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Anthocyanins from blueberry ameliorated arsenic-induced memory impairment, oxidative stress, and mitochondrial-biosynthesis imbalance in rat hippocampal neurons Cell. Signal. (IF 4.8) Pub Date : 2024-04-15 Xinbo Ma, Yang Liu, Bo Ding, Siqi Lu, Bangyao Ni, Yuting Chen, Liu Yang, Yanan Liu, Yuchen Zhang, Yuxi Wang, Yanmei Yang, Xiaona Liu
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Mapping the interaction site for β-arrestin-2 in the prokineticin 2 receptor Cell. Signal. (IF 4.8) Pub Date : 2024-04-15 R. Lattanzi, I. Casella, M.R. Fullone, M. Vincenzi, D. Maftei, R. Miele
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BRD4L cooperates with MYC to block local tumor invasion via suppression of S100A10 Cell. Signal. (IF 4.8) Pub Date : 2024-04-09 Yongyi Ma, Nan Liu, Yu Shi, Shuyan Ma, Yingjun Wang, Wen Zheng, Rong Sun, Yihua Song, Miaomiao Chen, Lishuai Qu, Renfang Mao, Yihui Fan
Targeted therapy based on BRD4 and MYC shows promise due to their well-researched oncogenic functions in cancer, but their tumor-suppressive roles are less understood. In this study, we employ a systematic approach to delete exons that encode the low-complexity domain (LCD) of BRD4L in cells by using CRISPR–Cas9. In particular, the deletion of exon 14 (BRD4–E14) results in cellular morphological changes
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Simvastatin activates the spindle assembly checkpoint and causes abnormal cell division by modifying small GTPases Cell. Signal. (IF 4.8) Pub Date : 2024-04-09 Junna Tanaka, Hiroki Kuwajima, Ryuzaburo Yuki, Yuji Nakayama
Simvastatin is an inhibitor of 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase, which is a rate-limiting enzyme of the cholesterol synthesis pathway. It has been used clinically as a lipid-lowering agent to reduce low-density lipoprotein (LDL) cholesterol levels. In addition, antitumor activity has been demonstrated. Although simvastatin attenuates the prenylation of small GTPases, its effects on
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Cadmium contributes to cardiac metabolic disruption by activating endothelial HIF1A-GLUT1 axis Cell. Signal. (IF 4.8) Pub Date : 2024-04-09 Xiaoyu Zhang, Wendan Zheng, Shiyu Sun, Yang Du, Wenjuan Xu, Zongguo Sun, Fuhong Liu, Manzhi Wang, Zuohui Zhao, Ju Liu, Qiang Liu
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Integration analysis of cell division cycle-associated family genes revealed potential mechanisms of gliomagenesis and constructed an artificial intelligence-driven prognostic signature Cell. Signal. (IF 4.8) Pub Date : 2024-04-09 Kai Yu, Qi Tian, Shi Feng, Yonggang Zhang, Ziqi Cheng, Mingyang Li, Hua Zhu, Jianying He, Mingchang Li, Xiaoxing Xiong
Cell division cycle-associated (CDCA) gene family members are essential cell proliferation regulators and play critical roles in various cancers. However, the function of the CDCA family genes in gliomas remains unclear. This study aims to elucidate the role of CDCA family members in gliomas using in vitro and in vivo experiments and bioinformatic analyses. We included eight glioma cohorts in this
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Transient stimulation of TRPMLs enhance the functionality of hDPCs and facilitate hair growth in mice Cell. Signal. (IF 4.8) Pub Date : 2024-04-09 Jiayi Sun, Hongyan Zhang, Bo Xie, Yuqing Shen, Yuqi Zhu, Wen Xu, Beilei Zhang, Xiuzu Song
Autophagy is essential for eliminating aging and organelle damage that maintaining cellular homeostasis. However, the dysfunction of autophagy has been proven in hair loss such as AGA. Despite the crucial role of TRPML channels in regulating autophagy, their specific function in hair growth remains unclarified. To investigate the biological functions and associated molecular mechanisms of TRPMLs in
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Inhibition of PRMT5-mediated regulation of DKK1 sensitizes colorectal cancer cells to chemotherapy Cell. Signal. (IF 4.8) Pub Date : 2024-04-06 Wafaa Abumustafa, Darko Castven, Diana Becker, Shahenaz Shaban Salih, Shaista Manzoor, Batoul Abi Zamer, Iman Talaat, Mawieh Hamad, Jens Uwe Marquardt, Jibran Sualeh Muhammad
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LncRNA HMOX1 alleviates renal ischemia-reperfusion-induced ferroptotic injury via the miR-3587/HMOX1 axis Cell. Signal. (IF 4.8) Pub Date : 2024-04-06 Wenqiang Tao, Yuanhua Lu, Rui Xiao, Jianguo Zhang, Ping Hu, Ning Zhao, Wei Peng, Kejian Qian, Fen Liu
Emerging evidence suggests that long non-coding RNAs (lncRNAs) play significant roles in renal ischemia reperfusion (RIR) injury. However, the specific mechanisms by which lncRNAs regulate ferroptosis in renal tubular epithelial cells remain largely unknown. The objective of this study was to investigate the biological function of lncRNA heme oxygenase 1 (lnc-HMOX1) in RIR and its potential molecular
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CircUGGT2 facilitates progression and cisplatin resistance of bladder cancer through nonhomologous end-joining pathway Cell. Signal. (IF 4.8) Pub Date : 2024-04-05 Fang Lyu, Sihuai Huang, Zhecheng Yan, Qingliu He, Chunyu Liu, Lulin Cheng, Yukun Cong, Kang Chen, Yarong Song, Yifei Xing
The development of resistance to cisplatin (CDDP) in bladder cancer presents a notable obstacle, with indications pointing to the substantial role of circular RNAs (circRNAs) in this resistance. Nevertheless, the precise mechanisms through which circRNAs govern resistance are not yet fully understood. Our findings demonstrate that circUGGT2 is significantly upregulated in bladder cancer, facilitating
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Unravelling the molecular interplay: SUMOylation, PML nuclear bodies and vascular cell activity in health and disease Cell. Signal. (IF 4.8) Pub Date : 2024-04-02 Janine Berkholz, Weronika Karle
In the seemingly well-researched field of vascular research, there are still many underestimated factors and molecular mechanisms. In recent years, SUMOylation has become increasingly important. SUMOylation is a post-translational modification in which small ubiquitin-related modifiers (SUMO) are covalently attached to target proteins. Sites where these SUMO modification processes take place in the
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Hsa_circ_0005320 affects cell proliferation and the cell cycle via the IGF2BP3/CDK2 axis in bladder cancer Cell. Signal. (IF 4.8) Pub Date : 2024-03-31 Quansong Ji, Feilu Ma, Xiling Zhang, Yili Liu, Ping Wang, Mingshan Li
Circular RNAs (circRNAs), which are covalently closed non-coding RNAs, are frequently dysregulated in cancer. However, their precise role in bladder cancer (BCa) remains largely unknown. Expression of hsa_circ_0005320 in tissues and cell lines was detected using quantitative real-time PCR. Proliferation and colony forming capacity of BCa cells were assessed using Cell Counting Kit-8, ethynyl-labeled
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MiR-3682-3p promotes esophageal cancer progression by targeting FHL1 and activating the Wnt/β-catenin signaling pathway Cell. Signal. (IF 4.8) Pub Date : 2024-03-31 Yuxin Cai, Lingling Xia, Hangjia Zhu, Hao Cheng, Yuanyuan Tian, Liying Sun, Jun Wang, Ning Lu, Jing Wang, Yongshun Chen
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Computational modelling of dynamic cAMP responses to GPCR agonists for exploration of GLP-1R ligand effects in pancreatic β-cells and neurons Cell. Signal. (IF 4.8) Pub Date : 2024-03-30 Lloyd Bridge, Shiqian Chen, Ben Jones
The glucagon-like peptide-1 receptor (GLP-1R) is a class B G protein-coupled receptor (GPCR) which plays important physiological roles in insulin release and promoting fullness. GLP-1R agonists initiate cellular responses by cyclic AMP (cAMP) pathway signal transduction. Understanding of the potential of GLP-1R agonists in the treatment of type 2 diabetes may be advanced by considering the cAMP dynamics
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Deciphering the role of SMARCA4 in cardiac disorders: Insights from single-cell studies on dilated cardiomyopathy and coronary heart disease Cell. Signal. (IF 4.8) Pub Date : 2024-03-27 Li Liu, Chengban Li, Linxing Yu, Yubo Wang, Xingshou Pan, Jianjun Huang
Dilated cardiomyopathy (DCM) and coronary heart disease (CHD) stand as two of the foremost causes of mortality. However, the comprehensive comprehension of the regulatory mechanisms governing DCM and CHD remains limited, particularly from the vantage point of single-cell transcriptional analysis. We used the GSE121893 dataset from the GEO database, analyzing single-cell expressions with tools like
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Prognostic value and potential function of a novel heme-related LncRNAs signature in gastric cancer Cell. Signal. (IF 4.8) Pub Date : 2024-03-26 Shuo Ma, Wei Liao, Yinhao Chen, Lin Gan
Heme is a coordination complex formed by the binding of iron ions and porphyrin rings. Its metabolic processes are associated with various cancers, including gastric cancer (GC). In recent years, long non-coding RNAs (LncRNAs) have been identified as key regulatory factors in GC. However, the role of LncRNAs associated with heme metabolism in GC and their relationship with prognosis have not been reported
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E2F8-CENPL pathway contributes to homologous recombination repair and chemoresistance in breast cancer Cell. Signal. (IF 4.8) Pub Date : 2024-03-22 Shan Wang, Yuhong Xia, Yu Sun, Wei Wang, Lianfeng Shan, Zhongbo Zhang, Chenghai Zhao
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Deciphering the role of glycosaminoglycans in GPCR signaling Cell. Signal. (IF 4.8) Pub Date : 2024-03-22 Sofya Savransky, Alex D. White, Jean-Pierre Vilardaga
G protein-coupled receptors (GPCR) and glycosaminoglycans (GAGs) are two essential components of the cell surface that regulate physiological processes in the body. GPCRs are the most extensive family of transmembrane receptors that control cellular responses to extracellular stimuli, while GAGs are polysaccharides that contribute to the function of the extracellular matrix (ECM). Due to their proximity
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E3 ubiquitin ligase CHIP interacts with transferrin receptor 1 for degradation and promotes cell proliferation through inhibiting ferroptosis in hepatocellular carcinoma Cell. Signal. (IF 4.8) Pub Date : 2024-03-21 Miaomiao Shao, Kangwei Qi, Lanxin Wang, Xiaoxuan Yu, Qingyu Zhang, Long Yu, Lan Wang, Caiting Yang, Lu Fan
Hepatocellular carcinoma (HCC) is the major form of liver malignancy with high incidence and mortality. Identifying novel biomarkers and understanding regulatory mechanisms underlying the development and progression of HCC are critical for improving diagnosis, treatment and patient outcomes. Carboxyl terminus of Hsc-70-interacting protein (CHIP) is a well-described U-box-type E3 ubiquitin ligase which
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Unraveling the mechanism in l-Caldesmon regulating the osteogenic differentiation of PDLSCs: An innovative perspective Cell. Signal. (IF 4.8) Pub Date : 2024-03-20 Yuejia Li, Ziyi Mei, Pingmeng Deng, Sha Zhou, Aizhuo Qian, Xiya Zhang, Jie Li
Maxillofacial bone defect is one of the common symptoms in maxillofacial, which affects the function and aesthetics of maxillofacial region. Periodontal ligament stem cells (PDLSCs) are extensively used in bone tissue engineering. The mechanism that regulates the osteogenic differentiation of PDLSCs remains not fully elucidated. Previous studies demonstrated that l-Caldesmon (l-CALD, or CALD1) might
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MZB1 regulates cellular proliferation, mitochondrial dysfunction, and inflammation and targets the PI3K-Akt signaling pathway in acute pancreatitis Cell. Signal. (IF 4.8) Pub Date : 2024-03-18 Mengtao Xu, Yong Feng, Xuelian Xiang, Li Liu, Guodu Tang
Acute pancreatitis (AP) is a pathological condition characterized by the premature release and activation of trypsinogens and other enzyme precursors. In severe cases, the mortality rates are in the range of 20–30% and may even be as high as 50%. Though various prophylaxes are available for AP, the mechanism of its progression is unclear. Marginal zone B and B-1 cell-specific protein 1 (MZB1) is found
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The PIEZO1/miR-155-5p/GDF6/SMAD2/3 signaling axis is involved in inducing the occurrence and progression of osteoarthritis under excessive mechanical stress. Cell. Signal. (IF 4.8) Pub Date : 2024-03-18 Chaoren Qin, Yan Feng, Zhaowei Yin, Changjiang Wang, Rui Yin, Yang Li, Kai Chen, Tianqi Tao, Kaibin Zhang, Yiqiu Jiang, Jianchao Gui
To elucidate the molecular mechanism of overloading-induced osteoarthritis (OA) and to find a novel therapeutic target. We utilized human cartilage specimens, mouse chondrocytes, a destabilization of the medial meniscus (DMM) mouse model, and a mouse hindlimb weight-bearing model to validate the role of overloading on chondrocyte senescence and OA development. Then, we observed the effect of PIEZO
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Microglial uptake of hADSCs-Exo mitigates neuroinflammation in ICH Cell. Signal. (IF 4.8) Pub Date : 2024-03-16 Lanqing Zhao, Jinwei Li
Intracerebral hemorrhage (ICH) is associated with secondary neuroinflammation, leading to severe central nervous system damage. Exosomes derived from human adipose-derived mesenchymal stem cells (hADSCs-Exo) have shown potential therapeutic effects in regulating inflammatory responses in ICH. This study aims to investigate the role of hADSCs-Exo in ICH and its underlying mechanism involving miRNA-mediated
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WDR4 promotes HCC pathogenesis through N7-methylguanosine by regulating and interacting with METTL1 Cell. Signal. (IF 4.8) Pub Date : 2024-03-16 Rui Dong, Chuanxu Wang, Bo Tang, Yayu Cheng, Xuehui Peng, Xiaomin Yang, Bing Ni, Jing Li
The N7-methylguanosine (m7G), a modification at defined internal positions within tRNAs and rRNAs, is correlated with tumor progression. Methyltransferase like 1 (METTL1)/ WD repeat domain 4 (WDR4) mediated tRNA m7G modification, which could alter many oncogenic mRNAs translation to promote progress of multiple cancer types. However, whether and how the internal mRNA m7G modification is involved in
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Circ_0007534 promotes cholangiocarcinoma stemness and resistance to anoikis through DDX3X-mediated positive feedback regulation of parental gene DDX42 Cell. Signal. (IF 4.8) Pub Date : 2024-03-16 Sidi Liu, Canghai Guan, Xiangjun Sha, Xin Gao, Xinlei Zou, Chengru Yang, Xinmiao Zhang, Xiangyu Zhong, Xingming Jiang
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Exploration of gut microbiome and inflammation: A review on key signalling pathways Cell. Signal. (IF 4.8) Pub Date : 2024-03-16 Manisha Nigam, Kanchan Devi, Henrique D.M. Coutinho, Abhay Prakash Mishra
The gut microbiome, a crucial component of the human system, is a diverse collection of microbes that belong to the gut of human beings as well as other animals. These microbial communities continue to coexist harmoniously with their host organisms and perform various functions that affect the host's general health. Each person's gut microbiota has a unique makeup. The gut microbiota is well acknowledged
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The regulatory role of miRNA and lncRNA on autophagy in diabetic nephropathy Cell. Signal. (IF 4.8) Pub Date : 2024-03-15 Siming Yu, Yue Li, Xinxin Lu, Zehui Han, Chunsheng Li, Xingxing Yuan, Dandan Guo
Diabetic nephropathy (DN) is a serious complication of diabetes that causes glomerular sclerosis and end-stage renal disease, leading to ascending morbidity and mortality in diabetic patients. Excessive accumulation of aberrantly modified proteins or damaged organelles, such as advanced glycation end-products, dysfunctional mitochondria, and inflammasomes is associated with the pathogenesis of DN.
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Deciphering alternative splicing events and their therapeutic implications in colorectal Cancer Cell. Signal. (IF 4.8) Pub Date : 2024-03-12 Wenbo Ding, Qianni Xiao, Yanzhe Yue, Shuyu Chen, Xiangjian She, Bei Pan, Linpeng Zhou, Yujuan Yin, Youyue Li, Shukui Wang, Mu Xu
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Early B Cell Factor 3 (EBF3) attenuates Parkinson's disease through directly regulating contactin-associated protein-like 4 (CNTNAP4) transcription: An experimental study Cell. Signal. (IF 4.8) Pub Date : 2024-03-11 Wentao Hu, Menghan Wang, Guifang Sun, Limin Zhang, Hong Lu
Parkinson's disease (PD) is a gradually debilitating neurodegenerative syndrome. Here, we analyzed GSE7621 chip data obtained from the Gene Expression Omnibus (GEO) database to explore the pathogenesis of PD. Early B Cell Factor 3 (EBF3), a member of the highly evolutionarily conserved EBF-transcription factor family, is involved in neuronal development. EBF3 expression is low in the substantia nigra
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Glucose regulates the HMGB1 signaling pathway through SIRT1 in glioma Cell. Signal. (IF 4.8) Pub Date : 2024-03-11 Yu Wang, Shuai Wang, Yuhao Wang, Chengcheng Wang, Yuhang Tang, Chao Zhang, Shiqiang Hou, Dong Yu, Ning Lin
Glucose is a fundamental substance for numerous cancers, including glioma. However, its influence on tumor cells regulatory mechanisms remains uncertain. SIRT1 is a regulator of deacetylation and a key player in the progression of malignant tumors. The objective of this study was to examine the role of glucose and SIRT1 in glioma. This study investigated the association of SIRT1 expression with clinicopathological
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microRNA-125b-1-3p mediates autophagy via the RRAGD/mTOR/ULK1 signaling pathway and mitigates atherosclerosis progression Cell. Signal. (IF 4.8) Pub Date : 2024-03-11 Xin Chen, Yanhong Cao, Yining Guo, Jing Liu, Xiaohan Ye, Huan Li, Lu Zhang, Wenwei Feng, Shaoxiang Xian, Zhongqi Yang, Lingjun Wang, Ting Wang
Atherosclerosis is characterised by lipid accumulation and formation of foam cells in arterial walls. Dysregulated autophagy is a crucial factor in atherosclerosis development. The significance of microRNA (miR)-125b-1-3p in cardiovascular disease is well-established; however, its precise role in regulating autophagy and impact on atherosclerosis in vascular smooth muscle cells (VSMCs) remain unclear
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COMP promotes pancreatic fibrosis by activating pancreatic stellate cells through CD36-ERK/AKT signaling pathways Cell. Signal. (IF 4.8) Pub Date : 2024-03-11 Yi Wang, Hai-Tao Li, Gang Liu, Chuan-Shen Jiang, Yan-Hong Ni, Jing-Hui Zeng, Xia Lin, Qing-Yun Wang, Da-Zhou Li, Wen Wang, Xiang-Peng Zeng
Pancreatic fibrosis is one of the most important pathological features of chronic pancreatitis (CP) and pancreatic stellate cells (PSCs) are the key cells of fibrosis. As an extracellular matrix (ECM) glycoprotein, cartilage oligomeric matrix protein (COMP) is critical for collagen assembly and ECM stability and recent studies showed that COMP exert promoting fibrosis effect in the skin, lungs and
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The polybasic region in Gαi proteins: Relevant or not? Insights from Gαi3 research Cell. Signal. (IF 4.8) Pub Date : 2024-03-11 Beata Rysiewicz, Ewa Błasiak, Marta Dziedzicka-Wasylewska, Agnieszka Polit
Heterotrimeric G proteins are responsible for signal transduction from G-protein-coupled receptors (GPCRs) to intracellular effectors. This process is only possible when G proteins are located on the inner side of the cell membrane due to the specific localization of GPCR receptors. The Gα subunit is directed to the cell membrane through several signals, including modification by fatty acid moieties
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HK2 promotes migration and invasion of intrahepatic cholangiocarcinoma via enhancing cancer stem-like cells' resistance to anoikis Cell. Signal. (IF 4.8) Pub Date : 2024-03-05 Xiaojing Du, Zhuoran Qi, Yunjia Jiao, Wenzhi Wu, Qingke Huang, Xuecheng Sun, Sunkuan Hu
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BRD4 promotes LPS-induced endothelial cells senescence via activating and cooperating STING-IRF3 pathway Cell. Signal. (IF 4.8) Pub Date : 2024-03-04 Ruigong Zhu, Lei Zhang, Hao Zhang, Zhifeng Hu
Endothelial cells (ECs) senescence is closely associated with the initiation and development of multiple age-related cardiovascular diseases. It is necessary to explore the underlying molecular mechanisms of ECs senescence, which is not only the basis to decipher cellular senescence, but also a novel therapeutic target for the endothelial senescence-related diseases. BRD4, a key epigenetic regulator
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AMPK-mediated autophagy pathway activation promotes ΔFosB degradation to improve levodopa-induced dyskinesia Cell. Signal. (IF 4.8) Pub Date : 2024-03-01 Ke Liu, Zhaoyuan Zhang, Yu Xu, Yi Wu, Piaopiao Lian, Zhuoran Ma, Zhicheng Tang, Xiaoqian Zhang, Xiaoman Yang, Heng Zhai, Lei Zhang, Yan Xu, Xuebing Cao
Parkinson's disease patients on chronic levodopa often suffer from motor complications, which tend to reduce their quality of life. Levodopa-induced dyskinesia (LID) is one of the most prevalent motor complications, often characterized by abnormal involuntary movements, and the pathogenesis of LID is still unclear but recent studies have suggested the involvement of autophagy. The onset of LID was
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VGLL1 stabilization of cytoplasmic TAZ promotes EGFR expression and maintains tumor initiating cells in breast cancer independent of TEAD Cell. Signal. (IF 4.8) Pub Date : 2024-02-28 Shubhashree Parimita, Amitava Das, Sanjoy Samanta
Vestigial-like family member 1 () is one of the X-linked genes whose expression is elevated in basal-like breast cancer (BLBC) because of X-chromosome isodisomy. As an approach towards understanding its function, we performed correlation study using transcript data of breast cancer patients from cBioPortal for Cancer Genomics. Our analysis identified EGFR as the most correlated transcript with VGLL1
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Adaptor protein HIP-55 promotes macrophage M1 polarization through promoting AP-1 complex activation Cell. Signal. (IF 4.8) Pub Date : 2024-02-27 Jingwei Bian, Yuzhong Zhu, Panhui Tian, Qiqi Yang, Zijian Li
Overwhelming macrophage M1 polarization induced by malfunction of the renin–angiotensin–aldosterone system (RAAS) initiates inflammatory responses, which play a crucial role in various cardiovascular diseases. However, the underlying regulatory mechanism remains elusive. Here, we identified adaptor protein HIP-55 as a critical regulator of macrophage M1 polarization. The expression of HIP-55 was upregulated
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mm9_circ_014683 regulates microglia polarization through canonical NFκB signaling pathway in diabetic retinopathy Cell. Signal. (IF 4.8) Pub Date : 2024-02-27 Tingting Chen, Congyao Wang, Wenhui Zhu, Fenfen Yu, Xia Dong, Yihua Su, Jingwen Huang, Lijun Huo, Pengxia Wan
Diabetic retinopathy (DR) is still the major cause of visual loss in working-aged people, one of the critical pathological processes are retinal microglia-mediated inflammation. Our previous study demonstrated that enhanced M1 microglial polarization was involved in retinal inflammation in DR, but the detailed mechanism needs further investigation. Circular RNAs (circRNAs) are important kind of noncoding
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Low shear stress induces macrophage infiltration and aggravates aneurysm wall inflammation via CCL7/CCR1/TAK1/ NF-κB axis Cell. Signal. (IF 4.8) Pub Date : 2024-02-27 Heng Wei, Guijun Wang, Qi Tian, Chengli Liu, Wenrui Han, Jianfeng Wang, Peibang He, Mingchang Li
This study aimed to elucidate the mechanism by which wall shear stress (WSS) influences vascular walls, accounting for the susceptibility of intracranial aneurysms (IAs) to rupture. We collected blood samples from the sacs of 24 ruptured and 28 unruptured IAs and analyzed the expression of chemokine CCL7 using enzyme-linked immunosorbent assay (ELISA). Univariate and multivariate logistic regression
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Approaches and challenges in identifying, quantifying, and manipulating dynamic mitochondrial genome variations Cell. Signal. (IF 4.8) Pub Date : 2024-02-27 Fei Li, Run Xiang, Yue Liu, Guoliang Hu, Quanbo Jiang, Tao Jia
Mitochondria, the cellular powerhouses, possess their own unique genetic system, including replication, transcription, and translation. Studying these processes is crucial for comprehending mitochondrial disorders, energy production, and their related diseases. Over the past decades, various approaches have been applied in detecting and quantifying mitochondrial genome variations with also the purpose
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Uptake pathways of cell-penetrating peptides in the context of drug delivery, gene therapy, and vaccine development Cell. Signal. (IF 4.8) Pub Date : 2024-02-24 Moataz Dowaidar
Cell-penetrating peptides have been extensively utilized for the purpose of facilitating the intracellular delivery of cargo that is impermeable to the cell membrane. The researchers have exhibited proficient delivery capabilities for oligonucleotides, thereby establishing cell-penetrating peptides as a potent instrument in the field of gene therapy. Furthermore, they have demonstrated a high level
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Identification of biomimetic nanoplatform-mediated delivery of si-ISG15 for treatment of triple-negative breast cancer Cell. Signal. (IF 4.8) Pub Date : 2024-02-23 Feiran Wang, Nannan Zhang, Ruishu Niu, Yunpeng Lu, Wei Zhang, Zhixian He
Triple-negative breast cancer (TNBC) is recognized as the most malicious form of breast cancer and exhibits an alarming tendency for recurrence, a heightened propensity for metastasis, and an overwhelmingly grim prognosis. Therefore, effective therapy approaches for TNBC are urgently required. In this study, the interferon-stimulated gene 15 (ISG15) expression level was analyzed by bioinformatics and
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Pan-cancer analysis reveals potential immunological and prognostic roles of COA6 in human cancers and preliminary exploration of COA6 in bladder cancer Cell. Signal. (IF 4.8) Pub Date : 2024-02-22 Hong Luo, Zhiyong Wang
Cytochrome C oxidase assembly factor 6 (COA6) is significantly involved in the progression of cancer and is aberrantly expressed in disease. Nevertheless, the comprehensive analysis of COA6 using many omics techniques, and its impact on the prognosis and immunological microenvironment of cancer patients, remains unexplored. We gathered data from 33 cancer cases and conducted a thorough analysis of
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Glial Cx43 hemichannels and neuronal Panx1 hemichannels and P2X7 receptors orchestrate presynaptic homeostatic plasticity Cell. Signal. (IF 4.8) Pub Date : 2024-02-22 Alberto Rafael, Marina Tizzoni, Cristian Justet, Andrea Cairus, Verónica Abudara, Nathalia Vitureira
The emerging role of glial cells in modulating neuronal excitability and synaptic strength is a growing field in neuroscience. In recent years, a pivotal role of gliotransmission in homeostatic presynaptic plasticity has been highlighted and glial-derived ATP arises as a key contributor. However, very little is known about the glial non-vesicular ATP-release pathway and how ATP participates in the
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LOC644656 promotes cisplatin resistance in cervical cancer by recruiting ZNF143 and activating the transcription of E6-AP Cell. Signal. (IF 4.8) Pub Date : 2024-02-21 Min Li, Jie Chen, Hong Zhang, Yi Zhang, Jiahui Wang, Zongji Shen, Youguo Chen, Wenjie Hou, Chi Chi
Cisplatin resistance remains a persistent challenge in cervical cancer (CC) treatment. Molecular biomarkers have garnered attention for their association with cisplatin resistance in various diseases. Long non-coding RNAs (lncRNAs) exert significant influence on CC development. This study explores the role of LOC644656 in regulating cisplatin resistance in CC. Parental and cisplatin-resistant CC cells
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CENPA promotes glutamine metabolism and tumor progression by up-regulating SLC38A1 in endometrial cancer Cell. Signal. (IF 4.8) Pub Date : 2024-02-20 Shuang Li, Zihui Zhang, Zhifang Li, Lian Yang, Jianfeng Liu, Yujie Liu, Yancai Liu, Yanmei Hou, Mei Mei, Yuqin Huang
Glutamine addiction is a significant hallmark of metabolic reprogramming in tumors and is crucial to the progression of cancer. Nevertheless, the regulatory mechanisms of glutamine metabolism in endometrial cancer (EC) remains elusive. In this research, we found that elevated expression of CENPA and solute carrier family 38 member 1 (SLC38A1) were firmly associated with worse clinical stage and unfavorable
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LncRNA HOST2 promotes NSUN2-mediated breast cancer progression via interaction with ELAVL1 Cell. Signal. (IF 4.8) Pub Date : 2024-02-20 Xuehui Wang, Diya Liu, Kaiyao Hua, Lin Fang
Breast cancer (BC) is the most prevalent malignant tumor in women worldwide with high morbidity and mortality. NSUN2, a crucial RNA methyltransferase, plays a pivotal role in regulating the proliferation and metastasis of tumor cells. Our study demonstrated that NSUN2 is upregulated in BC tissues and cell lines, and its high expression is associated with a poor prognosis in BC patients. Knockout of
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Uptake of ox-LDL by binding to LRP6 mediates oxidative stress-induced BMSCs senescence promoting obesity-related bone loss Cell. Signal. (IF 4.8) Pub Date : 2024-02-20 Senxiong Meng, Zhuan Wang, Xiaonan Liu, Ke Shen, Yuan Gu, Bin Yu, Lei Wang
Obesity has long been thought to be a main cause of hyperlipidemia. As a systemic disease, the impact of obesity on organs, tissues and cells is almost entirely negative. However, the relationship between obesity and bone loss is highly controversial. On the one hand, obesity has long been thought to have a positive effect on bone due to increased mechanical loading on the skeleton, conducive to increasing
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Clinical value of molecular subtypes identification based on anoikis-related lncRNAs in castration-resistant prostate cancer Cell. Signal. (IF 4.8) Pub Date : 2024-02-17 Kailei Chen, Yunxuan Zhang, Chengyong Li, Yuenan Liu, Qi Cao, Xiaoping Zhang
Anoikis is a distinctive type of apoptosis. It is involved in tumor progression and metastasis. But its function in castration-resistant prostate cancer (CRPC) remains veiled. We aimed to develop a prognostic indicator based on anoikis-related long non-coding RNAs (arlncRNAs) and to investigate their biological function in CRPC. Differentially expressed anoikis-related genes were extracted from two
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Platelet-rich plasma-derived extracellular vesicles inhibit NF-κB/NLRP3 pathway-mediated pyroptosis in intervertebral disc degeneration via the MALAT1/microRNA-217/SIRT1 axis Cell. Signal. (IF 4.8) Pub Date : 2024-02-17 Xueqiang Tao, Fen Xue, Jiayuan Xu, Wenbo Wang
Intervertebral disc degeneration (IDD) is a main contributor to lower back pain, and compression stress-induced apoptosis of nucleus pulposus (NP) cells and extracellular matrix (ECM) degradation has been implicated in the IDD progression. The functions of platelet-rich plasma (PRP)-derived extracellular vesicles (PRP-EVs) in regulating these biological processes remain unclear in IDD. Here, we aimed
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Imaging of extracellular and intracellular ATP in pancreatic beta cells reveals correlation between glucose metabolism and purinergic signalling Cell. Signal. (IF 4.8) Pub Date : 2024-02-17 Seyed M. Ghiasi, Nynne M. Christensen, Per A. Pedersen, Emil Z. Skovhøj, Ivana Novak
Adenosine triphosphate (ATP) is a universal energy molecule and yet cells release it and extracellular ATP is an important signalling molecule between cells. Monitoring of ATP levels outside of cells is important for our understanding of physiological and pathophysiological processes in cells/tissues. Here, we focus on pancreatic beta cells (INS-1E) and test the hypothesis that there is an association
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Artesunate-loaded solid lipid nanoparticles resist esophageal squamous cell carcinoma by inducing Ferroptosis through inhibiting the AKT/mTOR signaling Cell. Signal. (IF 4.8) Pub Date : 2024-02-16 Yu Xia, Yixin Tang, Zhixin Huang, Nantian Ke, Yue Zheng, Wanzhen Zhuang, Yi Zhang, Xiaoqing Yin, Mingshu Tu, Jianlin Chen, Yingshu Wang, Yi Huang
Esophageal squamous cell carcinoma (ESCC) is a severe malignancy with high incidence and mortality rate in China, while the application of standard chemotherapeutic drugs for ESCC meets the barriers of high toxicity and multiple drug resistance (MDR). In recent years, the anticancer effects of artesunate (ART), a Chinese medicine monomer have gained extensive attentions due to its characteristics of
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Pan-cancer analysis predicts CANT1 as a potential prognostic, immunologic biomarker Cell. Signal. (IF 4.8) Pub Date : 2024-02-16 Wei Yang, Zhidong Liu, Ting Liu
CANT1, calcium-activated nucleotidase 1, was reported to be upregulated in certain tumors. However, the function mechanism of CANT1 in pan-cancer is still unclear. We utilized the Cancer Genome Atlas Program (TCGA) and UALCAN databases to analyze CANT1 expression at the level of mRNA, protein, and promoter methylation in pan-cancer, and the cBioportal database to study the frequency of gene changes
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Deciphering disulfidptosis: Uncovering a lncRNA-based signature for prognostic assessment, personalized immunotherapy, and therapeutic agent selection in lung adenocarcinoma patients Cell. Signal. (IF 4.8) Pub Date : 2024-02-16 Chao Ma, Huan Zhao, Yang Sun, Weizheng Ding, Hui Wang, Yixin Li, Zhuoyu Gu
Disulfidptosis, a recently identified type of regulated cell death, plays critical roles in various biological processes of cancer; however, whether they can impact the prognosis of lung adenocarcinoma (LUAD) remains to be fully elucidated. We aimed to adopt this concept to develop and validate a lncRNA signature for LUAD prognostic prediction. For this study, the TCGA-LUAD dataset was used as the
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Insulin-stimulated translocation of the fatty acid transporter CD36 to the plasma membrane is mediated by the small GTPase Rac1 in adipocytes Cell. Signal. (IF 4.8) Pub Date : 2024-02-15 Man Piu Chan, Nobuyuki Takenaka, Yuki Abe, Takaya Satoh
Cluster of differentiation 36 (CD36) is a scavenger receptor (SR), recognizing diverse extracellular ligands in various types of mammalian cells. Long-chain fatty acids (FAs), which are important constituents of phospholipids and triglycerides, also utilize CD36 as a predominant membrane transporter, being incorporated from the circulation across the plasma membrane in several cell types, including
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Reactive oxygen species signalling in the deterioration of quality of mammalian oocytes cultured in vitro: Protective effect of antioxidants Cell. Signal. (IF 4.8) Pub Date : 2024-02-15 Ashutosh N. Pandey, Pramod K. Yadav, Karuppanan V Premkumar, Meenakshi Tiwari, Ajai K. Pandey, Shail K. Chaube
The fertilization (IVF) is the first choice of infertile couples worldwide to plan for conception. Besides having a significant advancement in IVF procedure, the success rate is still poor. Although several approaches have been tested to improve IVF protocol, minor changes in culture conditions, physical factors and/or drug treatment generate reactive oxygen species (ROS) in oocytes. Due to large size
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FTO regulates osteoclast development by modulating the proliferation and apoptosis of osteoclast precursors in inflammatory conditions Cell. Signal. (IF 4.8) Pub Date : 2024-02-15 Jinlin He, Yiqing Zhao, Yiwen Zhang, Zhanqi Zhang, Di Li, Qiong Xu
Periodontitis is an oral inflammatory disease that causes alveolar bone destruction by activating osteoclast. FTO, a crucial demethylase of N6-methyladenosine(mA), exerts essential function in maintaining bone homeostasis. However, the effects of FTO on periodontitis-related bone destruction remain unknown. To investigate its role in inflammatory osteoclastogenesis, we overexpressed FTO in osteoclast
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Exosomal miR-122-3p represses the growth and metastasis of MCF-7/ADR cells by targeting GRK4-mediated activation of the Wnt/β-catenin pathway Cell. Signal. (IF 4.8) Pub Date : 2024-02-15 Binbin Song, Guoxin Hou, Maoyi Xu, Ming Chen
Breast cancer (BC) is a common cancer whose incidence continues to grow while its medical progress has stagnated. miRNAs are vital messengers that facilitate communications among different cancer cells. This study was to reveal the correlation of miR-122-3p expression with BC metastasis and Adriamycin (ADM) resistance and its mechanism of inhibiting BC metastasis. We found that expression of miR-122-3p
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Corrigendum to “Ripk3 regulates cardiac microvascular reperfusion injury: The role of IP3R-dependent calcium overload, XO-mediated oxidative stress and F-action/filopodia based cellular migration” [Cell Signal. 45 (2018) 12–22] Cell. Signal. (IF 4.8) Pub Date : 2024-02-15 Hao Zhou, Jin Wang, Pingjun Zhu, Shunying Hu, Jun Ren