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Cleavage and polyadenylation machinery as a novel targetable vulnerability for human cancer Cancer Gene Ther. (IF 6.4) Pub Date : 2024-04-17 Giulia Pagani, Paolo Gandellini
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Inhibition of the galactosyltransferase C1GALT1 reduces osteosarcoma cell proliferation by interfering with ERK signaling and cell cycle progression Cancer Gene Ther. (IF 6.4) Pub Date : 2024-04-15 Kentaro Watanabe, Keiji Tasaka, Hideto Ogata, Shota Kato, Hiroo Ueno, Katsutsugu Umeda, Tomoya Isobe, Yasuo Kubota, Masahiro Sekiguchi, Shunsuke Kimura, Aiko Sato-Otsubo, Mitsuteru Hiwatari, Tetsuo Ushiku, Motohiro Kato, Akira Oka, Satoru Miyano, Seishi Ogawa, Junko Takita
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CRISPR-Cas gene knockouts to optimize engineered T cells for cancer immunotherapy Cancer Gene Ther. (IF 6.4) Pub Date : 2024-04-12 Valentine De Castro, Jeanne Galaine, Romain Loyon, Yann Godet
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Understanding, diagnosing, and treating pancreatic cancer from the perspective of telomeres and telomerase Cancer Gene Ther. (IF 6.4) Pub Date : 2024-04-09 Songting Shou, Yuanliang Li, Jiaqin Chen, Xing Zhang, Chuanlong Zhang, Xiaochen Jiang, Fudong Liu, Li Yi, Xiyuan Zhang, En Geer, Zhenqing Pu, Bo Pang
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RevCAR-expressing immune effector cells for targeting of Fn14-positive glioblastoma Cancer Gene Ther. (IF 6.4) Pub Date : 2024-04-06 Haidy A. Saleh, Nicola Mitwasi, Liliana R. Loureiro, Alexandra Kegler, Karla Elizabeth González Soto, Lydia Hoffmann, Eugenia Crespo, Claudia Arndt, Ralf Bergmann, Michael Bachmann, Anja Feldmann
In recent studies, we have established the unique adapter chimeric antigen receptor (CAR) platform RevCAR which uses, as an extracellular CAR domain, a peptide epitope instead of an antibody domain. RevCAR adapters (termed RevCAR target modules, RevTMs) are bispecific antibodies that enable the reversible ON/OFF switch of the RevCAR system, improving the safety compared to conventional CARs. Here,
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SDCBP modulates tumor microenvironment, tumor progression and anti-PD1 efficacy in colorectal cancer Cancer Gene Ther. (IF 6.4) Pub Date : 2024-03-30 Jiahua Yu, Shijun Yu, Jin Bai, Zhe Zhu, Yong Gao, Yandong Li
Anti-programmed cell death 1 (aPD1) therapy has yielded limited success in patients with colorectal cancer (CRC). Syndecan binding protein (SDCBP), encodes a PDZ domain-containing protein that is essential for cellular processes, including cell adhesion, migration, and signal transduction. Here, we investigated the effect of SDCBP on tumor progression, immunotherapy, and the tumor microenvironment
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Generation of glioblastoma in mice engrafted with human cytomegalovirus-infected astrocytes Cancer Gene Ther. (IF 6.4) Pub Date : 2024-03-29 Joris Guyon, Sandy Haidar Ahmad, Ranim El Baba, Mégane Le Quang, Andreas Bikfalvi, Thomas Daubon, Georges Herbein
Mounting evidence is identifying human cytomegalovirus (HCMV) as a potential oncogenic virus. HCMV has been detected in glioblastoma multiforme (GB). Herewith, we present the first experimental evidence for the generation of CMV-Elicited Glioblastoma Cells (CEGBCs) possessing glioblastoma-like traits that lead to the formation of glioblastoma in orthotopically xenografted mice. In addition to the already
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PANoptosis: bridging apoptosis, pyroptosis, and necroptosis in cancer progression and treatment Cancer Gene Ther. (IF 6.4) Pub Date : 2024-03-29 Jie Gao, Anying Xiong, Jiliu Liu, Xiaolan Li, Junyi Wang, Lei Zhang, Yao Liu, Ying Xiong, Guoping Li, Xiang He
This comprehensive review explores the intricate mechanisms of PANoptosis and its implications in cancer. PANoptosis, a convergence of apoptosis, pyroptosis, and necroptosis, plays a crucial role in cell death and immune response regulation. The study delves into the molecular pathways of each cell death mechanism and their crosstalk within PANoptosis, emphasizing the shared components like caspases
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Gastrointestinal infections and gastrointestinal haemorrhage are underestimated but serious adverse events in chimeric antigen receptor T-cell recipients: A real-world study Cancer Gene Ther. (IF 6.4) Pub Date : 2024-03-28 Zhiqiang Song, Yang Wang, Ping Liu, Yuke Geng, Na Liu, Jie Chen, Jianmin Yang
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Enhanced epithelial-mesenchymal transition signatures are linked with adverse tumor microenvironment, angiogenesis and worse survival in gastric cancer Cancer Gene Ther. (IF 6.4) Pub Date : 2024-03-26 Masanori Oshi, Arya Mariam Roy, Li Yan, Sachika Kinoshita, Yuko Tamura, Takashi Kosaka, Hirotoshi Akiyama, Chikara Kunisaki, Kazuaki Takabe, Itaru Endo
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Heterogeneity of hepatocellular carcinoma: from mechanisms to clinical implications Cancer Gene Ther. (IF 6.4) Pub Date : 2024-03-18 Fatema Safri, Romario Nguyen, Shadi Zerehpooshnesfchi, Jacob George, Liang Qiao
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miR-124-3p and miR-194-5p regulation of the PI3K/AKT pathway via ROR2 in medulloblastoma progression Cancer Gene Ther. (IF 6.4) Pub Date : 2024-03-19 Chen Wang, Runxi Fu, Yunkun Wang, Jia Wei, Ying Yu, Liuhua Hu, Chenran Zhang
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Hippo pathway in non-small cell lung cancer: mechanisms, potential targets, and biomarkers Cancer Gene Ther. (IF 6.4) Pub Date : 2024-03-18 Hongge Liang, Yan Xu, Jing Zhao, Minjiang Chen, Mengzhao Wang
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The pleiotropic nature of NONO, a master regulator of essential biological pathways in cancers Cancer Gene Ther. (IF 6.4) Pub Date : 2024-03-16 Domenica Ronchetti, Valentina Traini, Ilaria Silvestris, Giuseppina Fabbiano, Francesco Passamonti, Niccolò Bolli, Elisa Taiana
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The integrate profiling of single-cell and spatial transcriptome RNA-seq reveals tumor heterogeneity, therapeutic targets, and prognostic subtypes in ccRCC Cancer Gene Ther. (IF 6.4) Pub Date : 2024-03-13 Yanlong Zhang, Xuefeng Huang, Minghang Yu, Menghan Zhang, Li Zhao, Yong Yan, Liyun Zhang, Xi Wang
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Caffeic acid phenethyl ester suppresses the expression of androgen receptor variant 7 via inhibition of CDK1 and AKT Cancer Gene Ther. (IF 6.4) Pub Date : 2024-03-13 Ying-Yu Kuo, Chieh Huo, Chia-Yang Li, Chih-Pin Chuu
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Adeno-associated virus-mediated trastuzumab delivery to the central nervous system for human epidermal growth factor receptor 2+ brain metastasis Cancer Gene Ther. (IF 6.4) Pub Date : 2024-03-13 Marcela S. Werner, Shweta Aras, Ashleigh R. Morgan, Jillian Roamer, Nesteene J. Param, Kanyin Olagbegi, R. Jason Lamontagne, Jenny A. Greig, James M. Wilson
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Romidepsin exhibits anti-esophageal squamous cell carcinoma activity through the DDIT4-mTORC1 pathway Cancer Gene Ther. (IF 6.4) Pub Date : 2024-03-13 Wei-Feng Xia, Xiao-Li Zheng, Wen-Yi Liu, Yu-Tang Huang, Chun-Jie Wen, Hong-Hao Zhou, Qing-Chen Wu, Lan-Xiang Wu
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Heparanase interacting BCLAF1 to promote the development and drug resistance of ICC through the PERK/eIF2α pathway Cancer Gene Ther. (IF 6.4) Pub Date : 2024-03-11 Fengyan Yuan, Huiqin Zhou, Chongyang Liu, Yi Wang, Jing Quan, Jie Liu, Hao Li, Mark von Itzstein, Xing Yu
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Tumor stroma-derived ANGPTL2 potentiates immune checkpoint inhibitor efficacy Cancer Gene Ther. (IF 6.4) Pub Date : 2024-03-11 Haruki Horiguchi, Tsuyoshi Kadomatsu, Tomoya Yamashita, Shinsei Yumoto, Taichi Horino, Michio Sato, Kazutoyo Terada, Keishi Miyata, Yuki Ichigozaki, Toshihiro Kimura, Satoshi Fukushima, Toshiro Moroishi, Yuichi Oike
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Identification of EGR4 as a prospective target for inhibiting tumor cell proliferation and a novel biomarker in colorectal cancer Cancer Gene Ther. (IF 6.4) Pub Date : 2024-03-08 Bangting Wang, Shijie Zhang, Haiyang Wang, Min Wang, Yuwen Tao, Mujie Ye, Zhining Fan, Yan Wang, Li Liu
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CAR T therapies in multiple myeloma: unleashing the future Cancer Gene Ther. (IF 6.4) Pub Date : 2024-03-04 Mohsen Sheykhhasan, Amirhossein Ahmadieh-Yazdi, Rosario Vicidomini, Naresh Poondla, Hamid Tanzadehpanah, Ashkan Dirbaziyan, Hanie Mahaki, Hamed Manoochehri, Naser Kalhor, Paola Dama
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Single-cell atlas reveals the immunosuppressive microenvironment and Treg cells landscapes in recurrent Glioblastoma Cancer Gene Ther. (IF 6.4) Pub Date : 2024-03-01 Xingdong Wang, Yizhi Ge, Yuting Hou, Xiaodong Wang, Zhengcun Yan, Yuping Li, Lun Dong, Lei She, Can Tang, Min Wei, Hengzhu Zhang
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Identification of lineage-specific epigenetic regulators FOXA1 and GRHL2 through chromatin accessibility profiling in breast cancer cell lines Cancer Gene Ther. (IF 6.4) Pub Date : 2024-03-01 Liying Yang, Kohei Kumegawa, Sumito Saeki, Tomoyoshi Nakadai, Reo Maruyama
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Dual-inhibition of NAMPT and PAK4 induces anti-tumor effects in 3D-spheroids model of platinum-resistant ovarian cancer Cancer Gene Ther. (IF 6.4) Pub Date : 2024-02-29 Kei Kudo, Yoshimi Endo Greer, Teruhiko Yoshida, Brittney S. Harrington, Soumya Korrapati, Yusuke Shibuya, Leah Henegar, Jeffrey B. Kopp, Takeo Fujii, Stanley Lipkowitz, Christina M. Annunziata
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Genetic mutation patterns among glioblastoma patients in the Taiwanese population – insights from a single institution retrospective study Cancer Gene Ther. (IF 6.4) Pub Date : 2024-02-28 Yu-Fen Huang, Ming-Tsang Chiao, Tzu-Hung Hsiao, Yong-Xiang Zhan, Tse-Yu Chen, Chung-Hsin Lee, Szu-Yuan Liu, Chih-Hsiang Liao, Wen-Yu Cheng, Chun-Ming Yen, Chih-Ming Lai, Jun-Peng Chen, Chiung-Chyi Shen, Meng-Yin Yang
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Recent progress of CDK4/6 inhibitors’ current practice in breast cancer Cancer Gene Ther. (IF 6.4) Pub Date : 2024-02-26 Xueqing Wang, Shanshan Zhao, Qinghan Xin, Yunkun Zhang, Kainan Wang, Man Li
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A guardian turned rogue: TP53 promoter translocations rewire stress responses to oncogenic effectors in osteosarcoma Cancer Gene Ther. (IF 6.4) Pub Date : 2024-02-26 Nikolas Herold
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Transactivation of Met signaling by oncogenic Gnaq drives the evolution of melanoma in Hgf-Cdk4 mice Cancer Gene Ther. (IF 6.4) Pub Date : 2024-02-15 Miriam Mengoni, Andreas Dominik Braun, Sahithi Seedarala, Susanne Bonifatius, Evi Kostenis, Denny Schanze, Martin Zenker, Thomas Tüting, Evelyn Gaffal
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Cancer-associated fibroblast exosomes promote prostate cancer metastasis through miR-500a-3p/FBXW7/HSF1 axis under hypoxic microenvironment Cancer Gene Ther. (IF 6.4) Pub Date : 2024-02-14 Zhanliang Liu, Zhemin Lin, Mingxin Jiang, Guangyi Zhu, Tianyu Xiong, Fang Cao, Yun Cui, Y. N. Niu
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Emerging role of RNA modification and long noncoding RNA interaction in cancer Cancer Gene Ther. (IF 6.4) Pub Date : 2024-02-14 Liqiong Yang, Lu Tang, Qi Min, Hua Tian, Linwei Li, Yueshui Zhao, Xu Wu, Mingxing Li, Fukuan Du, Yu Chen, Wanping Li, Xiaobing Li, Meijuan Chen, Li Gu, Yuhong Sun, Zhangang Xiao, Jing Shen
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Utilizing nullomers in cell-free RNA for early cancer detection Cancer Gene Ther. (IF 6.4) Pub Date : 2024-02-14 Austin Montgomery, Georgios Christos Tsiatsianis, Ioannis Mouratidis, Candace S. Y. Chan, Maria Athanasiou, Anastasios D. Papanastasiou, Verena Kantere, Nikos Syrigos, Ioannis Vathiotis, Konstantinos Syrigos, Nelson S. Yee, Ilias Georgakopoulos-Soares
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The golden key to open mystery boxes of SMARCA4-deficient undifferentiated thoracic tumor: focusing immunotherapy, tumor microenvironment and epigenetic regulation Cancer Gene Ther. (IF 6.4) Pub Date : 2024-02-13 Xiang Li, Sen Tian, Hui Shi, Na Ta, Xiang Ni, Chenguang Bai, Zhanli Zhu, Yilin Chen, Dongchen Shi, Haidong Huang, Longpei Chen, Zhenhong Hu, Lei Qu, Yao Fang, Chong Bai
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Modification of the tumor microenvironment enhances immunity with plasmid gene therapy Cancer Gene Ther. (IF 6.4) Pub Date : 2024-02-09 Guilan Shi, Jody Synowiec, Julie Singh, Richard Heller
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Detection of (pre)cancerous colorectal lesions in Lynch syndrome patients by microsatellite instability liquid biopsy Cancer Gene Ther. (IF 6.4) Pub Date : 2024-02-09 Mattia Boeri, Stefano Signoroni, Chiara Maura Ciniselli, Manuela Gariboldi, Susanna Zanutto, Emanuele Rausa, Miriam Segale, Anna Zanghì, Maria Teresa Ricci, Paolo Verderio, Gabriella Sozzi, Marco Vitellaro
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Divergent transcriptomic signatures from putative mesenchymal stimuli in glioblastoma cells Cancer Gene Ther. (IF 6.4) Pub Date : 2024-02-09 William S. Hart, Paul J. Myers, Benjamin W. Purow, Matthew J. Lazzara
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Roles of circRNAs in the progression of colorectal cancer: novel strategies for detection and therapy Cancer Gene Ther. (IF 6.4) Pub Date : 2024-02-09 Jun Mao, Ying Lu
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Emerging roles of circular RNAs in regulating the hallmarks of thyroid cancer Cancer Gene Ther. (IF 6.4) Pub Date : 2024-02-05 Tianjiao Zhou, Zheng Li, Yumeng Jiang, Kaiming Su, Chuan Xu, Hongliang Yi
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Role of MARK2 in the nervous system and cancer Cancer Gene Ther. (IF 6.4) Pub Date : 2024-02-02 Yining Lei, Ruyi Zhang, Fei Cai
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Schwann cell derived pleiotrophin stimulates fibroblast for proliferation and excessive collagen deposition in plexiform neurofibroma Cancer Gene Ther. (IF 6.4) Pub Date : 2024-02-02 Zhuowei Tian, Zhong Du, Guo Bai, Qiyu Gong, Yuanhe You, Guisong Xu, Jialiang Liu, Meng Xiao, Yanan Wang, Yue He
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Histone 3 lysine 9 acetylation-specific reprogramming regulates esophageal squamous cell carcinoma progression and metastasis Cancer Gene Ther. (IF 6.4) Pub Date : 2024-01-30 Zhenhui Chen, Chenghao Li, Yue Zhou, Pengcheng Li, Guoquan Cao, Yunbo Qiao, Yinghao Yao, Jianzhong Su
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Neddylation of insulin receptor substrate acts as a bona fide regulator of insulin signaling and its implications for cancer cell migration Cancer Gene Ther. (IF 6.4) Pub Date : 2024-01-25 Jun Bum Park, Geon Ho Moon, Ara Cho, Minji Kwon, Jong-Wan Park, Eugene C. Yi, Haeryoung Kim, Junji Fukuda, Cheol Kwak, Young-Gyu Ko, Yang-Sook Chun
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GRIN2A mutation is a novel indicator of stratifying beneficiaries of immune checkpoint inhibitors in multiple cancers Cancer Gene Ther. (IF 6.4) Pub Date : 2024-01-24 Gan-xun Li, Rui-zhi Chang, Tong-tong Liu, Guan-nan Jin, Kan Lu, Tu-ying Yong, Zifu Li, Ji-hong Liu, Bixiang Zhang, Wan-guang Zhang, Ze-yang Ding
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The safety and efficacy of systemic delivery of a new liver-de-targeted TGFβ signaling inhibiting adenovirus in an immunocompetent triple negative mouse mammary tumor model Cancer Gene Ther. (IF 6.4) Pub Date : 2024-01-24 Soon Cheon Shin, Renee E. Vickman, Beniamin Filimon, Yuefeng Yang, Zebin Hu, Kathy A. Mangold, Bellur S. Prabhakar, Hans Schreiber, Weidong Xu
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LOXL1-AS1 inhibits JAK2 ubiquitination and promotes cholangiocarcinoma progression through JAK2/STAT3 signaling Cancer Gene Ther. (IF 6.4) Pub Date : 2024-01-24 Shaobo Yu, Xin Gao, Sidi Liu, Xiangjun Sha, Siyuan Zhang, Xinmiao Zhang, Dongsheng Sun, Xingming Jiang
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METTL3-mediated RanGAP1 promotes colorectal cancer progression through the MAPK pathway by recruiting YTHDF1 Cancer Gene Ther. (IF 6.4) Pub Date : 2024-01-24 Rui Yang, Cheng Yang, Danjie Su, Yang Song, Jie Min, Zhixin Qian, Xiangjing Shen, Junqiang Li, Haichuan Su
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Retinoids and EZH2 inhibitors cooperate to orchestrate anti-oncogenic effects on bladder cancer cells Cancer Gene Ther. (IF 6.4) Pub Date : 2024-01-17 Gizem Ozgun, Tutku Yaras, Burcu Akman, Gülden Özden-Yılmaz, Nick Landman, Gökhan Karakülah, Maarten van Lohuizen, Serif Senturk, Serap Erkek-Ozhan
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Redefining bioactive small molecules from microbial metabolites as revolutionary anticancer agents Cancer Gene Ther. (IF 6.4) Pub Date : 2024-01-10 Eileena F. Giurini, Aishvarya Godla, Kajal H. Gupta
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Targeting paraptosis in cancer: opportunities and challenges Cancer Gene Ther. (IF 6.4) Pub Date : 2024-01-04 Fangquan Chen, Hu Tang, Xiutao Cai, Junhao Lin, Limin Xiang, Rui Kang, Jiao Liu, Daolin Tang
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Sleeping Beauty transposon mutagenesis in mouse intestinal organoids identifies genes involved in tumor progression and metastasis Cancer Gene Ther. (IF 6.4) Pub Date : 2024-01-04 Naoko Iida, Yukari Muranaka, Jun Won Park, Shigeki Sekine, Neal G. Copeland, Nancy A. Jenkins, Yuichi Shiraishi, Masanobu Oshima, Haruna Takeda
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A novel intranasal peptide vaccine inhibits non-small cell lung cancer with KRAS mutation Cancer Gene Ther. (IF 6.4) Pub Date : 2024-01-04 Su He Wang, Zhengyi Cao, Mohammad Farazuddin, Jesse Chen, Katarzyna W. Janczak, Shengzhuang Tang, Jayme Cannon, James R. Baker
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BETA prime: a first-in-man phase 1 study of AdAPT-001, an armed oncolytic adenovirus for solid tumors Cancer Gene Ther. (IF 6.4) Pub Date : 2023-12-25 Anthony P. Conley, Christina L. Roland, Alberto Bessudo, Brian R. Gastman, Victoria M. Villaflor, Christopher Larson, Tony R. Reid, Scott Caroen, Bryan Oronsky, Meaghan Stirn, Jeannie Williams, Erica Burbano, Angelique Coyle, Minal A. Barve, Naveed Wagle, Nacer Abrouk, Santosh Kesari
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USP30 promotes the progression of breast cancer by stabilising Snail Cancer Gene Ther. (IF 6.4) Pub Date : 2023-12-25 Kai Sun, Shichong Liao, Xinrui Yao, Feng Yao
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Comparative study on genomic and epigenomic profiles of retinoblastoma or tuberous sclerosis complex via nanopore sequencing and a joint screening framework Cancer Gene Ther. (IF 6.4) Pub Date : 2023-12-25 Junting Wang, Chengyue Zhang, Li Zhang, Hong-juan Yao, Xiaohong Liu, Yuchen Shi, Junyang Zhao, Xiaochen Bo, Hebing Chen, Liang Li
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SPHK1 potentiates colorectal cancer progression and metastasis via regulating autophagy mediated by TRAF6-induced ULK1 ubiquitination Cancer Gene Ther. (IF 6.4) Pub Date : 2023-12-22 Da Chen, Jiangni Wu, Xinze Qiu, Shibo Luo, Shanpei Huang, Erdan Wei, Mengbin Qin, Jiean Huang, Shiquan Liu
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TSPAN1 inhibits metastasis of nasopharyngeal carcinoma via suppressing NF-kB signaling Cancer Gene Ther. (IF 6.4) Pub Date : 2023-12-22 Ming-Dian Wang, Hui-Ting Li, Li-Xia Peng, Yan Mei, Li-Sheng Zheng, Chang-Zhi Li, Dong-Fang Meng, Yan-Hong Lang, Liang Xu, Xing-Si Peng, Zhi-Jie Liu, De-Huan Xie, Ling-Ling Guo, Mao-Guang Ma, Liu-Yan Ding, Bi-Jun Huang, Yun Cao, Chao-Nan Qian
Nasopharyngeal carcinoma (NPC) originates in the epithelial cells of the nasopharynx and is a common malignant tumor in southern China and Southeast Asia. Metastasis of NPC remains the main cause of death for NPC patients even though the tumor is sensitive to radiotherapy and chemotherapy. Here, we found that the transmembrane protein tetraspanin1 (TSPAN1) potently inhibited the in vitro migration
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STAT5a and SH2B3 novel mutations display malignancy roles in a triple-negative primary myelofibrosis patient Cancer Gene Ther. (IF 6.4) Pub Date : 2023-12-22 Shubing Zhang, Jinhua Yan, Lan He, Zhiping Jiang, Hao Jiang
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The target atlas for antibody-drug conjugates across solid cancers Cancer Gene Ther. (IF 6.4) Pub Date : 2023-12-21 Jiacheng Fang, Lei Guo, Yanhao Zhang, Qing Guo, Ming Wang, Xiaoxiao Wang
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m6A reader IGF2BP2 promotes lymphatic metastasis by stabilizing DPP4 in papillary thyroid carcinoma Cancer Gene Ther. (IF 6.4) Pub Date : 2023-12-15 Wenlong Wang, Ying Ding, Yunzhe Zhao, Xinying Li
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Hsa_circ_0013561 promotes epithelial-mesenchymal transition and tumor progression by regulating ANXA2 via miR-23b-3p in ovarian cancer Cancer Gene Ther. (IF 6.4) Pub Date : 2023-12-15 Jia Lv, Yijun Zhang, Mengying Yang, Lianqiao Qiao, Huihui Wang, Huici Jiang, Mingxu Fu, Jinlong Qin, Shaohua Xu