 3.8) Pub Date : 2024-03-19 Xiaoli Cui, Huike Wang, Mingyang Chen, Samuel Seery, Peng Xue, Youlin Qiao, Yuhong Shang
Colposcopy plays an essential role in diagnosing cervical lesions and directing biopsy; however, there are few studies of the capabilities of colposcopists in medically underserved communities in China. This study aims to fill this gap by assessing colposcopists’ competencies in medically underserved communities of China. Colposcopists in medically underserved communities across China were considered
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Correction: Apolipoprotein A-IV concentrations and cancer in a large cohort of chronic kidney disease patients: results from the GCKD study BMC Cancer (IF 3.8) Pub Date : 2024-03-19 Barbara Kollerits, Simon Gruber, Inga Steinbrenner, Johannes P. Schwaiger, Hansi Weissensteiner, Sebastian Schönherr, Lukas Forer, Fruzsina Kotsis, Ulla T. Schultheiss, Heike Meiselbach, Christoph Wanner, Kai-Uwe Eckardt, Florian Kronenberg
Correction: BMC Cancer 24, 320 (2024) https://doi.org/10.1186/s12885-024-12053-8 Following publication of the original article [1], the author noticed an error in the affiliation of Inga Steinbrenner. Her affiliation should be 2, instead of affiliation 3. The correct affiliation for Inga Steinbrenner is: 2Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center—University of Freiburg
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Attitudes towards risk-stratified breast cancer screening: a population-based survey among 5,001 Danish women BMC Cancer (IF 3.8) Pub Date : 2024-03-19 Louise Hougaard Loft, Line Hjøllund Pedersen, Janne Bigaard, Stig Egil Bojesen
The individual woman’s risk of being diagnosed with breast cancer can now be estimated more precisely, and screening can be stratified accordingly. The risk assessment requires that women are willing to provide a blood test, additional personal information, to know their risk, and alter screening intervals. This study aimed to investigate Danish women’s attitudes towards risk-stratified breast cancer
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NanoLuc Binary Technology as a methodological approach: an important new tool for studying the localization of androgen receptor and androgen receptor splice variant V7 homo and heterodimers BMC Cancer (IF 3.8) Pub Date : 2024-03-19 Juan Guzman, Katrin Weigelt, Angela Neumann, Philipp Tripal, Benjamin Schmid, Zoltán Winter, Ralph Palmisano, Zoran Culig, Marcus V. Cronauer, Paul Muschler, Bernd Wullich, Helge Taubert, Sven Wach
The androgen/androgen receptor (AR)-signaling axis plays a central role in prostate cancer (PCa). Upon androgen-binding the AR dimerizes with another AR, and translocates into the nucleus where the AR-dimer activates/inactivates androgen-dependent genes. Consequently, treatments for PCa are commonly based on androgen deprivation therapy (ADT). The clinical benefits of ADT are only transitory and most
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Hsa_circ_0004872 alleviates meningioma progression by sponging miR-190a-3p/PTEN signaling BMC Cancer (IF 3.8) Pub Date : 2024-03-18 Yongkai Huang, Zhihui Wu, Zewei Peng, Anmin Liu, Wen Yuan, Deqing Han, Junmin Peng
Meningioma, the most prevalent intracranial tumor, possesses a significant propensity for malignant transformation. Circular RNAs (circ-RNAs), a class of non-coding RNAs, have emerged as crucial players in tumorigenesis. This study explores the functional relevance of hsa_circ_0004872, a specific circ-RNA, in the context of meningioma. Molecular structure and stability of hsa_circ_0004872 were elucidated
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Nomogram to predict overall survival of patients receiving radical gastrectomy and incomplete peri-operative adjuvant chemotherapy for stage II/III gastric cancer: a retrospective bi-center cohort study BMC Cancer (IF 3.8) Pub Date : 2024-03-18 Dian Liu, Hu Quan, Min Ma, Huijun Zhou, Xiaolin Yang, Zhengchun Wu, Jia Luo, Hua Xiao, Yanping Xiao
To establish a nomogram to predict the probability of survival of patients with stage II/III gastric cancer (GC) who received incomplete peri-operative adjuvant chemotherapy (PAC). The medical records of stage II/III GC patients who received curative resection and 1 to 5 cycles of PAC from two tertiary hospitals were retrospectively reviewed. Patients were randomly classified into either a training
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Correction: Impact of preoperative antiviral therapy on the prognosis of hepatitis B virus-related hepatocellular carcinoma BMC Cancer (IF 3.8) Pub Date : 2024-03-15 Yuxin Liang, Deyuan Zhong, Zilong Zhang, Yuhao Su, Su Yan, Chunyou Lai, Yutong Yao, Ying Shi, Xiaolun Huang, Jin Shang
Correction: BMC Cancer 24, 291 (2024) https://doi.org/10.1186/s12885-024-12031-0 Following publication of the original article [1], the author noticed a typesetting error. The equal contributions statement was erroneously omitted. The equal contributions statement is as follows: Yuxin Liang and Deyuan Zhong contributed equally to this manuscript. Further to this, affiliation 1 has been corrected. The
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Is low-dose computed tomography for lung cancer screening conveniently accessible in China? A spatial analysis based on cross-sectional survey BMC Cancer (IF 3.8) Pub Date : 2024-03-14 Jay Pan, Jianjian Wang, Wenjuan Tao, Chaohui Wang, Xiaojun Lin, Xiuli Wang, Ruicen Li
Regular Low-Dose Computed Tomography (LDCT) for lung cancer high-risk population has been proved to improve health outcomes and relieve disease burden efficiently for both individual and society. With geographical impedance becoming the major barrier preventing patients from getting timely healthcare service, this study incorporated health seeking behavior in estimating spatial accessibility of relative
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Establishment of a risk prediction model for bowel preparation failure prior to colonoscopy BMC Cancer (IF 3.8) Pub Date : 2024-03-14 Na Zhang, Miaomiao Xu, Xing Chen
This study aimed to determine the factors that contribute to the failure of bowel preparation in patients undergoing colonoscopy and to develop a risk prediction model. A total of 1115 outpatients were included. Patients were randomly divided into two groups: the modeling group (669 patients) and the validation group (446 patients). In the modeling group, patients were further divided into two groups
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Adult head and neck rhabdomyosarcoma: radiotherapy- based treatment, outcomes, and predictors of survival BMC Cancer (IF 3.8) Pub Date : 2024-03-14 Dan Zhao, Fang Zhou, Weixin Liu, Zhou Huang, Xiaolong Xu, Baomin Zheng, Changqing Liu, Chujie Bai, Jiayong Liu, Yan Sun, Weihu Wang, Shaowen Xiao
Adult head and neck rhabdomyosarcoma (HNRMS) is an exceptionally rare malignancy, and there is a paucity of data and research dedicated to understanding its characteristics and management in adult populations. This study aimed to assess the outcomes and identify survival predictors in adult HNRMS. We retrospectively evaluated 42 adult patients (> 16 years) with HNRMS who received radiotherapy (RT)-based
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Role of beta-(1→3)(1→6)-D-glucan derived from yeast on natural killer (NK) cells and breast cancer cell lines in 2D and 3D cultures BMC Cancer (IF 3.8) Pub Date : 2024-03-14 Abdelhadi Boulifa, Martin J. Raftery, Alexander Sebastian Franzén, Clarissa Radecke, Sebastian Stintzing, Jens-Uwe Blohmer, Gabriele Pecher
Beta-(1,3)(1,6)-D-glucan is a complex polysaccharide, which is found in the cell wall of various fungi, yeasts, bacteria, algae, barley, and oats and has immunomodulatory, anticancer and antiviral effects. In the present study, we investigated the effect of beta-(1,3)(1,6)-D-glucan derived from yeast on the proliferation of primary NK cells and breast cancer cell lines in 2D and 3D models, and on the
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Spectrum of malignant and premalignant skin lesions in 505 adult subjects at risk of skin cancers BMC Cancer (IF 3.8) Pub Date : 2024-03-14 Reetta Nevakivi, Hanna Siiskonen, Salla Haimakainen, Ilkka T. Harvima
Patients at risk of skin cancers can develop varying types of cutaneous malignancies. However, some subjects may develop only one type of lesion. In this cross-sectional study, the spectrum of premalignant (PM) and malignant skin lesions and their risk factors were studied. Therefore, 505 adult subjects (aged 21–79 years, 256 males and 249 females, 96 with immunosuppression) at risk of any type of
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Survival time prediction in patients with high-grade serous ovarian cancer based on 18F-FDG PET/CT- derived inter-tumor heterogeneity metrics BMC Cancer (IF 3.8) Pub Date : 2024-03-12 Dianning He, Xin Zhang, Zhihui Chang, Zhaoyu Liu, Beibei Li
The presence of heterogeneity is a significant attribute within the context of ovarian cancer. This study aimed to assess the predictive accuracy of models utilizing quantitative 18F-FDG PET/CT derived inter-tumor heterogeneity metrics in determining progression-free survival (PFS) and overall survival (OS) in patients diagnosed with high-grade serous ovarian cancer (HGSOC). Additionally, the study
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Impact of timing and format of patient decision aids for breast cancer patients on their involvement in and preparedness for decision making - the IMPACTT randomised controlled trial protocol BMC Cancer (IF 3.8) Pub Date : 2024-03-12 Bettina Mølri Knudsen, Stine Rauff Søndergaard, Dawn Stacey, Karina Dahl Steffensen
After curative surgery for early-stage breast cancer, patients face a decision on whether to undergo surgery alone or to receive one or more adjuvant treatments, which may lower the risk of recurrence. Variations in survival outcomes are often marginal but there are differences in the side effects and other features of the options that patients may value differently. Hence, the patient’s values and
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High-content analysis identified synergistic drug interactions between INK128, an mTOR inhibitor, and HDAC inhibitors in a non-small cell lung cancer cell line BMC Cancer (IF 3.8) Pub Date : 2024-03-12 Sijiao Wang, Juliano Oliveira-Silveira, Gang Fang, Jungseog Kang
The development of drug resistance is a major cause of cancer therapy failures. To inhibit drug resistance, multiple drugs are often treated together as a combinatorial therapy. In particular, synergistic drug combinations, which kill cancer cells at a lower concentration, guarantee a better prognosis and fewer side effects in cancer patients. Many studies have sought out synergistic combinations by