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Extracellular matrix hyaluronan modulates fat cell differentiation and primary cilia dynamics BBA Mol. Cell Biol. Lipids (IF 4.8) Pub Date : 2024-02-28 Krzysztof Drygalski, Romane Higos, Fatiha Merabtene, Patrycja Mojsak, Kamil Grubczak, Michal Ciborowski, Hady Razak, Karine Clément, Isabelle Dugail
Hyaluronan is an important extracellular matrix component, with poorly documented physiological role in the context of lipid-rich adipose tissue. We have investigated the global impact of hyaluronan removal from adipose tissue environment by exposure to exogenous hyaluronidase (or heat inactivated enzyme). Gene set expression analysis from RNA sequencing revealed downregulated adipogenesis as a main
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High-definition FT-IR reveals a synergistic effect on lipid accumulation in prostate cancer cells induced by a combination of X-rays and radiosensitizing drugs BBA Mol. Cell Biol. Lipids (IF 4.8) Pub Date : 2024-02-24 Maciej Roman, Tomasz P. Wrobel, Agnieszka Panek, Wojciech M. Kwiatek
Radiotherapy is one of the most commonly used cancer therapies with many benefits including low toxicity to healthy tissues. However, a major problem in radiotherapy is cancer radioresistance. To enhance the effect of this kind of therapy several approaches have been proposed such as the use of radiosensitizers. A combined treatment of radiotherapy and radiosensitizing drugs leads to a greater effect
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Vitamin D status alters genes involved in ovarian steroidogenesis in muskrat granulosa cells BBA Mol. Cell Biol. Lipids (IF 4.8) Pub Date : 2024-02-23 Wenjing Lu, Yuan Chen, María Daniela Artigas Ramírez, Yuning Liu, Haolin Zhang, Zhengrong Yuan, Yingying Han, Qiang Weng
This study aims to explore the relationship between altered vitamin D (VitD) status and ovarian steroidogenesis in muskrats during the breeding and non-breeding seasons. During the breeding season, the ovaries of muskrats were observably enlarged and increased in weight, accompanied by elevated serum and ovarian VitD status. Vitamin D receptor (VDR), VitD metabolic molecules (CYP2R1, CYP27B1, and CYP24A1)
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Specific labeling of newly synthesized lipopolysaccharide via metabolic incorporation of azido-galactose BBA Mol. Cell Biol. Lipids (IF 4.8) Pub Date : 2024-02-19 Yang Xu, Xiaoqi Wang, Esther A. Zaal, Celia R. Berkers, Joseph H. Lorent, Torben Heise, Ruud Cox, Roland J. Pieters, Eefjan Breukink
Gram-negative bacteria possess an asymmetric outer membrane (OM) primarily composed of lipopolysaccharides (LPS) on the outer leaflet and phospholipids on the inner leaflet. The outer membrane functions as an effective permeability barrier to compounds such as antibiotics. Studying LPS biosynthesis is therefore helpful to explore novel strategies for new antibiotic development. Metabolic glycan labeling
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Liver X receptor activation mitigates oxysterol-induced dysfunction in fetoplacental endothelial cells BBA Mol. Cell Biol. Lipids (IF 4.8) Pub Date : 2024-02-17 Meekha George, Hanna Helene Allerkamp, Zhanat Koshenov, Furkan E. Oflaz, Carmen Tam-Amersdorfer, Tatjana Kolesnik, Sonja Rittchen, Magdalena Lang, Eleonore Fröhlich, Wolfgang Graier, Herbert Strobl, Christian Wadsack
Maintaining the homeostasis of the placental vasculature is of paramount importance for ensuring normal fetal growth and development. Any disruption in this balance can lead to perinatal morbidity. Several studies have uncovered an association between high levels of oxidized cholesterol (oxysterols), and complications during pregnancy, including gestational diabetes mellitus (GDM) and preeclampsia
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Role of phosphatidic acid lipids on plasma membrane association of the Ebola virus matrix protein VP40 BBA Mol. Cell Biol. Lipids (IF 4.8) Pub Date : 2024-02-14 Michael D. Cioffi, Monica L. Husby, Bernard S. Gerstman, Robert V. Stahelin, Prem P. Chapagain
The Ebola virus matrix protein VP40 is responsible for the formation of the viral matrix by localizing at the inner leaflet of the human plasma membrane (PM). Various lipid types, including PI(4,5)P (i.e. PIP) and phosphatidylserine (PS), play active roles in this process. Specifically, the negatively charged headgroups of both PIP and PS interact with the basic residues of VP40 and stabilize it at
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Vacuolar ATPase-mediated regulation of neutral lipid dynamics: Insights into lipid droplet homeostasis and stress response mechanisms BBA Mol. Cell Biol. Lipids (IF 4.8) Pub Date : 2024-02-11 Vítor Costa, Vitor Teixeira
This study explores the intricate relationship between the yeast vacuolar H-ATPase (V-ATPase) and neutral lipid metabolism. We show that LD generation observed upon loss of V-ATPase activity is crucial for survival in lipotoxic conditions. Moreover, the study uncovers a link between V-ATPase function, inositol metabolism and the activation of the oxidative pentose phosphate pathway, highlighting its
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The Sphinx and the egg: Evolutionary enigmas of the (glyco)sphingolipid biosynthetic pathway BBA Mol. Cell Biol. Lipids (IF 4.8) Pub Date : 2024-02-02 Assaf Biran, Tania C.B. Santos, Tamir Dingjan, Anthony H. Futerman
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The function of sphingolipids in membrane trafficking and cell signaling in plants, in comparison with yeast and animal cells BBA Mol. Cell Biol. Lipids (IF 4.8) Pub Date : 2024-01-26 Louise Fougère, Sebastien Mongrand, Yohann Boutté
Sphingolipids are essential membrane components involved in a wide range of cellular, developmental and signaling processes. Sphingolipids are so essential that knock-out mutation often leads to lethality. In recent years, conditional or weak allele mutants as well as the broadening of the pharmacological catalog allowed to decipher sphingolipid function more precisely in a less invasive way. This
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Silencing ANGPTL8 reduces mouse preadipocyte differentiation and insulin signaling BBA Mol. Cell Biol. Lipids (IF 4.8) Pub Date : 2024-01-24 Anindya Ghosh, Yat Hei Leung, Jeffrey Yu, Robert Sladek, Isabelle Chénier, Abel K. Oppong, Marie-Line Peyot, S.R. Murthy Madiraju, Irina Al-Khairi, Thangavel Alphonse Thanaraj, Jehad Abubaker, Fahd Al-Mulla, Marc Prentki, Mohamed Abu-Farha
ANGPTL8, expressed mainly in the liver and adipose tissue, regulates the activity of lipoprotein lipase (LPL) present in the extracellular space and triglyceride (TG) metabolism through its interaction with ANGPTL3 and ANGPTL4. Whether intracellular ANGPTL8 can also exert effects in tissues where it is expressed is uncertain. ANGPTL8 expression was low in preadipocytes and much increased during differentiation
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SIRT1-dependent PGC-1α deacetylation by SRT1720 rescues progression of atherosclerosis by enhancing mitochondrial function BBA Mol. Cell Biol. Lipids (IF 4.8) Pub Date : 2024-01-18 Jin Young Sung, Seul Gi Kim, Young Jin Kang, So-Young Park, Hyoung Chul Choi
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Protective effect of oleic acid against very long-chain fatty acid-induced apoptosis in peroxisome-deficient CHO cells BBA Mol. Cell Biol. Lipids (IF 4.8) Pub Date : 2024-01-18 Hanif Ali, Mone Yamanishi, Keigo Sunagawa, Mizuki Kumon, Rumana Yesmin Hasi, Mutsumi Aihara, Ryushi Kawakami, Tamotsu Tanaka
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The role of areA in lipid accumulation in high lipid-producing fungus Mucor circinelloides WJ11 BBA Mol. Cell Biol. Lipids (IF 4.8) Pub Date : 2024-01-06 Haisu Hu, Pengcheng Li, Shaoqi Li, Xiuwen Wang, Hassan Mohamed, Sergio López-García, Qing Liu, Victoriano Garre, Yuanda Song
In the oleaginous fungus Mucor circinelloides, lipid accumulation is regulated by nitrogen metabolism, which is regulated by the areA gene, a member of the GATA zinc finger transporter family and a major regulator for nitrogen metabolism. However, the role of areA in lipid accumulation in this fungus has not been reported. In order to explore the regulatory effect of areA gene on nitrogen metabolism
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Sex modulates the diet-induced changes to the plasma lipidome in a rat model of cardiorespiratory fitness BBA Mol. Cell Biol. Lipids (IF 4.8) Pub Date : 2024-01-06 Johanna Y. Fleischman, James L. Casey, Jennifer L. Meijer, Mary K. Treutelaar, Thekkelnaycke M. Rajendiran, Tanu Soni, Charles R. Evans, Charles F. Burant
Objective Individuals with higher intrinsic cardiorespiratory fitness (CRF) experience decreased rates of cardiometabolic disease and mortality, and high CRF is associated with increased utilization of fatty acids (FAs) for energy. Studies suggest a complex relationship between CRF, diet, and sex with health outcomes, but this interaction is understudied. We hypothesized that FA utilization differences
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Discovery of novel diagnostic biomarkers for Sjögren-Larsson syndrome by untargeted lipidomics BBA Mol. Cell Biol. Lipids (IF 4.8) Pub Date : 2024-01-03 Frédéric M. Vaz, Pippa Staps, Jan Bert van Klinken, Henk van Lenthe, Martin Vervaart, Ronald J.A. Wanders, Mia L. Pras-Raves, Michel van Weeghel, Gajja S. Salomons, Sacha Ferdinandusse, Ron A. Wevers, Michèl A.A.P. Willemsen
Aim Sjögren-Larsson syndrome (SLS) is a rare neurometabolic disorder that mainly affects brain, eye and skin and is caused by deficiency of fatty aldehyde dehydrogenase. Our recent finding of a profoundly disturbed brain tissue lipidome in SLS prompted us to search for similar biomarkers in plasma as no functional test in blood is available for SLS. Methods and results We performed plasma lipidomics
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Sensing and regulation of long-chain polyunsaturated fatty acids pool in marine mollusks: Characterization of UBXD8 from the razor clam Sinonovacula constricta BBA Mol. Cell Biol. Lipids (IF 4.8) Pub Date : 2024-01-04 Zhaoshou Ran, Haixuan Xie, Xuxu Tian, Fei Kong, Kai Liao, Xiaojun Yan, Jilin Xu
The razor clam Sinonovacula constricta is known for its richness in long-chain polyunsaturated fatty acids (LC-PUFA, C ≥ 20). Previously, we demonstrated that it possesses a complete LC-PUFA biosynthetic pathway. However, the mechanisms by which it senses the LC-PUFA pool to regulate their biosynthesis remain unclear. Here, we presented the LC-PUFA sensor UBXD8 as a critical molecule in this intriguing
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Human ApoC3 overexpression aggravates hyperlipidemia but mitigates diet-induced coronary atherosclerotic disease in SR-BI and LDL receptor double knockout mice BBA Mol. Cell Biol. Lipids (IF 4.8) Pub Date : 2023-12-30 Jiawei Liao, Yuhui Wang, Yao Wang, Jinjin Zhang, Feng Wu, George Liu, Wei Huang, Ying Zhang
Abstract not available
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Changes in bile acid composition are correlated with reduced intestinal cholesterol uptake in intestine-specific WASH-deficient mice BBA Mol. Cell Biol. Lipids (IF 4.8) Pub Date : 2023-12-11 Andries Heida, Theo van Dijk, Marieke Smit, Martijn Koehorst, Mirjam Koster, Niels Kloosterhuis, Rick Havinga, Vincent W. Bloks, Justina C. Wolters, Alain de Bruin, Jan Albert Kuivenhoven, Jan Freark de Boer, Folkert Kuipers, Bart van de Sluis
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Hepatic oxylipin profiles in mouse models of Wilson disease: New insights into early hepatic manifestations BBA Mol. Cell Biol. Lipids (IF 4.8) Pub Date : 2023-12-09 Tagreed A. Mazi, Noreene M. Shibata, Gaurav V. Sarode, Valentina Medici
Hepatic inflammation is commonly identified in Wilson disease (WD), a genetic disease of hepatic and brain copper accumulation. Copper accumulation is associated with increased oxidative stress and reactive oxygen species generation which may result in non-enzymatic oxidation of membrane-bound polyunsaturated fatty acids (PUFA). PUFA can be oxidized enzymatically via lipoxygenases (LOX), cyclooxygenases
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Ceramide regulation of autophagy: A biophysical approach BBA Mol. Cell Biol. Lipids (IF 4.8) Pub Date : 2023-12-04 Yaiza R. Varela, Marina N. Iriondo, Félix M. Goñi, Alicia Alonso, L. Ruth Montes
Specific membrane lipids play unique roles in (macro)autophagy. Those include phosphatidylethanolamine, to which LC3/GABARAP autophagy proteins become covalently bound in the process, or cardiolipin, an important effector in mitochondrial autophagy (or mitophagy). Ceramide (Cer), or N-acyl sphingosine, is one of the simplest sphingolipids, known as a stress signal in the apoptotic pathway. Moreover
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AMP deaminase: A crucial regulator in nitrogen stress and lipid metabolism in Mucor circinelloides BBA Mol. Cell Biol. Lipids (IF 4.8) Pub Date : 2023-12-03 Shaoqi Li, Junhuan Yang, Hassan Mohamed, Xiuwen Wang, Wenyue Shi, Futing Xue, Sergio López-García, Qing Liu, Yuanda Song
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Interaction of ROMK2 channel with lipid kinases DGKE and AGK: Potential channel activation by localized anionic lipid synthesis BBA Mol. Cell Biol. Lipids (IF 4.8) Pub Date : 2023-12-04 Milena Krajewska, Mariusz Możajew, Sławomir Filipek, Piotr Koprowski
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Deficiency of Brummer lipase disturbs lipid mobilization and locomotion, and impairs reproduction due to defects in the eggshell ultrastructure in the insect vector Rhodnius prolixus BBA Mol. Cell Biol. Lipids (IF 4.8) Pub Date : 2023-11-30 Daniela Saar Arêdes, Thamara Rios, Luiz Fernando Carvalho-Kelly, Valdir Braz, Luciana O. Araripe, Rafaela V. Bruno, José Roberto Meyer-Fernandes, Isabela Ramos, Katia C. Gondim
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Palmitic acid activates NLRP3 inflammasome through NF-κB and AMPK-mitophagy-ROS pathways to induce IL-1β production in large yellow croaker (Larimichthys crocea) BBA Mol. Cell Biol. Lipids (IF 4.8) Pub Date : 2023-11-27 Xueshan Li, Kangsen Mai, Qinghui Ai
Studies on marine fish showed that vegetable oils substituted for excessive fish oil increased interleukin-1β (IL-1β) production. However, whether the nucleotide-binding oligomerization domain, leucine-rich repeat-containing family, pyrin domain-containing-3 (NLRP3) inflammasome has a substantial role in fatty acid-induced IL-1β production in fish remains unclear. The associated specific mechanism
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Taste receptor type 1 member 3 regulates Western diet-induced male infertility BBA Mol. Cell Biol. Lipids (IF 4.8) Pub Date : 2023-11-24 Hobin Seong, Jae Won Song, Keon-Hee Lee, Goo Jang, Dong-Mi Shin, Woo-Jeong Shon
Western diet (WD), characterized by a high intake of fats and sugary drinks, is a risk factor for male reproductive impairment. However, the molecular mechanisms underlying this remain unclear. Taste receptor type 1 member 3 (TAS1R3), activated by ligands of WD, is highly expressed in extra-oral tissues, particularly in the testes. Here, we investigated to determine the effects of WD intake on male
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Eicosanoid profiles in an arthritis model: Effects of a soluble epoxide hydrolase inhibitor BBA Mol. Cell Biol. Lipids (IF 4.8) Pub Date : 2023-11-19 Carlos Antonio Trindade-da-Silva, Jun Yang, Flavia Fonseca, Hoang Pham, Marcelo Henrique Napimoga, Henrique Ballassini Abdalla, Geanpaolo Aver, Márcio José Alves De Oliveira, Bruce D. Hammock, Juliana Trindade Clemente-Napimoga
Rheumatoid arthritis is a common systemic inflammatory autoimmune disease characterized by damage to joints, inflammation and pain. It is driven by an increase of inflammatory cytokines and lipids mediators such as prostaglandins. Epoxides of polyunsaturated fatty acids (PUFAs) are lipid chemical mediators in a group of regulatory compounds termed eicosanoids. These epoxy fatty acids (EpFA) have resolutive
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Molecular mechanism of calcitriol enhances membrane water permeability BBA Mol. Cell Biol. Lipids (IF 4.8) Pub Date : 2023-11-16 Zanxia Cao, Liling Zhao, Mingcui Chen, Zhihong Shi, Lei Liu
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Blood and tissue docosahexaenoic acid (DHA, 22:6n-3) turnover rates from Ahiflower® oil are not different than from DHA ethyl ester oil in a diet switch mouse model BBA Mol. Cell Biol. Lipids (IF 4.8) Pub Date : 2023-11-17 Adam H. Metherel, Brinley J. Klievik, Giulia Cisbani, Mackenzie E. Smith, Greg Cumberford, Richard P. Bazinet
Ahiflower® oil is high in α-linolenic and stearidonic acids, however, tissue/blood docosahexaenoic acid (DHA, 22:6n-3) turnover from dietary Ahiflower oil has not been investigated. In this study, we use compound-specific isotope analysis to determine tissue DHA synthesis/turnover from Ahiflower, flaxseed and DHA oils. Pregnant BALB/c mice (13–17 days) were placed on a 2 % algal DHA oil diet of high
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Role of ERA protein in enhancing glyceroglycolipid synthesis and phosphate starvation tolerance in Synechococcus elongatus PCC 7942 BBA Mol. Cell Biol. Lipids (IF 4.8) Pub Date : 2023-11-17 Junhao Li, Rui Wang, Yuhong Liu, Xiaoling Miao
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Modulation of angiogenic switch in reprogramming browning and lipid metabolism in white adipocytes BBA Mol. Cell Biol. Lipids (IF 4.8) Pub Date : 2023-11-11 Sreelekshmi Sreekumar, Karyath Palliyath Gangaraj, Manikantan Syamala Kiran
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Lauric acid epigenetically regulates lncRNA HOTAIR by remodeling chromatin H3K4 tri-methylation and modulates glucose transport in SH-SY5Y human neuroblastoma cells: Lipid switch in macrophage activation BBA Mol. Cell Biol. Lipids (IF 4.8) Pub Date : 2023-11-14 Venkatesan Ramya, Karuppiah Prakash Shyam, Arulanandu Angelmary, Balamuthu Kadalmani
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CRISPR/Cas9-meditated gene knockout in pigs proves that LGALS12 deficiency suppresses the proliferation and differentiation of porcine adipocytes BBA Mol. Cell Biol. Lipids (IF 4.8) Pub Date : 2023-11-11 Wenjing Wu, Yajun Yin, Jing Huang, Ruifei Yang, Qiuyan Li, Jianzhi Pan, Jin Zhang
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Docosahexaenoic acid (DHA) inhibits abdominal fat accumulation by promoting adipocyte apoptosis through PPARγ-LC3-BNIP3 pathway-mediated mitophagy BBA Mol. Cell Biol. Lipids (IF 4.8) Pub Date : 2023-11-11 Chenchen Bian, Xiangtong Yuan, Caihong Zeng, Jian Sun, Gen Kaneko, Hong Ji
Obesity has always been an overwhelming health concern worldwide. Docosahexaenoic acid (DHA) reduces abdominal fat accumulation by inducing adipocyte apoptosis, but the underlying mechanism remains unclear. Mitophagy, the process of maintaining mitochondrial homeostasis, has a double-edged sword effect that positively or negatively regulates apoptosis. In this study, grass carp (Ctenopharyngodon idellus)
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Obesity induced disruption on diurnal rhythm of insulin sensitivity via gut microbiome-bile acid metabolism BBA Mol. Cell Biol. Lipids (IF 4.8) Pub Date : 2023-11-10 Xiaozhen Guo, Jiawen Wang, Hualing Xu, Yangyang Wang, Yutang Cao, Yingquan Wen, Jiaqi Li, Yameng Liu, Kanglong Wang, Jue Wang, Xianchun Zhong, Chuying Sun, Yongxin Zhang, Jingyi Xu, Cuina Li, Pengxiang Mu, Lingyan Xu, Cen Xie
The disruption of the diurnal rhythm has been recognized as a significant contributing factor to metabolic dysregulation. The important role of gut microbiota and bile acid metabolism has attracted extensive attention. However, the function of the gut microbiota-bile acid axis in regulating the diurnal rhythms of metabolic homeostasis remains largely unknown. Herein, we aimed to investigate the interplay
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PNPLA-mediated lipid hydrolysis and transacylation – At the intersection of catabolism and anabolism BBA Mol. Cell Biol. Lipids (IF 4.8) Pub Date : 2023-11-09 Mariana Colaço-Gaspar, Peter Hofer, Monika Oberer, Rudolf Zechner
Patatin-like phospholipase domain containing proteins (PNPLAs) play diverse roles in lipid metabolism. In this review, we focus on the enzymatic properties and predicted 3D structures of PNPLA1-5, PNPLA2-4 exert both catabolic and anabolic functions. Whereas PNPLA1 is predominantly expressed in the epidermis and involved in sphingolipid biosynthesis, PNPLA2 and 4 are ubiquitously expressed and exhibit
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Abnormal expression of sphingolipid-metabolizing enzymes in the heart of spontaneously hypertensive rat models BBA Mol. Cell Biol. Lipids (IF 4.8) Pub Date : 2023-11-09 Giuseppe Pepe, Maria Cotugno, Federico Marracino, Luca Capocci, Ludovica Pizzati, Maurizio Forte, Rosita Stanzione, Pamela Scarselli, Alba Di Pardo, Sebastiano Sciarretta, Massimo Volpe, Speranza Rubattu, Vittorio Maglione
Sphingolipids exert important roles within the cardiovascular system and related diseases. Perturbed sphingolipid metabolism was previously reported in cerebral and renal tissues of spontaneously hypertensive rats (SHR). Specific defects related to the synthesis of sphingolipids and to the metabolism of Sphingosine-1-Phospahte (S1P) were exclusively identified in the stroke-prone (SHRSP) with the respect
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Corrigendum to “Dehydroepiandrosterone reduces accumulation of lipid droplets in primary chicken hepatocytes by biotransformation mediated via the cAMP/PKA-ERK1/2 signaling pathway” [BBA Mol. Cell Biol. Lipids 1863 (2018) 625–638] BBA Mol. Cell Biol. Lipids (IF 4.8) Pub Date : 2023-10-24 Longlong Li, Chongyang Ge, Dian Wang, Lei Yu, Jinlong Zhao, Haitian Ma
Abstract not available
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Aerobic exercise-induced decrease of chemerin improved glucose and lipid metabolism and fatty liver of diabetes mice through key metabolism enzymes and proteins BBA Mol. Cell Biol. Lipids (IF 4.8) Pub Date : 2023-10-21 Xiaojing Lin, Jing Qu, Lijun Yin, Ru Wang, Xiaohui Wang
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Global lipid remodelling by hypoxia aggravates migratory potential in pancreatic cancer while maintaining plasma membrane homeostasis BBA Mol. Cell Biol. Lipids (IF 4.8) Pub Date : 2023-09-23 Prema Kumari Agarwala, Shuai Nie, Gavin E. Reid, Shobhna Kapoor
Hypoxia plays an important role in pancreatic cancer progression. It drives various metabolic reprogramming in cells including that of lipids, which in turn, can modify the structure and function of cell membranes. Homeostatic adaptation of membranes is well-recognized, but how and if it is regulated in hypoxic pancreatic cancer and its relation to aggressive phenotype and metastasis remains elusive
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Regulation of low-density lipoprotein on lipid metabolism in macrophages of large yellow croaker (Larimichthys crocea) BBA Mol. Cell Biol. Lipids (IF 4.8) Pub Date : 2023-09-22 Tingting Hao, Dan Xu, Xiufei Cao, Qiuchi Chen, Fan Chen, Qiangde Liu, Yuhang Tang, Yan Zhou, Yueru Li, Kangsen Mai, Qinghui Ai
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Maresin-1 prevents blood-spinal cord barrier disruption associated with TRPV4 elevation in the experimental model of spinal cord injury BBA Mol. Cell Biol. Lipids (IF 4.8) Pub Date : 2023-09-18 Zarna Pathak, Tarang Jadav, Abhishek Roy, Manjeet Chopra, Nidhi Singh, Pinaki Sengupta, Hemant Kumar
Recently, we reported the TRPV4 ion channel activation and its association with secondary damage after spinal cord injury (SCI). TRPV4 activation is linked with blood-spinal cord barrier (BSCB) disruption, endothelial damage, and inflammation after SCI. Specialized pro-resolving mediators (SPM) are endogenous lipid mediators released for inflammation resolution. Studies suggest that SPM could act as
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Chlorogenic acid enhances PPARγ-mediated lipogenesis through preventing Lipin 1 nuclear translocation in Staphylococcus aureus-exposed bovine mammary epithelial cells BBA Mol. Cell Biol. Lipids (IF 4.8) Pub Date : 2023-09-17 Ruiyuan Yao, Manshulin Wang, Yue Zhao, Qiang Ji, Xue Feng, Linfeng Bai, Lili Bao, Yanfeng Wang, Huifang Hao, Xihe Li, Zhigang Wang
Chlorogenic acid (CGA) as one of the most ubiquitously dietary polyphenolic compounds, has been reported to have various antimicrobial effects and exhibit strong anti-inflammatory ability. Staphylococcus aureus is a gram-positive bacterium that can induce mastitis. However, the mechanism through which S. aureus infection affects lipid synthesis and whether CGA have protective effect on S. aureus reduced
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The expanding roles of PI4P and PI(4,5)P2 at the plasma membrane: Role of phosphatidylinositol transfer proteins BBA Mol. Cell Biol. Lipids (IF 4.8) Pub Date : 2023-09-13 Shamshad Cockcroft
Phosphoinositides are phosphorylated derivatives of phosphatidylinositol, a phospholipid that is synthesised at the endoplasmic reticulum. The plasma membrane contains the enzymes to phosphorylate phosphatidylinositol and is therefore rich in the phosphorylated derivatives, PI4P and PI(4,5)P2. PI(4,5)P2 is a substrate for phospholipase C and during cell signaling, PI(4,5)P2 levels are reduced. Here
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Integration of systematic review, lipidomics with experiment verification reveals abnormal sphingolipids facilitate diabetic retinopathy by inducing oxidative stress on RMECs BBA Mol. Cell Biol. Lipids (IF 4.8) Pub Date : 2023-09-01 Zhenshuang Yuan, Yue Tian, Cong Zhang, Mingshuang Wang, Jiaqi Xie, Can Wang, Jianmei Huang
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Role of sphingolipids in the host-pathogen interaction BBA Mol. Cell Biol. Lipids (IF 4.8) Pub Date : 2023-09-04 Gabriel Soares Matos, Caroline Mota Fernandes, Maurizio Del Poeta
Fungal pathogens have been under the spotlight as their expanding geographic range combined with their potential harm to vulnerable populations turns them into increasingly threats to public health. Therefore, it is ultimately important to unveil the mechanisms associated with their infection process for further new treatment discovery. With this purpose, sphingolipid-based research has gained attention
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Comprehensive analysis of the composition of the major phospholipids during the asexual life cycle of the filamentous fungus Aspergillus nidulans BBA Mol. Cell Biol. Lipids (IF 4.8) Pub Date : 2023-08-31 Ryo Iwama, Nobuyuki Okahashi, Tetsuki Suzawa, Chuner Yang, Fumio Matsuda, Hiroyuki Horiuchi
Filamentous fungi undergo significant cellular morphological changes during their life cycle. It has recently been reported that deletions of genes that are involved in phospholipid synthesis led to abnormal hyphal morphology and differentiation in filamentous fungi. Although these results suggest the importance of phospholipid balance in their life cycle, comprehensive analyses of cellular phospholipids
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Microbial oil, alone or paired with β-glucans, can control hypercholesterolemia in a zebrafish model BBA Mol. Cell Biol. Lipids (IF 4.8) Pub Date : 2023-08-30 Adnan H. Gora, Saima Rehman, Jorge Dias, Jorge M.O. Fernandes, Pål A. Olsvik, Mette Sørensen, Viswanath Kiron
Dyslipidemia is often associated with unhealthy dietary habits, and many mammalian studies have explored the mode of action of certain bioactive compounds such as β-glucans and n-3 PUFAs to understand their potential to normalize the lipid metabolism. There are only a few investigations that adopted omic approaches to unveil their combined effect on hypercholesterolemia. Zebrafish (Danio rerio) was
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Uncovering global lipid accumulation routes towards docosahexaenoic acid (DHA) production in Aurantiochytrium sp. SW1 using integrative proteomic analysis BBA Mol. Cell Biol. Lipids (IF 4.8) Pub Date : 2023-08-23 Pranesha Prabhakaran, Mohamed Yusuf Mohamed Nazir, Roypim Thananusak, Aidil Abdul Hamid, Wanwipa Vongsangnak, Yuanda Song
Aurantiochytrium sp., a marine thraustochytrid possesses a remarkable ability to produce lipid rich in polyunsaturated fatty acids (PUFAs), such as docosahexaenoic acid (DHA). Although gene regulation underlying lipid biosynthesis has been previously reported, proteomic analysis is still limited. In this study, high DHA accumulating strain Aurantiochytrium sp. SW1 has been used as a study model to
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Acetyl-coenzyme A acetyltransferase 1 promotes brown adipogenesis by activating the AMPK-PGC1α signaling pathway BBA Mol. Cell Biol. Lipids (IF 4.8) Pub Date : 2023-08-14 Kaixiang Zhu, Ling Ni, Jianxiong Han, Zhongkang Yan, Yin Zhang, Feifei Wang, Lili Wang, Xingyuan Yang
Brown adipose tissue (BAT) is thermogenic, expressing high levels of uncoupling protein-1 to convert nutrient energy to heat energy, bypassing ATP synthesis. BAT is a promising therapeutic target for treatment of obesity and type 2 diabetes since it converts fatty acids into heat but mechanisms controlling brown adipogenesis remain unclear. Knockdown of acetyl-Coenzyme A acetyltransferase 1 (ACAT1)
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Effects of kosmotropic, chaotropic, and neutral salts on Candida antarctica B lipase: An analysis of the secondary structure and its hydrolytic activity on triglycerides BBA Mol. Cell Biol. Lipids (IF 4.8) Pub Date : 2023-08-15 Martha Martin del Campo, Osvaldo Gómez-Secundino, Rosa M. Camacho-Ruíz, Juan C. Mateos Díaz, Marcelo Müller-Santos, Jorge A. Rodríguez
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Transcriptome profiling of differentiating adipose-derived stem cells across species reveals new genes regulating adipogenesis BBA Mol. Cell Biol. Lipids (IF 4.8) Pub Date : 2023-08-10 Jiangang Han, Xiaojie Li, Benmeng Liang, Sijia Ma, Yabin Pu, Fuqing Yu, Jian Lu, Yuehui Ma, David E. MacHugh, Lin Jiang
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Functionally diverse front-end desaturases are widespread in the phylum Annelida BBA Mol. Cell Biol. Lipids (IF 4.8) Pub Date : 2023-07-29 Marc Ramos-Llorens, Francisco Hontoria, Juan C. Navarro, David E.K. Ferrier, Óscar Monroig
Aquatic single-cell organisms have long been believed to be unique primary producers of omega-3 long-chain (≥C20) polyunsaturated fatty acids (ω3 LC-PUFA). Multiple invertebrates including annelids have been discovered to possess methyl-end desaturases enabling key steps in the de novo synthesis of ω3 LC-PUFA, and thus potentially contributing to their production in the ocean. Along methyl-end desaturases
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Preferential lipolysis of DGAT1 over DGAT2 generated triacylglycerol in Huh7 hepatocytes BBA Mol. Cell Biol. Lipids (IF 4.8) Pub Date : 2023-07-28 Rajakumar Selvaraj, Sarah V. Zehnder, Russell Watts, Jihong Lian, Chinmayee Das, Randal Nelson, Richard Lehner
Two distinct diacylglycerol acyltransferases (DGAT1 and DGAT2) catalyze the final committed step of triacylglycerol (TG) synthesis in hepatocytes. After its synthesis in the endoplasmic reticulum (ER) TG is either stored in cytosolic lipid droplets (LDs) or is assembled into very low-density lipoproteins in the ER lumen. TG stored in cytosolic LDs is hydrolyzed by adipose triglyceride lipase (ATGL)
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Nuclear and chromatin rearrangement associate to epigenome and gene expression changes in a model of in vitro adipogenesis and hypertrophy BBA Mol. Cell Biol. Lipids (IF 4.8) Pub Date : 2023-07-25 Francesca Baldini, Lama Zeaiter, Farah Diab, Hawraa Zbeeb, Lisa Cuneo, Aldo Pagano, Piero Portincasa, Alberto Diaspro, Laura Vergani
Hypertrophy of adipocytes represents the main cause of obesity. We investigated in vitro the changes associated with adipocyte differentiation and hypertrophy focusing on the nuclear morphometry and chromatin epigenetic remodelling. The 3 T3-L1 pre-adipocytes were firstly differentiated into mature adipocytes, then cultured with long-chain fatty acids to induce hypertrophy. Confocal and super-resolution
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Acute joint inflammation induces a sharp increase in the number of synovial fluid EVs and modifies their phospholipid profile BBA Mol. Cell Biol. Lipids (IF 4.8) Pub Date : 2023-07-18 Laura Varela, Chris H.A. van de Lest, Janneke Boere, Sten F.W.M. Libregts, Estefanía Lozano-Andrés, P. René van Weeren, Marca H.M. Wauben
Inflammation is the hallmark of most joint disorders. However, the precise regulation of induction, perpetuation, and resolution of joint inflammation is not entirely understood. Since extracellular vesicles (EVs) are critical for intercellular communication, we aim to unveil their role in these processes. Here, we investigated the EVs' dynamics and phospholipidome profile from synovial fluid (SF)
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Oxysterol-Binding Protein: new insights into lipid transport functions and human diseases BBA Mol. Cell Biol. Lipids (IF 4.8) Pub Date : 2023-07-16
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Endoplasmic reticulum stress and mitochondrial dysfunction during aging: Role of sphingolipids BBA Mol. Cell Biol. Lipids (IF 4.8) Pub Date : 2023-07-18 Qun Chen, Anna Kovilakath, Jeremy Allegood, Jeremy Thompson, Ying Hu, L. Ashley Cowart, Edward J. Lesnefsky
The endoplasmic reticulum (ER) plays a key role in the regulation of protein folding, lipid synthesis, calcium homeostasis, and serves as a primary site of sphingolipid biosynthesis. ER stress (ER dysfunction) participates in the development of mitochondrial dysfunction during aging. Mitochondria are in close contact with the ER through shared mitochondria associated membranes (MAM). Alteration of
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Mechanism of preventive effects of exendin-4 and des-fluoro-sitagliptin in a murine model of fructose-induced prediabetes BBA Mol. Cell Biol. Lipids (IF 4.8) Pub Date : 2023-07-08 María Cecilia Castro, Hernán Gonzalo Villagarcía, Guillermo Schinella, María Laura Massa, Flavio Francini
Protective effects of exendin-4 (glucagon-like peptide-1 -GLP-1- receptor agonist) and des-fluoro-sitagliptin (dipeptidyl peptidase-4 inhibitor) on fructose-induced hepatic disturbances were evaluated in prediabetic rats. Complementary, a possible direct effect of exendin-4 in human hepatoblastoma-derived cell line HepG2 incubated with fructose in presence/absence of exendin-9-39 (GLP-1 receptor antagonist)