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Organelle adaptations in response to mechanical forces during tumour dissemination Curr. Opin. Cell Biol. (IF 7.5) Pub Date : 2024-03-12 Vittoria Graziani, Eva Crosas-Molist, Samantha L. George, Victoria Sanz-Moreno
Cell migration plays a pivotal role in various biological processes including cancer dissemination and successful metastasis, where the role of mechanical signals is increasingly acknowledged. This review focuses on the intricate mechanisms through which cancer cells modulate their migratory strategies via organelle adaptations in response to the extracellular matrix (ECM). Specifically, the nucleus
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Advantages of integrating Brillouin microscopy in multimodal mechanical mapping of cells and tissues Curr. Opin. Cell Biol. (IF 7.5) Pub Date : 2024-03-11 Chenchen Handler, Claudia Testi, Giuliano Scarcelli
Recent research has highlighted the growing significance of the mechanical properties of cells and tissues in the proper execution of physiological functions within an organism; alterations to these properties can potentially result in various diseases. These mechanical properties can be assessed using various techniques that vary in spatial and temporal resolutions as well as applications. Due to
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Engines of change: Nonmuscle myosin II in mechanobiology Curr. Opin. Cell Biol. (IF 7.5) Pub Date : 2024-03-04 Marina Garrido-Casado, Gloria Asensio-Juárez, Vanessa C. Talayero, Miguel Vicente-Manzanares
The emergence of mechanobiology has unveiled complex mechanisms by which cells adjust intracellular force production to their needs. Most communicable intracellular forces are generated by myosin II, an actin-associated molecular motor that transforms adenosine triphosphate (ATP) hydrolysis into contraction in nonmuscle and muscle cells. Myosin II-dependent force generation is tightly regulated, and
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Recent advances in label-free imaging and quantification techniques for the study of lipid droplets in cells Curr. Opin. Cell Biol. (IF 7.5) Pub Date : 2024-02-29 Hyeonwoo Kim, Seungeun Oh, Seongsoo Lee, Kwang suk Lee, YongKeun Park
Lipid droplets (LDs), once considered mere storage depots for lipids, have gained recognition for their intricate roles in cellular processes, including metabolism, membrane trafficking, and disease states like obesity and cancer. This review explores label-free imaging techniques' applications in LD research. We discuss holotomography and vibrational spectroscopic microscopy, emphasizing their potential
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Neurofilaments: Novel findings and future challenges Curr. Opin. Cell Biol. (IF 7.5) Pub Date : 2024-02-23 Jessy V. van Asperen, Farah Kotaich, Damien Caillol, Pascale Bomont
Neurofilaments (NFs) are abundant cytoskeletal proteins that emerge as a critical hub for cell signalling within neurons. As we start to uncover essential roles of NFs in regulating microtubule and organelle dynamics, nerve conduction and neurotransmission, novel discoveries are expected to arise in genetics, with NFs identified as causal genes for various neurodegenerative diseases. This review will
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GFAP-isoforms in the nervous system: Understanding the need for diversity Curr. Opin. Cell Biol. (IF 7.5) Pub Date : 2024-02-23 Alexandra J.E.M. de Reus, Onur Basak, Werner Dykstra, Jessy V. van Asperen, Emma J. van Bodegraven, Elly M. Hol
Glial fibrillary acidic protein (GFAP) is an intermediate filament (IF) protein expressed in specific types of glial cells in the nervous system. The expression of GFAP is highly regulated during brain development and in neurological diseases. The presence of distinct GFAP-isoforms in various cell types, developmental stages, and diseases indicates that GFAP (post-)transcriptional regulation has a
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Editorial overview: Functional specialization of the cytoskeleton in diverse cell types Curr. Opin. Cell Biol. (IF 7.5) Pub Date : 2024-02-23 Adele L. Marston, Matthew J. Tyska
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Cytoskeletal crosstalk: A focus on intermediate filaments Curr. Opin. Cell Biol. (IF 7.5) Pub Date : 2024-02-14 Lucas Pradeau-Phélut, Sandrine Etienne-Manneville
The cytoskeleton, comprising actin microfilaments, microtubules, and intermediate filaments, is crucial for cell motility and tissue integrity. While prior studies largely focused on individual cytoskeletal networks, recent research underscores the interconnected nature of these systems in fundamental cellular functions like adhesion, migration, and division. Understanding the coordination of these
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Nuclear mechanotransduction on skin stem cell fate regulation Curr. Opin. Cell Biol. (IF 7.5) Pub Date : 2024-02-10 Leah C. Biggs, Yekaterina A. Miroshnikova
Mammalian skin is a highly dynamic and regenerative organ that has long been recognized as a mechanically active composite of tissues withstanding daily compressive and tensile forces that arise from body movement. Importantly, cell- and tissue-scale mechanical signals are critical regulators of skin morphogenesis and homeostasis. These signals are sensed at the cellular periphery and transduced by
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Cell competition and the regulation of protein homeostasis Curr. Opin. Cell Biol. (IF 7.5) Pub Date : 2024-02-01 Shruthi Krishnan, Pranab K. Paul, Tristan A. Rodriguez
The process of embryonic development involves remarkable cellular plasticity, which governs the coordination between cells necessary to build an organism. One role of this plasticity is to ensure that when aberrant cells are eliminated, growth adjustment occurs so that the size of the tissue is maintained. An important regulator of cellular plasticity that ensures cellular cooperation is a fitness-sensing
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Mechanotransduction through protein stretching Curr. Opin. Cell Biol. (IF 7.5) Pub Date : 2024-01-31 Yanyu Guo, Jie Yan, Benjamin T. Goult
Cells sense and respond to subtle changes in their physicality, and via a myriad of different mechanosensitive processes, convert these physical cues into chemical and biochemical signals. This process, called mechanotransduction, is possible due to a highly sophisticated machinery within cells. One mechanism by which this can occur is via the stretching of mechanosensitive proteins. Stretching proteins
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Forced back into shape: Mechanics of epithelial wound repair Curr. Opin. Cell Biol. (IF 7.5) Pub Date : 2024-01-30 Shu En Lim, Pablo Vicente-Munuera, Yanlan Mao
Wound repair, the closing of a hole, is inherently a physical process that requires the change of shape of materials, in this case, cells and tissues. Not only is efficient and accurate wound repair critical for restoring barrier function and reducing infection, but it is also critical for restoring the complex three-dimensional architecture of an organ. This re-sculpting of tissues requires the complex
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Lamins: The backbone of the nucleocytoskeleton interface Curr. Opin. Cell Biol. (IF 7.5) Pub Date : 2024-01-22 Joan M. Sobo, Nicholas S. Alagna, Sean X. Sun, Katherine L. Wilson, Karen L. Reddy
The nuclear lamina (NL) is a crucial component of the inner nuclear membrane (INM) and consists of lamin filaments and associated proteins. Lamins are type V intermediate filament proteins essential for maintaining the integrity and mechanical properties of the nucleus. In human cells, ‘B-type’ lamins (lamin B1 and lamin B2) are ubiquitously expressed, while ‘A-type’ lamins (lamin A, lamin C, and minor
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All the small things: Nanoscale matrix alterations in aging tissues Curr. Opin. Cell Biol. (IF 7.5) Pub Date : 2024-01-25 Avery Rui Sun, Ranmadusha M. Hengst, Jennifer L. Young
Cellular aging stems from multifaceted intra- and extracellular molecular changes that lead to the gradual deterioration of biological function. Altered extracellular matrix (ECM) properties that include biochemical, structural, and mechanical perturbations direct cellular- and tissue-level dysfunction. With recent advancements in high-resolution imaging modalities and nanomaterial strategies, the
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Cellular stress management by caspases Curr. Opin. Cell Biol. (IF 7.5) Pub Date : 2024-01-11 Luis Alberto Baena-Lopez, Li Wang, Franz Wendler
Cellular stress plays a pivotal role in the onset of numerous human diseases. Consequently, the removal of dysfunctional cells, which undergo excessive stress-induced damage via various cell death pathways, including apoptosis, is essential for maintaining organ integrity and function. The evolutionarily conserved family of cysteine-aspartic-proteases, known as caspases, has been a key player in orchestrating
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Engineering physiological environments to advance kidney organoid models from human pluripotent stem cells Curr. Opin. Cell Biol. (IF 7.5) Pub Date : 2024-01-09 Anisha Pahuja, Iphigénie Goux Corredera, Daniel Moya-Rull, Elena Garreta, Nuria Montserrat
During embryogenesis, the mammalian kidney arises because of reciprocal interactions between the ureteric bud (UB) and the metanephric mesenchyme (MM), driving UB branching and nephron induction. These morphogenetic processes involve a series of cellular rearrangements that are tightly controlled by gene regulatory networks and signaling cascades. Here, we discuss how kidney developmental studies have
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Local cellular interactions: From signaling to mechanics across development, evolution, and disease Curr. Opin. Cell Biol. (IF 7.5) Pub Date : 2024-01-12 Anna Bigas, David Sprinzak
Abstract not available
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Membrane fusion and fission during eukaryogenesis Curr. Opin. Cell Biol. (IF 7.5) Pub Date : 2024-01-14 Héctor Romero, Pablo S. Aguilar, Martin Graña, Mauricio Langleib, Virginia Gudiño, Benjamin Podbilewicz
All eukaryotes can be traced back to a single shared ancestral lineage that emerged from interactions between different prokaryotic cells. Current models of eukaryogenesis describe various selective forces and evolutionary mechanisms that contributed to the formation of eukaryotic cells. Central to this process were significant changes in cellular structure, resulting in the configuration of a new
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Scaling the cellular frontier: Mechanobiology, tissue dynamics and function Curr. Opin. Cell Biol. (IF 7.5) Pub Date : 2024-01-11 JoAnn Trejo, Giorgio Scita
Abstract not available
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Recent developments in membrane traffic and lipid dynamics Curr. Opin. Cell Biol. (IF 7.5) Pub Date : 2024-01-11 Aurélien Roux, Karin Reinisch
Abstract not available
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Decoding the cell nucleus Curr. Opin. Cell Biol. (IF 7.5) Pub Date : 2024-01-13 Hiroshi Kimura, Melike Lakadamyali
Abstract not available
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Jagged-mediated development and disease: Mechanistic insights and therapeutic implications for Alagille syndrome Curr. Opin. Cell Biol. (IF 7.5) Pub Date : 2024-01-09 Jan Mašek, Emma R. Andersson
Notch signaling controls multiple aspects of embryonic development and adult homeostasis. Alagille syndrome is usually caused by a single mutation in the jagged canonical Notch ligand 1 (JAG1), and manifests with liver disease and cardiovascular symptoms that are a direct consequence of JAG1 haploinsufficiency. Recent insights into Jag1/Notch-controlled developmental and homeostatic processes explain
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Staying away from the breaking point: Probing the limits of epithelial cell elimination Curr. Opin. Cell Biol. (IF 7.5) Pub Date : 2024-01-09 Romain Levayer
Epithelial tissues are dramatically remodelled during embryogenesis and tissue homeostasis and yet need to maintain their sealing properties to sustain their barrier functions at any time. Part of these remodellings involve the elimination of a large proportion of cells through apoptosis. Cell extrusion, the remodelling steps leading to seamless dying cell expulsion, helps to maintain tissue cohesion
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Extracellular matrix dynamics: A key regulator of cell migration across length-scales and systems Curr. Opin. Cell Biol. (IF 7.5) Pub Date : 2024-01-05 Dharma Pally, Alexandra Naba
The interactions between cells and their surrounding extracellular matrix (ECM) are dynamic and play critical roles in cell migration during development, health, and diseases. Recent advances have highlighted the complexity and diversity of ECM compositions, or “matrisomes”, of tissues resulting in ECMs of different physical, mechanical, and biochemical properties. Investigating the effects of these
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Creative processes during vertebrate organ morphogenesis: Biophysical self-organization at the supracellular scale Curr. Opin. Cell Biol. (IF 7.5) Pub Date : 2024-01-04 Charlotte R. Pfeifer, Amy E. Shyer, Alan R. Rodrigues
Here, we review recent developments in the literature that provide insight into self-organization at supracellular scales in vertebrate organ morphogenesis. We briefly present a historical and conceptual analysis of the term “self-organization.” Based on this analysis, we suggest that self-organizing processes, at their root, possess a form of causal relationship, reciprocal causality, that is markedly
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Cellular spartans at the pass: Emerging intricacies of cell competition in early and late tumorigenesis Curr. Opin. Cell Biol. (IF 7.5) Pub Date : 2024-01-04 Carlos Fernández Moro, Natalie Geyer, Marco Gerling
Cell competition is a mechanism for cellular quality control based on cell–cell comparisons of fitness. Recent studies have unveiled a central and complex role for cell competition in cancer. Early tumors exploit cell competition to replace neighboring normal epithelial cells. Intestinal adenomas, for example, use cell competition to outcompete wild-type epithelial cells. However, oncogenic mutations
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Pulling the strings on solid-to-liquid phase transitions in cell collectives Curr. Opin. Cell Biol. (IF 7.5) Pub Date : 2024-01-04 Diana Pinheiro, Jennifer Mitchel
Cell collectives must dynamically adapt to different biological contexts. For instance, in homeostatic conditions, epithelia must establish a barrier between body compartments and resist external stresses, while during development, wound healing or cancer invasion, these tissues undergo extensive remodeling. Using analogies from inert, passive materials, changes in cellular density, shape, rearrangements
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Mechanobiology of myeloid cells Curr. Opin. Cell Biol. (IF 7.5) Pub Date : 2024-01-04 Eline Janssen, Koen van den Dries, Maurizio Ventre, Alessandra Cambi
Tissue-resident myeloid cells sense and transduce mechanical signals such as stiffness, stretch and compression. In the past two years, our understanding of the mechanosensitive signalling pathways in myeloid cells has significantly expanded. Moreover, it is increasingly clear which mechanical signals induce myeloid cells towards a pro- or anti-inflammatory phenotype. This is especially relevant in
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Vimentin cage – A double-edged sword in host anti-infection defense Curr. Opin. Cell Biol. (IF 7.5) Pub Date : 2024-01-03 Shuangshuang Zhao, Chenglin Miao, Xuedi Gao, Zhifang Li, John E. Eriksson, Yaming Jiu
Vimentin, a type III intermediate filament, reorganizes into what is termed the ‘vimentin cage’ in response to various pathogenic infections. This cage-like structure provides an envelope to key components of the pathogen's life cycle. In viral infections, the vimentin cage primarily serves as a scaffold and organizer for the replication factory, promoting viral replication. However, it also occasionally
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Lipid nanodomains and receptor signaling: From actin-based organization to membrane mechanics Curr. Opin. Cell Biol. (IF 7.5) Pub Date : 2024-01-01 Changting Li, Yazmina Quintana Perez, Christophe Lamaze, Cedric M. Blouin
The plasma membrane serves as the primary barrier between the cell's interior and its external surroundings, which places it at the forefront of intercellular communication, receptor signal transduction and the integration of mechanical forces from outside. Most of these signals are largely dependent on the plasma membrane heterogeneity which relies on lipid-lipid and lipid-protein interactions and
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Astrocyte signaling and interactions in Multiple Sclerosis Curr. Opin. Cell Biol. (IF 7.5) Pub Date : 2023-12-24 Crystal Colón Ortiz, Cagla Eroglu
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Nuclear roles for non-lamin intermediate filament proteins Curr. Opin. Cell Biol. (IF 7.5) Pub Date : 2023-12-18 Pierre A. Coulombe, Christopher M. Pineda, Justin T. Jacob, Raji R. Nair
The nuclear-localized lamins have long been thought to be the only intermediate filaments (IFs) with an impact on the architecture, properties, and functions of the nucleus. Recent studies, however, uncovered significant roles for IFs other than lamins (here referred to as “non-lamin IFs”) in regulating key properties of the nucleus in various cell types and biological settings. In the cytoplasm, IFs
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Regulation of protein synthesis and stability by mechanical cues and its implications in cancer Curr. Opin. Cell Biol. (IF 7.5) Pub Date : 2023-12-18 Sara Göransson, Staffan Strömblad
Elevated tissue stiffness is a common feature of many solid tumors and the downstream mechanical signaling affects many cellular processes and contributes to cancer progression. Significant progress has been made in understanding how the mechanical properties of the matrix affect cancer cell behavior as well as transcription. However, how the same mechanical cues impact protein synthesis and stability
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Mechanotransduction through membrane tension: It's all about propagation? Curr. Opin. Cell Biol. (IF 7.5) Pub Date : 2023-12-14 Andrea Ghisleni, Nils C. Gauthier
Over the past 25 years, membrane tension has emerged as a primary mechanical factor influencing cell behavior. Although supporting evidences are accumulating, the integration of this parameter in the lifecycle of cells, organs, and tissues is complex. The plasma membrane is envisioned as a bilayer continuum acting as a 2D fluid. However, it possesses almost infinite combinations of proteins, lipids
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Organelle morphology and positioning orchestrate physiological and disease-associated processes Curr. Opin. Cell Biol. (IF 7.5) Pub Date : 2023-12-13 Katerina Jerabkova-Roda, Rituraj Marwaha, Tamal Das, Jacky G. Goetz
In cells, organelles are distributed nonrandomly to regulate cells' physiological and disease-associated processes. Based on their morphology, position within the cell, and contacts with other organelles, they exert different biological functions. Endo-lysosomes are critical cell metabolism and nutrient-sensing regulators modulating cell growth and cellular adaptation in response to nutrient availability
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Autoinhibition and activation of kinesin-1 and their involvement in amyotrophic lateral sclerosis Curr. Opin. Cell Biol. (IF 7.5) Pub Date : 2023-12-13 Kyoko Chiba, Shinsuke Niwa
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Compartmentalization, cooperation, and communication: The 3Cs of Hepatocyte zonation Curr. Opin. Cell Biol. (IF 7.5) Pub Date : 2023-12-07 Natalie Porat-Shliom
The unique architecture of the liver allows for spatial compartmentalization of its functions, also known as liver zonation. In contrast to organelles and cells, this compartment is devoid of a surrounding membrane, rendering traditional biochemical tools ineffective for studying liver zonation. Recent advancements in tissue imaging and single-cell technologies have provided new insights into the complexity
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Cell cycle control by cell-matrix interactions Curr. Opin. Cell Biol. (IF 7.5) Pub Date : 2023-12-05 Michael J. Jones, Matthew C. Jones
Cell adhesion to the extracellular matrix (ECM) is required for normal cell cycle progression and accurate cell division. However, how cell adhesion to the wide range of ECM proteins found in human tissues influences the cell cycle is not fully understood. The composition and physical properties of the ECM can have profound effects on cell proliferation but can also promote cell cycle exit and quiescence
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The ubiquitous nanocluster: A molecular scale organizing principle that governs cellular information flow Curr. Opin. Cell Biol. (IF 7.5) Pub Date : 2023-12-06 Maria F. Garcia-Parajo, Satyajit Mayor
The language of biology at the scale of the cell is constituted of alphabets represented by biomolecules. These are stitched together in a variety of ways to create meaning. We argue that the phrases of this language are nanoscale molecular assemblies or nano-hubs for the purpose of information flow. At the cell surface information is sensed and processed via membrane receptors, often configured as
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AAA ATPase protein–protein interactions as therapeutic targets in cancer Curr. Opin. Cell Biol. (IF 7.5) Pub Date : 2023-12-05 Dhiraj Mannar, Sana Ahmed, Sriram Subramaniam
AAA ATPases are a conserved group of enzymes that couple ATP hydrolysis to diverse activities critical for cellular homeostasis by targeted protein–protein interactions. Some of these interactions are potential therapeutic targets because of their role in cancers which rely on increased AAA ATPase activities for maintenance of genomic stability. Two well-characterized members of this family are p97/VCP
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Cytoskeletal dynamics in parasites Curr. Opin. Cell Biol. (IF 7.5) Pub Date : 2023-12-03 Simone Reber, Mirko Singer, Friedrich Frischknecht
Cytoskeletal dynamics are essential for cellular homeostasis and development for both metazoans and protozoans. The function of cytoskeletal elements in protozoans can diverge from that of metazoan cells, with microtubules being more stable and actin filaments being more dynamic. This is particularly striking in protozoan parasites that evolved to enter metazoan cells. Here, we review recent progress
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How nuclear envelope dynamics can direct laminopathy phenotypes Curr. Opin. Cell Biol. (IF 7.5) Pub Date : 2023-12-03 David van Heerden, Stefanie Klima, Iman van den Bout
The nuclear envelope separates the genome from the cytoplasmic environment. However, the nuclear envelope is also physically associated with the genome and exerts influence on gene expression and genome modification. The nucleus is dynamic, changing shape and responding to cell movement, disassembling and assembling during cell division, and undergoing rupture and repair. These dynamics can be impacted
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Mechanisms and functions of multiciliary coordination Curr. Opin. Cell Biol. (IF 7.5) Pub Date : 2023-11-30 Kirsty Y. Wan, Rebecca N. Poon
Ciliated organisms are present in virtually every branch of the eukaryotic tree of life. In diverse systems, cilia operate in a coordinated manner to drive fluid flows, or even propel entire organisms. How do groups of motile cilia coordinate their activity within a cell or across a tissue to fulfil essential functions of life? In this review, we highlight the latest developments in our understanding
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Microtubule control of migration: Coordination in confinement Curr. Opin. Cell Biol. (IF 7.5) Pub Date : 2023-12-01 Christanny J. Schmidt, Samantha J. Stehbens
The microtubule cytoskeleton has a well-established, instrumental role in coordinating cell migration. Decades of research has focused on understanding how microtubules couple intracellular trafficking with cortical targeting and spatial organization of signaling to facilitate locomotion. Movement in physically challenging environments requires coordination of forces generated by the actin cytoskeleton
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Disturbed endothelial cell signaling in tumor progression and therapy resistance Curr. Opin. Cell Biol. (IF 7.5) Pub Date : 2023-11-28 Andreas Fischer, Elisenda Alsina-Sanchis
Growth of new blood vessels is considered requisite to cancer progression. Recent findings revealed that in addition to inducing angiogenesis, tumor-derived factors alter endothelial cell gene transcription within the tumor mass but also systemically throughout the body. This subsequently contributes to immunosuppression, altered metabolism, therapy resistance and metastasis. Clinical studies demonstrated
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The keratin-desmosome scaffold of internal epithelia in health and disease – The plot is thickening Curr. Opin. Cell Biol. (IF 7.5) Pub Date : 2023-11-24 Diana M. Toivola, Lauri Polari, Tobias Schwerd, Nicolas Schlegel, Pavel Strnad
Keratin (K) intermediate filaments are attached to desmosomes and constitute the orchestrators of epithelial cell and tissue architecture. While their relevance in the epidermis is well recognized, our review focuses on their emerging importance in internal epithelia. The significance of keratin-desmosome scaffolds (KDSs) in the intestine is highlighted by transgenic mouse models and individuals with
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Stress-protecting harbors for hematopoietic stem cells Curr. Opin. Cell Biol. (IF 7.5) Pub Date : 2023-11-23 Zhe Yang, Ruochen Dong, Xinjian Mao, Xi C. He, Linheng Li
Hematopoietic stem cells (HSCs) rely on specialized microenvironments known as niches to maintain their self-renewal and multilineage potential to generate diverse types of blood cells continuously. Over the last two decades, substantial advancements have been made in unraveling the niche cell components and HSC localizations under homeostatic and stressed circumstances. Advances in imaging, combined
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The redox-responsive roles of intermediate filaments in cellular stress detection, integration and mitigation Curr. Opin. Cell Biol. (IF 7.5) Pub Date : 2023-11-20 Dolores Pérez-Sala, Roy A. Quinlan
Intermediate filaments are critical for cell and tissue homeostasis and for stress responses. Cytoplasmic intermediate filaments form versatile and dynamic assemblies that interconnect cellular organelles, participate in signaling and protect cells and tissues against stress. Here we have focused on their involvement in redox signaling and oxidative stress, which arises in numerous pathophysiological
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Transmit and protect: The mechanical functions of intermediate filaments Curr. Opin. Cell Biol. (IF 7.5) Pub Date : 2023-11-18 Katarzyna Pogoda, Paul A Janmey
New aspects of the unique mechanical properties of intermediate filaments (IFs) continue to emerge from studies that illuminate the structure and mechanical response of single filaments, the interaction of intermediate filaments with each other or with other cytoskeletal elements, and the viscoelasticity of the networks that these intermediate filaments form. The relation of purified IF network mechanics
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Drivers of heterogeneity in the glioblastoma immune microenvironment Curr. Opin. Cell Biol. (IF 7.5) Pub Date : 2023-11-18 Alina Brosque, Dinorah Friedmann-Morvinski
Glioblastoma is the most common and aggressive primary brain tumor, characterized by a highly complex and heterogeneous tumor immune microenvironment (TIME). In this review, we discuss the impact of tumor-intrinsic and tumor-extrinsic drivers that contribute to heterogeneity in the adult glioblastoma TIME, focusing on four main factors: genetic drivers, sex, age, and standard of care therapy. We describe
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Cytoplasm mechanics and cellular organization Curr. Opin. Cell Biol. (IF 7.5) Pub Date : 2023-11-16 María Isabel Arjona, Javad Najafi, Nicolas Minc
As cells organize spatially or divide, they translocate many micron-scale organelles in their cytoplasm. These include endomembrane vesicles, nuclei, microtubule asters, mitotic spindles, or chromosomes. Organelle motion is powered by cytoskeleton forces but is opposed by viscoelastic forces imparted by the surrounding crowded cytoplasm medium. These resistive forces associated to cytoplasm physcial
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Intermediate filaments in the heart: The dynamic duo of desmin and lamins orchestrates mechanical force transmission Curr. Opin. Cell Biol. (IF 7.5) Pub Date : 2023-11-15 Gun West, Sogol Sedighi, Giulio Agnetti, Pekka Taimen
The intermediate filament (IF) cytoskeleton supports cellular structural integrity, particularly in response to mechanical stress. The most abundant IF proteins in mature cardiomyocytes are desmin and lamins. The desmin network tethers the contractile apparatus and organelles to the nuclear envelope and the sarcolemma, while lamins, as components of the nuclear lamina, provide structural stability
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Roles of ESCRT-III polymers in cell division across the tree of life Curr. Opin. Cell Biol. (IF 7.5) Pub Date : 2023-11-08 Jeremy Graham Carlton, Buzz Baum
Every cell becomes two through a carefully orchestrated process of division. Prior to division, contractile machinery must first be assembled at the cell midzone to ensure that the cut, when it is made, bisects the two separated copies of the genetic material. Second, this contractile machinery must be dynamically tethered to the limiting plasma membrane so as to bring the membrane with it as it constricts
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Cadherin-linked morphogen gradient actualizes robust tissue patterning Curr. Opin. Cell Biol. (IF 7.5) Pub Date : 2023-11-07 Tohru Ishitani
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Exploring the dynamic behavior of leukocytes with zebrafish Curr. Opin. Cell Biol. (IF 7.5) Pub Date : 2023-11-11 Cassia Michael, Sofia de Oliveira
Cell migration is a complex and intricate network of physical, chemical, and molecular events that ultimately leads to cell motility. This phenomenon is involved in both physiological and pathological processes such as proper immune and inflammatory responses. Dysregulation of cell migration machinery in immune cells can have a tremendous impact on the trajectory of inflammation, infection, and resolution
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Posttranslational modifications of keratins and their associated proteins as therapeutic targets in keratin diseases Curr. Opin. Cell Biol. (IF 7.5) Pub Date : 2023-11-03 Pei Li, Katrin Rietscher, Henriette Jopp, Thomas M. Magin, M. Bishr Omary