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Abatacept: A Promising Repurposed Solution for Myocardial Infarction-Induced Inflammation in Rat Models Oxidative Med. Cell. Longev. (IF 7.31) Pub Date : 2024-3-13 Vipin Kumar Verma, Ekta Mutneja, Salma Malik, Anil Kumar Sahu, Vaishali Prajapati, Priya Bhardwaj, Ruma Ray, Tapas Chandra Nag, Jagriti Bhatia, Dharamvir Singh Arya
Myocardial infarction (MI) is irreversible damage to the myocardial tissue caused by prolonged ischemia/hypoxia, subsequently leading to loss of contractile function and myocardial damage. However, after a perilous period, ischemia-reperfusion (IR) itself causes the generation of oxygen free radicals, disturbance in cation homeostasis, depletion of cellular energy stores, and activation of innate and
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ACA-28, an ERK MAPK Signaling Modulator, Exerts Anticancer Activity through ROS Induction in Melanoma and Pancreatic Cancer Cells Oxidative Med. Cell. Longev. (IF 7.31) Pub Date : 2024-3-11 Teruaki Takasaki, Yasuyuki Hamabe, Kenta Touchi, Golam Iftakhar Khandakar, Takeshi Ueda, Hitoshi Okada, Kazuko Sakai, Kazuto Nishio, Genzoh Tanabe, Reiko Sugiura
The extracellular signal-regulated kinase (ERK) MAPK pathway is dysregulated in various human cancers and is considered an attractive therapeutic target for cancer. Therefore, several inhibitors of this pathway are being developed, and some are already used in the clinic. We have previously identified an anticancer compound, ACA-28, with a unique property to preferentially induce ERK-dependent apoptosis
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BACE1 Inhibition Utilizing Organic Compounds Holds Promise as a Potential Treatment for Alzheimer’s and Parkinson’s Diseases Oxidative Med. Cell. Longev. (IF 7.31) Pub Date : 2024-2-22 Razieh Amini, Shadi Moradi, Rezvan Najafi, Mehrdokht Mazdeh, Amir Taherkhani
Background. Neurological disorders like Alzheimer’s disease (AD) and Parkinson’s disease (PD) manifest through gradually deteriorating cognitive functions. An encouraging strategy for addressing these disorders involves the inhibition of precursor-cleaving enzyme 1 (BACE1). Objectives. In the current research, a virtual screening technique was employed to identify potential BACE1 inhibitors among selected
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Synergistic Cytotoxicity of Extracts of Chaga Mushroom and Microalgae against Mammalian Cancer Cells In Vitro Oxidative Med. Cell. Longev. (IF 7.31) Pub Date : 2024-1-17 Sajeev Wagle, Julie Anne Lee, H. P. Vasantha Rupasinghe
Chaga mushroom (Inonotus obliquus) contains bioactive metabolites and has been used to treat various ailments, including cancer. Similarly, marine microalgae are considered a sustainable food supplement with anticancer and antioxidant properties. This study investigated the cytotoxicity of different extracts prepared from I. obliquus and microalgae using cultured human and canine cancer cell lines
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The Molecular Blueprint for Chronic Obstructive Pulmonary Disease (COPD): A New Paradigm for Diagnosis and Therapeutics Oxidative Med. Cell. Longev. (IF 7.31) Pub Date : 2023-12-21 Ilma Shakeel, Anam Ashraf, Mohammad Afzal, Sukhwinder Singh Sohal, Asimul Islam, Syed Naqui Kazim, Md. Imtaiyaz Hassan
The global prevalence of chronic obstructive pulmonary disease (COPD) has increased over the last decade and has emerged as the third leading cause of death worldwide. It is characterized by emphysema with prolonged airflow limitation. COPD patients are more susceptible to COVID-19 and increase the disease severity about four times. The most used drugs to treat it show numerous side effects, including
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P-Glycoprotein Exacerbates Brain Injury Following Experimental Cerebral Ischemia by Promoting Proinflammatory Microglia Activation Oxidative Med. Cell. Longev. (IF 7.31) Pub Date : 2023-12-16 Yan Chen, Xuan Fei, Ge Liu, Xiang Li, Liangliang Huang, Lele Zixin Yang, Yunman Li, Baohui Xu, Weirong Fang
Microglia are activated following cerebral ischemic insult. P-glycoprotein (P-gp) is an efflux transporter on microvascular endothelial cells and upregulated after cerebral ischemia. This study evaluated the effects and possible mechanisms of P-gp on microglial polarization/activation in mice after ischemic stroke. P-gp-specific siRNA and adeno-associated virus (p-AAV) were used to silence and overexpress
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Relationship among Dietary Intake of Vitamin E, Lipid Peroxidation Markers, and C-Reactive Protein in Flu-Like Patients Diagnosed with COVID-19 Oxidative Med. Cell. Longev. (IF 7.31) Pub Date : 2023-11-6 Maísa Guimarães Silva Primo, Liriane Andressa Alves da Silva, Vanessa Brito Lira de Carvalho, Margarete Almeida Freitas de Azevedo, Nayara Vieira do Nascimento Monteiro, Vitória Ribeiro Mendes, Jaynara Keylla Moreira da Silva, Amanda Suellenn da Silva Santos Oliveira, Ana Karolinne da Silva Brito, Ana Lina de Carvalho Cunha Sales, Jacenir Reis dos Santos Mallet, José Miguel Luz Parente, Emídio Marques
Objective. This research aimed to assess the intake of vitamin E and its relationship with lipid peroxidation markers and C-reactive protein levels in patients with flu symptoms and COVID-19 diagnosis. Methods. A cross-sectional study with 121 patients of both sexes assisted at two basic health units in the city of Teresina, Piauí, with COVID-19 diagnosis confirmed through real-time reverse transcription
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Retracted: Puerarin Attenuates LPS-Induced Inflammatory Responses and Oxidative Stress Injury in Human Umbilical Vein Endothelial Cells through Mitochondrial Quality Control. Oxidative Med. Cell. Longev. (IF 7.31) Pub Date : 2023-10-11 Oxidative Medicine And Cellular Longevity
[This retracts the article DOI: 10.1155/2021/6659240.].
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Retracted: Melatonin Attenuates Ischemia/Reperfusion-Induced Oxidative Stress by Activating Mitochondrial Fusion in Cardiomyocytes. Oxidative Med. Cell. Longev. (IF 7.31) Pub Date : 2023-10-11 Oxidative Medicine And Cellular Longevity
[This retracts the article DOI: 10.1155/2022/7105181.].
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Retracted: Novel Insights into the Molecular Features and Regulatory Mechanisms of Mitochondrial Dynamic Disorder in the Pathogenesis of Cardiovascular Disease. Oxidative Med. Cell. Longev. (IF 7.31) Pub Date : 2023-10-11 Oxidative Medicine And Cellular Longevity
[This retracts the article DOI: 10.1155/2021/6669075.].
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Retracted: Protective Effect of Nicorandil on Cardiac Microvascular Injury: Role of Mitochondrial Integrity. Oxidative Med. Cell. Longev. (IF 7.31) Pub Date : 2023-10-11 Oxidative Medicine And Cellular Longevity
[This retracts the article DOI: 10.1155/2021/4665632.].
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Retracted: Modulation of Mitochondrial Quality Control Processes by BGP-15 in Oxidative Stress Scenarios: From Cell Culture to Heart Failure. Oxidative Med. Cell. Longev. (IF 7.31) Pub Date : 2023-10-11 Oxidative Medicine And Cellular Longevity
[This retracts the article DOI: 10.1155/2021/6643871.].
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Retracted: Epicardial Adipose Tissue Volume Is Associated with High Risk Plaque Profiles in Suspect CAD Patients. Oxidative Med. Cell. Longev. (IF 7.31) Pub Date : 2023-10-11 Oxidative Medicine And Cellular Longevity
[This retracts the article DOI: 10.1155/2021/6663948.].
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Retracted: The Role of Posttranslational Modification and Mitochondrial Quality Control in Cardiovascular Diseases. Oxidative Med. Cell. Longev. (IF 7.31) Pub Date : 2023-10-11 Oxidative Medicine And Cellular Longevity
[This retracts the article DOI: 10.1155/2021/6635836.].
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Retracted: Recurrence of Early Hepatocellular Carcinoma after Surgery May Be Related to Intestinal Oxidative Stress and the Development of a Predictive Model. Oxidative Med. Cell. Longev. (IF 7.31) Pub Date : 2023-09-27 Oxidative Medicine And Cellular Longevity
[This retracts the article DOI: 10.1155/2022/7261786.].
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Retracted: Systematic Analysis of Tumor Microenvironment Patterns and Oxidative Stress Characteristics of Endometrial Carcinoma Mediated by 5-Methylcytosine Regulators. Oxidative Med. Cell. Longev. (IF 7.31) Pub Date : 2023-09-27 Oxidative Medicine And Cellular Longevity
[This retracts the article DOI: 10.1155/2022/6431164.].
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Retracted: KLHDC8A Expression in Association with Macrophage Infiltration and Oxidative Stress Predicts Unfavorable Prognosis for Glioma. Oxidative Med. Cell. Longev. (IF 7.31) Pub Date : 2023-09-27 Oxidative Medicine And Cellular Longevity
[This retracts the article DOI: 10.1155/2022/2694377.].
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Retracted: Colostomy Delays Cell Loss in the Brain and Improves Juvenile Survival in a Neonatal Rat Model of Hirschsprung's Disease. Oxidative Med. Cell. Longev. (IF 7.31) Pub Date : 2023-09-27 Oxidative Medicine And Cellular Longevity
[This retracts the article DOI: 10.1155/2022/3792798.].
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Retracted: Perioperative Management and Long-Term Outcomes in Ocular Cicatricial Pemphigoid Patients Undergoing Cataract Surgery. Oxidative Med. Cell. Longev. (IF 7.31) Pub Date : 2023-09-27 Oxidative Medicine And Cellular Longevity
[This retracts the article DOI: 10.1155/2022/2496649.].
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MicroRNAs Regulate Function in Atherosclerosis and Clinical Implications Oxidative Med. Cell. Longev. (IF 7.31) Pub Date : 2023-8-29 Zhaoyi Li, Yidan Zhao, Sei Suguro, Rinkiko Suguro
Background. Atherosclerosis is considered the most common cause of morbidity and mortality worldwide. Athermanous plaque formation is pathognomonic of atherosclerosis. The main feature of atherosclerosis is the formation of plaque, which is inseparable from endothelial cells, vascular smooth muscle cells, and macrophages. MicroRNAs, a small highly conserved noncoding ribonucleic acid (RNA) molecule
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Photobiomodulation at Defined Wavelengths Regulates Mitochondrial Membrane Potential and Redox Balance in Skin Fibroblasts Oxidative Med. Cell. Longev. (IF 7.31) Pub Date : 2023-8-24 Vito Antonio Baldassarro, Giuseppe Alastra, Luca Lorenzini, Luciana Giardino, Laura Calzà
Starting from the discovery of phototherapy in the beginning of the last century, photobiomodulation (PBM) has been defined in late 1960s and, since then, widely described in different in vitro models. Robust evidence indicates that the effect of light exposure on the oxidative state of the cells and on mitochondrial dynamics, suggesting a great therapeutic potential. The translational scale-up of
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Erythropoietin Suppresses the Hepatic Fibrosis Caused by Thioacetamide: Role of the PI3K/Akt and TLR4 Signaling Pathways Oxidative Med. Cell. Longev. (IF 7.31) Pub Date : 2023-8-22 Marawan A. Elbaset, Bassim M. S. A. Mohamed, Passant E. Moustafa, Dina F. Mansour, Sherif M. Afifi, Tuba Esatbeyoglu, Sahar S. M. Abdelrahman, Hany M. Fayed
Erythropoietin (EPO) is recognized for its function in erythropoiesis; however, its potential antifibrotic effect against liver fibrosis remains unknown. This study examined whether EPO affects thioacetamide (TAA)-induced liver fibrosis by concentrating on the Toll-like receptor 4 (TLR4) cascade and the phosphatidylinositol 3-kinase (PI3K)/Akt pathway as possible pathways. Male Wistar rats were randomized
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Clinical Significance of Carnitine in the Treatment of Cancer: From Traffic to the Regulation Oxidative Med. Cell. Longev. (IF 7.31) Pub Date : 2023-8-10 Raheleh Farahzadi, Mohammad Saeid Hejazi, Ommoleila Molavi, Elahe Pishgahzadeh, Soheila Montazersaheb, Sevda Jafari
Metabolic reprogramming is a common hallmark of cancer cells. Cancer cells exhibit metabolic flexibility to maintain high proliferation and survival rates. In other words, adaptation of cellular demand is essential for tumorigenesis, since a diverse supply of nutrients is required to accommodate tumor growth and progression. Diversity of carbon substrates fueling cancer cells indicate metabolic heterogeneity
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Retracted: The RPL4P4 Pseudogene Is a Prognostic Biomarker and Is Associated with Immune Infiltration in Glioma. Oxidative Med. Cell. Longev. (IF 7.31) Pub Date : 2023-08-09 Oxidative Medicine And Cellular Longevity
[This retracts the article DOI: 10.1155/2022/7967722.].
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Retracted: Molecular Typing Based on Oxidative Stress Genes and Establishment of Prognostic Characteristics of 7 Genes in Lung Adenocarcinoma. Oxidative Med. Cell. Longev. (IF 7.31) Pub Date : 2023-08-09 Oxidative Medicine And Cellular Longevity
[This retracts the article DOI: 10.1155/2022/9683819.].
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Retracted: Characterization of the Prognostic Values of CXCL Family in Epstein-Barr Virus Associated Gastric Cancer. Oxidative Med. Cell. Longev. (IF 7.31) Pub Date : 2023-08-09 Oxidative Medicine And Cellular Longevity
[This retracts the article DOI: 10.1155/2022/2218140.].
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Extraintestinal Manifestations in Induced Colitis: Controversial Effects of N-Acetylcysteine on Colon, Liver, and Kidney Oxidative Med. Cell. Longev. (IF 7.31) Pub Date : 2023-8-5 Amylly Sanuelly da Paz Martins, Kívia Queiroz de Andrade, Orlando Roberto Pimentel de Araújo, Glenn Côsallin Melquiades da Conceição, Amanda da Silva Gomes, Marília Oliveira Fonseca Goulart, Fabiana Andréa Moura
Ulcerative colitis (UC) is a chronic and recurrent inflammatory bowel disease (IBD) characterized by continuous inflammation in the colonic mucosa. Extraintestinal manifestations (EIM) occur due to the disruption of the intestinal barrier and increased permeability caused by redox imbalance, dysbiosis, and inflammation originating from the intestine and contribute to morbidity and mortality. The aim
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Retracted: Identification of Oxidative Stress-Associated Molecular Subtypes and Signature for Predicting Survival Outcome of Cervical Squamous Cell Carcinoma. Oxidative Med. Cell. Longev. (IF 7.31) Pub Date : 2023-08-02 Oxidative Medicine And Cellular Longevity
[This retracts the article DOI: 10.1155/2022/1056825.].
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Retracted: A Novel Approach Combined with MIPO Technique for the Treatment of Type C Pilon Fractures. Oxidative Med. Cell. Longev. (IF 7.31) Pub Date : 2023-08-02 Oxidative Medicine And Cellular Longevity
[This retracts the article DOI: 10.1155/2022/7427255.].
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Retracted: Glymphatic System: Emerging Therapeutic Target for Neurological Diseases. Oxidative Med. Cell. Longev. (IF 7.31) Pub Date : 2023-08-02 Oxidative Medicine And Cellular Longevity
[This retracts the article DOI: 10.1155/2022/6189170.].
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Retracted: Comparative Analysis of Early Clinical Features and Complications of Different Types of Acute Pancreatitis. Oxidative Med. Cell. Longev. (IF 7.31) Pub Date : 2023-08-02 Oxidative Medicine And Cellular Longevity
[This retracts the article DOI: 10.1155/2022/3771610.].
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Retracted: Automatic Detection and Segmentation of Ovarian Cancer Using a Multitask Model in Pelvic CT Images. Oxidative Med. Cell. Longev. (IF 7.31) Pub Date : 2023-08-02 Oxidative Medicine And Cellular Longevity
[This retracts the article DOI: 10.1155/2022/6009107.].
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Retracted: Carveol Promotes Nrf2 Contribution in Depressive Disorders through an Anti-inflammatory Mechanism. Oxidative Med. Cell. Longev. (IF 7.31) Pub Date : 2023-08-02 Oxidative Medicine And Cellular Longevity
[This retracts the article DOI: 10.1155/2022/4509204.].
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Retracted: Fibroblasts in Scar Formation: Biology and Clinical Translation. Oxidative Med. Cell. Longev. (IF 7.31) Pub Date : 2023-08-02 Oxidative Medicine And Cellular Longevity
[This retracts the article DOI: 10.1155/2022/4586569.].
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Retracted: Potential Benefits of Music Therapy on Stroke Rehabilitation. Oxidative Med. Cell. Longev. (IF 7.31) Pub Date : 2023-08-02 Oxidative Medicine And Cellular Longevity
[This retracts the article DOI: 10.1155/2022/9386095.].
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Retracted: Involvement of Mitochondrial Dynamics and Mitophagy in Sevoflurane-Induced Cell Toxicity. Oxidative Med. Cell. Longev. (IF 7.31) Pub Date : 2023-08-02 Oxidative Medicine And Cellular Longevity
[This retracts the article DOI: 10.1155/2021/6685468.].
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Oxidative Stress in End-Stage Renal Disease: Pathophysiology and Potential Interventions. Oxidative Med. Cell. Longev. (IF 7.31) Pub Date : 2023-07-05 Stefanos Roumeliotis,Vassilios Liakopoulos,Evangelia Dounousi,Patrick B Mark
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Single-Step Synthesis of Ag Hexagonal Nanoplate-Decorated Reduced Graphene Oxide and Its Cytotoxicity Studies Oxidative Med. Cell. Longev. (IF 7.31) Pub Date : 2023-7-1 Gnanaprakasam Periyasamy, Selvaraju Thangavelu, Saravanan Muthupandian
Graphene-based Ag nanocomposites are of specific interest because of their unique properties and applications, especially in the field of cytotoxicity. However, developing a simple method to synthesize reduced graphene oxide (rGO)/silver hexagonal nanoplate (Ag HNPT) (rGO–Ag HNPT) nanocomposites with well-defined morphology has been believed to be a major challenge. In this work, a facile, robust,
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Retracted: Novel Therapeutic Mechanism of Adipose-Derived Mesenchymal Stem Cells in Osteoarthritis via Upregulation of BTG2. Oxidative Med. Cell. Longev. (IF 7.31) Pub Date : 2023-06-21 Oxidative Medicine And Cellular Longevity
[This retracts the article DOI: 10.1155/2022/9252319.].
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Retracted: ZFP36 Inhibits Tumor Progression of Human Prostate Cancer by Targeting CDK6 and Oxidative Stress. Oxidative Med. Cell. Longev. (IF 7.31) Pub Date : 2023-06-21 Oxidative Medicine And Cellular Longevity
[This retracts the article DOI: 10.1155/2022/3611540.].
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Retracted: Identification of ATG7 as a Regulator of Proferroptosis and Oxidative Stress in Osteosarcoma. Oxidative Med. Cell. Longev. (IF 7.31) Pub Date : 2023-06-21 Oxidative Medicine And Cellular Longevity
[This retracts the article DOI: 10.1155/2022/8441676.].
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Improvement of Antioxidant Defences in Keratinocytes Grown in Physioxia: Comparison of 2D and 3D Models Oxidative Med. Cell. Longev. (IF 7.31) Pub Date : 2023-6-17 Nadira Chettouh-Hammas, Fabienne Fasani, Amandine Boileau, David Gosset, Giovanni Busco, Catherine Grillon
Keratinocytes prevent skin photoaging by ensuring the defence against oxidative stress, an excessive production of reactive oxygen species (ROS). They are localized within the epidermis where the oxygen level (1-3% O2), named physioxia, is low compared to other organs. Oxygen is essential for life but also generates ROS. Most of the in vitro studies on keratinocyte antioxidant capacities are performed
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Increased Iron Levels and Oxidative Stress Mediate Age-Related Impairments in Male and Female Drosophila melanogaster Oxidative Med. Cell. Longev. (IF 7.31) Pub Date : 2023-6-9 Karen Kich Gomes, Ana Beatriz dos Santos, Jaciana Sousa dos Anjos, Luana Paganotto Leandro, Maria Takemura Mariano, Felipe Lima Pinheiro, Marcelo Farina, Jeferson Luis Franco, Thais Posser
Aging is characterized by a functional decline in the physiological functions and organic systems, causing frailty, illness, and death. Ferroptosis is an iron- (Fe-) dependent regulated cell death, which has been implicated in the pathogenesis of several disorders, such as cardiovascular and neurological diseases. The present study investigated behavioral and oxidative stress parameters over the aging
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A Glance at Biogenesis and Functionality of MicroRNAs and Their Role in the Neuropathogenesis of Parkinson’s Disease Oxidative Med. Cell. Longev. (IF 7.31) Pub Date : 2023-6-8 Adam Szelągowski, Mariusz Kozakiewicz
MicroRNAs (miRNAs) are short, noncoding RNA transcripts. Mammalian miRNA coding sequences are located in introns and exons of genes encoding various proteins. As the central nervous system is the largest source of miRNA transcripts in living organisms, miRNA molecules are an integral part of the regulation of epigenetic activity in physiological and pathological processes. Their activity depends on
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Carbon Dots for the Treatment of Inflammatory Diseases: An Appraisal of In Vitro and In Vivo Studies Oxidative Med. Cell. Longev. (IF 7.31) Pub Date : 2023-5-25 Anshul Sharma, Hyo-Kyoung Choi, Hae-Jeung Lee
In recent decades, several studies demonstrating various applications of carbon dots (C-dots), including metal sensing, bioimaging, pH sensing, and antimicrobial activities, have been published. Recent developments have shifted this trend toward biomedical applications that target various biomarkers relevant to chronic diseases. However, relevant developments and research results regarding the anti-inflammatory
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Ferroptosis-Related lncRNAs Act as Novel Prognostic Biomarkers in the Gastric Adenocarcinoma Microenvironment, Immunotherapy, and Chemotherapy Oxidative Med. Cell. Longev. (IF 7.31) Pub Date : 2023-5-19 Yushi Zheng, Shanshan Wu, Xueshan Huang, Lianxiang Luo
Ferroptosis, a form of programmed cell death akin to necrosis, is managed by iron and is distinguished by lipid peroxidation. Gastric cancer is a highly aggressive form of cancer, responsible for the third highest number of cancer-related deaths globally. Despite this, the potential of ferroptosis to predict the occurrence of this cancer is yet to be determined. In this research, a comprehensive examination
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Evaluation of Antidiabetic Effect of Combined Leaf and Seed Extracts of Moringa oleifera (Moringaceae) on Alloxan-Induced Diabetes in Mice: A Biochemical and Histological Study Oxidative Med. Cell. Longev. (IF 7.31) Pub Date : 2023-5-12 Badriyah Aljazzaf, Sassia Regeai, Sana Elghmasi, Nadia Alghazir, Amal Balgasim, Ismail M. Hdud Ismail, Areej A. Eskandrani, Ghalia Shamlan, Wafa S. Alansari, Ammar AL-Farga, Rabia Alghazeer
Moringa oleifera (Moringaceae) is a medicinal plant rich in biologically active compounds. The aim of the present study was to screen M. oleifera methanolic leaf (L) extract, seed (S) extract, and a combined leaf/seed extract (2L : 1S ratio) for antidiabetic and antioxidant activities in mice following administration at a dose level of 500 mg/kg of body weight/day. Diabetes was induced by alloxan administration
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Phytochemicals: Alternative for Infertility Treatment and Associated Conditions Oxidative Med. Cell. Longev. (IF 7.31) Pub Date : 2023-5-11 Saziini H. Chorosho, Neha Malik, Gulsheen Panesar, Pratima Kumari, Sarita Jangra, Rupinder Kaur, Mariam S. Al-Ghamdi, Tasahil S. Albishi, Hitesh Chopra, Ravinder Singh, H. C. Ananda Murthy
Infertility and obstetric complications have become global health issues in the past few years. Infertility is defined as the inability of a couple to conceive even after twelve months or more of regular and unprotected intercourse. According to WHO data published in the year 2020, 186 million people have infertility globally. Factors leading to infertility are variable in both males and females. But
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Autophagy and Its Lineage-Specific Roles in the Hematopoietic System Oxidative Med. Cell. Longev. (IF 7.31) Pub Date : 2023-5-3 Kazi Md Mahmudul Hasan, Md Anwarul Haque
Autophagy is a dynamic process that regulates the selective and nonselective degradation of cytoplasmic components, such as damaged organelles and protein aggregates inside lysosomes to maintain tissue homeostasis. Different types of autophagy including macroautophagy, microautophagy, and chaperon-mediated autophagy (CMA) have been implicated in a variety of pathological conditions, such as cancer
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HSP90AB1 as the Druggable Target of Maggot Extract Reverses Cisplatin Resistance in Ovarian Cancer Oxidative Med. Cell. Longev. (IF 7.31) Pub Date : 2023-5-2 Daojuan Wang, Xun Tang, Jianguo Ruan, Zhengquan Zhu, Rong Wang, Yajing Weng, Yaling Zhang, Tingyu Wang, Ying Huang, Hongwei Wang, Zhenzi Su, Xiaoke Wu, Gaojian Tao, Yong Wang
Cisplatin resistance is a crucial factor affecting ovarian cancer patient’s survival rate, but the primary mechanism underlying cisplatin resistance in ovarian cancer remains unclear, and this prevents the optimal use of cisplatin therapy. Maggot extract (ME) is used in traditional Chinese medicine for patients with comas and patients with gastric cancer when combined with other drug treatments. In
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Redox Systems Biology in Chronic Kidney Disease. Oxidative Med. Cell. Longev. (IF 7.31) Pub Date : 2023-05-03 Stefanos Roumeliotis,Vassilios Liakopoulos,Andrej Veljkovic,Evangelia Dounousi
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Substance P-Mediated Vascular Protection Ameliorates Bone Loss Oxidative Med. Cell. Longev. (IF 7.31) Pub Date : 2023-4-29 Doyoung Kim, Jiyuan Piao, Jeong Seop Park, Dahyun Lee, Dae Yeon Hwang, Hyun Sook Hong
Estrogen deficiency causes bone loss via diverse pathological cellular events. The involvement of the vasculature in bone formation has been widely studied, and type H vasculature has been found to be closely related to bone healing. Ovariectomy- (OVX-) induced estrogen deficiency reduces type H vessel density and promotes reduction of bone density. Analysis of early events after OVX showed that estrogen
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Epiisopiloturine, an Alkaloid from Pilocarpus microphyllus, Attenuates LPS-Induced Neuroinflammation by Interfering in the TLR4/NF-κB-MAPK Signaling Pathway in Microglial Cells Oxidative Med. Cell. Longev. (IF 7.31) Pub Date : 2023-4-28 João Antônio Costa de Sousa, Francisco Vinícius Clemente Serra Azul, Ana Bruna de Araújo, Rebeca Colares Tomé, Francisca Raysse Mesquita Silva, Silvânia Maria Mendes de Vasconcelos, Francisco José Rios, Luzia Kalyne Almeida Moreira Leal
Neuroinflammation is present in the pathophysiological mechanisms of several diseases that affect the central nervous system (CNS). Microglia have a prominent role in initiating and sustaining the inflammatory process. Epiisopiloturine (EPI) is an imidazole alkaloid obtained as a by-product of pilocarpine extracted from Pilocarpus microphyllus (jaborandi) and has shown promising anti-inflammatory and
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lncRNA PDCD4-AS1 Promotes the Progression of Glioma by Regulating miR-30b-3p/METTL7B Signaling Oxidative Med. Cell. Longev. (IF 7.31) Pub Date : 2023-4-28 Zuowei Li, Yelin Song, Jimei Zhang
Background. Gliomas are the most common and most malignant primary tumors of the adult central nervous system, but their etiology and pathogenesis remain unclear. This study was aimed at investigating the expression and function of lncRNA PDCD4-AS1 in glioma and elucidating the mechanism by which PDCD4-AS1 regulates the biological features of glioma. Method. The expression of PDCD4-AS1 was determined
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Thymus linearis Extracts Ameliorate Indices of Metabolic Syndrome in Sprague Dawley Rats Oxidative Med. Cell. Longev. (IF 7.31) Pub Date : 2023-4-27 Yamema Younatan, Muhammad Majid, Abdul Rehman Phull, Muhammad Waleed Baig, Nadeem Irshad, Humaira Fatima, Bakht Nasir, Aroosa Zafar, Abdul Majid, Amna Parveen, Ihsan-ul Haq
Ethnopharmacological Relevance. Thymus linearis Benth. in Wall is extensively used and sold in Gilgit Baltistan province of Pakistan for the amelioration of conditions like obesity and diabetes. However, this ethnomedicinal use still lacks any scientific backing. Based upon this traditional use, the present study was designed to scientifically validate its role in the prevention of metabolic syndrome
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Phytosterols Alleviate Hyperlipidemia by Regulating Gut Microbiota and Cholesterol Metabolism in Mice Oxidative Med. Cell. Longev. (IF 7.31) Pub Date : 2023-4-26 Wei-Jie Lv, Jie-Yi Huang, Jin Lin, Yi-Mu Ma, Shi-Qi He, Ying-Wen Zhang, Tian-Ze Wang, Ke Cheng, Ying Xiong, Feng-Gang Sun, Zhong-Chao Pan, Jing-Bo Sun, Wei Mao, Shi-Ning Guo
Phytosterols (PS) have been shown to regulate cholesterol metabolism and alleviate hyperlipidemia (HLP), but the mechanism is still unclear. In this study, we investigated the mechanism by which PS regulates cholesterol metabolism in high-fat diet (HFD) mice. The results showed that PS treatment reduced the accumulation of total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol
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Machine Learning Predicts the Oxidative Stress Subtypes Provide an Innovative Insight into Colorectal Cancer Oxidative Med. Cell. Longev. (IF 7.31) Pub Date : 2023-4-21 Haitao Zhong, Le Yang, Qingshang Zeng, Weidong Chen, Haibo Zhao, Linlin Wu, Lei Qin, Qing-Qing Yu
So far, it has been reached the academic consensus that the molecular subtypes are via genomic heterogeneity and immune infiltration patterns. Considering that oxidative stress (OS) is involved in tumorigenesis and prognosis prediction, we propose an innovative classification of colorectal cancer- (CRC-) OS subtypes. We obtain three datasets from The Cancer Genome Atlas Program (TCGA) and Gene Expression
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The Diagnostic Power of Circulating miR-1246 in Screening Cancer: An Updated Meta-analysis Oxidative Med. Cell. Longev. (IF 7.31) Pub Date : 2023-4-20 Khanh Quang Huynh, Anh Tuan Le, Thang Thanh Phan, Toan Trong Ho, Suong Phuoc Pho, Hang Thuy Nguyen, Binh Thanh Le, Thuc Tri Nguyen, Son Truong Nguyen
Background. MicroRNA-1246 (miR-1246), an oncomiR that regulates the expression of multiple cancer-related genes, has been attracted and studied as a promising indicator of various tumors. However, diverse conclusions on diagnostic accuracy have been shown due to the small sample size and limited studies included. This meta-analysis is aimed at systematically assessing the performance of extracellular
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Role of Gut Microbiota and Oxidative Stress in the Progression of Transplant-Related Complications following Hematopoietic Stem Cell Transplantation Oxidative Med. Cell. Longev. (IF 7.31) Pub Date : 2023-4-18 Mingxuan Chi, Tao Jiang, Xing He, Haoyu Peng, Yunlong Li, Jiong Zhang, Li Wang, Qing Nian, Kuai Ma, Chi Liu
Hematopoietic stem cell transplantation (HSCT), also known as bone marrow transplantation, has curative potential for various hematologic malignancies but is associated with risks such as graft-versus-host disease (GvHD), severe bloodstream infection, viral pneumonia, idiopathic pneumonia syndrome (IPS), lung fibrosis, and sinusoidal obstruction syndrome (SOS), which severely deteriorate clinical outcomes
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α-Synuclein Attenuates Maneb Neurotoxicity through the Modulation of Redox-Sensitive Transcription Factors Oxidative Med. Cell. Longev. (IF 7.31) Pub Date : 2023-4-18 M. A. Conde, N. P. Alza, M. I. Funk, A. Maniscalchi, O. N. Benzi Juncos, I. Berge, R. M. Uranga, G. A. Salvador
The accumulation and aggregation of α-synuclein is a pathognomonic sign of Parkinson’s disease (PD). Maneb (MB) exposure has also been reported as one environmental triggering factor of this multifactorial neurodegenerative disease. In our laboratory, we have previously reported that mild overexpression of α-synuclein (200% increase with respect to endogenous neuronal levels) can confer neuroprotection