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JAML inhibits colorectal carcinogenesis by modulating the tumor immune microenvironment In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-04-16 Shiliang Cheng, Meng Li, Chunguang Li, Yonggang Dai, Jinhua Zhuo, Jue Wang, Jingrong Qian, Zhihao Hao
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Tumor endothelial cell-derived Sfrp1 supports the maintenance of cancer stem cells via Wnt signaling In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-04-16 Yumiko Hayashi, Masakazu Hashimoto, Katsuyoshi Takaoka, Tatsuya Takemoto, Nobuyuki Takakura, Hiroyasu Kidoya
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Anti-apoptotic protein Bcl-2 contributes to the determination of reserve cells during myogenic differentiation of C2C12 cells In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-04-15 Yosuke Nagata, Jun Tomimori, Tomoharu Hagiwara
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3,3′-Diindolylmethane inhibits Th17 cell differentiation via impairing IRF-7-mediated plasmacytoid dendritic cell activation in imiquimod-induced psoriasis mice In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-04-11 Mahaboobkhan Rasool, Manupati Srikanth, Arulkumaran Rithvik
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Protective effect of avicularin against lung cancer via inhibiting inflammation, oxidative stress, and induction of apoptosis: an in vitro and in vivo study In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-04-09 Zhiguo Dang, Songbo Liu, XiaoJuan Wang, Fangfang Ren, Shaik Althaf Hussain, Dong Jia
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Rutin alleviates Sjogren’s syndrome via CaR/NLRP3/NF-κB signal pathway In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-04-08 Jing He, Meimei Xu, Suling Wu
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Role of the Ror family receptors in Wnt5a signaling In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-04-08 Koki Kamizaki, Yasuhiro Minami, Michiru Nishita
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A comparative study on targeted gene expression in zebrafish and its gill cell line exposed to chlorpyrifos In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-04-08 Abdul Wazith M. J., Taju G., Abdul Majeed S., Mithra S., Nafeez Ahmed A., Badhusha A., Rajkumar V., Sahul Hameed A. S.
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High yield killing of lymphoma cells by anti-CD22 CAR-NK cell therapy In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-04-08 Mahnoosh Abbaszade Dibavar, Masoud Soleimani, Mohammad Hossein Mohammadi, Mina Soufi Zomorrod
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Inhibition of circ_0073932 attenuates myocardial ischemia‒reperfusion injury via miR-493-3p/FAF1/JNK In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-04-05 Yang Su, Lili Zhao, Dongli Lei, Xiaoming Yang
Oxidative stress and apoptosis play crucial roles in myocardial ischemia‒reperfusion injury (MIRI). In this study, we investigated the role of circ_0073932 in MIRI as well as its molecular mechanism. A hypoxia/reoxygenation (H/R) cardiomyocyte model was established with H9C2 cardiomyocytes, and RT–qPCR was used to measure gene expression. We observed that circ_0073932 expression was abnormally increased
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Vitamin D3 reduces the symptoms of ovarian hyperstimulation syndrome in mice and inhibits the release of granulosa cell angiogenic factor through pentraxin 3 In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-04-04 Minping Zhang, Li Chen, Qunping Xu, Xiaohua Yang, Xiang Liu, Luanmei Liu
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Eco-friendly green synthesis of N‑pyrazole amino chitosan using PEG-400 as an anticancer agent against gastric cancer cells via inhibiting EGFR In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-04-02 Limin Zhang, Chunfeng Li
The present study was conducted to develop a green process that provides access to the development of Schiff base derivatives of chitosan with the heterocyclic moiety as a novel class of anti-gastric cancer agent. In the present study, we have synthesized these derivatives by reacting various pyrazoles with chitosan using CAN in PEG400. The compounds were synthesized in 20 min in excellent yield by
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The R436Q missense mutation in WWP1 disrupts autoinhibition of its E3 ubiquitin ligase activity, leading to self-degradation and loss of function In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-04-01 Michihiro Imamura, Hirokazu Matsumoto, Hideyuki Mannen, Shin’ichi Takeda, Yoshitsugu Aoki
Muscular dystrophy in the NH-413 chicken is caused by a missense mutation in the WWP1 gene. WWP1 is a HECT-type E3 ubiquitin ligase containing four tandem WW domains that interact with proline-rich peptide motifs of target proteins, and a short region connecting the second and third WW domains is crucial for the E3 ligase to maintain an autoinhibitory state. A mutation of the arginine in the WW2–WW3
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Differences between cultured astrocytes from neonatal and adult Wistar rats: focus on in vitro aging experimental models In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-03-28
Abstract Astrocytes play key roles regulating brain homeostasis and accumulating evidence has suggested that glia are the first cells that undergo functional changes with aging, which can lead to a decline in brain function. In this context, in vitro models are relevant tools for studying aged astrocytes and, here, we investigated functional and molecular changes in cultured astrocytes obtained from
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PRDX6 alleviated heart failure by inhibiting doxorubicin-induced ferroptosis through the JAK2/STAT1 pathway inactivation In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-03-26 Jie Xiong, Rong Zhou, Xu Deng
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Influence of the storage conditions of embryo culture media on mouse development In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-03-20 Marten Davenport, Yingming Wang, Lev M. Fedorov
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In vitro generation of epidermal keratinocytes from human CD34-positive hematopoietic stem cells In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-03-19 Kodavala Sireesha, Echambadi Loganathan Samundeshwari, Kattaru Surekha, Chodimella Chandrasekhar, Potukuchi Venkata Gurunadha Krishna Sarma
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The molecular mechanisms underlying the regeneration process in the earthworm, Perionyx excavatus exhibit indications of apoptosis-induced compensatory proliferation (AICP) In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-03-19 Kamarajan Rajagopalan, Jackson Durairaj Selvan Christyraj, Karthikeyan Subbiahanadar Chelladurai, Johnson Retnaraj Samuel Selvan Christyraj, Puja Das, Apoorva Roy, Chaughule Vrushali, Nehla Siraj M. Chemmet
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Ocu-miR-10a-5p promotes the chondrogenic differentiation of rabbit BMSCs by targeting BTRC-mediated Wnt/β-catenin signaling pathway In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-03-19 Donghua Liu, Wang Tang, Dongming Tang, Haixia Yan, Feng Jiao
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Kinase PIM1 governs ferroptosis to reduce retinal microvascular endothelial cell dysfunction triggered by high glucose In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-03-14
Abstract Previous studies have implicated targeting Pim-1 proto-oncogene, serine/threonine kinase (PIM1) as a preventive measure against high glucose–induced cellular stress and apoptosis. This study aimed to reveal the potential role and regulatory mechanism of PIM1 in diabetic retinopathy. Human retinal microvascular endothelial cells (hRMECs) underwent high glucose induction, and fluctuations in
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Programmed cell death-1-modified pig developed using electroporation-mediated gene editing for in vitro fertilized zygotes In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-03-14 Thanh-Van Nguyen, Lanh Thi Kim Do, Qingyi Lin, Megumi Nagahara, Zhao Namula, Manita Wittayarat, Maki Hirata, Takeshige Otoi, Fuminori Tanihara
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Ginsenoside Rg1 relieves rat intervertebral disc degeneration and inhibits IL-1β-induced nucleus pulposus cell apoptosis and inflammation via NF-κB signaling pathway In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-03-14 Lei Yu, Ying-Jie Hao, Zhi-Nan Ren, Guang-Duo Zhu, Wei-Wei Zhou, Xu Lian, Xue-Jian Wu
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Secondary Publication: Proposal for Points of Consideration for Pluripotent Stem Cell Culture In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-03-12
Abstract Human pluripotent stem cells, such as human embryonic stem cells and human induced pluripotent stem cells, are used in basic research and various applied fields, including drug discovery and regenerative medicine. Stem cell technologies have developed rapidly in recent years, and the supply of culture materials has improved. This has facilitated the culture of human pluripotent stem cells
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CDC-like kinase 3 deficiency aggravates hypoxia-induced cardiomyocyte apoptosis through AKT signaling pathway In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-03-04 Xiue Ma, Liming Gao, Rucun Ge, Tianyou Yuan, Bowen Lin, Lixiao Zhen
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Human embryonic stem cells maintain their stemness in three-dimensional microenvironment In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-03-04 Jasmeet Kaur Virdi, Prasad Pethe
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Serum starvation is as efficient as roscovitine on the cycle synchronization in G0/G1 of red-rumped agouti fibroblasts In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-03-01 Érika Almeida Praxedes, Lhara Ricarliany Medeiros de Oliveira, João Vitor da Silva Viana, Luanna Lorenna Vieira Rodrigues, José de Brito Vieira Neto, Sarah Leyenne Alves Sales, Maria Claudia dos Santos Luciano, Moacir Franco de Oliveira, Cláudia Pessoa, Alexsandra Fernandes Pereira
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Knockdown of ANGPTL4 inhibits adipogenesis of preadipocyte via autophagy In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-02-29 Mingfa Ling, Heying Qian, Huiduo Guo
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Long-term preservation of established fibroblast lines from six‐banded armadillos (Euphractus sexcintus, Linnaeus, 1758) by extended passage and cryopreservation In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-02-29 Denilsa Pires Fernandes, Érika Almeida Praxedes, João Vitor da Silva Viana, Maria Valéria de Oliveira Santos, Alexandre Rodrigues Silva, Carlos Iberê Alves Freitas, Alexsandra Fernandes Pereira
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Adiponectin attenuates H2O2-induced apoptosis in chicken skeletal myoblasts through the lysosomal-mitochondrial axis In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-02-26 Han Wang, Chi Li, Longbo Zhu, Zhengqun Liu, Ning Li, Zi Zheng, Shiyue Liang, Jun Yan
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Preclinical assessments of safety and tumorigenicity of very high doses of allogeneic human umbilical cord mesenchymal stem cells In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-02-29 Sze-Piaw Chin, Nik Syazana Saffery, Kong-Yong Then, Soon-Keng Cheong
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Characterization and establishment of an immortalized rabbit ovary granulosa cell line for reproductive biology experiments In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-02-28 Zhiyuan Bao, Yang Chen, Jiali Li, Jiawei Cai, Bohao Zhao, Xinsheng Wu
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The effect of bta-miR-1296 on the proliferation and extracellular matrix synthesis of bovine mammary fibroblasts In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-02-26 Yuejie Yang, Tao Yuan, Rui Wu, Zijian Geng, Shuai Lian, Jianfa Wang
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TGFβ2 mediates oxidative stress–induced epithelial-to-mesenchymal transition of bladder smooth muscle In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-02-26 Jingwen Geng, Xiaofan Zhang, Yansong Zhang, Xiaojia Meng, Jinqi Sun, Bo Zhou, Jun Ma
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The origins of human pluripotent stem cells: the road from a cancer to regenerative medicine In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-02-23 Peter W. Andrews
The notion of using pluripotent stem cells (PSCs) as a source of differentiated cell types for replacement of disease or damaged tissues in regenerative medicine is now an active area of research, with approaches to treating eye diseases such as age-related macular degeneration or Parkinson’s disease now on the horizon. But the foundations for this research lie in a quite different area of science
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WAY-262611 ameliorates the inflammatory bowel disease by activating Wnt/β-catenin pathway In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-02-23
Abstract Inflammatory bowel disease (IBD) is a non-specific and relapsing intestinal inflammation. The injury and repair of intestinal epithelial together determine the occurrence and development of IBD. Wnt/β-catenin pathway is considered as the key role in the proliferation and differentiation of intestinal stem cells which is negative regulated by Dickkiop (DKKs). WAY-262611 is a novel inhibitor
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Generation of chimpanzee induced pluripotent stem cell lines for cross-species comparisons In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-02-22 Masanori Imamura, Risako Nakai, Mari Ohnuki, Yusuke Hamazaki, Hideyuki Tanabe, Momoka Sato, Yu Harishima, Musashi Horikawa, Mao Watanabe, Hiroki Oota, Masato Nakagawa, Shunsuke Suzuki, Wolfgang Enard
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New insights in ubiquitin-dependent Wnt receptor regulation in tumorigenesis In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-02-21 Tadasuke Tsukiyama
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Wnt/β-catenin signaling pathway in liver biology and tumorigenesis In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-02-20 Shinji Matsumoto, Akira Kikuchi
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Generation of allogenic chimera carrying mutations in PDX1 and TP53 genes via phytohemagglutinin-mediated blastomere aggregation in pigs In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-02-20 Thanh-Van Nguyen, Koki Takebayashi, Lanh Thi Kim Do, Zhao Namula, Manita Wittayarat, Megumi Nagahara, Maki Hirata, Takeshige Otoi, Fuminori Tanihara
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Understanding and manipulating extracellular behaviors of Wnt ligands In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-02-20 Yusuke Mii
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Avoiding aggregation of human bone marrow–derived mesenchymal stem cells stored in cell preservation solutions In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-02-15 Takeshi Kikuchi, Masuhiro Nishimura, Chikage Shirakawa, Yasutaka Fujita, Takeshige Otoi
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The interplay between Wnt signaling pathways and microtubule dynamics Wnt signaling, microtubule dynamics In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-02-13 Koji Kikuchi, Masaki Arata
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REMOVER-PITCh: microhomology-assisted long-range gene replacement with highly multiplexed CRISPR-Cas9 In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-02-09
Abstract A variety of CRISPR-Cas9-based gene editing technologies have been developed, including gene insertion and gene replacement, and applied to the study and treatment of diseases. While numerous studies have been conducted to improve the efficiency of gene insertion and to expand the system in various ways, there have been relatively few reports on gene replacement technology; therefore, further
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DUSP4 maintains the survival and LSD1 protein stability in esophageal squamous cell carcinoma cells by inhibiting JNK signaling-dependent autophagy In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-01-29 Xinxin Liu, Zhou Ye, Dingyu Rao, Qianshun Chen, Zuxiong Zhang
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Dihydrotanshinone I reduces H9c2 cell damage by regulating AKT and MAPK signaling pathways In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-01-22 Ya-chao Wang, Yi-da Shao, Chang-le Shao, Xiao-qi Guan, Ping-ping Lu, Ke Ning, Bao-nian Liu, Hai-dong Guo
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Administration with curcumin alleviates spinal cord ischemia-reperfusion injury by regulating anti-oxidative stress and microglia activation-mediated neuroinflammation via Nrf2/NF-κB axis In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-01-16 Fengchun Wu, Yu Lin, Lili Xiao, Qiyong Chen, Fengfei Lin, Renbin Li
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Modulating effect of Eunkyo-san on expression of inflammatory cytokines and angiotensin-converting enzyme 2 in human mast cells In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-01-16
Abstract Eunkyo-san is widely used in the treatment of severe respiratory infections. Mast cells not only serve as host cells for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but also they also exacerbate Coronavirus disease in 2019 (COVID-19) by causing a cytokine storm. Here we investigated whether Eunkyo-san and its active compound naringenin regulate the expression of inflammatory
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Bilirubin impairs neuritogenesis and synaptogenesis in NSPCs by downregulating NMDAR-CREB-BDNF signaling In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-01-12 Yan Zhang, Siyu Li, Ling Li, Hongmei Huang, Zhou Fu, Ziyu Hua
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Trisomy 12 compromises the mesendodermal differentiation propensity of human pluripotent stem cells In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2024-01-02 Kana Yanagihara, Yohei Hayashi, Yujung Liu, Tomoko Yamaguchi, Yasuko Hemmi, Minako Kokunugi, Kozue Uchio Yamada, Ken Fukumoto, Mika Suga, Satoshi Terada, Hiroki Nikawa, Kenji Kawabata, Miho Furue
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The effect of miR-223-3p on endothelial cells in coronary artery disease In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2023-12-28
Abstract Endothelial cell damage and dysfunction are crucial factors in the development and early stages of coronary artery disease (CAD) and apoptosis plays a significant role in this process. In this study, We aimed to simulate the CAD vascular microenvironment by treating endothelial cells with tumor necrosis factor alpha (TNF-α) to construct an endothelial cell apoptosis model. Our findings revealed
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Establishment of Capra hircus somatic cells and induction of pluripotent stem-like cells In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2023-12-28 Anshuman Singh, Suraj Kumar Singh, Manoj Kumar, Devojit Kumar Sarma, Samradhi Singh, Vinod Verma
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Sea buckthorn oil regulates primary myoblasts proliferation and differentiation in vitro In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2023-12-28 Jiamin Zhao, Lin Liang, Weipeng Zhang, Xuan Liu, Guoqiang Huo, Xiangdong Liu, Xiaoyang Lv, Junxing Zhao
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Effect and mechanism of hypoxia on differentiation of porcine-induced pluripotent stem cells into vascular endothelial cells In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2023-12-26 Yimei Li, Danyang Song, Zhuoran Yu, Yu Zhang, Zhonghua Liu, Tingsheng Yan
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Establishment and characterization of a novel lung cell line derived from the common bottlenose dolphin In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2023-12-26 Kaede Tashiro, Kyosuke Hikobe, Takao Segawa, Miwa Suzuki, Ken Maeda, Takuya Itou
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Isolation, identification, and induced differentiation of satellite cells from skeletal muscle of adult tree shrews In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2023-12-21 Shenghui Ke, Yiwei Feng, Liying Luo, Wanzhao Qin, Huayu Liu, Jingchong Nie, Beijiang Liang, Hongjie Ma, Mao Xie, Jingyu Li, Zhijie Niu, Guojian Li, Anzhou Tang, Wei Xia, Guangyao He
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LINC00467 mediates the 5-fluorouracil resistance in breast cancer cells In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2023-12-21 Lan Li, Yan Zhang, Yuwei Zhan, Yuanke Zhong, Xuehong Li
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Cucumber seed polypeptides regulate RANKL-induced osteoclastogenesis through OPG/RANKL/RANK and NF-κB In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2023-12-20 Tao Yu, Xiao Liu, Meng Jiang, Yuanyue Li, Heng Su, Ben Niu
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Polycaprolactone/poly l-lactic acid nanofibrous scaffold improves osteogenic differentiation of the amniotic fluid-derived stem cells In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2023-12-20 Seyyedeh Masoumeh Pishnamazi, Sayyed Mohammad Hossein Ghaderian, Shiva Irani, Abdolreza Ardeshirylajimi
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Decreased ZMIZ1 suppresses melanogenesis in vitiligo by regulating mTOR/AKT/GSK-3β-mediated glucose uptake In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2023-12-20 Wenli Lu, Zhuo Chen, Hui Xu, Zhengyu Shen, Zhouwei Wu, Meng Li
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Taurine promotes insulin synthesis by enhancing Isl-1 expression through miR-7a/RAF1/ERK1/2 pathway In Vitro Cell. Dev. Biol. Anim. (IF 2.1) Pub Date : 2023-12-20 Hui Liu, Tongjuan Niu, Guobin Qiu, Sheng Cui, Di Zhang