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Editorial Board/Publication Information Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2024-01-04
Abstract not available
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Editorial Board/Publication Information Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-11-30
Abstract not available
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Editorial Board/Publication Information Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-11-03
Abstract not available
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Editorial Board/Publication Information Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-10-19
Abstract not available
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Thrombospondin proteins – Versatile extracellular proteins with multiple biological functions Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-09-18 Kenneth W. Adolph
Abstract not available
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Editorial on “Vascular cell fate in health and disease” Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-09-18 Christine Cheung
Abstract not available
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The Calvin Benson Bassham cycle Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-09-14 Christine A. Raines, Amanda P. Cavanagh
Abstract not available
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Control of coronary vascular cell fate in development and regeneration Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-09-14 Ian R. McCracken, Nicola Smart
The coronary vasculature consists of a complex hierarchal network of arteries, veins, and capillaries which collectively function to perfuse the myocardium. However, the pathways controlling the temporally and spatially restricted mechanisms underlying the formation of this vascular network remain poorly understood. In recent years, the increasing use and refinement of transgenic mouse models has played
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New insights into the role of thrombospondin-1 in glioblastoma development Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-09-09 Andreas Bikfalvi, Joris Guyon, Thomas Daubon
Glioblastoma (GB), the most malignant subtype of diffuse glioma, is highly aggressive, invasive and vascularized. Its median survival is still short even with maximum standard care. There is a need to identify potential new molecules and mechanisms, that are involved in the interactions of GB cells with the tumor microenvironment (TME), for therapeutic intervention. Thrombospondin-1 (TSP1) is a multi-faceted
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Epigenetic regulation of inflammation Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-09-07 Aamir Ahmad
Abstract not available
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A journey through translational control Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-09-01 Huili Guo
Abstract not available
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C. elegans as a model for health and disease Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-08-09 Steven Zuryn
Abstract not available
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The Calvin-Benson-Bassham cycle in C4 and Crassulacean acid metabolism species Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-08-04 Martha Ludwig, James Hartwell, Christine A. Raines, Andrew J. Simkin
The Calvin-Benson-Bassham (CBB) cycle is the ancestral CO2 assimilation pathway and is found in all photosynthetic organisms. Biochemical extensions to the CBB cycle have evolved that allow the resulting pathways to act as CO2 concentrating mechanisms, either spatially in the case of C4 photosynthesis or temporally in the case of Crassulacean acid metabolism (CAM). While the biochemical steps in the
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Editorial Board/Publication Information Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-08-03
Abstract not available
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Thrombospondin-1 in vascular development, vascular function, and vascular disease Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-07-27 Bo Liu, Huan Yang, Yong-Seok Song, Christine M. Sorenson, Nader Sheibani
Angiogenesis is vital to developmental, regenerative and repair processes. It is normally regulated by a balanced production of pro- and anti-angiogenic factors. Alterations in this balance under pathological conditions are generally mediated through up-regulation of pro-angiogenic and/or downregulation of anti-angiogenic factors, leading to growth of new and abnormal blood vessels. The pathological
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Blood endothelium transition and phenotypic plasticity: A key regulator of integrity/permeability in response to ischemia Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-07-20 Nicolas Bréchot, Alexandre Rutault, Iris Marangon, Stéphane Germain
In the human body, the 1013 blood endothelial cells (ECs) which cover a surface of 500–700 m2 (Mai et al., 2013) are key players of tissue homeostasis, remodeling and regeneration. Blood vessel ECs play a major role in the regulation of metabolic and gaz exchanges, cell trafficking, blood coagulation, vascular tone, blood flow and fluid extravasation (also referred to as blood vascular permeability)
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Maintenance of neuronal identity in C. elegans and beyond: Lessons from transcription and chromatin factors Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-07-11
Neurons are remarkably long-lived, non-dividing cells that must maintain their functional features (e.g., electrical properties, chemical signaling) for extended periods of time – decades in humans. How neurons accomplish this incredible feat is poorly understood. Here, we review recent advances, primarily in the nematode C. elegans, that have enhanced our understanding of the molecular mechanisms
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Thrombospondins modulate cell function and tissue structure in the skeleton Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-07-07 Andrea I. Alford, Kurt D. Hankenson
Thrombospondins (TSPs) belong to a functional class of ECM proteins called matricellular proteins that are not primarily structural, but instead influence cellular interactions within the local extracellular environment. The 3D arrangement of TSPs allow interactions with other ECM proteins, sequestered growth factors, and cell surface receptors. They are expressed in mesenchymal condensations and limb
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The C. elegans anchor cell: A model to elucidate mechanisms underlying invasion through basement membrane Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-07-06 Isabel W. Kenny-Ganzert, David R. Sherwood
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Thrombospondin-1 in drug activity and tumor response to therapies Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-07-04 Elisa Longhi, Laura Carminati, Elena Carlessi, Dorina Belotti, Giulia Taraboletti
Thrombospondins (TSPs) have numerous different roles in cancer, regulating the behavior of cancer cells and non-neoplastic cells, and defining the responses of tumor cells to environmental changes, thorough their ability to orchestrate cellular and molecular interactions in the tumor microenvironment (TME). As a result of these activities, TSPs can also control drug delivery and activity, tumor response
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Building human artery and vein endothelial cells from pluripotent stem cells, and enduring mysteries surrounding arteriovenous development Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-06-29 Kyle M. Loh, Lay Teng Ang
Owing to their manifold roles in health and disease, there have been intense efforts to synthetically generate blood vessels in vitro from human pluripotent stem cells (hPSCs). However, there are multiple types of blood vessel, including arteries and veins, which are molecularly and functionally different. How can we specifically generate either arterial or venous endothelial cells (ECs) from hPSCs
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Pathophysiological roles of thrombospondin-4 in disease development Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-06-28 Karina Genaro, Z. David Luo
Thrombospondin-4 (TSP-4) belongs to the extracellular matrix glycoprotein family of thrombospondins (TSPs). The multidomain, pentameric structure of TSP-4 allows its interactions with numerous extracellular matrix components, proteins and signaling molecules that enable its modulation to various physiological and pathological processes. Characterization of TSP-4 expression under development and pathogenesis
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Anticodon stem-loop tRNA modifications influence codon decoding and frame maintenance during translation Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-06-28 Tyler J. Smith, Rachel N. Giles, Kristin S. Koutmou
RNAs are central to protein synthesis, with ribosomal RNA, transfer RNAs and messenger RNAs comprising the core components of the translation machinery. In addition to the four canonical bases (uracil, cytosine, adenine, and guanine) these RNAs contain an array of enzymatically incorporated chemical modifications. Transfer RNAs (tRNAs) are responsible for ferrying amino acids to the ribosome, and are
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High-resolution omics of vascular ageing and inflammatory pathways in neurodegeneration Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-06-26 Andrew J. Kwok, Jianning Lu, Junzhe Huang, Bonaventure Y. Ip, Vincent C.T. Mok, Hei Ming Lai, Ho Ko
High-resolution omics, particularly single-cell and spatial transcriptomic profiling, are rapidly enhancing our comprehension of the normal molecular diversity of gliovascular cells, as well as their age-related changes that contribute to neurodegeneration. With more omic profiling studies being conducted, it is becoming increasingly essential to synthesise valuable information from the rapidly accumulating
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Cell death or survival: Insights into the role of mRNA translational control Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-06-23 Nupur Bhatter, Sergey E. Dmitriev, Pavel Ivanov
Cellular stress is an intrinsic part of cell physiology that underlines cell survival or death. The ability of mammalian cells to regulate global protein synthesis (aka translational control) represents a critical, yet underappreciated, layer of regulation during the stress response. Various cellular stress response pathways monitor conditions of cell growth and subsequently reshape the cellular translatome
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Towards a molecular understanding of the 5′TOP motif in regulating translation of ribosomal mRNAs Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-06-12 Tobias Hochstoeger, Jeffrey A. Chao
Vertebrate cells have evolved a simple, yet elegant, mechanism for coordinated regulation of ribosome biogenesis mediated by the 5′ terminal oligopyrimidine motif (5′TOP). This motif allows cells to rapidly adapt to changes in the environment by specifically modulating translation rate of mRNAs encoding the translation machinery. Here, we provide an overview of the origin of this motif, its characterization
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Developmental heterogeneity of vascular cells: Insights into cellular plasticity in atherosclerosis? Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-06-12 Alexander Lin, Yogambha Ramaswamy, Ashish Misra
Smooth muscle cells, endothelial cells and macrophages display remarkable heterogeneity within the healthy vasculature and under pathological conditions. During development, these cells arise from numerous embryological origins, which confound with different microenvironments to generate postnatal vascular cell diversity. In the atherosclerotic plaque milieu, all these cell types exhibit astonishing
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Hox genes: The original body builders Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-06-07 Richard S. Mann, William J. Glassford
Abstract not available
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Thrombospondins in the tumor microenvironment Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-06-05 James Petrik, Sylvia Lauks, Bianca Garlisi, Jack Lawler
Many cancers begin with the formation of a small nest of transformed cells that can remain dormant for years. Thrombospondin-1 (TSP-1) initially promotes dormancy by suppressing angiogenesis, a key early step in tumor progression. Over time, increases in drivers of angiogenesis predominate, and vascular cells, immune cells, and fibroblasts are recruited to the tumor mass forming a complex tissue, designated
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Emerging functions of thrombospondin-1 in immunity Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-05-29 Sukhbir Kaur, David D. Roberts
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Editorial Board/Publication Information Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-05-29
Abstract not available
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Non-coding RNAs mediated inflammation in breast cancers Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-05-25 Dan Wang, Guang-Hao Yin
Breast cancer is the major cancer that affects women all over the world. The awareness over past several decades has led to intensive screening and detection as well as successful treatments. Still, the breast cancer mortality is unacceptable and needs to be urgently addressed. Among many factors, inflammation has often been associated with tumorigenesis, including breast cancer. More than a third
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Epigenetic regulation of pulmonary inflammation Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-05-23 Shama Ahmad, Xiao Lu Zhang, Aftab Ahmad
Pulmonary disease such as chronic obstructive pulmonary disease (COPD), asthma, pulmonary fibrosis and pulmonary hypertension are the leading cause of deaths. More importantly, lung diseases are on the rise and environmental factors induced epigenetic modifications are major players on this increased prevalence. It has been reported that dysregulation of genes involved in epigenetic regulation such
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Molecular evolution of the Thrombospondin superfamily Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-05-16 Richard P. Tucker, Josephine C. Adams
Thrombospondins (TSPs) are multidomain, calcium-binding glycoproteins that have wide-ranging roles in vertebrates in cell interactions, extracellular matrix (ECM) organisation, angiogenesis, tissue remodelling, synaptogenesis, and also in musculoskeletal and cardiovascular functions. Land animals encode five TSPs, which assembly co-translationally either as trimers (subgroup A) or pentamers (subgroup
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Origins and functional differences of blood endothelial cells Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-05-16 Chun-Yi Ng, Christine Cheung
The interests in blood endothelial cells arise from their therapeutic potential in vascular repair and regeneration. Our understanding of blood endothelial cells that exist in the circulation has been evolving significantly from the original concept of endothelial progenitor cells. Many studies have uncovered heterogeneities of blood endothelial subtypes where some cells express both endothelial and
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Cell biology of the gut Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-05-09 Danijela Matic Vignjevic
Abstract not available
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Editorial Board/Publication Information Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-05-06
Abstract not available
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C. elegans as a model to study mitochondrial biology and disease Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-05-05 Tessa Onraet, Steven Zuryn
Mitochondria perform a myriad of essential functions that ensure organismal homeostasis, including maintaining bioenergetic capacity, sensing and signalling the presence of pathogenic threats, and determining cell fate. Their function is highly dependent on mitochondrial quality control and the appropriate regulation of mitochondrial size, shape, and distribution during an entire lifetime, as well
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Epigenetics of inflammation in hypothalamus pituitary gonadal and neuroendocrine disorders Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-05-02 Chun-Yang Zheng, Yue-Xin Yu, Shi-Yue Cao, Xue Bai
The hormone producing hypothalamus, pituitary and gonadal are arranged in hierarchy to form the hypothalamic–pituitary–gonadal axis (HPG axis). The axis is neuroendocrine in nature and releases hormones in response to the inputs from nervous systems. The axis maintains homeostasis and ensures smooth body functions, particularly those related to growth and reproduction. A deregulated HPG axis, such
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Epigenetic control of inflammation in Atopic Dermatitis Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-04-27 Sabah Akhtar, Reem Khaled M.E. Alsayed, Fareed Ahmad, Ayda AlHammadi, Sara Al-Khawaga, Sara Mohamed A.M. AlHarami, Majid Ali Alam, Khalifa Abdulla H.N. Al Naama, Joerg Buddenkotte, Shahab Uddin, Martin Steinhoff, Aamir Ahmad
Atopic dermatitis (AD), also known as atopic eczema, is a common but also complex chronic, itchy skin condition with underlying inflammation of the skin. This skin ailment is prevalent worldwide and affects people of all ages, particularly children below five years of age. The itching and resulting rashes in AD patients are often the result of inflammatory signals, thus necessitating a closer look
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The adenomatous polyposis coli protein 30 years on Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-04-22 James Abbott, Inke S. Näthke
Mutations in the gene encoding the Adenomatous polyposis coli protein (APC) were discovered as driver mutations in colorectal cancers almost 30 years ago. Since then, the importance of APC in normal tissue homeostasis has been confirmed in a plethora of other (model) organisms spanning a large evolutionary space. APC is a multifunctional protein, with roles as a key scaffold protein in complexes involved
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Editorial Board/Publication Information Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-04-21
Abstract not available
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Perspectives on improving crop Rubisco by directed evolution Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-04-20 Matteo Gionfriddo, Timothy Rhodes, Spencer M. Whitney
Rubisco catalyses the entry of almost all CO2 into the biosphere and is often the rate-limiting step in plant photosynthesis and growth. Its notoriety as the most abundant protein on Earth stems from the slow and error-prone catalytic properties that require plants, cyanobacteria, algae and photosynthetic bacteria to produce it in high amounts. Efforts to improve the CO2-fixing properties of plant
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Inflammation in Hernia and the epigenetic control Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-04-18 Jin-Long Li, Ying-Bo Han, Gui-Yun Yang, Miao Tian, Chang-Sai Shi, Dan Tian
Inflammation is much more intrinsic to hernia then is what is generally appreciated. The occurrence of hernias is associated with swelling, stress and inflammation. Surgery remains an important intervention to treat hernias and for many years, post-surgical levels of inflammatory cytokines have been evaluated to compare the different strategies for their comparative advantages. All surgical procedures
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Recent advances in understanding microRNA function and regulation in C. elegans Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-04-11 Kasuen Kotagama, Katherine McJunkin
MicroRNAs (miRNAs) were first discovered in C. elegans as essential post-transcriptional regulators of gene expression. Since their initial discovery, miRNAs have been implicated in numerous areas of physiology and disease in all animals examined. In recent years, the C. elegans model continues to contribute important advances to all areas of miRNA research. Technological advances in tissue-specific
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Editorial Board/Publication Information Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-04-10
Abstract not available
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Editorial Board/Publication Information Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-04-06
Abstract not available
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Establishing and maintaining Hox profiles during spinal cord development Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-04-05 Alexander Miller, Jeremy S. Dasen
The chromosomally-arrayed Hox gene family plays central roles in embryonic patterning and the specification of cell identities throughout the animal kingdom. In vertebrates, the relatively large number of Hox genes and pervasive expression throughout the body has hindered understanding of their biological roles during differentiation. Studies on the subtype diversification of spinal motor neurons (MNs)
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Plant pathogens: Masters of manipulation Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-04-03 Brian Kvitko
Abstract not available
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Rearrangement of co-cultured cellular systems: Biological and physical aspects Semin. Cell Dev. Biol. (IF 7.3) Pub Date : 2023-04-01 Ivana Pajic-Lijakovic
Abstract not available