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Dietary Inflammatory Index and Cognitive Function: Findings from a Cross-Sectional Study in Obese Chinese Township Population from 45 to 75 Years J. Inflammation Res. (IF 4.5) Pub Date : 2024-04-18 Hongying Huang, Jinchen Li, Jingyi Shen, Tong Zhao, Rong Xiao, Weiwei Ma
Background and Objective: Cognitive dysfunction is highly prevalent in obese people, and food is a key factor in obesity, and dietary inflammatory index (DII) can reflect whether diet has anti-inflammatory or pro-inflammatory potential. In addition, dietary fatty acid consumption is linked to inflammation, obesity, and cognitive impairment. Erythrocyte membrane fatty acids can reflect dietary fatty
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Endovascular Repair and Prognosis of Patients with Brucella abortus Infection-Induced Aorto-Iliac Aneurysm J. Inflammation Res. (IF 4.5) Pub Date : 2024-04-17 Yujing Zhang, Haiqian Wang, Lei Bai, Xiaodong Li, Li Liu, Liang Wang
Objective: To establish the endovascular repair and prognosis of patients with aorto-iliac aneurysm and Brucella abortus infection. Methods: From September 2018 to September 2021, seven cases of Brucella abortus infection with aorto-iliac aneurysm were treated by the endovascular aneurysm repair (EVAR) procedure. Clinical and imaging data were collected to evaluate the therapeutic results, including
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Emerging Insights into Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Induced by Immune Checkpoint Inhibitor and Tumor-Targeted Therapy J. Inflammation Res. (IF 4.5) Pub Date : 2024-04-17 Min Lin, Ting Gong, Shifan Ruan, Xiaoqing Lv, Rongying Chen, Xinhong Su, Bo Cheng, Chao Ji
Objective: Anticancer drugs have revolutionized tumor therapy, with cutaneous toxicities such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) being common immune-related adverse events. The debate over the efficacy of systemic corticosteroids in treating these conditions persists, while tumor necrosis factor (TNF)-alpha inhibitors show promise. This study aims to evaluate the
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Correlation Analysis of IL-17, IL-21, IL-23 with Non-Alcoholic Liver Fibrosis and Cirrhosis J. Inflammation Res. (IF 4.5) Pub Date : 2024-04-17 Xiaoyan Yang, Liyin Liao, Zizhen Liang, Shenglong Yu, Zhonghui Guo
Objective: This research aimed to explore the involvement of interleukins (IL) - IL-6, IL-17, IL-21, and IL-23 - in the evolution and diagnosis of non-alcoholic liver fibrosis and cirrhosis. Methods: The study subjects were selected from the patients who visited the Department of Hepatology of X Hospital in Y City from August 2021 to April 2023. Peripheral blood samples were collected. All participants
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LINC00998 Modulating M2 Macrophage Activation in Allergic Rhinitis by Stabilizing BOB.1 mRNA J. Inflammation Res. (IF 4.5) Pub Date : 2024-04-16 Yan He, Yulei Tang, Silu Wen, Lin Dong, Fen Li, Yuqing Deng, Zezhang Tao
Background: Allergic rhinitis (AR) is globally recognized as a considerable threat to human health with a rising prevalence and a substantial medical and socioeconomic burden. Numerous studies have emphasized the significance of long noncoding RNAs (lncRNAs) in allergic responses. Hence, this research dealt with exploring the involvement of the lncRNA LINC00998 in the mechanism of AR. Methods: LINC00998
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Therapeutic Plasma Exchange in AChR-Ab Positive Generalized Myasthenia Gravis: A Real World Study About Its Early Response J. Inflammation Res. (IF 4.5) Pub Date : 2024-04-16 Jiaxin Chen, Li Feng, Shiyin Li, Haiyan Wang, Xin Huang, Cunzhou Shen, Huiyu Feng
Background: Since there is no clear priority or selection principle in the guidelines for myasthenia crisis, therapeutic plasma exchange (TPE) and intravenous immunoglobulin are often administered randomly. However, it should be more prudent in taking TPE due to its higher cost and risk. Studying its early response factors is crucial for managing myasthenia crisis and can improve medical and economic
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Integrated Analysis Identified TGFBI as a Biomarker of Disease Severity and Prognosis Correlated with Immune Infiltrates in Patients with Sepsis J. Inflammation Res. (IF 4.5) Pub Date : 2024-04-15 Mingjie Shi, Yue Wei, Runmin Guo, Fei Luo
Background: Sepsis is a major contributor to morbidity and mortality among hospitalized patients. This study aims to identify markers associated with the severity and prognosis of sepsis, providing new approaches for its management and treatment. Methods: Data were mined from the Gene Expression Omnibus (GEO) databases and were analyzed by multiple statistical methods like the Spearman correlation
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Yunnan Baiyao Might Mitigate Periodontitis Bone Destruction by Inhibiting Autophagy and Promoting Osteoblast Differentiation in vivo, ex vivo and in vitro J. Inflammation Res. (IF 4.5) Pub Date : 2024-04-15 Wang Liu, Yanjie Li, Yuanyuan An, Ruoyu Zhao, Chenxi Wei, Xiaobin Ren, Hongbing He
Background and Objective: Periodontitis is an inflammatory disease that eventually destroys tooth-supporting tissue. Yunnan Baiyao (YNBY), a traditional Chinese medicine compound with haemostatic and anti-inflammatory properties has shown therapeutic potential in several diseases. Our previous study revealed that YNBY suppressed osteoclast differentiation in periodontitis. The purpose of this study
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Piezo1 Knockout Improves Post-Stroke Cognitive Dysfunction by Inhibiting the Interleukin-6 (IL-6)/Glutathione Peroxidase 4 (GPX4) Pathway J. Inflammation Res. (IF 4.5) Pub Date : 2024-04-13 Lujia Tang, Di Xie, Shangyuan Wang, Chengjin Gao, Shuming Pan
Background: Cerebral infarction often results in post-stroke cognitive impairment, which impairs the quality of life and causes long-term disability. Astrocytes, the most abundant glial cells in the central nervous system, have a crucial role in cerebral ischemia and neuroinflammation. We explored the possible advantages of interleukin-6 (IL-6), a powerful pro-inflammatory cytokine produced by astrocytes
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Reactive Oxygen Species Induced Upregulation of TRPV1 in Dorsal Root Ganglia Results in Low Back Pain in Rats J. Inflammation Res. (IF 4.5) Pub Date : 2024-04-11 Xinyong Chen, Zhe Chen, Gongchang Ma, Jianjun Sha, Shan Zhao, Zuoqing Liu, Nong Chen, Huilin Yang
Background: Dorsal root ganglia (DRGs) contain sensory neurons that innervate intervertebral discs (IVDs) and may play a critical role in mediating low-back pain (LBP), but the potential pathophysiological mechanism needs to be clarified. Methods: A discogenic LBP model in rats was established by penetration of a lumbar IVD. The severity of LBP was evaluated through behavioral analysis, and the gene
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Valsartan Mitigates the Progression of Methotrexate-Induced Acute Kidney Injury in Rats via the Attenuation of Renal Inflammation and Oxidative Stress J. Inflammation Res. (IF 4.5) Pub Date : 2024-04-11 Dina Kutbi, Riyadh S Almalki
Background: Methotrexate (MTX) is a folic acid antagonist, commonly administered for the treatment of a variety of cancers. However, methotrexate toxicity including bone marrow suppression and hepatic and renal toxicity limits its use. Angiotensin AT1 receptor blockers including Valsartan (Val) possess the ability to ameliorate MTX-induced toxicity through various mechanisms. In this study, we explored
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FBL Promotes LPS-Induced Neuroinflammation by Activating the NF-κB Signaling Pathway J. Inflammation Res. (IF 4.5) Pub Date : 2024-04-11 Zhuoyuan Zhang, Dan Liu, Rui Lv, Haoyan Zhao, Tianjing Li, Yutao Huang, Zhicheng Tian, Xiangyu Gao, Peng Luo, Xin Li
Purpose: Neuroinflammation occurs in response to central nervous system (CNS) injury, infection, stimulation by toxins, or autoimmunity. We previously analyzed the downstream molecular changes in HT22 cells (mouse hippocampal neurons) upon lipopolysaccharide (LPS) stimulation. We detected elevated expression of Fibrillarin (FBL), a nucleolar methyltransferase, but the associated proinflammatory mechanism
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Tat-CIRP Peptide Facilitates Frozen Wound Healing by Ameliorating Inflammation and Promoting Angiogenesis J. Inflammation Res. (IF 4.5) Pub Date : 2024-04-11 Jiayan Li, Jie Ding, Haoyang Wu, Chenyan Lu, Jian Wu, Qianqian Luo
Background: Frostbite is a chemia resulting from cold-induced skin damage. The process of frostbite is often accompanied by inflammation, and the therapeutic strategies focusing on anti-inflammation are the main direction to data. Tat-CIRP is a 15 amino acid peptide containing HIV protein and cold-inducible RNA-binding protein (CIRP), which is believed to compete with endogenous CIRP for myeloid differentiation
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The Role of Infiltrated T Lymphocyte in Oral Squamous Cell Carcinoma: Insights into Clinicopathological Characteristics and Prognosis J. Inflammation Res. (IF 4.5) Pub Date : 2024-04-11 Wei Liao, Jiaxuan Lu, Yuyuan Xu, Chulin Yang, Hongjie Chen, Shaohang Cai, Lili Liu, Shuwei Chen
Background: To compare and analyze the presence of CD4+ and CD8 + lymphocyte infiltrates in Oral squamous cell carcinoma (OSCC) tissue versus adjacent tissue and their clinical significance. Methods: We enrolled a total of 152 patients diagnosed with OSCC, all of whom had confirmed diagnoses through pathological reports. Clinical and demographics data were extracted from medical records. Tissue microarrays
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Intestinal Mucosal Immune Barrier: A Powerful Firewall Against Severe Acute Pancreatitis-Associated Acute Lung Injury via the Gut-Lung Axis J. Inflammation Res. (IF 4.5) Pub Date : 2024-04-10 Fan Li, Zhengjian Wang, Yinan Cao, Boliang Pei, Xinyu Luo, Jin Liu, Peng Ge, Yalan Luo, Shurong Ma, Hailong Chen
Abstract: The pathogenesis of severe acute pancreatitis-associated acute lung injury (SAP-ALI), which is the leading cause of mortality among hospitalized patients in the intensive care unit, remains incompletely elucidated. The intestinal mucosal immune barrier is a crucial component of the intestinal epithelial barrier, and its aberrant activation contributes to the induction of sustained pro-inflammatory
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Long COVID-19 and Peripheral Serotonin: A Commentary and Reconsideration J. Inflammation Res. (IF 4.5) Pub Date : 2024-04-11 George M Anderson, Edwin H Cook, Randy D Blakely, James S Sutcliffe, Jeremy Veenstra-VanderWeele
Abstract: We believe there are serious problems with a recently published and highly publicized paper entitled “Serotonin reduction in post-acute sequelae of viral infection.” The blood centrifugation procedure reportedly used by Wong et al would produce plasma that is substantially (over 95%) depleted of platelets. Given this, their published mean plasma serotonin values of 1.2 uM and 2.4 uM for the
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Effect of Intraoperative Opioid Dose on Perioperative Neutrophil-to-Lymphocyte Ratio and Lymphocyte-to-Monocyte Ratio in Glioma J. Inflammation Res. (IF 4.5) Pub Date : 2024-04-10 Xuejiao Liu, Lei Teng, Junzhu Dai, Hongxue Shao, Rui Chen, Haixiang Li, Jing Li, Huichao Zou
Background: The neutrophil-to-lymphocyte ratio (NLR) and lymphocyte-to-monocyte ratio (LMR) are inflammatory biomarkers. Until now, it is unknown the impact of opioid dosage on perioperative immunity in glioma patients. The aim of this study was to explore the effect of intraoperative opioid dosage on perioperative immune perturbations using NLR and LMR as inflammatory biomarkers and evaluate the correlation
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TAK-3 Inhibits Lipopolysaccharide-Induced Neuroinflammation in Traumatic Brain Injury Rats Through the TLR-4/NF-κB Pathway J. Inflammation Res. (IF 4.5) Pub Date : 2024-04-09 Pengwei Hou, Yang Yang, Ziqi Li, Dan Ye, Li Chen, Tianshun Feng, Jiateng Zeng, Liangfeng Wei, Shousen Wang
Purpose: The activation of the inflammatory response is regarded as a pivotal factor in the pathogenesis of TBI. Central nervous system infection often leads to the exacerbation of neuroinflammation following TBI, primarily caused by Gram-negative bacteria. This study aims to elucidate the effects of the novel anti-inflammatory drug TAK-3 on LPS-induced neuroinflammation in TBI rats. Methods: In conjunction
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High Monocyte-to-Lymphocyte Ratio is Associated with Obstructive Sleep Apnea Hypopnea Syndrome J. Inflammation Res. (IF 4.5) Pub Date : 2024-04-08 Wenyu Bao, Junkang Gao, Siyu Fang, Shiwei Zhang, Yufeng Wan
Objective: This study aims to explore the correlation between serum monocyte-to-lymphocyte ratio (MLR) and other inflammatory parameters with the occurrence of obstructive sleep apnea-hypopnea syndrome (OSAHS) in patients. Methods: This study included 310 patients who underwent polysomnography monitoring at our hospital between January 2021 and January 2023. Routine blood inflammatory parameters and
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Identification of Key Immune Infiltration Related Genes Involved in Aortic Dissection Using Bioinformatic Analyses and Experimental Verification J. Inflammation Res. (IF 4.5) Pub Date : 2024-04-05 Lin Zheng, Yusi Yang, Jie Liu, Tianliang Zhao, Xin Zhang, Lihua Chen
Purpose: Immune microenvironment plays an important role in aortic dissection (AD). Therefore, novel immune biomarkers may facilitate AD prevention, diagnosis, and treatment. This study aimed at mining key immune-related genes and relevant mechanisms involved in AD pathogenesis. Patients and Methods: Key immune cells in AD were identified by ssGESA algorithm. Next, genes associated with key immune
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The Role of Immune Cells in DKD: Mechanisms and Targeted Therapies J. Inflammation Res. (IF 4.5) Pub Date : 2024-04-06 Qiu-Yue Peng, Ying An, Zong-Zhe Jiang, Yong Xu
Abstract: Diabetic kidney disease (DKD), is a common microvascular complication and a major cause of death in patients with diabetes. Disorders of immune cells and immune cytokines can accelerate DKD development of in a number of ways. As the kidney is composed of complex and highly differentiated cells, the interactions among different cell types and immune cells play important regulatory roles in
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A Nomogram Model Based on the Inflammation-Immunity-Nutrition Score (IINS) and Classic Clinical Indicators for Predicting Prognosis in Extranodal Natural Killer/T-Cell Lymphoma J. Inflammation Res. (IF 4.5) Pub Date : 2024-04-04 Yanxia He, Zhumei Luo, Haoqing Chen, Liqing Ping, Cheng Huang, Yan Gao, Huiqiang Huang
Background: Systemic inflammation, immunity, and nutritional status are closely related to patients’ outcomes in several kinds of cancers. This study aimed to establish a new nomogram based on inflammation-immunity-nutrition score (IINS) to predict the prognosis of extranodal natural killer/T-cell lymphoma (ENKTL) patients. Methods: The clinical data of 435 patients with ENTKL were retrospectively
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NcRNA Regulated Pyroptosis in Liver Diseases and Traditional Chinese Medicine Intervention: A Narrative Review J. Inflammation Res. (IF 4.5) Pub Date : 2024-04-03 Jiasheng Deng, Le Qin, Sulang Qin, Ruisheng Wu, Guidong Huang, Yibin Fang, Lanlan Huang, Zhipin Zhou
Abstract: Pyroptosis is a novel pro-inflammatory mode of programmed cell death that differs from ferroptosis, necrosis, and apoptosis in terms of its onset and regulatory mechanisms. Pyroptosis is dependent on cysteine aspartate protein hydrolase (caspase)-mediated activation of GSDMD, NLRP3, and the release of pro-inflammatory cytokines, interleukin-1 (IL-1β), and interleukin-18 (IL-18), ultimately
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Predictive Value of a Diagnostic Five-Gene Biomarker for Pediatric Sepsis J. Inflammation Res. (IF 4.5) Pub Date : 2024-04-04 Yulong Xiao, Genhao Zhang
Background: Pediatric sepsis has a very high morbidity and mortality rate. The purpose of this study was to evaluate diagnostic biomarkers and immune cell infiltration in pediatric sepsis. Methods: Three datasets (GSE13904, GSE26378, and GSE26440) were downloaded from the gene expression omnibus (GEO) database. After identifying overlapping genes in differentially expressed genes (DEGs) and modular
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The Role of Different Systemic Inflammatory Indexes Derived from Complete Blood Count in Differentiating Acute from Chronic Calculus Cholecystitis and Predicting Its Severity J. Inflammation Res. (IF 4.5) Pub Date : 2024-04-03 Liling Chen, Xinyuan Chen
Purpose: This study aimed to evaluate the diagnostic value of the different Complete blood count-derived systemic inflammation indexes, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), and neutrophil to lymphocyte × platelet ratio (NLPR) in differential diagnosing the chronic calculus cholecystitis (CCC) and the acute calculus
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Assessment of Immune Status in Patients with Mismatch Repair Deficiency Endometrial Cancer J. Inflammation Res. (IF 4.5) Pub Date : 2024-04-02 Jincheng Ma, Jiansong Lin, Xite Lin, Yuan Ren, Dabin Liu, Shuting Tang, Leyi Huang, Shuxia Xu, Xiaodan Mao, Pengming Sun
Objective: This study introduced a novel subtype classification method for endometrial cancer (EC) with mismatch repair deficiency (MMRd) by employing immune status and prognosis as the foundational criteria. The goal was to enhance treatment guidance through precise subtype delineation. Methods: Study Cohort: This study encompassed a cohort of 119 patients diagnosed with MMRd-EC between 2015 and 2022
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Selenium Yeast Alleviates Dextran Sulfate Sodium-Induced Chronic Colitis in Mice by Reducing Proinflammatory Cytokines and Regulating the Gut Microbiota and Their Metabolites J. Inflammation Res. (IF 4.5) Pub Date : 2024-03-30 Zeyu Wu, Yan Li, Min Jiang, Lixuan Sang, Bing Chang
Background: Inflammatory bowel disease (IBD) is a chronic recurrent gastrointestinal inflammatory disease. Selenium has been reported to have therapeutic potential in IBD. Selenium yeast is a common selenium supplement that is convenient to access. This study explored the effect of selenium yeast on dextran sulfate sodium- (DSS-)induced chronic colitis in mice. Methods: Mice were randomly divided into
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A Correlation Evaluation Between the Peripheral Blood Index and the Prognosis of Advanced Esophageal Squamous Cell Carcinoma Patients Treated with Camrelizumab J. Inflammation Res. (IF 4.5) Pub Date : 2024-03-29 Haotian Shang, Yanan Chen, Qiulu Wang, Yongliang Yang, Jingyu Zhang
Purpose: This study aimed to investigate the relationship between peripheral blood indices and the efficacy and prognosis of advanced esophageal squamous cell carcinoma (ESCC) patients treated with camrelizumab. Patients and Methods: We retrospectively analyzed 64 patients who received camrelizumab for advanced ESCC at the Second People’s Hospital of Lianyungang City between July 2020 and June 2022
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The Prognostic Value and Potential Immune Mechanisms of lncRNAs Related to Immunogenic Cell Death in Papillary Thyroid Carcinoma J. Inflammation Res. (IF 4.5) Pub Date : 2024-03-29 Yixian Wang, Xin Li, Yinde Huang, Qingwei Gang, Mingyu Liu, Han Zhang, Shikai Shen, Yao Qi, Jian Zhang
Background: Long non-coding RNAs (lncRNAs) associated with immunogenic cell death (ICD) play a pivotal role in tumorigenesis and offer prognostic insights for papillary thyroid carcinoma (PTC) patients. This study delves into the impact of ICD-related lncRNAs on the prognosis of PTC. Methods: PTC samples were accessed from The Cancer Genome Atlas-Thyroid carcinoma database (TCGA-THCA) and consensus
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Gastroprotective Effect of 2,3-Dimethylquinoxaline Against Indomethacin-Induced Gastric Ulcer in Rat J. Inflammation Res. (IF 4.5) Pub Date : 2024-03-29 Abdelbagi Alfadil
Background: Gastric ulcers pose a significant health risk due to an imbalance between protective and aggressive factors on the mucous membrane. Nonsteroidal anti-inflammatory drug (NSAID)-induced gastric damage affects 25% of users. Quinoxaline compounds, known for their diverse biological properties, have potential applications in cancer therapy and as antimicrobial agents targeting various pathogens
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NAD-Dependent Protein Deacetylase Sirtuin-1 Mediated Mitophagy Regulates Early Brain Injury After Subarachnoid Hemorrhage J. Inflammation Res. (IF 4.5) Pub Date : 2024-03-28 Gen Wang, Ning Lin
Background: This study focuses on the role of SIRT1 in neuroinflammation caused by early brain injury (EBI) after subarachnoid hemorrhage (SAH), and explores its mechanism in mitophagy after SAH. Methods: C57BL/6J mice and primary microglia SAH in vivo and in vitro models were constructed to explore the expression level of SIRT1 in neuroinflammation after SAH. Subsequently, the brain edema content
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In-Depth Review of Loeffler Endocarditis: What Have We Learned? J. Inflammation Res. (IF 4.5) Pub Date : 2024-03-28 Shitong Su, Lianjing Liang, Lin Lü, Mingfeng Li, Xiaoling Zhang, Yongmei Jin, Wei Wei, Zhi Wan
Abstract: Loeffler endocarditis, eosinophilic endocarditis or eosinophilic endomyocardial disease are conditions associated with hypereosinophilia and they affect the heart function. Loeffler endocarditis is a rare endomyocardial disorder thought to be caused by eosinophilic damage. The disorder is characterized by inflammatory infiltration, formation of thrombus within cardiovascular system, and ultimately
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Identification and Analysis of PANoptosis-Related Genes in Sepsis-Induced Lung Injury by Bioinformatics and Experimental Verification J. Inflammation Res. (IF 4.5) Pub Date : 2024-03-28 Zhen Yang, Xingyu Kao, Na Huang, Kang Yuan, Jingli Chen, Mingfeng He
Purpose: Sepsis-induced lung injury (SLI) is a serious complication of sepsis. PANoptosis, a novel form of inflammatory programmed cell death that is not yet to be fully investigated in SLI. Our research aims to screen and validate the signature genes of PANoptosis in SLI by bioinformatics and in vivo experiment. Methods: SLI-related datasets were downloaded from NCBI Gene Expression Omnibus (GEO)
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Shared Immune Associations Between COVID-19 and Inflammatory Bowel Disease: A Cross-Sectional Observational Study in Shanghai, China J. Inflammation Res. (IF 4.5) Pub Date : 2024-03-27 Shan Li, Fengdi Zhang, Ritian Lin, Qinjuan Sun, Lihong Qu, Lan Zhong
Purpose: The rapid global spread of the SARS-CoV-2 Omicron variant introduces a novel complication: the emergence of IBD (inflammatory bowel disease)-like ulcers in certain patients. This research delves into this new challenge by juxtaposing the clinical manifestations and genetic expression patterns of individuals affected by the Omicron variant of COVID-19 with those diagnosed with IBD. It aims
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Triggering Receptor Expressed on Myeloid Cells 2 Mediates the Involvement of M2-Type Macrophages in Pulmonary Tuberculosis Infection J. Inflammation Res. (IF 4.5) Pub Date : 2024-03-27 Xiaoqian Shang, Naifeisha Maimaiti, Jiahui Fan, Liang Wang, Yuanyuan Wang, Hu Sun, Jie Lv, Xiufeng Zhang, Jing Wang, Xiumin Ma
Background: Macrophage play a significant work in the development of tuberculosis. This study aims to investigate the relationship between TREM2 and macrophage polarization, as well as the related cytokines. Methods: This study involved 43 pulmonary tuberculosis patients and 37 healthy controls. Enzyme-linked immunosorbent assay (ELISA) was used to detect the expression levels of M1/M2 macrophage-related
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Revolutionizing Treatment Strategies for Autoimmune and Inflammatory Disorders: The Impact of Dipeptidyl-Peptidase 4 Inhibitors J. Inflammation Res. (IF 4.5) Pub Date : 2024-03-23 Kashif Rahim, Muhammad Shan, Ihtisham Ul Haq, Muhammad Naveed Nawaz, Sajida Maryam, Mansour S Alturki, Abdulaziz H Al Khzem, Kamel Metwally, Simona Cavalu, Saleh F Alqifari, Galal Yahya
Abstract: DPP4 (Dipeptidyl-peptidase 4) a versatile protease, emerges as a prominent player in soluble and membrane-bound forms. Its heightened expression has been intimately linked to the initiation and severity of diverse autoimmune diseases, spanning rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis (SSc), inflammatory bowel disease, autoimmune diabetes, and even SARS-CoV-2
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Identification of Shared Signature Genes and Immune Microenvironment Subtypes for Heart Failure and Chronic Kidney Disease Based on Machine Learning J. Inflammation Res. (IF 4.5) Pub Date : 2024-03-21 Xuefu Wang, Jin Rao, Xiangyu Chen, Zhinong Wang, Yufeng Zhang
Background: A complex interrelationship exists between Heart Failure (HF) and chronic kidney disease (CKD). This study aims to clarify the molecular mechanisms of the organ-to-organ interplay between heart failure and CKD, as well as to identify extremely sensitive and specific biomarkers. Methods: Differentially expressed tandem genes were identified from HF and CKD microarray datasets and enrichment
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FTO Stabilizes MIS12 to Inhibit Vascular Smooth Muscle Cell Senescence in Atherosclerotic Plaque J. Inflammation Res. (IF 4.5) Pub Date : 2024-03-20 Jingzhao Sun, Mengqi Wang, Fengming Jia, Jiantao Song, Jinlin Ren, Bo Hu
Purpose: Atherosclerosis is the main cause of atherosclerotic cardiovascular disease (CVD). Here, we aimed to uncover the role and mechanisms of fat mass and obesity-associated genes (FTO) in the regulation of vascular smooth muscle cell (VSMC) senescence in atherosclerotic plaques. Methods: ApoE−/− mice fed a high-fat diet (HFD) were used to establish an atherosclerotic animal model. Immunohistochemistry
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The Simplified Thrombo-Inflammatory Score as a Novel Predictor of All-Cause Mortality in Patients with Heart Failure: A Retrospective Cohort Study J. Inflammation Res. (IF 4.5) Pub Date : 2024-03-20 Meng-Die Cheng, Ying-Ying Zheng, Xing-Yan Zhang, Tuersun Ruzeguli, Yisimayili Sureya, Yisha Didaer, Mahemuti Ailiman, Jin-Ying Zhang
Background: The simplified thrombo-inflammatory score (sTIPS) has recently emerged as a novel prognostic score. Hence, we investigated the prognostic value of sTIPS for predicting long-term mortality in patients with heart failure (HF). Methods: A total of 3741 patients were analyzed in this study. The sTIPS was calculated based on the white blood cell count (WBC) and the mean platelet volume to platelet
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Cogan’s Syndrome Combined with Hypertrophic Pachymeningitis: A Case Report J. Inflammation Res. (IF 4.5) Pub Date : 2024-03-20 Ci Lu, Panpan Lv, Xiaoying Zhu, Yongmei Han
Abstract: Cogan’s syndrome (CS) is a rare chronic inflammatory disease, characterized by interstitial keratitis and vestibular auditory dysfunction. Hypertrophic pachymeningitis (HP) is a rare chronic aseptic inflammatory disease of the central nervous system. This article reports a patient with CS coexisting with HP. The patient was a 66-year-old male with fever, headache, red eyes, hearing loss,
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TRPA1 Ion Channel Mediates the Analgesic Effects of Acupuncture at the ST36 Acupoint in Mice Suffering from Arthritis J. Inflammation Res. (IF 4.5) Pub Date : 2024-03-20 Kaifang Yao, Zhihan Chen, Yanwei Li, Baomin Dou, Zhifang Xu, Yajing Ma, Simin Du, Jiangshan Wang, Jiangjiang Fu, Qi Liu, Zezhi Fan, Yangyang Liu, Xiaowei Lin, Yuan Xu, Yuxin Fang, Shenjun Wang, Yi Guo
Purpose: Acupuncture (ACU) has been demonstrated to alleviate inflammatory pain. Mechanoreceptors are present in acupuncture points. When acupuncture exerts mechanical force, these ion channels open and convert the mechanical signals into biochemical signals. TRPA1 (T ransient receptor potential ankyrin 1) is capable of sensing various physical and chemical stimuli and serves as a sensor for inflammation
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Analysis of Risk Factors and Intervention Strategies for Acute Kidney Injury After Cardiac Valve Replacement [Letter] J. Inflammation Res. (IF 4.5) Pub Date : 2024-03-19 Yanyan Song, Jian Yang
Letter for the article Analysis of Risk Factors and Intervention Strategies for Acute Kidney Injury After Cardiac Valve Replacement
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Coactosin-Like Protein 1 (COTL1) Could Be an Immunological and Prognostic Biomarker: From Pan-Cancer Analysis to Low-Grade Glioma Validation J. Inflammation Res. (IF 4.5) Pub Date : 2024-03-19 Xiaoyun Wang, Yuwei Bai, Bei Wang
Background: Cancer represents a widespread global health challenge impacting millions of individuals worldwide. Identifying new targets for cancer treatment is a crucial step in developing more effective therapies. Among these potential targets, Coactosin-like protein 1 (COTL1), a cytoskeleton-associated protein with critical roles in cell migration, adhesion, and signaling, has shown involvement in
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Intestinal Flora Imbalance Induced by Antibiotic Use in Rats J. Inflammation Res. (IF 4.5) Pub Date : 2024-03-19 Guojun Tong, Hai Qian, Dongli Li, Jing Li, Jing Chen, Xiongfeng Li, Zhenhua Tan
Aim: This study aims to explore the effect of different doses of antibiotics on rats in order to observe alterations in their fecal microbiota, inflammatory changes in the colonic mucosa and four types of inflammatory markers in blood serum. Methods: Our methodology involved separating 84 female Sprague Dawley rats into groups A-G, with each group consisting of 12 rats. We collected the rat feces for
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Targeting Neutrophil Extracellular Traps in Gouty Arthritis: Insights into Pathogenesis and Therapeutic Potential J. Inflammation Res. (IF 4.5) Pub Date : 2024-03-19 Cantao Li, Chenxi Wu, Fenfen Li, Wenjing Xu, Xiaoxi Zhang, Yan Huang, Daozong Xia
Abstract: Gouty arthritis (GA) is an immune-mediated disorder characterized by severe inflammation due to the deposition of monosodium urate (MSU) crystals in the joints. The pathophysiological mechanisms of GA are not yet fully understood, and therefore, the identification of effective therapeutic targets is of paramount importance. Neutrophil extracellular traps (NETs), an intricate structure of
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Prognostic Nutritional Index Predicts Efficacy and Immune-Related Adverse Events of First-Line Chemoimmunotherapy in Patients with Extensive-Stage Small-Cell Lung Cancer J. Inflammation Res. (IF 4.5) Pub Date : 2024-03-18 Baishen Zhang, Jing Chen, Hui Yu, Meichen Li, Muyan Cai, Likun Chen
Background: Currently, there is a lack of well-established markers to predict the efficacy of chemoimmunotherapy in small-cell lung cancer (SCLC). Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), advanced lung cancer inflammation index (ALI) and prognostic nutritional index (PNI) are associated with prognosis in several tumors, whereas their predictive role in SCLC remains
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CSF Findings in Chinese Patients with NMDAR, LGI1 and GABABR Antibody-Associated Encephalitis J. Inflammation Res. (IF 4.5) Pub Date : 2024-03-18 Shan Qiao, Haiyun Li, Caisan Cui, Chong Zhang, Aihua Wang, Wenjing Jiang, Shanchao Zhang
Purpose: CSF inflammation in subtypes of antibody-defined autoimmune encephalitis (AE) ranges in intensity from moderate to severe. In a retrospective, cross-sectional study, we characterized CSF findings in Chinese patients with anti-N-methyl-D-aspartate receptor encephalitis (NMDAR-E), anti-leucine-rich glioma-inactivated 1 encephalitis (LGI1-E), and anti-gamma aminobutyric acid-B receptor encephalitis
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High Level of Serum Complement C3 Expression is Associated with Postoperative Vasculopathy Progression in Moyamoya Disease J. Inflammation Res. (IF 4.5) Pub Date : 2024-03-18 Min-Jie Wang, Jiayu Wang, Houdi Zhang, Fang-Bin Hao, Gan Gao, Si-Meng Liu, Xiao-Peng Wang, Jing-Jie Li, Zheng-Xing Zou, Qing-Bao Guo, He-Guan Fu, Yi-Qin Han, Cong Han, Lian Duan
Background: The immune system plays an important role in the onset and development of moyamoya disease (MMD), but the specific mechanisms remain unclear. This study aimed to explore the relationship between the expression of complements and immunoglobulin in serum and progression of MMD. Methods: A total of 84 patients with MMD and 70 healthy individuals were enrolled. Serum immunoglobulin and complement
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Lactobacillus Plantarum Promotes Wound Healing by Inhibiting the NLRP3 Inflammasome and Pyroptosis Activation in Diabetic Foot Wounds J. Inflammation Res. (IF 4.5) Pub Date : 2024-03-16 Xiaojun Wang, Xu Li, Jianjun Liu, Yue Tao, Tao Wang, Limeng Li
Objective: Diabetic foot ulcer (DFU) impairs the quality of life of diabetic patients and overburdens healthcare systems and society. It is crucial to comprehend the pathophysiology of DFU and develop effective treatment strategies. The aim of this study was to to evaluate the therapeutic potential of Lactobacillus Plantarum (LP) on wound healing in DFU and to explore the underlying mechanisms. Methods:
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Envoplakin Inhibits Macrophage Polarization by Altering the Inflammatory Tumor Microenvironment of Melanoma Through the RAS / ERK Signaling Pathway J. Inflammation Res. (IF 4.5) Pub Date : 2024-03-15 Weilin Cai, Minliang Chen
Purpose: Tumor growth induces the tumor margin to become a transition zone rich in immune cells. EVPL is a potential prognostic biomarker for melanoma. Melanoma is difficult to cure because of its high metastasis, so it is urgent to find effective genes to inhibit tumor progression and regulate tumor microenvironment. Methods: Firstly, differentially expressed genes (DEGs) among normal skin, nevus
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Serum Homer1 is a Novel Biomarker for Predicting the Clinical Outcomes of Acute Ischemic Stroke Patients [Letter] J. Inflammation Res. (IF 4.5) Pub Date : 2024-03-15 Jumraini Tammasse
Letter for the article Serum Homer1 is a Novel Biomarker for Predicting the Clinical Outcomes of Acute Ischemic Stroke Patients
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Identification of VRK1 as a Novel Potential Biomarker for Prognosis and Immunotherapy in Hepatocellular Carcinoma J. Inflammation Res. (IF 4.5) Pub Date : 2024-03-14 Xiaoyan He, Guozhen Zai, Lidan Zhou, Shengyang Chen, Guizhi Wang
Background: Research has indicated that VRK1 is essential for the tumor cell cycle. However, its prognostic and immunotherapeutic predictive significance has not been documented in hepatocellular carcinoma (HCC). Methods: The TCGA, ICGC, and GSE14520 datasets were used to investigate VRK1 expression and its predictive significance of survival outcomes. The qRT-PCR and immunohistochemistry (IHC) were
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Predictive and Prognostic Potentials of Lymphocyte-C-Reactive Protein Ratio Upon Hospitalization in Adult Patients with Acute Pancreatitis J. Inflammation Res. (IF 4.5) Pub Date : 2024-03-13 Xiao-Yu Xu, Yang Gao, Chuang-Shi Yue, Yu-Jia Tang, Zhao-Jin Zhang, Feng-Jie Xie, Hong Zhang, Yu-Cheng Zhu, Yan Zhang, Qi-Qi Lai, Xin-Tong Wang, Jia-Xi Xu, Jia-Ning Zhang, Bo-Wen Liu, Jian-Nan Zhang, Kai Kang
Purpose: In this study, our objective was to investigate the potential utility of lymphocyte-C-reactive protein ratio (LCR) as a predictor of disease progression and a screening tool for intensive care unit (ICU) admission in adult patients with acute pancreatitis (AP). Methods: We included a total of 217 adult patients with AP who were admitted to the First Affiliated Hospital of Harbin Medical University
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Pretreated MSCs with IronQ Transplantation Attenuate Microglia Neuroinflammation via the cGAS-STING Signaling Pathway J. Inflammation Res. (IF 4.5) Pub Date : 2024-03-13 Guoqiang Yang, Jiraporn Kantapan, Maryam Mazhar, Qiongdan Hu, Xue Bai, Yuanxia Zou, Honglian Wang, Sijin Yang, Li Wang, Nathupakorn Dechsupa
Background: Intracerebral hemorrhage (ICH), a devastating form of stroke, is characterized by elevated morbidity and mortality rates. Neuroinflammation is a common occurrence following ICH. Mesenchymal stem cells (MSCs) have exhibited potential in treating brain diseases due to their anti-inflammatory properties. However, the therapeutic efficacy of MSCs is limited by the intense inflammatory response
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The Critical Role of Pyroptosis in Peri-Implantitis J. Inflammation Res. (IF 4.5) Pub Date : 2024-03-12 Liangwen Chen, Ziqiao Tang, Liangliang Fu, Yang Xie, Junyi Xu, Haibin Xia, Ting Xia, Min Wang
Background: Peri-implantitis (PI) is a prevalent complication of implant treatment. Pyroptosis, a distinctive inflammatory programmed cell death, is crucial to the pathophysiology of PI. Despite its importance, the pyroptosis-related genes (PRGs) influencing PI’s progression remain largely unexplored. Methods: This study conducted histological staining and transcriptome analyze from three datasets
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The Function and Mechanism of Anti-Inflammatory Factor Metrnl Prevents the Progression of Inflammatory-Mediated Pathological Bone Osteolytic Diseases J. Inflammation Res. (IF 4.5) Pub Date : 2024-03-11 Nan Liu, Jinlei Dong, Lianxin Li, Dongsheng Zhou, Fanxiao Liu
Abstract: Metrnl, recently identified as an adipokine, is a secreted protein notably expressed in white adipose tissue, barrier tissues, and activated macrophages. This adipokine plays a pivotal role in counteracting obesity-induced insulin resistance. It enhances adipose tissue functionality by promoting adipocyte differentiation, activating metabolic pathways, and exerting anti-inflammatory effects
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Caffeine in Hepatocellular Carcinoma: Cellular Assays, Animal Experiments, and Epidemiological Investigation J. Inflammation Res. (IF 4.5) Pub Date : 2024-03-11 Liang Shan, Ning Zhao, Fengling Wang, Dandan Zhai, Jianjun Liu, Xiongwen Lv
Abstract: The use of caffeine in treating various liver diseases has made substantial progress in the past decade owing to advances in science, technology, and medicine. However, whether caffeine has a preventive effect on hepatocellular carcinoma (HCC) and its mechanism are still worth further investigation. In this review, we summarize and analyze the efficacy and safety of caffeine in the prevention
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The Impact of Laparoscopic Appendectomy and Open Appendectomy on B7-H3-Mediated Intrinsic Immune Response in Children with Acute Suppurative Appendicitis J. Inflammation Res. (IF 4.5) Pub Date : 2024-03-11 Chunsheng Duan, Yuan Li, Jiansu Ma, Yanglin Song, Lixia Zhou
Purpose: Surgery impairs immune function and increases postoperative complications. B7H3, a co-stimulatory molecule, plays a crucial role in immune regulation. The present study examined the impact of B7H3 on the postoperative immune response in children with acute suppurative appendicitis (ASA) by comparing preoperative and postoperative B7H3 levels in laparoscopic surgery (LA) and open appendectomy
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Integrated Bioinformatics Exploration and Preliminary Clinical Verification for the Identification of Crucial Biomarkers in Severe Cases of COVID-19 J. Inflammation Res. (IF 4.5) Pub Date : 2024-03-11 Zhisheng Huang, Zuowang Cheng, Xia Deng, Ying Yang, Na Sun, Peibin Hou, Ruyue Fan, Shuai Liu
Background: Coronavirus disease 2019 (COVID-19) is a respiratory infectious illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The objective of this study is to identify reliable and accurate biomarkers for the early stratification of disease severity, a crucial aspect that is currently lacking for the impending phases of the next COVID-19 pandemic. Methods: In this study
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A Nomogram for Predicting Mortality in Patients with Pneumonia-Associated Acute Respiratory Distress Syndrome (ARDS) J. Inflammation Res. (IF 4.5) Pub Date : 2024-03-08 Dong Huang, Dingxiu He, Linjing Gong, Wei Jiang, Rong Yao, Zongan Liang
Background: There is no predictive tool developed for pneumonia-associated acute respiratory distress syndrome (ARDS) specifically so far, and the clinical risk classification of these patients is not well defined. Our study aims to construct an early prediction model for hospital mortality in patients with pneumonia-associated ARDS. Methods: In this single-center retrospective study, consecutive patients