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Glycolanguage of the oral microbiota Mol. Oral Microbiol. (IF 3.7) Pub Date : 2024-03-22 Fiona F. Hager‐Mair, Susanne Bloch, Christina Schäffer
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Identification of temporal shifts of oral bacteria in bone regeneration following mandibular bone defect injury and therapeutic surgery in a porcine model Mol. Oral Microbiol. (IF 3.7) Pub Date : 2024-03-21 Fatemeh Sanjar, David T. Silliman, Ian J. Johnson, Zayer Htut, Trent J. Peacock, Samira F. Thompson, Gregory R. Dion, Md A. Nahid, John F. Decker, Kai P. Leung
BackgroundConsidered the second largest and most diverse microbiome after the gut, the human oral ecosystem is complex with diverse and niche‐specific microorganisms. Although evidence is growing for the importance of oral microbiome in supporting a healthy immune system and preventing local and systemic infections, the influence of craniomaxillofacial (CMF) trauma and routine reconstructive surgical
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Microbial composition and diversity in intraradicular biofilm formed in situ: New concepts based on next‐generation sequencing Mol. Oral Microbiol. (IF 3.7) Pub Date : 2024-03-18 Felipe Barros Matoso, Francisco Montagner, Fabiana Soares Grecca, Pabulo Henrique Rampelotto, Patrícia Maria Poli Kopper
This study aimed to characterize the taxonomic composition of intraradicular multispecies biofilms (IMBs) formed in situ in a model to reproduce clinical conditions. Twelve palatal roots of maxillary molars had its canals prepared. Two roots were randomly selected to sterility control. Ten intraoral prosthetic appliances with lateral slots were fabricated. The roots were positioned in the slots with
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“Regulation of Metabolism and Inflammation: Links with Oral and Systemic Health” Mol. Oral Microbiol. (IF 3.7) Pub Date : 2024-03-08 Ping Zhang, Sinem Esra Sahingur, Shauna Culshaw
The oral cavity has one of the most complex microbial communities in the human body, harboring over 1000 species of microorganisms (Lamont et al., 2018). This microbial ecosystem interacts dynamically and bidirectionally with the host, influencing various physiological processes. Under normal conditions, the oral microbiome and host are in a state of equilibrium. However, disruptions in this equilibrium
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Characterization of c‐di‐AMP signaling in the periodontal pathobiont, Treponema denticola Mol. Oral Microbiol. (IF 3.7) Pub Date : 2024-03-04 Aidan D. Moylan, Dhara T. Patel, Claire O'Brien, Edward J. A. Schuler, Annie N. Hinson, Richard T. Marconi, Daniel P. Miller
Pathobionts associated with periodontitis, such as Treponema denticola, must possess numerous sensory transduction systems to adapt to the highly dynamic subgingival environment. To date, the signaling pathways utilized by T. denticola to rapidly sense and respond to environmental stimuli are mainly unknown. Bis‐(3′–5′) cyclic diadenosine monophosphate (c‐di‐AMP) is a nucleotide secondary messenger
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Oral Lactobacillus zeae exacerbates the pathological manifestation of periodontitis in a mouse model Mol. Oral Microbiol. (IF 3.7) Pub Date : 2024-02-22 Yi‐Wen Chen, Yu‐Wen Hou, Chuang‐Wei Wang, Shih‐Jung Cheng, Wei‐Ting Kuo, Chun‐Pin Lin, Hsin‐Han Hou
IntroductionThe worldwide prevalence of periodontitis is considerably high, and its pathogenic mechanisms must be investigated and understood in order to improve clinical treatment outcomes and reduce the disease prevalence and burden. The exacerbation of the host immune system induced by oral microbial dysbiosis and the subsequent tissue destruction are the hallmarks of the periodontitis. However
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Impact of treatment of rheumatoid arthritis on periodontal disease: A review Mol. Oral Microbiol. (IF 3.7) Pub Date : 2024-02-16 Catherine Petit, Shauna Culshaw, Roland Weiger, Olivier Huck, Philipp Sahrmann
Numerous studies support a bidirectional association between rheumatoid arthritis (RA), a chronic autoimmune degenerative inflammatory joint disease, and periodontitis, a chronic inflammatory disease caused by the immune reaction to bacteria organized in biofilms. RA and periodontitis are both multifactorial chronic inflammatory diseases that share common modifiable and non-modifiable risk factors
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Porphyromonas gingivalis GroEL exacerbates orthotopic allograft transplantation vasculopathy via impairment of endothelial cell function Mol. Oral Microbiol. (IF 3.7) Pub Date : 2024-02-04 Chien-Sung Tsai, Chun-Yao Huang, Yi-Ting Tsai, Chun-Ming Shih, Ze-Hao Lai, Chen-Wei Liu, Yi-Wen Lin, Feng-Yen Lin
Orthotopic allograft transplantation (OAT) is a significant approach to addressing organ failure. However, persistent immune responses to the allograft affect chronic rejection, which induces OAT vasculopathy (OATV) and organ failure. Porphyromonas gingivalis can infiltrate remote organs via the bloodstream, thereby intensifying the severity of cardiovascular, respiratory, and neurodegenerative diseases
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Tobacco-enhanced biofilm formation by Porphyromonas gingivalis and other oral microbes Mol. Oral Microbiol. (IF 3.7) Pub Date : 2024-01-16 Jinlian Tan, Gwyneth J. Lamont, David A. Scott
Microbial biofilms promote pathogenesis by disguising antigens, facilitating immune evasion, providing protection against antibiotics and other antimicrobials and, generally, fostering survival and persistence. Environmental fluxes are known to influence biofilm formation and composition, with recent data suggesting that tobacco and tobacco-derived stimuli are particularly important mediators of biofilm
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Extracellular vesicles—Potential link between periodontal disease and diabetic complications Mol. Oral Microbiol. (IF 3.7) Pub Date : 2024-01-16 Shengyuan Huang, Jiang Lin, Xiaozhe Han
It has long been suggested that a bidirectional impact exists between periodontitis and diabetes. Periodontitis may affect diabetes glycemic control, insulin resistance, and diabetic complications. Diabetes can worsen periodontitis by delaying wound healing and increasing the chance of infection. Extracellular vesicles (EVs) are heterogeneous particles of membrane-enclosed spherical structure secreted
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Inhibition of Streptococcus mutans growth and biofilm formation through protein acetylation Mol. Oral Microbiol. (IF 3.7) Pub Date : 2024-01-15 Yongwang Lin, Qizhao Ma, Jiangchuan Yan, Tao Gong, Jun Huang, Jiamin Chen, Jing Li, Yang Qiu, Xiaowan Wang, Zixue Lei, Jumei Zeng, Lingyun Wang, Xuedong Zhou, Yuqing Li
Numerous cellular processes are regulated in response to the metabolic state of the cell, and one such regulatory mechanism involves lysine acetylation. Lysine acetylation has been proven to play an important role in the virulence of Streptococcus mutans, a major cariogenic bacterial species. S. mutans’ glucosyltransferases (Gtfs) are responsible for synthesizing extracellular polysaccharides (EPS)
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Polyketides/nonribosomal peptides from Streptococcus mutans and their ecological roles in dental biofilm Mol. Oral Microbiol. (IF 3.7) Pub Date : 2024-01-11 Wenxin Luo, Mengdie Zhang, Xuedong Zhou, Xin Xu, Xingqun Cheng
Streptococcus mutans is the major etiological agent of dental caries in humans. S. mutans overgrowth within dental biofilms can trigger biofilm dysbiosis, ultimately leading to the initiation or progression of dental caries. Polyketides and nonribosomal peptides (PKs/NRPs) are secondary metabolites with complex structures encoded by a cluster of biosynthetic genes. Although not essential for microbial
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Nicotinamide employs a starvation strategy against Porphyromonas gingivalis virulence by inhibiting the heme uptake system and gingipain activities Mol. Oral Microbiol. (IF 3.7) Pub Date : 2024-01-10 Zixue Lei, Qizhao Ma, Yeting Tu, Yang Qiu, Tao Gong, Yongwang Lin, Xuedong Zhou, Yuqing Li
Periodontitis is a common oral bacterial infection characterized by inflammatory responses. Its high prevalence lowers the quality of life for individuals and increases the global economic and disease burden. As microorganisms in dental plaque are responsible for this oral disease, antibacterial drug treatments are effective strategies for preventing and treating periodontitis. In this study, we investigated
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The ways Fusobacterium nucleatum translocate to breast tissue and contribute to breast cancer development Mol. Oral Microbiol. (IF 3.7) Pub Date : 2024-01-03 Xinyu Guo, Ke Yu, Ruijie Huang
Breast cancer is among the most prevalent malignancies in women worldwide. Epidemiological findings suggested that periodontal diseases may be associated with breast cancer, among which Fusobacterium nucleatum is considered an important cross-participant. In this work, we comprehensively summarize the known mechanisms of how F. nucleatum translocates to, colonizes in mammary tumors, and promotes the
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Activation of liver X receptors suppresses the abundance and osteoclastogenic potential of osteoclast precursors and periodontal bone loss Mol. Oral Microbiol. (IF 3.7) Pub Date : 2023-12-18 Yanfang Zhao, Kai Yang, Thalyta Amanda Ferreira, Xuejia Kang, Xu Feng, Jannet Katz, Suzanne M Michalek, Ping Zhang
Liver-X receptors (LXRs) are essential nuclear hormone receptors involved in cholesterol and lipid metabolism. They are also believed to regulate inflammation and physiological and pathological bone turnover. We have previously shown that infection with the periodontal pathogen Porphyromonas gingivalis (Pg) in mice increases the abundance of CD11b+c-fms+Ly6Chi cells in bone marrow (BM), spleen (SPL)
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Filifactor alocis enhances survival of Porphyromonas gingivalis W83 in response to H2O2-induced stress Mol. Oral Microbiol. (IF 3.7) Pub Date : 2023-12-01 Arunima Mishra, Yuetan Dou, Charles Wang, Hansel M Fletcher
A dysbiotic microbial community whose members have specific/synergistic functions that are modulated by environmental conditions, can disturb homeostasis in the subgingival space leading to destructive inflammation, plays a role in the progression of periodontitis. Filifactor alocis, a gram-positive, anaerobic bacterium, is a newly recognized microbe that shows a strong correlation with periodontal
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Dual function of the O-antigen WaaL ligase of Aggregatibacter actinomycetemcomitans Mol. Oral Microbiol. (IF 3.7) Pub Date : 2023-11-08 David R. Danforth, Marcella Melloni, Richard Thorpe, Avi Cohen, Richard Voogt, Jake Tristano, Keith P. Mintz
Protein glycosylation is critical to the quaternary structure and collagen-binding activity of the extracellular matrix protein adhesin A (EmaA) associated with Aggregatibacter actinomycetemcomitans. The glycosylation of this large, trimeric autotransporter adhesin is postulated to be mediated by WaaL, an enzyme with the canonical function to ligate the O-polysaccharide (O-PS) antigen with a terminal
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The potential impact of periodontitis on cerebral small vessel disease Mol. Oral Microbiol. (IF 3.7) Pub Date : 2023-11-06 Beatriz Bezerra, Mark Fisher, Flavia Q. Pirih, Maísa Casarin
Cerebral small vessel disease (CSVD) is a term used to describe abnormalities in the intracranial microvasculature affecting small arteries, arterioles, capillaries, and venules. The etiology of these conditions is not fully understood but inflammation appears to play a significant role. Periodontal diseases have been associated with conditions such as stroke and dementia, which are clinical consequences
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Effects of IL-34 and anti-IL-34 neutralizing mAb on alveolar bone loss in a ligature-induced model of periodontitis Mol. Oral Microbiol. (IF 3.7) Pub Date : 2023-10-30 Carolina Duarte, Chiaki Yamada, Bidii Ngala, Christopher Garcia, Juliet Akkaoui, Maxim Birsa, Anny Ho, Amilia Nusbaum, Hawra AlQallaf, Vanchit John, Alexandru Movila
Macrophage colony-stimulating factor (M-CSF) and interleukin-34 (IL-34) are ligands for the colony-stimulating factor-1 receptor (CSF-1r) expressed on the surface of monocyte/macrophage lineage cells. The importance of coordinated signaling between M-CSF/receptor activator of the nuclear factor kappa-Β ligand (RANKL) in physiological and pathological bone remodeling and alveolar bone loss in response
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Primed inflammatory response by fibroblast subset is necessary for proper oral and cutaneous wound healing Mol. Oral Microbiol. (IF 3.7) Pub Date : 2023-10-30 Zhaoxu Chen, Rahul Debnath, Ifeoma Chikelu, Jonathan X. Zhou, Kang I. Ko
Fibroblasts are ubiquitous mesenchymal cells that exhibit considerable molecular and functional heterogeneity. Besides maintaining stromal integrity, oral fibroblast subsets are thought to play an important role in host–microbe interaction during injury repair, which is not well explored in vivo. Here, we characterize a subset of fibroblast lineage labeled by paired-related homeobox-1 promoter activity
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Enhanced transformation efficiency in Treponema denticola enabled by SyngenicDNA-based plasmids lacking restriction–modification target motifs Mol. Oral Microbiol. (IF 3.7) Pub Date : 2023-10-25 Christopher D. Johnston, M. Paula Goetting-Minesky, Kelly Kennedy, Valentina Godovikova, Sara M. Zayed, Richard J. Roberts, J. Christopher Fenno
Oral spirochetes are among a small group of keystone pathogens contributing to dysregulation of tissue homeostatic processes that leads to breakdown of the tissue and bone supporting the teeth in periodontal disease. Additionally, our group has recently demonstrated that Treponema are among the dominant microbial genera detected intracellularly in tumor specimens from patients with oral squamous cell
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Metabolism of serine/glycine lipids by human gingival cells in culture Mol. Oral Microbiol. (IF 3.7) Pub Date : 2023-10-18 Tyler M. Guido, Samuel D. Ratcliffe, Amanda Rahmlow, Matthew A. Zambrello, Anthony A. Provates, Robert B. Clark, Michael B. Smith, Frank C. Nichols
Porphyromonas gingivalis produces five classes of serine/glycine lipids that are recovered in lipid extracts from periodontitis-afflicted teeth and diseased gingival tissues, particularly at sites of periodontitis. Because these lipids are recovered in diseased gingival tissues, the purpose of the present study was to evaluate the capacity of cultured human gingival fibroblasts (HGF), keratinocytes
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Critical review of 16S rRNA gene sequencing workflow in microbiome studies: From primer selection to advanced data analysis Mol. Oral Microbiol. (IF 3.7) Pub Date : 2023-10-07 Alba Regueira-Iglesias, Carlos Balsa-Castro, Triana Blanco-Pintos, Inmaculada Tomás
The multi-batch reanalysis approach of jointly reevaluating gene/genome sequences from different works has gained particular relevance in the literature in recent years. The large amount of 16S ribosomal ribonucleic acid (rRNA) gene sequence data stored in public repositories and information in taxonomic databases of the same gene far exceeds that related to complete genomes. This review is intended
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Histone acetylation, BET proteins, and periodontal inflammation Mol. Oral Microbiol. (IF 3.7) Pub Date : 2023-10-06 Nicholas Clayton, David Pellei, Zhao Lin
Periodontitis is one of the most common inflammatory diseases in humans. The susceptibility to periodontitis is largely determined by the host response, and the severity of inflammation predicts disease progression. Upon microbial insults, host cells undergo massive changes in their transcription program to trigger an appropriate response (inflammation). It is not surprising that successful keystone
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Dying for a cause: The pathogenic manipulation of cell death and efferocytic pathways Mol. Oral Microbiol. (IF 3.7) Pub Date : 2023-10-02 Kelley N. Cooper, Jan Potempa, Juhi Bagaitkar
Cell death is a natural consequence of infection. However, although the induction of cell death was solely thought to benefit the pathogen, compelling data now show that the activation of cell death pathways serves as a nuanced antimicrobial strategy that couples pathogen elimination with the generation of inflammatory cytokines and the priming of innate and adaptive cellular immunity. Following cell
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Oral microbial biomap in the drought environment: Sjogren's syndrome Mol. Oral Microbiol. (IF 3.7) Pub Date : 2023-09-28 Laura Bustos-Lobato, Maria J. Rus, Carlos Saúco, Aurea Simon-Soro
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Exploring the genetic and functional diversity of Porphyromonas gingivalis long fimbriae Mol. Oral Microbiol. (IF 3.7) Pub Date : 2023-09-26 Hendrik Leonhard Meyer, Mohamed M. H. Abdelbary, Eva Miriam Buhl, Christoph Kuppe, Georg Conrads
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Requirements for anti-aquaporin 5 autoantibody production in a mouse model Mol. Oral Microbiol. (IF 3.7) Pub Date : 2023-09-18 Sabin Acharya, Ahreum Lee, Hyunjin Kim, Hyeong-jin Kim, Youngnim Choi
Several oral bacteria, including Prevotella melaninogenica (Pm), have aquaporin (AQP) proteins homologous to human AQP5, a major water channel protein targeted in Sjogren's syndrome. This study aimed to understand the antigenic characteristics that induce autoantibodies against an AQP5 “E” epitope (AQP5E) in a mouse model using C57BL/6 mice. Immunization with a PmE-L peptide derived from Pm AQP, which
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Fusobacterium nucleatum triggers senescence phenotype in gingival epithelial cells Mol. Oral Microbiol. (IF 3.7) Pub Date : 2023-09-18 Emmanuel Albuquerque-Souza, Benjamin Shelling, Min Jiang, Xia-Juan Xia, Kantapon Rattanaprukskul, Sinem Esra Sahingur
The prevalence of periodontitis increases with physiological aging. However, whether bacteria associated with periodontal diseases foster aging and the mechanisms by which they may do so are unknown. Herein, we hypothesize that Fusobacterium nucleatum, a microorganism associated with periodontitis and several other age-related disorders, triggers senescence, a chief hallmark of aging responsible to
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A novel SUCNR1 inhibitor alleviates dysbiosis through inhibition of host responses without direct interaction with host microbiota Mol. Oral Microbiol. (IF 3.7) Pub Date : 2023-09-16 Scott C. Thomas, Yuqi Guo, Fangxi Xu, Deepak Saxena, Xin Li
Type 2 diabetes (T2D) is a chronic metabolic disorder in which insulin resistance and impaired insulin secretion result in altered metabolite balance, specifically elevated levels of circulating glucose and succinate, which increases the risk of many pathologies, including periodontitis. Succinate, a tricarboxylic acid (TCA) cycle intermediate, can be produced and metabolized by both host cells and
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Tannerella forsythia scavenges Fusobacterium nucleatum secreted NOD2 stimulatory molecules to dampen oral epithelial cell inflammatory response Mol. Oral Microbiol. (IF 3.7) Pub Date : 2023-07-17 Rajendra P. Settem, Angela Ruscitto, Sreedevi Chinthamani, Kiyonobu Honma, Ashu Sharma
The oral organism Tannerella forsythia is auxotrophic for peptidoglycan amino sugar N-acetylmuramic acid (MurNAc). It survives in the oral cavity by scavenging MurNAc- and MurNAc-linked peptidoglycan fragments (muropeptides) secreted by co-habiting bacteria such as Fusobacterium nucleatum with which it forms synergistic biofilms. Muropeptides, MurNAc-l-Ala-d-isoGln (MDP, muramyl dipeptide) and d-γ-glutamyl-meso-DAP
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Gene expression and metabolic activity of Streptococcus mutans during exposure to dietary carbohydrates glucose, sucrose, lactose, and xylitol Mol. Oral Microbiol. (IF 3.7) Pub Date : 2023-07-13 Veronika Jurakova, Veronika Farková, Jiri Kucera, Katerina Dadakova, Martina Zapletalova, Katerina Paskova, Roman Reminek, Zdenek Glatz, Lydie Izakovicova Holla, Filip Ruzicka, Jan Lochman, Petra Borilova Linhartova
Recent RNA sequencing studies have given us a deeper insight into the cariogenic impact of carbohydrate sources in the bacterium Streptococcus mutans, the principal microbial agent in dental caries etiopathogenesis. The process of dental caries development is facilitated by the ability of this bacterium to ferment some carbohydrates into organic acids contributing to a pH decrease in the oral cavity
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Loss of signal transducer and activator of transcription 3 in osteoblasts impaired the bone healing in inflammatory microenvironment Mol. Oral Microbiol. (IF 3.7) Pub Date : 2023-06-22 Jingyi Feng, Zijing Huang, Jiarui Lu, Laiting Chan, Xin Feng, Lizhen Lei, Zhuwei Huang, Lichieh Lin, Yichen Yao, Xiaolei Zhang
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Accessory fimbrial subunits and PPAD are necessary for TLR2 activation by Porphyromonas gingivalis Mol. Oral Microbiol. (IF 3.7) Pub Date : 2023-06-22 Aleksandra Wielento, Grzegorz P. Bereta, Katarzyna Szczęśniak, Anna Jacuła, Marina Terekhova, Maxim N. Artyomov, Yoshiaki Hasegawa, Aleksander M. Grabiec, Jan Potempa
Porphyromonas gingivalis is an oral pathogen that promotes dysbiosis by quenching the bactericidal activity of the host immune system while maintaining chronic inflammation, leading to periodontitis. This involves the secretion of virulence factors such as P. gingivalis peptidyl arginine deiminase (PPAD), which converts the C-terminal Arg residues of bacterial and host-derived proteins and peptides
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A conditional gene expression system in Porphyromonas gingivalis for study of the secretion mechanisms of lipoproteins and T9SS cargo proteins Mol. Oral Microbiol. (IF 3.7) Pub Date : 2023-06-20 Yuko Sasaki, Mikio Shoji, Takayuki Sueyoshi, Satoshi Shibata, Takehiro Matsuo, Hideharu Yukitake, Matthias Wolf, Mariko Naito
The Gram-negative anaerobe, Porphyromonas gingivalis, is known to be a pathogen associated with chronic periodontitis. P. gingivalis possesses virulence factors such as fimbriae and gingipain proteinases. Fimbrial proteins are secreted to the cell surface as lipoproteins. In contrast, gingipain proteinases are secreted into the bacterial cell surface via the type IX secretion system (T9SS). The transport
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Functional profile of oral plaque microbiome: Further insight into the bidirectional relationship between type 2 diabetes and periodontitis Mol. Oral Microbiol. (IF 3.7) Pub Date : 2023-05-31 Nicoletta Favale, Roberto Farina, Alberto Carrieri, Anna Simonelli, Mattia Severi, Silvia Sabbioni, Leonardo Trombelli, Chiara Scapoli
Increasing evidence support the association between the oral microbiome and human systemic diseases. This association may be attributed to the ability of many oral microbes to influence the inflammatory microenvironment. Herein, we focused our attention on the bidirectional relationship between periodontitis and type 2 diabetes using high-resolution whole metagenomic shotgun analysis to explore the
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One-carbon metabolism and microbial pathogenicity Mol. Oral Microbiol. (IF 3.7) Pub Date : 2023-05-24 Kendall S. Stocke, Richard J. Lamont
One-carbon metabolism (OCM) pathways are responsible for several functions, producing a number of one-carbon unit intermediates (formyl, methylene, methenyl, methyl) that are required for the synthesis of various amino acids and other biomolecules such as purines, thymidylate, redox regulators, and, in most microbes, folate. As humans must acquire folate from the diet, folate production is a target
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miR-27a-5p alleviates periodontal inflammation by targeting phosphatase and tensin homolog deleted on chromosome ten Mol. Oral Microbiol. (IF 3.7) Pub Date : 2023-05-22 Li Deng, Peng-cheng Huo, Mei-ting Feng, Rui-ling Wang, Rui Jing, Li-jun Luo
MicroRNAs (miRNAs), a type of non-coding RNA, have been demonstrated to be essential posttranscriptional modulators in oral diseases and inflammatory responses. However, the specific role of miR-27a-5p in periodontitis requires further investigation. In this study, we used both cellular and animal models to determine how miR-27a-5p affects the pathogenesis of periodontitis and its associated biological
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GroEL of Porphyromonas gingivalis-induced microRNAs accelerate tumor neovascularization by downregulating thrombomodulin expression in endothelial progenitor cells Mol. Oral Microbiol. (IF 3.7) Pub Date : 2023-05-15 Feng-Yen Lin, Yi-Ting Tsai, Chun-Yao Huang, Ze-Hao Lai, Chien-Sung Tsai, Chun-Ming Shih, Cheng-Yen Lin, Yi-Wen Lin
We found that GroEL in Porphyromonas gingivalis accelerated tumor growth and increased mortality in tumor-bearing mice; GroEL promoted proangiogenic function, which may be the reason for promoting tumor growth. To understand the regulatory mechanisms by which GroEL increases the proangiogenic function of endothelial progenitor cells (EPCs), we explored in this study. In EPCs, MTT assay, wound-healing
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The involvement of CdhR in Porphyromonas gingivalis during nitric oxide stress Mol. Oral Microbiol. (IF 3.7) Pub Date : 2023-05-03 Marie-Claire Boutrin, Arunima Mishra, Charles Wang, Yuetan Dou, Hansel M. Fletcher
Porphyromonas gingivalis, the causative agent of adult periodontitis, must gain resistance to frequent oxidative and nitric oxide (NO) stress attacks from immune cells in the periodontal pocket to survive. Previously, we found that, in the wild-type and under NO stress, the expression of PG1237 (CdhR), the gene encoding for a putative LuxR transcriptional regulator previously called community development
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Human papillomavirus and Epstein-Barr virus co-infection in oral and oropharyngeal squamous cell carcinomas: A systematic review and meta-analysis Mol. Oral Microbiol. (IF 3.7) Pub Date : 2023-04-04 Rifat Rahman, Mushfiq H. Shaikh, Divya Gopinath, Adi Idris, Newell W. Johnson
Squamous cell carcinoma of the oral cavity (OSCC) is the most common head-and-neck malignancy. Importantly, we are experiencing an alarming rise in the incidence of oropharyngeal squamous cell carcinoma (OPSCC) globally. Oncogenic viruses, human papillomavirus (HPV) and Epstein-Barr virus (EBV), are known to be co-associated with OSCC and OPSCC cases. However, the reported incidence of HPV and EBV
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Gingipains are the important virulence factors of Porphyromonas gingivalis downregulating B10 cells Mol. Oral Microbiol. (IF 3.7) Pub Date : 2023-04-02 Hang Zou, Niu Zhou, Xiao Cheng, Yi Qiu, Wenhong Hou, Jianbo Sun
Porphyromonas gingivalis is a keystone pathogen in periodontitis. Our previous study indicated that periodontitis induced by P. gingivalis increased the percentage of CD19+ B cells but decreased the ratio of IL-10-producing regulatory B cells (B10) in collagen-induced arthritis (CIA) mice. It is still unclear which virulence factors of P. gingivalis are involved in these processes. Here, we compared
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Small noncoding RNA in Streptococci: From regulatory functions to drug development Mol. Oral Microbiol. (IF 3.7) Pub Date : 2023-03-23 Yang Yang, Liu Wang, Liu Liu, Jian Zou, Dingming Huang, Yuqing Li
Streptococci are a genus of gram-positive coccus of spherical bacteria, including many commensal bacteria and opportunistic pathogens that threaten the public health system. Small noncoding RNAs (sRNAs) are a class of noncoding RNAs regulating gene expression via various regulatory mechanisms, which have been illustrated to play vital roles in regulations of virulence factor expressions. Recent advances
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Regulation of adhesin synthesis in Aggregatibacter actinomycetemcomitans Mol. Oral Microbiol. (IF 3.7) Pub Date : 2023-03-04 Jake Tristano, David R. Danforth, Matthew J. Wargo, Keith P. Mintz
Aggregatibacter actinomycetemcomitans is a gram-negative bacterium associated with periodontal disease and a variety of disseminated extra-oral infections. Tissue colonization is mediated by fimbriae and non-fimbriae adhesins resulting in the formation of a sessile bacterial community or biofilm, which confers enhanced resistance to antibiotics and mechanical removal. The environmental changes experienced
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Metabolism of periodontal pathobionts: Their regulatory roles in the dysbiotic microbiota Mol. Oral Microbiol. (IF 3.7) Pub Date : 2023-02-22 Jing Ding, Chuanjiang Zhao, Li Gao
The onset and development of periodontitis centers around microbiota dysbiosis and disrupted host responses. Dynamic metabolic activities of the subgingival microbiota modify the polymicrobial community, shape the microenvironment, and modulate the host response. A complicated metabolic network exists in interspecies interactions between periodontal pathobionts and commensals, which can lead to the
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Efficacy of Cetylpyridinium Chloride mouthwash against SARS-CoV-2: A systematic review of randomized controlled trials Mol. Oral Microbiol. (IF 3.7) Pub Date : 2023-02-20 Filippo D'Amico, Matteo Moro, Marco Saracino, Marilena Marmiere, Maria Bernadette Cilona, Graham Lloyd-Jones, Alberto Zangrillo
COVID-19 is a transmissible respiratory and multisystem disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Viral transmission occurs mainly through the spread of salivary droplets or aerosol from an infected subject. Studies suggest that salivary viral load is correlated with disease severity and probability of transmission. Cetylpyridinium chloride mouthwash has been found
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vicR overexpression in Streptococcus mutans causes aggregation and affects interspecies competition Mol. Oral Microbiol. (IF 3.7) Pub Date : 2023-02-13 Jiangchuan Yan, Tao Gong, Qizhao Ma, Ting Zheng, Jiamin Chen, Jing Li, Meiling Jing, Yongwang Lin, Xiaowan Wang, Lei Lei, Shida Wang, Jumei Zeng, Yuqing Li
Streptococcus mutans is considered to be a major causative agent of dental caries. VicRK is a two-component signal transduction system (TCSTS) of S. mutans, which can regulate the virulence of S. mutans, such as biofilm formation, exopolysaccharide production, acid production, and acid resistance. Meanwhile, it can also regulate the production of mutacins (nlmC) through the TCSTS ComDE. In this study
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Localization and pathogenic role of the cysteine protease dentipain in Treponema denticola Mol. Oral Microbiol. (IF 3.7) Pub Date : 2023-01-15 Yuri Miyai-Murai, Kazuko Okamoto-Shibayama, Toru Sato, Yuichiro Kikuchi, Eitoyo Kokubu, Jan Potempa, Kazuyuki Ishihara
The Msp protein complex and the serine protease dentilisin are the best-characterized virulence factors in Treponema denticola, the major etiological agent of chronic periodontitis. In addition to these outer sheath factors, the cysteine protease dentipain contributes to pathogenicity, but its secretion, processing, cellular localization, and role in T. denticola virulence are not fully understood
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ZccE, a P-type ATPase contributing to biofilm formation and competitiveness in Streptococcus mutans Mol. Oral Microbiol. (IF 3.7) Pub Date : 2023-01-09 Yangyang Pan, Jing Zou, Keke Zhang, Xiping Wang, Qizhao Ma, Liqin Mei, Yuqing Li, Yihuai Pan
Most living organisms require zinc for survival; however, excessive amounts of this trace element can be toxic. Therefore, the frequent fluctuations of salivary zinc, caused by the low physiological level and the frequent introduction of exogenous zinc ions, present a serious challenge for bacteria colonizing the oral cavity. Streptococcus mutans is considered one of the main bacterial pathobiont in
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Dental calculus microbiome correlates with dietary intake Mol. Oral Microbiol. (IF 3.7) Pub Date : 2022-12-11 Gabriel Innocenti, Maria Elena Martino, Edoardo Stellini, Adolfo Di Fiore, Andrea Quagliariello
Dental calculus is the result of dental plaque mineralization, originating from the tooth-associated bacterial biofilm. Recent evidence revealed that the dental calculus microbiome has a more complex composition than previously considered, including an unstructured mix of both aerobes and anaerobes bacteria. Actually, we lack information about the influence of host lifestyle factors, such as diet and
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Role of oral microbiome in oral oncogenesis, tumor progression, and metastasis Mol. Oral Microbiol. (IF 3.7) Pub Date : 2022-11-24 Ruohan Li, Li Xiao, Tao Gong, Jiaxin Liu, Yuqing Li, Xuedong Zhou, Yi Li, Xin Zheng
Squamous cell carcinoma is the most common malignant tumor of the oral cavity and its adjacent sites, which endangers the physical and mental health of patients and has a complex etiology. Chronic infection is considered to be a risk factor in cancer development. Evidence suggests that periodontal pathogens, such as Porphyromonas gingivalis, Fusobacterium nucleatum, and Treponema denticola, are associated
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Characterization of FA1654: A putative DPS protein in Filifactor alocis Mol. Oral Microbiol. (IF 3.7) Pub Date : 2022-11-22 Malissa Mangar, Arunima Mishra, Zhengrong Yang, Champion Deivanayagam, Hansel M. Fletcher
The survival/adaptation of Filifactor alocis, a fastidious Gram-positive asaccharolytic anaerobe, to the inflammatory environment of the periodontal pocket requires an ability to overcome oxidative stress. Moreover, its pathogenic characteristics are highlighted by its capacity to survive in the oxidative-stress microenvironment of the periodontal pocket and a likely ability to modulate the microbial
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Effects of Bdellovibrio bacteriovorus HD100 on experimental periodontitis in rats Mol. Oral Microbiol. (IF 3.7) Pub Date : 2022-11-22 Pedro Henrique Felix Silva, Luiz Fernando Ferreira Oliveira, Renata Silva Cardoso, Sandro Isaias Santana, Renato Correa Casarin, Edilson Ervolino, Sergio Luiz Salvador, Daniela Bazan Palioto, Flávia Aparecida Chaves Furlaneto, Michel Reis Messora
The aim of this study was to evaluate the effects of Bdellovibrio bacteriovorus HD100 on experimental periodontitis (EP) in rats.
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A GntR family transcription factor in Porphyromonas gingivalis regulates bacterial growth, acylpeptidyl oligopeptidase, and gingipains activity Mol. Oral Microbiol. (IF 3.7) Pub Date : 2022-11-09 Yang Qiu, Xuelian Tan, Zixue Lei, Xuan Chen, Jiamin Chen, Tao Gong, Yajie Wu, Yuqing Li, Dingming Huang
Porphyromonas gingivalis is a keystone pathogen for periodontitis. The function of the GntR family transcription factor is poorly studied in P. gingivalis. Numerous processes govern bacterial growth. The survival and pathogenicity of P. gingivalis depend heavily on its capacity to acquire amino acids as nutritional sources. In this investigation, a GntR transcription factor, pg1007, was identified
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Transcriptional analysis of the mfa-cluster genes in Porphyromonas gingivalis strains with one and two mfa5 genes Mol. Oral Microbiol. (IF 3.7) Pub Date : 2022-11-04 Mari Fujita, Chen-Hsuan Chiu, Keiji Nagano
The Porphyromonas gingivalis Mfa1 fimbria is composed of the Mfa1 to Mfa5 proteins, encoded by the mfa1 to mfa5 genes, respectively, which are tandemly arranged on chromosomes. A recent study discovered that many P. gingivalis strains possess two mfa5 genes (called herein mfa5-1 and mfa5-2), which are also in tandem. This study examined the transcriptional unit and activity of mfa-cluster genes in
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Characterization of Leuconostoc mesenteroides MJM60376 as an oral probiotic and its antibiofilm activity Mol. Oral Microbiol. (IF 3.7) Pub Date : 2022-10-28 Mingkun Gu, Huong Thi Nguyen, Joo-Hyung Cho, Joo-Won Suh, Jinhua Cheng
Lactic acid bacteria have been widely used as probiotics for improving gut health. However, studies on oral probiotics were very limited. In this study, 67 lactic acid bacteria (LAB) were isolated from fermented food and screened for antagonistic activity against Streptococcus mutans, the causative pathogen of dental caries. Leuconostoc mesenteroides MJM60376 showed the highest antagonistic activity