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Ginkgo biloba extract ameliorates skin fibrosis in a bleomycin-induced mouse model of systemic sclerosis Anim. Cells Syst. (IF 2.9) Pub Date : 2024-04-18 Beomgu Lee, Jong Seong Roh, Hoim Jeong, Yerin Kim, Jihyeon Lee, Changun Yun, Jiyoung Park, Da-sol Kim, Jungsoo Lee, Min Wook So, Aran Kim, Dong Hyun Sohn, Seung-Geun Lee
Systemic sclerosis (SSc) is a chronic autoimmune disease characterized by skin and internal organ fibrosis and obliterative vasculopathy. Few effective treatments are currently available for fibros...
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Effect of aerobic exercise and particulate matter exposure duration on the diversity of gut microbiota Anim. Cells Syst. (IF 2.9) Pub Date : 2024-04-08 Saba Imdad, Jin-Hee Kim, Byunghun So, Junho Jang, Jinhan Park, Wonchung Lim, Yoon-Kwang Lee, Woo Shik Shin, Trae Hillyer, Chounghun Kang
Inhalation of ambient particulate matter (PM) can disrupt the gut microbiome, while exercise independently influences the gut microbiome by promoting beneficial bacteria. In this study, we analyzed...
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Reprogramming of tumor-associated macrophages by metabolites generated from tumor microenvironment Anim. Cells Syst. (IF 2.9) Pub Date : 2024-04-03 Seung Woo Kim, Chan Woo Kim, Young-Ah Moon, Hong Seok Kim
The tumor microenvironment comprises both tumor and non-tumor stromal cells, including tumor-associated macrophages (TAMs), endothelial cells, and carcinoma-associated fibroblasts. TAMs, major comp...
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The impact of MEIS1 TALE homeodomain transcription factor knockdown on glioma stem cell growth Anim. Cells Syst. (IF 2.9) Pub Date : 2024-03-13 Hyun-Jin Kim, Don Carlo Batara, Young-Jun Jeon, Seongsoo Lee, Samuel Beck, Sung-Hak Kim
Myeloid ecotropic virus insertion site 1 (MEIS1) is a HOX co-factor necessary for organ development and normal hematopoiesis. Recently, MEIS1 has been linked to the development and progression of v...
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Tortoise-shell glue ameliorates male infertility through the hypothalamic-pituitary-gonadal axis in obese rats Anim. Cells Syst. (IF 2.9) Pub Date : 2024-03-15 Wen Sheng, Yingqiu Li, Lumei Liu, Bonan Li, Tiansong Sun, Congxu Zhu, Qinghu He
Male infertility is a worldwide population health concern, but its etiology remains poorly understood. Tortoise-shell glue (TSG) is widely utilized as a pharmaceutical or dietary supplement for var...
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Factors affecting the cleavage efficiency of the CRISPR-Cas9 system Anim. Cells Syst. (IF 2.9) Pub Date : 2024-03-03 Won Jun Jung, Soo-Ji Park, Seongkwang Cha, Kyoungmi Kim
The CRISPR-Cas system stands out as a promising genome editing tool due to its cost-effectiveness and time efficiency compared to other methods. This system has tremendous potential for treating va...
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Inducing aortic aneurysm/dissection in zebrafish: evaluating the efficacy of β-Aminopropionic Nitrile as a model Anim. Cells Syst. (IF 2.9) Pub Date : 2024-03-01 Jiarui Zhang, Yaowen Liang, Weiyue Zeng, Xiaoyan Gao, Dingchen Wang, Cong Mai, Zhuoheng Lin, Haishan Zhao, Xin Li
Aortic aneurysm/dissection (AAD) poses a life-threatening cardiovascular emergency with complex mechanisms and a notably high mortality rate. Zebrafish (Danio rerio) serve as valuable models for AA...
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Transcriptional corepressor activity of CtBP1 is regulated by ISG15 modification Anim. Cells Syst. (IF 2.9) Pub Date : 2024-02-22 Yun Hwan Lim, Yoon Jin Park, Jieun Lee, Jung Hwa Kim
C-terminal binding protein 1 (CtBP1) is a critical transcriptional corepressor of many tumor suppressor genes and plays diverse roles in the progression of cancers. The transcriptional repression f...
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Scoparone attenuates PD-L1 expression in human breast cancer cells by MKP-3 upregulation Anim. Cells Syst. (IF 2.9) Pub Date : 2024-02-09 Seung-Woo Kim, Chan Woo Kim, Hong Seok Kim
Breast cancer is a frequently occurring malignant tumor that is one of the leading causes of cancer-related deaths in women worldwide. Monoclonal antibodies that block programed cell death 1 (PD-1)...
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Dietary exposure of the water flea Daphnia galeata to microcystin-LR Anim. Cells Syst. (IF 2.9) Pub Date : 2024-01-29 Eun-jeong Kim, Donggu Jeon, Yeon-jeong Park, Hyunmin Woo, Seong-il Eyun
Harmful substances like the cyanotoxin microcystin-leucine-arginine (MC-LR) are commonly found in eutrophic freshwater environments, posing risks to aquatic organisms. The water flea, Daphnia, is a...
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The nasal lymphatic route of CSF outflow: implications for neurodegenerative disease diagnosis and monitoring Anim. Cells Syst. (IF 2.9) Pub Date : 2024-01-29 Jiwon Chae, Mina Choi, Juyoung Choi, Seung-Jun Yoo
Cerebrospinal fluid (CSF) plays a crucial role in the brain's lymphatics as it traverses the central nervous system (CNS). Its primary function is to facilitate the outward transport of waste. Amon...
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Eugenol ameliorates uveitis in mice with experimental autoimmune encephalomyelitis through the suppression of key inflammatory genes Anim. Cells Syst. (IF 2.9) Pub Date : 2024-01-18 Sungmoo Hong, Kyungsook Jung, Meejung Ahn, Jeongtae Kim, Changjong Moon, Taekyun Shin
Visual impairment associated with uveitis is among the potential complications in multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). Bioinformatics analy...
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Role of Carbohydrate response element-binding protein in mediating dexamethasone-induced glucose transporter 5 expression in Caco-2BBE cells and during the developmental phase in mice Anim. Cells Syst. (IF 2.9) Pub Date : 2024-01-04 Soonjae Hwang, Sangbin Park, Jaewan Kim, Ah-Reum Oh, Ho-Jae Lee, Ji-Young Cha
Glucose transporter 5 (GLUT5), the main fructose transporter in mammals, is primarily responsible for absorbing dietary fructose in the small intestine. The expression of this intestinal gene signi...
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Endothelial periostin regulates vascular remodeling by promoting endothelial dysfunction in pulmonary arterial hypertension Anim. Cells Syst. (IF 2.9) Pub Date : 2024-01-03 Dawn Lee, Heeyoung Lee, Ha-neul Jo, Eunsik Yun, Byung Su Kwon, Jongmin Kim, Aram Lee
Pulmonary arterial hypertension (PAH) is characterized by vascular remodeling associated with extracellular matrix (ECM) deposition, vascular cell hyperproliferation, and neointima formation in the...
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Core clock gene, Bmal1, is required for optimal second-level interval production Anim. Cells Syst. (IF 2.9) Pub Date : 2023-12-14 Yoon Kyoung Kim, Han Kyoung Choe
Perception and production of second-level temporal intervals are critical in several behavioral and cognitive processes, including adaptive anticipation, motor control, and social communication. Th...
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Dopamine depletion alters neuroplasticity-related signaling in the rat hippocampus Anim. Cells Syst. (IF 2.9) Pub Date : 2023-12-14 Bohye Kim, Joong-Sun Kim, BuHyun Youn, Changjong Moon
Dopamine (DA) plays a significant role in regulating hippocampal function, particularly in modulating synaptic plasticity. Despite this, a comprehensive understanding of the molecular mechanisms in...
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The 5-/12-lipoxygenase-BLT2 cascade induces elevated expression of c-Myc, thus mediating the proliferation and migration of KRAS mutant colorectal cancer cells Anim. Cells Syst. (IF 2.9) Pub Date : 2023-12-11 Jaein Park, Jae-Hyun Jang, Jun-Dong Wei, Jae-Hong Kim
Colorectal cancer (CRC) is the most common malignant tumor and one of the leading causes of cancer-related death worldwide. Oncogene KRAS is a commonly mutated in CRC and plays crucial roles in the...
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Plate-curving cell culture as a model for assessing curvature-induced cellular responses during neural tube morphogenesis Anim. Cells Syst. (IF 2.9) Pub Date : 2023-12-11 Hyung-Min Ahn, Woong Sun
Neurulation is an important shape-transforming event during embryonic development where a flat neural plate is converted into a neural tube. Failure in this morphogenetic process accounts for one o...
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Inhibition of ubiquitin specific peptidase 14 (USP14) promotes ER-phagy by inducing ER stress in human hepatoma HepG2 cells Anim. Cells Syst. (IF 2.9) Pub Date : 2023-11-27 Joon Bum Kim, Ji-Eun Bae, Na Yeon Park, Doo Sin Jo, Yong Hwan Kim, Kwiwan Jeong, Pansoo Kim, Won-Ha Lee, Eunbyul Yeom, Dong-Hyung Cho
Autophagy plays a critical role in regulating the quality and quantity of cellular compartments; however, the mechanisms governing endoplasmic reticulum (ER) autophagy (ER-phagy) are still largely ...
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Genetic structure of Rhodeus sinensis reflects historical imprints of East Asian paleo-drainages Anim. Cells Syst. (IF 2.9) Pub Date : 2023-11-27 Hyung-Bae Jeon, Ho Young Suk
A complete reconstruction of the history regarding the distribution of a species requires a separate analysis of the events before and after colonizing the current distribution. In a freshwater spe...
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Mitochondrial genome-based synthesis and timeline of Eurasian otter (Lutra lutra) phylogeography Anim. Cells Syst. (IF 2.9) Pub Date : 2023-11-27 Sarah J. du Plessis, Sungwon Hong, Boyoung Lee, Klaus-Peter Koepfli, Elizabeth A. Chadwick, Frank Hailer
Eurasian otters (Lutra lutra) have a broad distribution across Eurasia, but biogeographic data outside of western Europe is limited to disconnected pockets. Based on current subspecies designations...
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Potent of strategic approaches for tauopathies ranging from single-cell transcriptome to microbiome Anim. Cells Syst. (IF 2.9) Pub Date : 2023-11-27 Sung-Hyun Kim, Sumin Yang, Eunjeong Yang, Mingon Kang, Jae-Yeol Joo
Tauopathies as one of the typical neurodegenerative diseases are characterized by pathologically aggregated tau in neuron and glia, which causes dysfunction, synapse loss, and cognitive impairments...
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Stigmast-4-en-6β-ol-3-one decreases viability and induces apoptosis and ferroptosis in liver cancer cells by reducing E2F1 Anim. Cells Syst. (IF 2.9) Pub Date : 2023-11-22 Zhiyun Zhang, Jian Wang, Weiping Wan, Zhengchao Shen, Aixue Zuo, Rong Chen, Qinyi Wu, Enli Cai, Feng Huang, Rongping Zhang, Xinan Shi
Hepatocellular carcinoma (HCC) is a frequently occurring malignant gastrointestinal cancer. The 5-year survival rate of HCC is still below 8%, and thus, identifying more effective therapeutic metho...
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Hippo-YAP/TAZ pathway regulation: the crucial roles of lncRNAs in cancer Anim. Cells Syst. (IF 2.9) Pub Date : 2023-11-21 Wonyi Jang, Mijung Im, Jungwook Roh, JiHoon Kang, Wanyeon Kim
The Hippo signaling pathway is a conserved signaling pathway that regulates cell proliferation, apoptosis, and differentiation and plays essential roles in the maintenance of organ size and tissue ...
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Role of gut commensal bacteria in juvenile developmental growth of the host: insights from Drosophila studies Anim. Cells Syst. (IF 2.9) Pub Date : 2023-11-15 Hyun Myoung Yun, Seogang Hyun
The gut microbiome plays a crucial role in maintaining health in a variety of organisms, from insects to humans. Further, beneficial symbiotic microbes are believed to contribute to improving the q...
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Internal ribosomal entry site-mediated translational activity of nitric oxide synthase 2 Anim. Cells Syst. (IF 2.9) Pub Date : 2023-11-14 Kyung-Ha Lee
The internal ribosome entry site (IRES) is a unique structure found in the 5’ untranslated region (5'-UTR) of specific messenger RNAs (mRNAs) that allows ribosomes to bind and initiate translation ...
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The neural basis underlying female vulnerability to depressive disorders Anim. Cells Syst. (IF 2.9) Pub Date : 2023-11-10 Minsoo Kim, Woonhee Kim, ChiHye Chung
Depressive disorders are more prevalent and severe in women; however, our knowledge of the underlying factors contributing to female vulnerability to depression remains limited. Additionally, femal...
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A push–pull strategy for controlling Riptortus pedestris (Hemiptera: Alydidae) using host plant semiochemicals Anim. Cells Syst. (IF 2.9) Pub Date : 2023-10-26 Junyong Song, Yu-Hyeon Park, Taein Kim, Soo-Kwon Park, Tae-Hwan Jun, Sang-Gyu Kim
Riptortus pedestris is a major pest of soybean in East Asia that feeds on maturing seeds, reducing nutritional quality and causing seed abortion. Aggregation pheromone of the bean bug has been conv...
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Amelioration of rotenone-induced Parkinson's disease; comparing therapeutic role of erythropoietin versus low-level laser activation of mesenchymal stem cells (an in-vivo and in-vitro study) Anim. Cells Syst. (IF 2.9) Pub Date : 2023-10-26 Eman Mumtaz El Mahdy, Maha Gamal, Basma Emad Aboulhoda, Basent Adel Al Dreny, Ashraf Shamaa, Laila Rashed, Ahmed Nour Eldine Abdallah, Asmaa M. Shamseldeen
Parkinson's disease (PD), the second common neurodegenerative disease, is characterized by the loss of the dopaminergic neurons in the substantia nigra (SN). Because of L-dopa's side effects, new t...
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Effects of prenatal bisphenol S and bisphenol F exposure on behavior of offspring mice Anim. Cells Syst. (IF 2.9) Pub Date : 2023-10-11 Ha Jung Moon, Hyun Seung Shin, Seung Hyun Lee, Eui-Ju Hong, Changhwan Ahn, Yeong-Min Yoo, Eui-Bae Jeung, Geun-Shik Lee, Beum-Soo An, Eui-Man Jung
Bisphenol A (BPA) is a representative endocrine-disrupting chemical that exhibits hormonal disturbance reactions. Various alternatives, such as Bisphenol S (BPS) and Bisphenol F (BPF), are being de...
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Comparative transcriptome analysis between long- and short-term survival after pig-to-monkey cardiac xenotransplantation reveals differential heart failure development Anim. Cells Syst. (IF 2.9) Pub Date : 2023-10-04 Byeonghwi Lim, Min-Jae Jang, Seung-Mi Oh, Jin Gu No, Jungjae Lee, Sang Eun Kim, Sun A. Ock, Ik Jin Yun, Junseok Kim, Hyun Keun Chee, Wan Seop Kim, Hee Jung Kang, Kahee Cho, Keon Bong Oh, Jun-Mo Kim
Cardiac xenotransplantation is the potential treatment for end-stage heart failure, but the allogenic organ supply needs to catch up to clinical demand. Therefore, genetically-modified porcine hear...
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Compensatory enhancement of paternal care in maternally neglected mice family Anim. Cells Syst. (IF 2.9) Pub Date : 2023-10-06 Jaewon Jang, Hea-jin Kim, Hae-Young Koh
Parental care strategies, ranging from biparental to uniparental, evolve based on factors affecting sexual conflict over care. Plasticity in how parents respond to reduction in each other’s care ef...
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Effect of TRAF6-knockout on gene expression and lncRNA expression in Epithelioma papulosum cyprini (EPC) cells Anim. Cells Syst. (IF 2.9) Pub Date : 2023-10-04 Najib Abdellaoui, Seon Young Kim, Min Sun Kim
TRAF6 is a key immune gene that plays a significant role in toll-like receptor signal transduction and activates downstream immune genes involved in antiviral immunity in fish. To explore the role ...
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The RNA ligation method using modified splint DNAs significantly improves the efficiency of circular RNA synthesis Anim. Cells Syst. (IF 2.9) Pub Date : 2023-10-04 Yoon-Seob Kim, Do-Hyung Kim, Daegi An, Younghyun Lim, Young-Jin Seo, Hak Kyun Kim, Ho-Young Kang
Circular RNA (circRNA) is a non-coding RNA with a covalently closed loop structure and usually more stable than messenger RNA (mRNA). However, coding sequences (CDSs) following an internal ribosome...
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Retinal transcriptome profiling identifies novel candidate genes associated with visual impairment in a mouse model of multiple sclerosis Anim. Cells Syst. (IF 2.9) Pub Date : 2023-10-04 Sungmoo Hong, Poornima D. E. Weerasinghe-Mudiyanselage, Sohi Kang, Changjong Moon, Taekyun Shin
Visual impairment is occasionally observed in multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). Although uveitis and optic neuritis have been reported i...
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Spexin-based galanin receptor 2 agonist improves renal injury in mice with type 2 diabetes Anim. Cells Syst. (IF 2.9) Pub Date : 2023-09-30 Jin Joo Cha, Boo Yeon Park, Sung Gi Yoon, Hye Jin Park, Ji Ae Yoo, Jung Yeon Ghee, Dae Ryong Cha, Jae Young Seong, Young Sun Kang
The spexin-based GALR2 agonist (NS200) is a novel drug, which has shown antidepressant and anxiolytic action in a recent experimental study. In this study, we investigated the effects of NS200 on r...
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A genomic estimated breeding value-assisted reduction method of single nucleotide polymorphism sets: a novel approach for determining the cutoff thresholds in genome-wide association studies and best linear unbiased prediction Anim. Cells Syst. (IF 2.9) Pub Date : 2023-09-02 Young-Sup Lee, Jae-Don Oh, Jun-Yeong Lee, Donghyun Shin
ABSTRACT Traditionally, the p-value is the criterion for the cutoff threshold to determine significant markers in genome-wide association studies (GWASs). Choosing the best subset of markers for the best linear unbiased prediction (BLUP) for improved prediction ability (PA) has become an interesting issue. However, when dealing with many traits having the same marker information, the p-values’ themselves
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Chloromethylisothiazolinone induces ER stress-induced stress granule formation in human keratinocytes Anim. Cells Syst. (IF 2.9) Pub Date : 2023-08-23 Da-Min Jung, Kee K. Kim, Eun-Mi Kim
ABSTRACT Chloromethylisothiazolinone (CMIT), a humidifier disinfectant, is known to be toxic to the respiratory system. While the toxic effect of CMIT on the lungs has been widely investigated, its effect on the skin is well unknown. In this study, we examined stress granule (SG) formation to investigate the cytotoxic effects of CMIT on human keratinocytes. We assessed the viability of the cells following
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Ginsenoside Rg3 attenuates pulmonary fibrosis by inhibiting endothelial to mesenchymal transition Anim. Cells Syst. (IF 2.9) Pub Date : 2023-08-04 Eunsik Yun, Byung Su Kwon, Jongmin Kim, Aram Lee
ABSTRACT Pulmonary fibrosis (PF) is a progressive and chronic lung disease characterized by excessive extracellular matrix (ECM) deposition and fibroblast proliferation. Endothelial-to-mesenchymal transition (EndMT) serves as a source of fibroblasts and contributes to PF progression. Ginsenoside Rg3 (Rg3), a steroidal saponin extracted from ginseng, is known to have pharmacological effects on vascular
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Glucose metabolic reprogramming in autoimmune diseases Anim. Cells Syst. (IF 2.9) Pub Date : 2023-07-16 Hoim Jeong, Beomgu Lee, Seung Jin Han, Dong Hyun Sohn
ABSTRACT Autoimmune diseases are conditions in which the immune system mistakenly targets and damages healthy tissue in the body. In recent decades, the incidence of autoimmune diseases has increased, resulting in a significant disease burden. The current autoimmune therapies focus on targeting inflammation or inducing immunosuppression rather than addressing the underlying cause of the diseases. The
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The impacts of resveratrol on the retinal degeneration in a rat model of retinitis pigmentosa induced by alkylation: an in-vivo study Anim. Cells Syst. (IF 2.9) Pub Date : 2023-06-26 Weiming Yan, Yan Sun, Yutong Wang, Wangjiao Liang, Yuxin Xia, Weihua Yan, Meizhu Chen, Tao Chen, Dongliang Li
ABSTRACT Upregulation of Sirtuin Type 1 (SIRT1), a nicotinamide adeninedinucleotide (NAD+)-dependent deacetylase, has been proved to protect against ample ocular diseases, while its effect on retinitis pigmentosa (RP) has not been illustrated. The study was aimed to explore the impacts of resveratrol (RSV), a SIRT1 activator, on the photoreceptor degeneration in a rat model of RP induced by N-methyl-N-nitrosourea
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Estradiol and progesterone regulate NUCB2/nesfatin-1 expression and function in GH3 pituitary cells and THESC endometrial cells Anim. Cells Syst. (IF 2.9) Pub Date : 2023-06-20 Jinah Ha, Jungwoo Shin, Eunji Seok, Soohyun Kim, Sojung Sun, Hyunwon Yang
ABSTRACT Estradiol (E2) and progesterone (P4) are essential sex steroid hormones that play critical roles in the pituitary gland and uterus. Recently, nesfatin-1, a polypeptide hormone that regulates appetite and energy homeostasis in the hypothalamus, was found to be expressed in the pituitary gland and uterus. In this study, we aimed to investigate the relationship between these two steroid hormones
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NUCB2/nesfatin-1 suppresses the acrosome reaction in sperm within the mouse epididymis Anim. Cells Syst. (IF 2.9) Pub Date : 2023-05-13 Soohyun Kim, Sojung Sun, Minbi Kim, Jinah Ha, Eunji Seok, Hyunwon Yang
ABSTRACT Nesfatin-1, a polypeptide hormone derived from the nucleobindin 2 (NUCB2) precursor protein, is known to regulate appetite and energy metabolism. Recent studies have also shown that NUCB2/nesfatin-1 is expressed in the reproductive organs of mice. However, the expression and potential role of NUCB2/nesfatin-1 in the mouse epididymis remain unclear. Therefore, we investigated the expression
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Puromycin-induced kidney injury and subsequent regeneration in adult zebrafish Anim. Cells Syst. (IF 2.9) Pub Date : 2023-04-20 Soonil Koun, Hye-jin Park, Su-min Jung, Jin Joo Cha, Dae Ryong Cha, Young Sun Kang
ABSTRACT Puromycin treatment can cause glomerular injury to the kidney, leading to proteinuria. However, the pathogenesis of acute kidney injury and subsequent regeneration after puromycin administration in animal models remain unclear. In this work, we examined the characteristics of kidney injury and subsequent regeneration following puromycin treatment in adult zebrafish. We intraperitoneally injected
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NAA10 Hypomethylation is associated with particulate matter exposure and worse prognosis for patients with non-small cell lung cancer Anim. Cells Syst. (IF 2.9) Pub Date : 2023-04-04 Ji Yun Lee, Su Man Lee, Won Kee Lee, Jae Yong Park, Dong Sun Kim
ABSTRACT Airborne particulate matter (PM) is a major health hazard worldwide and is a key factor in lung cancer, which remains the most common type of malignancy and the leading cause of cancer-related deaths. DNA methylation is a critical mechanism underlying the detrimental effects of PM, however, the molecular link between PM exposure and lung cancer remains to be elucidated. N-α-acetyltransferase
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Association of overexpressed carboxyl-terminal amyloid precursor protein in brains with altered glucose metabolism and liver toxicity Anim. Cells Syst. (IF 2.9) Pub Date : 2023-04-04 Sungguan Hong, Seungwoo Hong, Sung Hoon Lee
ABSTRACT Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease. The deposition of amyloid plaques mainly composed of amyloid beta (Aβ) is observed in brain regions in AD patients. AD presents with similar pathophysiology to that of metabolic syndrome, including glucose and insulin resistance. In addition, epidemiological studies indicate diabetes, impaired glucose metabolism, and
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Effective derivation of ventricular cardiomyocytes from hPSCs using ascorbic acid-containing maturation medium Anim. Cells Syst. (IF 2.9) Pub Date : 2023-03-24 Ji-eun Kim, Eun-Mi Kim, Hyang-Ae Lee, Ki-Suk Kim
ABSTRACT Cardiomyocytes derived from human pluripotent stem cells (hPSCs) can be used in various applications including disease modeling, drug safety screening, and novel cell-based cardiac therapies. Here, we report an optimized selection and maturation method to induce maturation of cardiomyocytes into a specific subtype after differentiation driven by the regulation of Wnt signaling. The medium
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Cell-autonomous reduction of CYFIP2 is insufficient to induce Alzheimer's disease-like pathologies in the hippocampal CA1 pyramidal neurons of aged mice Anim. Cells Syst. (IF 2.9) Pub Date : 2023-03-24 Ruiying Ma, Yinhua Zhang, Huiling Li, Hyae Rim Kang, Yoonhee Kim, Kihoon Han
ABSTRACT Cytoplasmic FMR1-interacting protein 2 (CYFIP2) is an evolutionarily conserved multifunctional protein that regulates the neuronal actin cytoskeleton, mRNA translation and transport, and mitochondrial morphology and function. Supporting its critical roles in proper neuronal development and function, human genetic studies have repeatedly identified variants of the CYFIP2 gene in individuals
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Emerging roles of polyunsaturated fatty acid synthesis pathway in colorectal cancer Anim. Cells Syst. (IF 2.9) Pub Date : 2023-03-20 Young-Ah Moon
ABSTRACT The development of colorectal cancer typically involves the accumulated influences of genetic alterations, medical issues, lifestyle, and diet. Dietary fatty acids appear to affect the tumorigenesis and progression of colorectal cancer. Despite conflicting results, the current consensus on the effects of very long-chain polyunsaturated fatty acids on colorectal cancer is that low levels of
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FAT10 Induces cancer cell migration by stabilizing phosphorylated ABI3/NESH Anim. Cells Syst. (IF 2.9) Pub Date : 2023-03-11 Hyojin Um, Hoim Jeong, Beomgu Lee, Yerin Kim, Jihyeon Lee, Jong Seong Roh, Seung-Geun Lee, Hae Ryoun Park, William H. Robinson, Dong Hyun Sohn
ABSTRACT The WAVE regulatory complex (WRC) is involved in various cellular processes by regulating actin polymerization. The dysregulation of WRC components is associated with cancer development. ABI family member 3 (ABI3)/new molecule including SH3 (NESH) is one of the WRC components and it has been reported that ABI3 phosphorylation can affect WRC function. Although several residues of ABI3 have
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The role of microRNAs in the molecular link between circadian rhythm and autism spectrum disorder Anim. Cells Syst. (IF 2.9) Pub Date : 2023-02-23 Ji Young Kim, Wanil Kim, Kyung-Ha Lee
ABSTRACT Circadian rhythm regulates physiological cycles of awareness and sleepiness. Melatonin production is primarily regulated by circadian regulation of gene expression and is involved in sleep homeostasis. If the circadian rhythm is abnormal, sleep disorders, such as insomnia and several other diseases, can occur. The term ‘autism spectrum disorder (ASD)’ is used to characterize people who exhibit
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Crosstalk between endoplasmic reticulum stress response and autophagy in human diseases Anim. Cells Syst. (IF 2.9) Pub Date : 2023-02-23 Junhee Kwon, Jihyun Kim, Keun Il Kim
ABSTRACT Cells activate protective mechanisms to overcome stressful conditions that threaten cellular homeostasis, including imbalances in calcium, redox, and nutrient levels. Endoplasmic reticulum (ER) stress activates an intracellular signaling pathway, known as the unfolded protein response (UPR), to mitigate such circumstances and protect cells. Although ER stress is sometimes a negative regulator
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Long non-coding RNA in glioma: novel genetic players in temozolomide resistance Anim. Cells Syst. (IF 2.9) Pub Date : 2023-02-15 Jungwook Roh, Mijung Im, JiHoon Kang, BuHyun Youn, Wanyeon Kim
ABSTRACT Glioma is the most common primary malignant brain tumor in adults and accounts for approximately 80% of brain and central nervous system tumors. In 2021, the World Health Organization (WHO) published a new taxonomy for glioma based on its histological features and molecular alterations. Isocitrate dehydrogenase (IDH) catalyzes the decarboxylation of isocitrate, a critical metabolic reaction
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Fine structural aspects on the web glue production in the golden orb-web spider Trichonephila clavata Anim. Cells Syst. (IF 2.9) Pub Date : 2023-01-30 Yan Sun, Seung-Min Lee, Bon-Jin Ku, Myung-Jin Moon
ABSTRACT The water-soluble glue substance of the capture threads in Trichonephila clavata is solely produced from two pairs of aggregate silk glands. During the web glue production, secretory vesicles were synthesized via the extensive rough endoplasmic reticulum of epithelial cells. Unlike the clearly described fibrous web production in spiders, the process of aqueous web glue production appears to
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Suppressive effects of (-)-tubaic acid on RANKL-induced osteoclast differentiation and bone resorption Anim. Cells Syst. (IF 2.9) Pub Date : 2023-01-12 Soomin Lim, Hye Jung Ihn, Ju Ang Kim, Jong-Sup Bae, Jung-Eun Kim, Yong Chul Bae, Hong-In Shin, Tae Hoon Kim, Eui Kyun Park
ABSTRACT Regulation of osteoclastogenesis and bone-resorbing activity can be an efficacious strategy for treating bone loss diseases because excessive osteoclastic bone resorption leads to the development of such diseases. Here, we investigated the role of (-)-tubaic acid, a thermal degradation product of rotenone, in osteoclast formation and function in an attempt to identify alternative natural compounds
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LRRK2 decreases microglial actin dynamics by filamentous actin depolymerization and Rac1 inhibition Anim. Cells Syst. (IF 2.9) Pub Date : 2022-12-22 Beomsue Kim, Young Ho Suh, Eunhye Joe
ABSTRACT An active actin dynamic is a crucial feature of brain microglia. Here we report that LRRK2, a primary familial Parkinson’s disease-associated gene, negatively regulates microglia’s actin dynamics. LRRK2 depolymerized filamentous actin (F-actin) by directly binding to it or inhibiting microglia’s Rac-PAK signaling. LRRK2 knockdown resulted in a reduced ruffle and enhanced lamellipodia formation
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Drug discovery inspired by bioactive small molecules from nature Anim. Cells Syst. (IF 2.9) Pub Date : 2022-12-21 Seyun Kim, Seol-Wa Lim, Jiyeon Choi
ABSTRACT Natural products (NPs) have greatly contributed to the development of novel treatments for human diseases such as cancer, metabolic disorders, and infections. Compared to synthetic chemical compounds, primary and secondary metabolites from medicinal plants, fungi, microorganisms, and our bodies are promising resources with immense chemical diversity and favorable properties for drug development
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LncRNA SNHG6 promotes glycolysis reprogramming in hepatocellular carcinoma by stabilizing the BOP1 protein Anim. Cells Syst. (IF 2.9) Pub Date : 2022-12-06 Kai Chen, Xi Wang, Bowen Wei, Rongcun Sun, Chunlin Wu, Hong-ji Yang
ABSTRACT Metabolic reprogramming is an important feature in tumor progression. Long noncoding RNA’s (lncRNA) small nucleolar RNA host gene 6 (SNHG6) acts as a proto-oncogene in hepatocellular carcinoma (HCC) but its role in glycolysis is mostly unknown. The role of SNHG6 and Block of proliferation 1 (BOP1) on glycolysis is assessed by glucose uptake, lactate production, oxygen consumptive rate (OCR)
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1,2,3,4,6-Penta-O-galloyl-β-D-glucose Inhibits CD44v3, a cancer stem cell marker, by regulating its transcription factor, in human pancreatic cancer cell line Anim. Cells Syst. (IF 2.9) Pub Date : 2022-12-03 Eun-Young Kim, Seong-Uk Lee, Yoon Hee Kim
ABSTRACT Inhibition of cluster of differentiation 44 (CD44), a pancreatic cancer stem cell (CSC) marker, is a potential treatment for pancreatic ductal adenocarcinoma (PDAC). In this study, we evaluated the effect of 1,2,3,4,6-penta-O-galloyl-β-D-glucose (PGG), a gallotannin contained in various medicinal plants, on CD44 standard (CD44s) and CD44 variant 3 (CD44v3) in Mia-PaCa-2, human pancreatic cancer
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Immortalization of primary marmoset skin fibroblasts by CRISPR-Cas9-mediated gene targeting Anim. Cells Syst. (IF 2.9) Pub Date : 2022-11-30 Yeon-Ju Jeong, Jeongin Cho, Jina Kwak, Young Hoon Sung, Byeong-Cheol Kang
ABSTRACT Immortalized cell lines can be used for diverse in vitro experiments, providing invaluable data before conducting in vivo studies Callithrix jacchus, the common marmoset, is a non-human primate model utilized for studying various human diseases. However, only a few immortalized marmoset cell lines are currently available. In the present study, we reveal that CRISPR-Cas9-mediated targeting