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LncRNA NEAT1 in the pathogenesis of liver‐related diseases Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-04-16 Raed Obaid Saleh, Adnan Taan Alkhafaji, Jaafaru Sani Mohammed, Pooja Bansal, Harpreet Kaur, Irfan Ahmad, Ahmed Hjazi, Israa Hussein Mohammed, Mohammed Abed Jawad, Ahmed Hussein Zwamel
Nuclear paraspeckle assembly transcript 1 (NEAT1) is a long noncoding RNA (lncRNA) that is widely expressed in a variety of mammalian cell types. Altered expression levels of the lncRNA NEAT1 have been reported in liver‐related disorders including cancer, fatty liver disease, liver fibrosis, viral hepatitis, and hepatic ischemia. lncRNA NEAT1 mostly acts as a competing endogenous RNA (ceRNA) to sponge
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Urolithin A affects cellular migration and modulates matrix metalloproteinase expression in colorectal cancer cells Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-04-16 Mohammad S. El‐Wetidy, Mohamad I. Rady, Islam Rady, Hamed Helal
Colorectal cancer (CRC) is the world's second most common gastrointestinal malignancy. Preventing tumor cell proliferation and dissemination is critical for patient survival. Polyphenols have a variety of health advantages and can help prevent cancer. The current study examined different cellular activities of the gut‐microbiota metabolite urolithin A (UA) on several colon cancer cell lines. The results
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Molecular insights into the potential effects of selective estrogen receptor β agonists in Alzheimer's and Parkinson's diseases Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-04-15 Emdormi Rymbai, Deepa Sugumar, Amritha Chakkittukandiyil, Ram Kothandan, Divakar Selvaraj
Alzheimer's disease (AD) and Parkinson's disease (PD) are the most common neurodegenerative disorders. Pathologically, AD and PD are characterized by the accumulation of misfolded proteins. Hence, they are also called as proteinopathy diseases. Gender is considered as one of the risk factors in both diseases. Estrogens are widely accepted to be neuroprotective in several neurodegenerative disorders
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Expression of concern: LncRNA TUG1 facilitates proliferation, invasion and stemness of ovarian cancer cell via miR‐186‐5p/ZEB1 axis Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-04-13
Zhan F-L, Chen C-F, Yao M-Z. LncRNA TUG1 facilitates proliferation, invasion and stemness of ovarian cancer cell via miR-186-5p/ZEB1 axis. Cell Biochem Funct. 2020; 38: 1069–1078. https://doi.org/10.1002/cbf.3544 This Expression of Concern is for the above article, published online on 11 May 2020 in Wiley Online Library (wileyonlinelibrary.com), and has been published by agreement between the journal's
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Therapeutic benefit of oregano oil in the acute idiosyncratic hepatotoxicity induced by carbon tetrachloride in rats: Adverse effects of high dose of oreganum Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-04-13 Damir Suljević, Muhamed Fočak, Rifat Škrijelj, Maja Mitrašinović‐Brulić
Toxicity caused by carbon tetrachloride (CCl4) can lead to serious liver injury. The aim of the study is to investigate the protective effects of oregano oil (Origanum minutiflorum extract oil) against CCl4‐induced liver injury. Two doses of oregano oil were used in the experiment: a low dose (LD; 20 mg/kg) and a high dose (HD; 60 mg/kg) during 2 weeks. CCl4 caused severe liver damage, nucleolus destruction
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Single dose human perinatal stem cells accelerate healing of cold‐induced rat burn wound Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-04-13 Fatima Jameel, Irfan Khan, Tuba Shakil Malick, Rida‐e‐Maria Qazi, Midhat Batool Zaidi, Asmat Salim, Enam A. Khalil
Temporal phases of wound healing and their corresponding healing factors are essential in wound regeneration. Mesenchymal stem cells (MSCs) accelerate wound healing via their paracrine secretions by enhancing cell migration, angiogenesis, and reducing inflammation. This study evaluated the local therapeutic effect of human umbilical cord MSCs (hUCMSCs) in the healing of cold‐induced burn wounds. An
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Adenosine increases PD‐L1 expression in mesenchymal stromal cells derived from cervical cancer through its interaction with A2AR/A2BR and the production of TGF‐β1 Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-04-13 Luis Antonio Marín‐Aquino, María de Lourdes Mora‐García, Martha C. Moreno‐Lafont, Rosario García‐Rocha, Juan José Montesinos‐Montesinos, Ruben López‐Santiago, Luvia Enid Sánchez‐Torres, Daniela Berenice Torres‐Pineda, Benny Weiss‐Steider, Jorge Hernández‐Montes, Christian Azucena Don‐López, Alberto Monroy‐García
Mesenchymal stromal cells (MSCs) together with malignant cells present in the tumor microenvironment (TME), participate in the suppression of the antitumor immune response through the production of immunosuppressive factors, such as transforming growth factor beta 1 (TGF‐β1). In previous studies, we reported that adenosine (Ado), generated by the adenosinergic activity of cervical cancer (CeCa) cells
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EH domain‐containing protein 2 (EHD2): Overview, biological function, and therapeutic potential Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-04-13 Guoqiang Zhu, Hu Zhang, Min Xia, Yiqi Liu, Mingyong Li
EH domain‐containing protein 2 (EHD2) is a member of the EHD protein family and is mainly located in the plasma membrane, but can also be found in the cytoplasm and endosomes. EHD2 is also a nuclear‐cytoplasmic shuttle protein. After entering the cell nuclear, EHD2 acts as a corepressor of transcription to inhibit gene transcription. EHD2 regulates a series of biological processes. As a key regulator
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Functions of HP1 in preventing chromosomal instability Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-04-11 Zexian Ding, Lei Peng, Jinghua Zeng, Kejia Yuan, Yan Tang, Qi Yi
Chromosomal instability (CIN), caused by errors in the segregation of chromosomes during mitosis, is a hallmark of many types of cancer. The fidelity of chromosome segregation is governed by a sophisticated cellular signaling network, one crucial orchestrator of which is Heterochromatin protein 1 (HP1). HP1 dynamically localizes to distinct sites at various stages of mitosis, where it regulates key
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Atypical chemokine receptor 4 (ACKR4/CCX‐CKR): A comprehensive exploration across physiological and pathological landscapes in contemporary research Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-04-10 Israa Habeeb Naser, Asia Ali Hamza, Ahmed Alhili, Ahmed Naser Faisal, Mohammed Shnain Ali, Noor Abdulaala Kadhim, Muath Suliman, Mohammad Y. Alshahrani, Ahmed Alawadi
Atypical chemokine receptor 4 (ACKR4), also known as CCX‐CKR, is a member of the chemokine receptor family that lacks typical G protein signaling activity. Instead, ACKR4 functions as a scavenger receptor that can bind and internalize a wide range of chemokines, influencing their availability and activity in the body. ACKR4 is involved in various physiological processes, such as immune cell trafficking
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Inhibition of neuronal pentraxin 2 relieved epileptic seizure via reducing GluA1 phosphorylation Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-04-10 Mengnan Xing, Xinlei Yang, Sinan Jin, Xiangping Xu
Neuronal pentraxin 2 (Nptx2), a member of the synaptic protein family linked to excitatory synaptic formation, is found to be upregulated in epileptic mice, yet its role in epilepsy has been unclear. In vivo, we constructed a mouse model of epilepsy by using kainic acid induction. In vitro experiments, a Mg2+‐free medium was used to induce epileptiform discharges in neurons. The results showed that
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Cell viability and cytotoxicity assays: Biochemical elements and cellular compartments Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-04-09 Lefsih Khalef, Radja Lydia, Khettar Filicia, Berkoud Moussa
Cell viability and cytotoxicity assays play a crucial role in drug screening and evaluating the cytotoxic effects of various chemicals. The quantification of cell viability and proliferation serves as the cornerstone for numerous in vitro assays that assess cellular responses to external factors. In the last decade, several studies have developed guidelines for defining and interpreting cell viability
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Expression of semaphorin‐3A in the joint and role in osteoarthritis Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-04-08 Xiang Li, Sara Martinez‐Ramos, Freija T. Heedge, Andrew Pitsillides, George Bou‐Gharios, Blandine Poulet, Chantal Chenu
Osteoarthritis (OA) is characterised by the deterioration of cartilage in the joints and pain. We hypothesise that semaphorin‐3A (sema‐3A), a chemorepellent for sensory nerves, plays a role in joint degradation and pain. We used the mechanical joint loading (MJL) model of OA to investigate sema‐3A expression in the joint and examine its association with the development of OA and pain. We also analyse
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A narrative review on therapeutic potential of naringenin in colorectal cancer: Focusing on molecular and biochemical processes Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-04-07 Mohammad Yasin Zamanian, Maryam Golmohammadi, Bekhzod Abdullaev, María Olalla García, Adeeb Abdulally Abdulhussien Alazbjee, Abhinav Kumar, Sameer S. Mohaamed, Beneen M. Hussien, Fattaneh Khalaj, Seyede Mahsa Hodaei, Niyousha Shirsalimi, Gervason Moriasi
Colorectal cancer (CRC) is a common and highly metastatic cancer affecting people worldwide. Drug resistance and unwanted side effects are some of the limitations of current treatments for CRC. Naringenin (NAR) is a naturally occurring compound found in abundance in various citrus fruits such as oranges, grapefruits, and tomatoes. It possesses a diverse range of pharmacological and biological properties
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Icariin alleviates renal inflammation and tubulointerstitial fibrosis via Nrf2‐mediated attenuation of mitochondrial damage Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-04-07 Nannan Ding, Shanyue Sun, Shuting Zhou, Zhimei Lv, Rong Wang
Tubulointerstitial fibrosis is an inevitable consequence of all progressive chronic kidney disease (CKD) and contributes to a substantial health burden worldwide. Icariin, an active flavonoid glycoside obtained from Epimedium species, exerts potential antifibrotic effect. The study aimed to explore the protective effects of icariin against tubulointerstitial fibrosis in unilateral ureteral obstruction
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A novel method for enrichment of Morganella morganii in fecal samples using designed culture medium Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-04-07 Rekha Jalandra, Nishu Dalal, Anand Mohan, Pratima Rathi Solanki, Anil Kumar
Morganella morganii is a gram negative, facultative anaerobic rod‐shaped bacterium, commonly found in environment and in the intestine of human, mammals, and reptiles as a part of their gut microbiome. M. morganii can cause Gram‐negative folliculitis, black nail infection, acute retiform purpura, fetal demise, and subdural empyema. The increasing frequency of M. morganii infections generate the need
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Effects of down‐regulated carbonic anhydrase 8 on cell survival and glucose metabolism in human colorectal cancer cell lines Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-04-04 Cheng‐Yen Wu, Jia‐Yo Yu, Yi‐Shan Chen, Hui‐Ping Chang, Benjamin Y. Hsieh, Yu‐Hsin Lin, Chung‐Yung Ma, Shang‐Feng Tsai, Mingli Hsieh
Carbonic anhydrase 8 (CA8) is a member of the α‐carbonic anhydrase family but does not catalyze the reversible hydration of carbon dioxide. In the present study, we examined the effects of CA8 on two human colon cancer cell lines, SW480 and SW620, by suppressing CA8 expression through shRNA knockdown. Our results showed that knockdown of CA8 decreased cell growth and cell mobility in SW620 cells, but
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The value of intratumoral microbiota in the diagnosis and prognosis of tumors Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-04-04 Lujia Zhou, Wenjie Zhang, Shiying Fan, Daorong Wang, Dong Tang
Intratumoral microbiota (ITM) are microorganisms present in tumor cells. ITM participate in tumor development by affecting tumor cells directly and the tumor microenvironment (TME), indirectly. Alterations in ITM instigate changes in tumor DNA, activate oncogenic pathways, induce tumor inflammatory responses, disrupt normal immune activity, and facilitate the secretion of effectors leading to tumor
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SOX9 promotes stemness in the CAL27 cell line of tongue squamous cell carcinoma Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-04-03 Nanning Sheng, Rong Fu, Chuhuan Zhou, Ying Li, Yawei Fan, Jue Wang, Xinrong Nan
Tongue squamous cell carcinoma (TSCC) is a prevalent form of oral malignancy, with increasing incidence. Unfortunately, the 5‐year survival rate for patients has not exceeded 50%. Studies have shown that sex‐determining region Y box 9 (SOX9) correlates with malignancy and tumor stemness in a variety of tumors. To investigate the role of SOX9 in TSCC stemness, we analyzed its influence on various aspects
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PDP1 promotes the progression of breast cancer through STAT3 pathway Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-04-03 Yufeng Wang, Huifen Dang, Hui Qiao, Yinxia Tian, Quanlin Guan
This study aimed to investigate the expression pattern and mechanisms of Pyruvate Dehydrogenase Phosphatase Catalytic Subunit 1 (PDP1) in the progression of breast cancer (BC). PDP1, known for its involvement in cell energy metabolism, was found to be overexpressed in BC tissues. Notably, low PDP1 expression aligns with improved overall survival (OS) in BC patients. In this study, we found that PDP1
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The PI3K/AKT/mTOR signaling pathway in breast cancer: Review of clinical trials and latest advances Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-04-02 Ayda Baghery Saghchy Khorasani, Nasim Hafezi, Mohammad‐Javad Sanaei, Farideh Jafari‐Raddani, Atieh Pourbagheri‐Sigaroodi, Davood Bashash
Breast cancer (BC) is the most commonly diagnosed cancer and the leading cause of cancer mortality in women. As the phosphatidylinositol 3‐kinase (PI3K) signaling pathway is involved in a wide range of physiological functions of cells including growth, proliferation, motility, and angiogenesis, any alteration in this axis could induce oncogenic features; therefore, numerous preclinical and clinical
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Epitranscriptomic orchestrations: Unveiling the regulatory paradigm of m6A, A‐to‐I editing, and m5C in breast cancer via long noncoding RNAs and microRNAs Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-04-02 Qinan Yin, Zhifeng Qu, Regina Mathew, Li Zeng, Zhe Du, Yun Xue, Dechun Liu, Xuewei Zheng
Breast cancer (BC) poses a persistent global health challenge, particularly in countries with elevated human development indices linked to factors such as increased life expectancy, education, and wealth. Despite therapeutic progress, challenges persist, and the role of epitranscriptomic RNA modifications in BC remains inadequately understood. The epitranscriptome, comprising diverse posttranscriptional
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Immunomodulation in allergic rhinitis: Insights from Th2 cells and NLRP3/IL‐18 pathway Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-03-31 Xiaoyan Hu, Shuang Liu, Zhang Jing, Yuxiao He, Gang Qin, Liang Jiang
Allergic rhinitis (AR) is characterized by nasal symptoms such as rubbing and sneezing, often triggered by allergen exposure. The purpose of this study is to dissect the roles of NLRP3‐mediated immune modulation and macrophage pyroptosis in modulating T cell differentiation within the context of ovalbumin (OVA)‐induced AR in mice. OVA‐induced AR was established in mice, evaluating nasal symptoms, macrophage
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Nucleic acid vaccines‐based therapy for triple‐negative breast cancer: A new paradigm in tumor immunotherapy arena Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-03-29 Raed Obaid Saleh, Fatma M. Ibrahim, Harikumar Pallathadka, Irwanjot Kaur, Irfan Ahmad, Saad Hayif Jasim Ali, Ahmed Huseen Redhee, Pallavi Ghildiyal, Mohammed Abed Jawad, Salim B. Alsaadi
Nucleic acid vaccines (NAVs) have the potential to be economical, safe, and efficacious. Furthermore, just the chosen antigen in the pathogen is the target of the immune responses brought on by NAVs. Triple‐negative breast cancer (TNBC) treatment shows great promise for nucleic acid‐based vaccines, such as DNA (as plasmids) and RNA (as messenger RNA [mRNA]). Moreover, cancer vaccines offer a compelling
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Recent progress of atmospheric and room‐temperature plasma as a new and promising mutagenesis technology Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-03-27 Dongao Li, Jie Shen, Qiang Ding, Jinyong Wu, Xiangsong Chen
At present, atmospheric and room‐temperature plasma (ARTP) is regarded as a new and powerful mutagenesis technology with the advantages of environment‐friendliness, operation under mild conditions, and fast mutagenesis speed. Compared with traditional mutagenesis strategies, ARTP is used mainly to change the structure of microbial DNA, enzymes, and proteins through a series of physical, chemical, and
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Malignance‐restriction activity exhibited by bioactive compounds of selected actinobacteria as silver nanoparticles against A549 lung cancer cell lines Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-03-27 Naushin Bano, Anamika Gupta, Mohammad Amir, Mohd. Rehan Zaheer, Roohi Roohi
This article deals with the antibacterial and anticancer potential of secondary metabolites produced by actinomycetes also reported as actinobacteria, Microbacterium proteolyticum (MN560041), and Streptomycetes rochei, where preliminary studies were done with the well diffusion method. These actinobacteria's silver nanoparticles were synthesized and characterized using transmission electron microscopy
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Therapeutic significance of long noncoding RNAs in estrogen receptor‐positive breast cancer Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-03-27 Abdullah Ali Alzahrani, Raed Obaid Saleh, Amaliya latypova, Dmitry Olegovich Bokov, Anaheed Hussein Kareem, Hayder Abdullah Talib, Noora M. Hameed, Atreyi Pramanik, Ahmed Alawadi, Ali Alsalamy
About 70% of cases of breast cancer are compromised by Estrogen‐positive breast cancer. Through its regulation of several processes, including cell proliferation, cell cycle progression, and apoptosis, Estrogen signaling plays a pivotal role in the genesis and progression of this particular kind of breast cancer. One of the best treatment strategies for treating Estrogen‐positive breast cancer is blocking
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Nucleic acid‐based vaccine for ovarian cancer cells; bench to bedside Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-03-22 Sulieman Ibraheem Shelash Al‐Hawary, Saade Abdalkareem Jasim, Ahmed Hjazi, Enwa Felix Oghenemaro, Irwanjot Kaur, Abhinav Kumar, Ahmed Muzahem Al‐Ani, Enas R. Alwaily, Ahmed Huseen Redhee, Yasser Fakri Mustafa
Ovarian cancer continues to be a difficult medical issue that affects millions of individuals worldwide. Important platforms for cancer immunotherapy include checkpoint inhibitors, chimeric antigen receptor T cells, bispecific antibodies, cancer vaccines, and other cell‐based treatments. To avoid numerous infectious illnesses, conventional vaccinations based on synthetic peptides, recombinant subunit
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The association between ferroptosis and autophagy in cardiovascular diseases Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-03-21 Yifan Zhang, Junjun Yang, Chenxi Ouyang, Ning Meng
Autophagy is a process in which cells degrade intracellular substances and play a variety of roles in cells, such as maintaining intracellular homeostasis, preventing cell overgrowth, and removing pathogens. It is highly conserved during the evolution of eukaryotic cells. So far, the study of autophagy is still a hot topic in the field of cytology. Ferroptosis is an iron‐dependent form of cell death
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The interaction between lncRNAs and transcription factors regulating autophagy in human cancers: A comprehensive and therapeutical survey Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-03-21 Saade Abdalkareem Jasim, Yasir Qasim Almajidi, Reyadh R. Al‐Rashidi, Ahmed Hjazi, Irfan Ahmad, Ahmed Hussien Radie Alawadi, Enas R. Alwaily, Hashem O. Alsaab, Ali Haslany, Mohamood Hameed
Autophagy, as a highly conserved cellular process, participates in cellular homeostasis by degradation and recycling of damaged organelles and proteins. Besides, autophagy has been evidenced to play a dual role through cancer initiation and progression. In the early stage, it may have a tumor‐suppressive function through inducing apoptosis and removing damaged cells and organelles. However, late stages
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Tolerogenic probiotics Lactobacillus delbrueckii and Lactobacillus rhamnosus promote anti‐inflammatory profile of macrophages‐derived monocytes of newly diagnosed patients with systemic lupus erythematosus Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-03-21 Zahra Javanmardi, Mahmoud Mahmoudi, Houshang Rafatpanah, Zahra Rezaieyazdi, Abbas Shapouri‐Moghaddam, Parisa Ahmadi, Samaneh Mollazadeh, Nafiseh Sadat Tabasi, Seyed‐Alireza Esmaeili
Systemic lupus erythematosus (SLE) is known as an autoimmune disorder that is characterized by the breakdown of self‐tolerance, resulting in disease onset and progression. Macrophages have been implicated as a factor in the development of SLE through faulty phagocytosis of dead cells or an imbalanced M1/M2 ratio. The study aimed to investigate the immunomodulatory effects of Lactobacillus delbrueckii
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Split Gp41‐1 intein splicing as a model to evaluate the cellular location of the oncosuppressor Maspin in an in vitro model of osteosarcoma Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-03-21 Alessia Mariano, Samuele Di Cristofano, Domenico Raimondo, Anna Scotto d'Abusco
Inteins are proteins involved in the protein splicing mechanism, an autoprocessing event, where sequences (exteins) separated by inteins become ligated each other after recombination. Two kinds of inteins have been described, contiguous inteins and split inteins. The former ones are transcribed and translated as a single peptide along with their exteins, while the latter are fragmented between two
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Cisplatin‐resistance induces lung squamous carcinoma cell growth by nicotine‐mediated α7nAchR/HDAC1/Cyclin D1/pRb cell cycle activation Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-03-20 Leh Rao, Dan Guo, Jia‐Ping Wu
The majority of adenocarcinoma lung cancer is found in nonsmokers. A history of tobacco use is more common in squamous cell carcinoma of the lung. The aim of this study is to identify the cisplatin (CDDP)‐resistance that promotes lung squamous carcinoma cell growth through nicotine‐mediated HDAC1/7nAchR/E2F/pRb cell cycle activation. Squamous cell carcinoma (NCI‐H520 and NCI‐H157) cells were examined
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Establishment and evaluation of detection methods for process‐specific residual host cell protein and residual host cell DNA in biological preparation Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-03-20 Yixiao Tian, Xinyue Wang, Dongyan Shao, Wen Zhao, Renan Chen, Qingsheng Huang
To establish accurate detection methods of process‐specific Escherichia coli residual host cell protein (HCP) and residual host cell DNA (rcDNA) in recombinant biological preparations. Taking the purification process of GLP expressed by E. coli as a specific‐process model, the HCP of empty E. coli was intercepted to immunize mice and rabbits. Using IgG from immunized rabbits as the coating antibody
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The role of fat‐soluble vitamins in efferocytosis Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-03-19 Mona Jamalvandi, Sayyed Saeid Khayyatzadeh, Mohammad Javad Hayati, Seyed Mohammad Gheibihayat
Cell death and the efficient removal of dead cells are two basic mechanisms that maintain homeostasis in multicellular organisms. efferocytosis, which includes four steps recruitment, recognition, binding and signaling, and engulfment. Effectively and quickly removes apoptotic cells from the body. Any alteration in efferocytosis can lead to several diseases, including autoimmune and inflammatory conditions
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POFUT1 and PLAGL2 are characteristic markers of mucinous colorectal cancer associated with MUC2 expression Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-03-19 Masayoshi Monno, Masayo Ogiri, Ryo Seishima, Yoshiyuki Suzuki, Kaoru Hattori, Shimpei Matsui, Kohei Shigeta, Koji Okabayashi, Yuko Kitagawa
Colorectal mucinous adenocarcinoma (MAC) is one of the most lethal histological types of colorectal cancer, and its mechanism of development is not well understood. In this study, we aimed to clarify the molecular characteristics of MAC via in silico analysis using The Cancer Genome Atlas database. The expression of genes on chromosome 20q (Chr20q) was negatively associated with the expression of MUC2
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Yinxieling decoction ameliorates psoriasis by regulating the differentiation and functions of Langerhans cells via the TGF‐β1/PU.1/IL‐23 signal axis Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-03-18 Ning Li, Jiagu Ke, Qihua Yu, Xiong Li, Lipeng Tang, Miaomiao Zhang, Xiaoshu Chai, Qiaoling Wu, Chuanjian Lu, Dinghong Wu
Langerhans cells (LCs) play a critical role in skin immune responses and the development of psoriasis. Yinxieling (YXL) is a representative Chinese herbal medicine for the treatment of psoriasis in South China. It was found to improve psoriasis without obvious side effects in the clinic. Here we attempted to clarify whether and how YXL regulates the differentiation and functions of LCs in Imiquimod
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The regulatory role of autophagy between TAMs and tumor cells Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-03-18 Min Hu, Jiao‐Xiu Fan, Zi‐Yue He, Jun Zeng
Cancer has become a global public health problem and its harmful effects have received widespread attention. Conventional treatments such as surgical resection, radiotherapy and other techniques are applicable to clinical practice, but new drugs are constantly being developed and other therapeutic approaches, such as immunotherapy are being applied. In addition to studying the effects on individual
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Aglycemia induces apoptosis under hypoxic conditions in A549 cells Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-03-17 Yüksel Öğünç Keçeci, Zerrin İncesu
Many of the cancer cells produce energy with accelerated glycolysis and perform lactic acid production even under normoxic conditions called the “Warburg effect”. Metabolism can directly or indirectly regulate the apoptotic mechanism so that cancer cells take advantage of reprogrammed metabolism to avoid apoptosis. The aim of this study is to examine the mechanism of apoptosis by incubating human lung
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Tissue engineering innovations to enhance osseointegration in immediate dental implant loading: A narrative review Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-03-16 Mohammad Saleh Hasani Jebelli, Amir Yari, Nariman Nikparto, Sahar Cheperli, Amirali Asadi, Amirmohammad Arabi Darehdor, Sayna Nezaminia, Dorara Dortaj, Saeed Hasani Mehraban, Lotfollah Kamali Hakim
The demand for efficient and accelerated osseointegration in dental implantology has led to the exploration of innovative tissue engineering strategies. Immediate implant loading reduces treatment duration and necessitates robust osseointegration to ensure long‐term implant success. This review article discusses the current studies of tissue engineering innovations for enhancing osseointegration in
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Dual role of mesenchymal stem/stromal cells and their cell‐free extracellular vesicles in colorectal cancer Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-03-16 Mohamed J. Saadh, Asma'a H. Mohamed, Muhammad Ali Abdullah Almoyad, Omer Qutaiba B. Allela, Ali H. Amin, April Ann Malquisto, Wong Tze Jin, Ioan Sârbu, Faisal AlShamsi, Fahmy Gad Elsaid, Reza Akhavan‐Sigari
Colorectal cancer (CRC) is one of the main causes of cancer‐related deaths. However, the surgical control of the CRC progression is difficult, and in most cases, the metastasis leads to cancer‐related mortality. Mesenchymal stem/stromal cells (MSCs) with potential translational applications in regenerative medicine have been widely researched for several years. MSCs could affect tumor development through
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Attenuation of cannabis withdrawal symptoms by Prosopis farcta extract, its luteolin and melatonin in mice: Involvement of brain‐derived neurotrophic factor and dopamine Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-03-16 Javad Ghasemian‐Yadegari, Ahmad Adineh, Hamidreza Mohammadi, Shima Davari, Yousef Veisani, Hori Ghaneialvar, Ali Aidy, Naser Abbasi, Elahe Karimi
The aim of this study was the identification of luteolin in Prosopis farcta extract (PFE) and melatonin to evaluate its effect on THC withdrawal syndrome in mice. Luteolin was identified by high‐performance liquid chromatography (HPCL). Signs of toxicity of mice in PFE and luteolin were monitored for LD50 calculation. The behavioral symptoms of THC withdrawal (stereotypies, ambulation, and inactivity
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Betaine postpones hyperglycemia‐related senescence in ovarian and testicular cells: Involvement of RAGE and β‐galactosidase Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-03-16 Neda Mohammadi, Mina Hemmati, Behrouz Motlagh, Arezou Biyabani
The structural and functional disorders of the testis and ovary are one of the main complications of hyperglycemia. Betaine is a trimethyl glycine with antioxidant, antidiabetic, and anti‐inflammatory potential. The aim of this study is to investigate the potential of betaine on the expression of aging and oxidative stress markers in ovarian and testicular cells under hyperglycemic conditions. Testicular
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Adaptive responses of the ileum of NOD mice to low‐dose fluoride: A proteomic exploratory study Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-03-16 Juliana S. Trevizol, Nathalia R. Buzalaf, Aline Dionizio, Aislan Q. Delgado, João P. Z. de Lara, Ana C. Magalhães, José R. Bosqueiro, Marília A. R. Buzalaf
Fluoride (F) has been employed worldwide to control dental caries. More recently, it has been suggested that the consumption of low doses of F in the drinking water may reduce blood glucose levels, introducing a new perspective for the use of F for the management of blood glucose. However, the exact mechanism by which F affects blood glucose levels remains largely unexplored. Given that the small gut
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Goat mammary epithelial cells provide a better expression system for production of recombinant human bone morphogenetic protein 2 compared to Chinese hamster ovarian cells Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-03-16 Venkateswaran Ganesan, Goutam Ulgekar, Anandhi Ramalingam, Souvik Sen Sharma, Nirmalya Ganguli, Subeer S. Majumdar
Bone Morphogenetic Protein 2 (BMP2), a member of the Transforming Growth Factor‐β (TGF‐β) super family of proteins and is instrumental in the repair of fractures. The synthesis of BMP2 involves extensive post‐translational processing and several studies have demonstrated the abysmally low production of rhBMP2 in eukaryotic systems, which may be due to the short half‐life of the bioactive protein. Consequently
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Multifaceted impact of adipose conditioned media: Obesity‐driven promotion of prostate cancer and cancer stem cell dynamics Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-03-14 Suat Erdogan, Riza Serttas, Ilker Dibirdik, Kader Turkekul
Obesity is an established risk factor for the development and progression of prostate cancer (PC). This study used adipose conditioned media (ACM) from differentiated adipocytes to assess its effect on PC development and aggressiveness. Due to limited research on ACM's impact on isolated PC stem cells (PCSCs), we also examined CD44+ PCSCs. ACM notably boosted interleukin‐1β (IL‐1β), IL‐6, and IL‐8
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A comprehensive review on potential drug–drug interactions of proton pump inhibitors with antidiabetic drugs metformin and DPP‐4 inhibitors Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-03-14 Jarin Tasnim, Najihah Mohd Hashim, Heh Choon Han
A drug interaction is a condition in which two or more drugs are taken at the same time. Type 2 diabetes mellitus is a significant contributor to polypharmacy. Proton pump inhibitors (PPIs) are often prescribed in combination with metformin or DPP‐4 inhibitors (sitagliptin, saxagliptin, linagliptin, and alogliptin) or a combined dose of metformin and DPP‐4 inhibitor to treat gastritis in diabetic patients
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Regulation and mechanism of organic selenium on quorum sensing, biofilm, and antioxidant effects of Lactobacillus paracasei Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-03-13 Zaixiang Lou, Jiale Dong, Hongwei Tao, Yeexuan Tan, Hongxin Wang
Different organic compounds can have varying degrees of impact on the activity of Lactobacillus paracasei. The study focused on the impact and action mechanism of different organic selenium products on the bioactivity of two strains of L. paracasei. The growth, antioxidant activity, extracellular polysaccharide secretion, quorum sensing (QS), and biofilm formation of the strains before and after the
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Therapeutic gene delivery by mesenchymal stem cell for brain ischemia damage: Focus on molecular mechanisms in ischemic stroke Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-03-12 Raed Obaid Saleh, Ali A. Majeed, Ria Margiana, Ola Kamal A. Alkadir, Sami G. Almalki, Pallavi Ghildiyal, Vadim Samusenkov, Noura Kareem Jabber, Yasser Fakri Mustafa, Ahmed Elawady
Cerebral ischemic damage is prevalent and the second highest cause of death globally across patient populations; it is as a substantial reason of morbidity and mortality. Mesenchymal stromal cells (MSCs) have garnered significant interest as a potential treatment for cerebral ischemic damage, as shown in ischemic stroke, because of their potent intrinsic features, which include self‐regeneration, immunomodulation
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Cells in the liver microenvironment regulate the process of liver metastasis Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-03-09 Pei Wang, Yu Jie, Lin Yao, Yi‐meng Sun, Da‐peng Jiang, Shi‐qi Zhang, Xiao‐yan Wang, Yu Fan
The research of liver metastasis is a developing field. The ability of tumor cells to invade the liver depends on the complicated interactions between metastatic cells and local subpopulations in the liver (including Kupffer cells, hepatic stellate cells, liver sinusoidal endothelial cells, and immune‐related cells). These interactions are mainly mediated by intercellular adhesion and the release of
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Exploring the emerging bidirectional association between inflamm‐aging and cellular senescence in organismal aging and disease Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-03-08 Rohit Sharma
There is strong evidence that most individuals in the elderly population are characterized by inflamm‐aging which refers to a subtle increase in the systemic pro‐inflammatory environment and impaired innate immune activation. Although a variety of distinct factors are associated with the progression of inflamm‐aging, emerging research is demonstrating a dynamic relationship between the processes of
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Reduction characteristic of chlorobenzene by a newly isolated Paenarthrobacter ureafaciens LY from a pharmaceutical wastewater treatment plant Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-03-08 Nan Liu, Yan‐yan Yao, Jin Zhang, Ji‐guo Zhang, Chao Wu, Du‐juan Ouyang, Chang‐yong Zou, Zhen‐qiang Yang, Ji‐xiang Li
A highly efficient chlorobenzene‐degrading strain was isolated from the sludge of a sewage treatment plant associated with a pharmaceutical company. The strain exhibited a similarity of over 99.9% with multiple strains of Paenarthrobacter ureafaciens. Therefore, the strain was suggested to be P. ureafaciens LY. This novel strain exhibited a broad spectrum of pollutant degradation capabilities, effectively
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The role and molecular mechanism of NOP16 in the pathogenesis of nasopharyngeal carcinoma Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-03-08 Wenmin Xiong, Daojing Li, Fenghua Ao, Ziwei Tu, Jianping Xiong
We aimed to explore the effects of NOP16 on the pathogenesis of nasopharyngeal carcinoma (NPC) and the related mechanism. In this study, the expression level of NOP16 in NPC tissues and adjacent tissues was measured by qRT‐polymerase chain reaction (PCR) and immunohistochemistry (IHC) tests. In the in vitro study, the expression levels of NOP16 and RhoA/phosphatidylinositol 3‐kinase (PI3K)/Akt/c‐Myc
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Characterization of two bacteriophages specific to Acinetobacter baumannii and their effects on catheters biofilm Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-03-06 Hilal Basak Erol, Banu Kaskatepe, Sulhiye Yildiz, Nurten Altanlar, Fatma Bayrakdar
Multidrug‐resistant strains of Acinetobacter baumannii cause major nosocomial infections. Bacteriophages that are specific to the bacterial species and destroy bacteria can be effectively used for treatment. In this study, we characterized lytic bacteriophages specific to A. baumannii strains. We isolated lytic bacteriophages from environmental water samples and then investigated their morphology,
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The role of ncRNAs‐mediated pyroptosis in diabetes and its vascular complications Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-03-05 Xinyao Feng, Xiaoxu Yang, Yancheng Zhong, Xihua Cheng
Over the past decade, the prevalence of diabetes has increased significantly worldwide, leading to an increase in vascular complications of diabetes (VCD), such as diabetic cardiomyopathy (DCM), diabetic nephropathy (DN), and diabetic retinopathy (DR). Noncoding RNAs (ncRNAs), such as microRNAs (miRNAs), long Noncoding RNAs (lncRNAs), and circular RNAs (circRNAs), play a key role in cellular processes
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Exploring the mechanisms of kaempferol in neuroprotection: Implications for neurological disorders Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-03-05 Amir Mohammad Nezhad Salari, Zahra Rasoulizadeh, Arezoo Gowhari Shabgah, Roghayyeh Vakili‐Ghartavol, Ghasem Sargazi, Jamshid Gholizadeh Navashenaq
Kaempferol, a flavonoid compound found in various fruits, vegetables, and medicinal plants, has garnered increasing attention due to its potential neuroprotective effects in neurological diseases. This research examines the existing literature concerning the involvement of kaempferol in neurological diseases, including stroke, Parkinson's disease, Alzheimer's disease, neuroblastoma/glioblastoma, spinal
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Leukemia cancer cells and immune cells derived‐exosomes: Possible roles in leukemia progression and therapy Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-03-01 Dyar Mudhafar Salman, Talar Ahmad Merza Mohammad
Exosomes have a significant impact on tumor survival, proliferation, metastasis, and recurrence. They also open up new therapeutic options and aid in the pathological identification and diagnosis of cancers. Exosomes have been shown in numerous studies to be essential for facilitating cell‐to‐cell communication. In B‐cell hematological malignancies, the proteins and RNAs that are encased by circulating
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The role of lncRNA HCG18 in human diseases Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-03-01 Feng Long, Xuan Zhou, Jinhua Zhang, Cuixia Di, Xue Li, Hailin Ye, Jingyu Pan, Jing Si
A substantial number of long noncoding RNAs (lncRNAs) have been identified as potent regulators of human disease. Human leukocyte antigen complex group 18 (HCG18) is a new type of lncRNA that has recently been proven to play an important role in the occurrence and development of various diseases. Studies have found that abnormal expression of HCG18 is closely related to the clinicopathological characteristics
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Fullertubes inhibit mycobacterial viability and prevent biofilm formation by disrupting the cell wall Cell Biochem. Funct. (IF 3.6) Pub Date : 2024-03-01 Varun Shenoy, Rashmika Gunda, Cora Noble, Annalisa Haraguchi, Steven Stevenson, Jaiyanth Daniel
Mycobacterium tuberculosis and nontuberculous mycobacteria such as Mycobacterium abscessus cause diseases that are becoming increasingly difficult to treat due to emerging antibiotic resistance. The development of new antimicrobial molecules is vital for combating these pathogens. Carbon nanomaterials (CNMs) are a class of carbon‐containing nanoparticles with promising antimicrobial effects. Fullertubes