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A novel immune-related LncRNA prognostic signature for cutaneous melanoma Mol. Cell. Toxicol. (IF 1.7) Pub Date : 2024-04-01 Nan Hu, Cancan Huang, Yancheng He, Shuyang Li, Jingyi Yuan, Guishu Zhong, Yan Chen
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Cheong-sang-gyeon-tong-tang improves hepatic steatosis by regulating cholesterol metabolism Mol. Cell. Toxicol. (IF 1.7) Pub Date : 2024-03-08 Yun-Mi Kang, Kwang-Youn Kim, Tae In Kim, Yeon-Ji Kim, Han-Hae Kim, Kyungho Kim
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Induction of glioblastoma invasion triggered by system Xc−-mediated glutamate release Mol. Cell. Toxicol. (IF 1.7) Pub Date : 2024-03-07
Abstract Backgrounds Glioblastoma (GBM) is a highly aggressive brain cancer associated with poor prognosis, primarily attributed to its profound invasive characteristics. Glutamate is the main cause of invasion, and invasion is promoted by system Xc− (cystine/glutamate antiporter), which is highly expressed in GBM. To date, no studies have examined the relationship between invasion and the specific
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A systematic review of the carcinogenicity of rats and mice by sex due to exposure to phenyl compounds Mol. Cell. Toxicol. (IF 1.7) Pub Date : 2024-03-05 Kyung-Taek Rim
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MicroRNA-34b-5p increases chemosensitivity of hepatocellular carcinoma cells Mol. Cell. Toxicol. (IF 1.7) Pub Date : 2024-03-04 JinSuo Chen, LiNa Wang, XueMei Wu, ZhiJie Ding, WenXi Cao, LeiLei Yang, YongPing Zhou, Li Xia, Zhao Song
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Prediction of herb–drug interaction between hyperforin and sedative hypnotics (zolpidem, alprazolam, and midazolam) using physiologically-based pharmacokinetic modeling Mol. Cell. Toxicol. (IF 1.7) Pub Date : 2024-02-24 Anna Shin, Boyun Jang, Sunyoung Cho, Youngsoo Kim, Min Soo Park, Kwang-Il Park, Young Woo Kim, Choon Ok Kim
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VD/VDR-mediated ATG16L1 activation reduces Alzheimer’s disease-like pathology and cognitive decline Mol. Cell. Toxicol. (IF 1.7) Pub Date : 2024-02-24 Zhixiong Huang, Wei Ang, Hefei Huang, Yanyan Wang
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Dual suppressive effect of p-coumaric acid on pigmentation in B16F10 cells Mol. Cell. Toxicol. (IF 1.7) Pub Date : 2024-02-22 Sohee Jang, Chang-Woo Ha, Sung-Hyeok Kim, Jung Hun Choi, Seung Namkoong, Sungsil Hong, Hyun Jung Koo, Youn-Kyu Kim, Mediana Hadiwidjaja, Sung Ryul Lee, Eun-Hwa Sohn
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Bergenin ameliorates the progression of atherosclerosis by inhibiting oxidative stress, inflammation, and monocytes adhesion in human umbilical vein endothelial cells Mol. Cell. Toxicol. (IF 1.7) Pub Date : 2024-02-21 Liyuan Liang, Wei Yang
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Mechanistic insight of mitochondrial dysfunctions in cardiovascular diseases with potential biomarkers Mol. Cell. Toxicol. (IF 1.7) Pub Date : 2024-02-20 Md. Nazmul Islam, Vineet Kumar Mishra, Rina Munalisa, Farzana Parveen, Saieeda Fabia Ali, Khadiza Akter, Tanvir Ahmed, Tsung-Jung Ho, Chih-Yang Huang
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The atypical protein kinase RIOK3 contributes to the phenotypic modulation of vascular smooth muscle cells in intracranial aneurysms Mol. Cell. Toxicol. (IF 1.7) Pub Date : 2024-02-09 Jianzhu Wei, Yang Zhang, Bo Xie, Ziyi Zhu, Jingyu Qian, Yulin Tan
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Lycopene mitigates DHT-induced apoptosis and oxidative stress in human granulosa cell line KGN by regulating the Nrf2 pathway Mol. Cell. Toxicol. (IF 1.7) Pub Date : 2024-02-05 Yue Chen, Mengmeng Zhao, Xiaoqing Li, Yuanyuan Liu, Yuhong Shang
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CARD9 regulates myocardial inflammation, oxidative stress, and vascular dysfunction in hypertensive rats by activating MAPK/p38 pathway in combination with NOD2 Mol. Cell. Toxicol. (IF 1.7) Pub Date : 2024-02-01
Abstract Objective This study aimed to uncover the related mechanism of CARD9 in myocardial inflammation, oxidative stress, and vascular dysfunction following hypertension. Methods Spontaneous hypertension rats were injected with shRNA adenovirus vector or adenovirus overexpression vector. Blood pressure was measured. Cardiac tissue and aortic tissue were harvested to observe pathological damage by
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Evaluation of the antinociceptive effect and standardization of Platycladus orientalis (L.) Franco extract Mol. Cell. Toxicol. (IF 1.7) Pub Date : 2024-01-26
Abstract Background Platycladus orientalis (L.) Franco (PO) has been used in Oriental medicine to treat rheumatism and diarrhea; however, its antinociceptive effects remain unclear. Objective This study aimed to reveal the antinociceptive effect of the PO extract and standardize this extract in RAW 264.7 cells and mice with monosodium uric acid (MSU)-induced pain. Results PO extracts were prepared
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Bone marrow mesenchymal stem cell transplantation protects rats from myocardial infarction by regulating TXNIP/NLRP3 pathway-mediated inflammation and fibrosis Mol. Cell. Toxicol. (IF 1.7) Pub Date : 2024-01-25 JianNan Bai, Cong Wang, HongQiang Yu, QingChao Wang, JinFeng Zhang, DanDan Shao, ZhiQiang Yu, Bo Meng, You Li
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Olaparib synergically exacerbates the radiation-induced intestinal apoptosis in mice Mol. Cell. Toxicol. (IF 1.7) Pub Date : 2024-01-20
Abstract Background Olaparib, a poly [ADP-ribose] polymerase (PARP) inhibitor, is used in cancer treatment and in other diseases and achieves local cancer control in combination with radiotherapy. Objectives We investigated the effects of olaparib on irradiation-induced intestinal damage using both in vitro and in vivo model systems. In particular, we evaluated how olaparib affects irradiation-induced
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Genotoxicity evaluation of collagen peptide derived from skate (Raja kenojei) skin: In vitro and in vivo studies Mol. Cell. Toxicol. (IF 1.7) Pub Date : 2024-01-19 Heung-Sik Seo, Ji-Soo Kim, Myeong-Kyu Park, Nak-Won Seong, Geun-Hee Kang, Sang-Ho Kim, Joong-Sun Kim, Sung-Ho Kim, Jong-Choon Kim, Changjong Moon
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LINC00174 targeting miR-486-5p/EIF5A2 is an oncogenic driver in oral squamous cell carcinoma Mol. Cell. Toxicol. (IF 1.7) Pub Date : 2023-12-22 Xiao Feng, Jia Tu, Yan Guan
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Phenotypic and functional alterations of bone marrow MSCs exposed to multiple myeloma cells Mol. Cell. Toxicol. (IF 1.7) Pub Date : 2023-12-16
Abstract Backgrounds The direct and indirect interactions between multiple myeloma (MM) cells and bone marrow mesenchymal stromal cells (MSCs) play crucial roles in the formation of the bone marrow environment, disease progression, and drug resistance development. However, it remains unclear how MM cells and MSCs individually influence each other to induce these phenomena. Objective In this study,
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Maslinic acid induces apoptosis in thyroid cancer cells via endoplasmic reticulum stress Mol. Cell. Toxicol. (IF 1.7) Pub Date : 2023-12-12 Jing Zhu, Pinghui Tu, Yu Yang, Dandan Zhang, Fengling Chen
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Long noncoding RNA MAFG-AS1 enhances proliferation, invasion, and epithelial–mesenchymal transition of melanoma cells through promoting KIT expression by competitively binding to miR-331-3p Mol. Cell. Toxicol. (IF 1.7) Pub Date : 2023-12-07 Zongjiang Yao, Peiwu Li, Hong Liu
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The mechanism of 5-aminolevulinic acid-photodynamic therapy pretreatment repressing keloid fibroblast proliferation and invasion by mediating forkhead box protein O6 (FoxO6) antioxidant stress Mol. Cell. Toxicol. (IF 1.7) Pub Date : 2023-12-07 Qiong Wang, Weihui Zeng, Shuang Wang, Songmei Geng, Chen Tu
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Impact of diesel particulate matter on the olfactory bulb of mice: insights from behavioral, histological, and molecular assessments Mol. Cell. Toxicol. (IF 1.7) Pub Date : 2023-12-01 Jeongmin Lee, Poornima D. E. Weerasinghe-Mudiyanselage, Bohye Kim, Sohi Kang, Joong-Sun Kim, Changjong Moon
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Silibinin alleviates DNA damage, mitochondrial dysfunction, and apoptosis caused by oxidative stress in human retinal pigment epithelial cells Mol. Cell. Toxicol. (IF 1.7) Pub Date : 2023-11-25 Yung Hyun Choi
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Circ_101692 promotes the proliferation, invasion and glycolysis of colorectal cancer through the regulation of miR-449b-5p/GOLPH3 axis Mol. Cell. Toxicol. (IF 1.7) Pub Date : 2023-11-24 Xiang Feng, Qian Zhang
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Heme oxygenase-1 mediates the inhibitory effect of ginseng (Panax ginseng) leaf extract on differentiation in 3T3-L1 adipocytes Mol. Cell. Toxicol. (IF 1.7) Pub Date : 2023-11-20 Hyuk Gyoon Lee, Jinwoo Hur, Jun Pil Won, Han Geuk Seo
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Neuregulin-1 suppresses anti-apoptotic effect of Der p 38 on neutrophils by inhibition of cytokine secretion Mol. Cell. Toxicol. (IF 1.7) Pub Date : 2023-11-14 Yujin Hong, Ji Hyeon Choi, Min Hwa Hong, Geunyeong Kim, Ji-Sook Lee, Ran-Sook Woo, Eun Ju Yang, In Sik Kim
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Claudin-5 overexpression correlates with proliferation and migration in gastric cancer Mol. Cell. Toxicol. (IF 1.7) Pub Date : 2023-11-11 Sandang Li, Taizhe Zhang, Fuchen Xie, Zhaohui Du, Jie Du, Zhenjie Wang
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HDAC3 deacetylates H3K27ac and H3K9ac on the TrkC promoter to exacerbate sevoflurane-induced neurotoxicity Mol. Cell. Toxicol. (IF 1.7) Pub Date : 2023-11-09 Jiegang Zhou, Xinwei Feng, Dan Wang
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Role of CREB1 dysregulation in calcium oxalate monohydrate crystals-induced tubular epithelial cell injury Mol. Cell. Toxicol. (IF 1.7) Pub Date : 2023-11-02 Anqing Yang, Jianian Zhang, Tao Huang, Zhongwei Yu, Chenhui Zhao, Yongzhi Xu, Binbin Ma
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Alveolar damage and development of emphysema in rats with carbon monoxide poisoning Mol. Cell. Toxicol. (IF 1.7) Pub Date : 2023-11-04 Seok Jeong Lee, Taeyeong Kim, Yong Sung Cha, Min Kim, Ji Yong Lee, Won-Yeon Lee
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Carcinogenicity assessment of industrial chemicals 1,2-dichlorobenzene, 2-methoxyethanol and anisol via Bhas 42 cell transformation assay Mol. Cell. Toxicol. (IF 1.7) Pub Date : 2023-10-17 Cheol Hong Lim, Dong Seok Seo
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Scallop-derived plasmalogen attenuates amyloid beta-induced inflammation and apoptosis in SH-SY5Y cells Mol. Cell. Toxicol. (IF 1.7) Pub Date : 2023-10-15 Jin-Young Han, Miey Park, Hae-Jeung Lee
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Fucoidan ameliorates amyloid-β 42 oligomer-induced neuronal apoptosis by activating the PI3K/Akt signaling pathway and MAPK cascades in human neuroblastoma SH-SY5Y cells Mol. Cell. Toxicol. (IF 1.7) Pub Date : 2023-10-15 Chae-Won Kang, Miey Park, Hae-Jeung Lee
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SEC61G knockdown enhances the sensitivity of gastric cancer cells to etoposide through EGFR and glycolytic-mediated pathways Mol. Cell. Toxicol. (IF 1.7) Pub Date : 2023-10-14 Dengfeng Wu, Chunying Fang, Yazhi Chen, Xuefeng Xu, Xiongbo Wu, Sijie Chen
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LncRNA-SNHG3 promotes neuroinflammation post-intracerebral hemorrhage by regulating the miR-106b-5p/TXNIP axis Mol. Cell. Toxicol. (IF 1.7) Pub Date : 2023-10-13 Fenggang Zhou, Fei Wu, Xinran Wang, Shihua Yu, Wenqi Tian, Ou Lv
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miR-20b-5p exerts protective effects against experimental autoimmune encephalomyelitis in mice by inhibiting NLRP3 transcription and NLRP3/ASC/caspase-1 axis activation Mol. Cell. Toxicol. (IF 1.7) Pub Date : 2023-10-13 Fenggang Zhou, Fei Wu, Xinran Wang, Shihua Yu, Wenqi Tian, Ou Lv
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Inhibiting poly (ADP-ribose) polymerase 1 activation alleviates acetaminophen-induced acute liver injury in mice Mol. Cell. Toxicol. (IF 1.7) Pub Date : 2023-10-09 Jiarui Tang, Cuiting Liao, Kai Hu, Longhui Li, Yongqiang Yang, Jiayi Huang, Li Tang, Li Zhang, Longjiang Li
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Oral health effect of an oral rinse containing cetylpyridinium chloride: a randomized clinical trial Mol. Cell. Toxicol. (IF 1.7) Pub Date : 2023-09-28 Md. Habibur Rahman, Jayson M. Antonio, Yun-Seon Lee, Ailyn Fadriquela, Soo-Min Kim, Sun-Young Han, Yeonkyung Lee, Jaeeun You, Cheol-Su Kim, Kyu-Jae Lee
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Knockout of METTL3 promotes neural functional recovery after spinal cord injury in mice via the USP4/YTHDF2 axis Mol. Cell. Toxicol. (IF 1.7) Pub Date : 2023-09-27 Yanbo Yu, Zhisheng Wu, Ziqiang Yu, Daying Zhang
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ML385 suppresses the proliferation, migration, and invasion of thyroid carcinoma cells by impairing aerobic glycolysis Mol. Cell. Toxicol. (IF 1.7) Pub Date : 2023-09-20 Wentian Zheng, Huan Yang, Hehua Lin, Hanxing Huang
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Scutellarein ameliorates inflammation and oxidative stress in L-arginine induced acute pancreatitis in mice through regulating the expression of VEGF Mol. Cell. Toxicol. (IF 1.7) Pub Date : 2023-09-20 Haicheng Dong, Weixing Ying, Shifeng Zhu
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Molecular mechanism of long non-coding RNA SNHG12 regulating bladder cancer cell activities Mol. Cell. Toxicol. (IF 1.7) Pub Date : 2023-09-17 Li Chen, Chao Feng, Wei Zhou, WenXin Ye
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Circ_0000732 promotes breast cancer cell proliferation, metastasis and stemness by mediating COL11A1 through the regulation of miR-1253 Mol. Cell. Toxicol. (IF 1.7) Pub Date : 2023-09-14 Wenjian Ming, Yuanbo Wu, Fang Wang, Xin Liu
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Sublethal effects of acetaminophen exposure on benthic aquatic animal (Hydra magnipapillata) Mol. Cell. Toxicol. (IF 1.7) Pub Date : 2023-09-01 Ade Yamindago, Yejin Jo, Hyokyoung Won, Seungshic Yum
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CHL1 promotes autophagy and apoptosis of multiple myeloma cells via inhibiting the Hedgehog pathway Mol. Cell. Toxicol. (IF 1.7) Pub Date : 2023-08-29 Xinyu Gao, Yongfang Jiang
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Myricetin alleviates pancreatic microcirculation and inflammation in rats with severe acute pancreatitis through FOXO1 and NF-κB pathways Mol. Cell. Toxicol. (IF 1.7) Pub Date : 2023-08-24 Ke Ren, Jinfeng Lin, Yadong Wang, Xiaoyan Ji
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Chemically induced bacterial ghosts: a novel approach for advancing biomedical applications Mol. Cell. Toxicol. (IF 1.7) Pub Date : 2023-08-21 Shin-Young Park
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Chronic toxic effects of fragmented polyvinyl chloride on the water flea Moina macrocopa Mol. Cell. Toxicol. (IF 1.7) Pub Date : 2023-08-18 Jaehee Kim, Yugyeong Sim, Jinyoung Jeong, Jee-Hyun Jung, Jae-Sung Rhee
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miR-365b-3p adsorbed by HCG18 inhibits the proliferation and angiogenesis of stomach adenocarcinoma by downregulating STC1 Mol. Cell. Toxicol. (IF 1.7) Pub Date : 2023-08-14 Hui Li, Jian Song, Rui Hou, Yingdong Cao, Huaili Xu
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Evaluations of carcinogens from comparison of cancer slope factors: meta-analysis and systemic literature reviews Mol. Cell. Toxicol. (IF 1.7) Pub Date : 2023-08-14 Kyung-Taek Rim
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In silico molecular docking validation of procalcitonin-binding aptamer and sepsis diagnosis Mol. Cell. Toxicol. (IF 1.7) Pub Date : 2023-08-07 Dae-Young Park, Woo-Ri Shin, Sang Yong Kim, Quang-Thai Nguyen, Jin-Pyo Lee, Do-Young Kim, Ji-Young Ahn, Yang-Hoon Kim
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MicroRNA-1271-5p suppresses the proliferation, invasion and migration of oral squamous cell carcinoma by inhibiting F13A1 expression Mol. Cell. Toxicol. (IF 1.7) Pub Date : 2023-08-04 Pei Xu, Jia Wang, Ye Tao, Chen Zhang, Yan Xia
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WTAP accelerates keloids formation by mediating m6A modification of HOXA5 to suppress p53 pathway Mol. Cell. Toxicol. (IF 1.7) Pub Date : 2023-08-02 Lin Liu, Kun Du, Miao Chen
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CircPGPEP1 promotes the growth and metastasis of breast cancer cells by targeting miR-30b Mol. Cell. Toxicol. (IF 1.7) Pub Date : 2023-08-02 Yongjia Tan, Xiang Wang
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β-hydroxybutyrate impairs nasopharyngeal carcinoma cell aggressiveness via histone deacetylase 4 inhibition Mol. Cell. Toxicol. (IF 1.7) Pub Date : 2023-07-24 Jinqiao Huang, Xian Chen, Hong Lin, Xiufen Chen
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Liquiritin inhibits TGF-β1-induced epithelial mesenchymal transition and extracellular matrix deposition in human renal proximal tubular epithelial cells by suppressing the MAPK signaling Mol. Cell. Toxicol. (IF 1.7) Pub Date : 2023-07-25 Zhen Chen, Yi jue Liu, Bo Yu, Wei Li, Mengli Zhang, Xian Wu, Feng Gui, Huan Peng, Fen Ai
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Oleamide–PDMS copolymer for coating urinary catheters with anti-adhesive and anti-biofilm properties Mol. Cell. Toxicol. (IF 1.7) Pub Date : 2023-07-24 Jiwon Park, Eunseok Seo, Yang-Hoon Kim, Ji-Young Ahn, Da Hyeon Choi, Kyeong Eun Lee, Yoon Shin Park
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The cytotoxic and antitumoral effects of Remdesivir, an antiviral RdRp inhibitor, on different cancer cells in vitro Mol. Cell. Toxicol. (IF 1.7) Pub Date : 2023-07-22 Isil Ezgi Eryilmaz, Ceyda Colakoglu Bergel, Unal Egeli, Gulsah Cecener
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3D structural analysis of aptamer and diagnostic platforms for detecting hepatocellular carcinoma Mol. Cell. Toxicol. (IF 1.7) Pub Date : 2023-07-05 Woo-Ri Shin, Dae-Young Park, Hyun-Ju Um, Gna Ahn, Sang Yong Kim, Ji-Young Ahn, Yang-Hoon Kim