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Analysis of Toxic Effects of Fluoride on Ovine Follicular Granulosa Cells Using RNA-Seq Antioxidants (IF 7.0) Pub Date : 2024-04-24 Tian Ma, Wanruo Liu, Didi Jiang, Guolin Zhang, Xingxu Zhao, Yong Zhang, Zongshuai Li
Fluoride is abundant in the environment and is an essential trace element in living organisms. However, prolonged excessive fluoride intake can lead to fluorosis, which poses a threat to the reproductive health of animals and humans. Although previous research has mainly focused on animal models, the impact of fluoride on ovine follicular granulosa cells (GCs) has not been comprehensively elucidated
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Supplementing Boar Diet with Nicotinamide Mononucleotide Improves Sperm Quality Probably through the Activation of the SIRT3 Signaling Pathway Antioxidants (IF 7.0) Pub Date : 2024-04-24 Haize Zhang, Jiawen Chai, Chaoyue Cao, Xiaolin Wang, Weijun Pang
Sperm quality is an important indicator to evaluate the reproduction ability of animals. Nicotinamide mononucleotide (NMN) participates in cell energy metabolism and reduces cell oxidative stress. However, the effect and regulatory mechanism of NMN on porcine sperm quality are still unknown. Here, 32 Landrace boars were randomly assigned to four groups (n = 8) and fed with different levels of NMN (0
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Changes in Oxidised Phospholipids in Response to Oxidative Stress in Microtubule-Associated Protein Tau (MAPT) Mutant Dopamine Neurons Antioxidants (IF 7.0) Pub Date : 2024-04-24 Xanthe Bradford, Hugo J. R. Fernandes, Stuart G. Snowden
Microtubule-associated protein Tau (MAPT) is strongly associated with the development of neurodegenerative diseases. In addition to driving the formation of neurofibrillary tangles (NFT), mutations in the MAPT gene can also cause oxidative stress through hyperpolarisation of the mitochondria. This study explores the impact that MAPT mutation is having on phospholipid metabolism in iPSC-derived dopamine
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A Bayesian Reanalysis of the Overall and Sex-Disaggregated Results of the Neonatal Oxygenation Prospective Meta-Analysis (NeOProM) Antioxidants (IF 7.0) Pub Date : 2024-04-24 Maurice Jacob Huizing, Tamara Maria Hundscheid, František Bartoš, Eduardo Villamor
Data from the Neonatal Oxygenation Prospective Meta-analysis (NeOProM) indicate that targeting a higher (91–95%) versus lower (85–89%) pulse oximeter saturation (SpO2) range may reduce mortality and necrotizing enterocolitis (NEC) and increase retinopathy of prematurity (ROP). Aiming to re-evaluate the strength of this evidence, we conducted a Bayesian reanalysis of the NeOProM data. We used Bayes
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The Impact of Curcumin, Resveratrol, and Cinnamon on Modulating Oxidative Stress and Antioxidant Activity in Type 2 Diabetes: Moving beyond an Anti-Hyperglycaemic Evaluation Antioxidants (IF 7.0) Pub Date : 2024-04-24 Michalina Banaszak, Ilona Górna, Dagmara Woźniak, Juliusz Przysławski, Sławomira Drzymała-Czyż
Research indicates that up to half of the population resorts to dietary supplements for managing diseases such as type 2 diabetes rather than changing their nutritional habits. These supplements not only aim to have an anti-hyperglycaemic effect but also seek to reduce oxidative stress to prevent diabetes complications. This systematic literature systematic review aims to evaluate the efficacy of curcumin
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Differences in Airway Remodeling and Emphysematous Lesions between Rats Exposed to Smoke from New-Type and Conventional Tobacco Varieties Antioxidants (IF 7.0) Pub Date : 2024-04-24 Keqiang Wei, Yuanyuan Li, Bin Du, Juan Wu
Genes from Perilla frutescens and Ocimum basilicum were introduced into N. tabacum L. var. HHY via distant hybridization, and the new-type tobacco varieties “Zisu” and “Luole” were developed, with noticeable differences in chemical composition. Smoking is the leading cause of chronic obstructive pulmonary disease (COPD), and its pathogenesis is complex. In the present study, 48 male Sprague-Dawley
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Lipid Oxidation Products and the Risk of Cardiovascular Diseases: Role of Lipoprotein Transport Antioxidants (IF 7.0) Pub Date : 2024-04-24 Markku Ahotupa
Cholesterol has for decades ruled the history of atherosclerotic cardiovascular diseases (CVDs), and the present view of the etiology of the disease is based on the transport of cholesterol by plasma lipoproteins. The new knowledge of the lipoprotein-specific transport of lipid oxidation products (LOPs) has introduced another direction to the research of CVD, revealing strong associations between lipoprotein
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Comparative Analysis of Polyphenolic Compounds in Different Amaranthus Species: Influence of Genotypes and Harvesting Year Antioxidants (IF 7.0) Pub Date : 2024-04-22 Jun-Hyoung Bang, Ick-Hyun Jo, Raveendar Sebastin, Won Tea Jeong, Sangtaek Oh, Tae-Young Heo, Jeehye Sung, Tae kyung Hyun, Yoon-Sup So, Ju-Kyung Yu, Amal Mohamed AlGarawi, Ashraf Atef Hatamleh, Gi-Ho Sung, Jong-Wook Chung
Amaranth is a nutritionally valuable crop, as it contains phenolic acids and flavonoids, yielding diverse plant secondary metabolites (PSMs) like phytosterol, tocopherols, and carotenoids. This study explored the variations in the contents of seventeen polyphenolic compounds within the leaves of one hundred twenty Amaranthus accessions representing nine Amaranthus species. The investigation entailed
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Ginger Polyphenols Reverse Molecular Signature of Amygdala Neuroimmune Signaling and Modulate Microbiome in Male Rats with Neuropathic Pain: Evidence for Microbiota–Gut–Brain Axis Antioxidants (IF 7.0) Pub Date : 2024-04-23 Chwan-Li Shen, Julianna Maria Santos, Moamen M. Elmassry, Viren Bhakta, Zarek Driver, Guangchen Ji, Vadim Yakhnitsa, Takaki Kiritoshi, Jacob Lovett, Abdul Naji Hamood, Shengmin Sang, Volker Neugebauer
Emerging evidence shows that the gut microbiota plays an important role in neuropathic pain (NP) via the gut–brain axis. Male rats were divided into sham, spinal nerve ligation (SNL), SNL + 200 mg GEG/kg BW (GEG200), and SNL + 600 mg GEG/kg BW (GEG600) for 5 weeks. The dosages of 200 and 600 mg GEG/kg BW for rats correspond to 45 g and 135 g raw ginger for human daily consumption, respectively. Both
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The Vascular Function of Resistance Arteries Depends on NADPH Oxidase 4 and Is Exacerbated by Perivascular Adipose Tissue Antioxidants (IF 7.0) Pub Date : 2024-04-23 Patrick Diaba-Nuhoho, Jennifer Mittag, Coy Brunssen, Henning Morawietz, Heike Brendel
The NADPH oxidase NOX4 that releases H2O2 can mediate vasoprotective mechanisms under pathophysiological conditions in conductive arteries. However, the role of NOX4 in resistance arteries and in perivascular adipose tissue is not well understood. We hypothesized that NOX4 is of functional importance in resistance arteries and perivascular adipose tissue under dyslipidemia conditions. We detected elevated
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Modulating Nitric Oxide: Implications for Cytotoxicity and Cytoprotection Antioxidants (IF 7.0) Pub Date : 2024-04-23 Igor Belenichev, Olena Popazova, Nina Bukhtiyarova, Dmytrо Savchenko, Valentyn Oksenych, Oleksandr Kamyshnyi
Despite the significant progress in the fields of biology, physiology, molecular medicine, and pharmacology; the designation of the properties of nitrogen monoxide in the regulation of life-supporting functions of the organism; and numerous works devoted to this molecule, there are still many open questions in this field. It is widely accepted that nitric oxide (•NO) is a unique molecule that, despite
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Dietary Lysophosphatidylcholine Improves the Uptake of Astaxanthin and Modulates Cholesterol Transport in Pacific White Shrimp Litopenaeus vannamei Antioxidants (IF 7.0) Pub Date : 2024-04-23 Ziling Song, Yang Liu, Huan Liu, Zhengwei Ye, Qiang Ma, Yuliang Wei, Lindong Xiao, Mengqing Liang, Houguo Xu
Astaxanthin (AST), functioning as an efficient antioxidant and pigment, is one of the most expensive additives in shrimp feeds. How to improve the uptake efficiency of dietary astaxanthin into farmed shrimp is of significance. The present study investigated the effects of lysophosphatidylcholine (LPC), an emulsifier, on dietary astaxanthin efficiency, growth performance, body color, body composition
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Litchi Pericarp Extract Treats Type 2 Diabetes Mellitus by Regulating Oxidative Stress, Inflammatory Response, and Energy Metabolism Antioxidants (IF 7.0) Pub Date : 2024-04-21 Ziming Yang, Li Zhang, Jinlei Liu, Dianpeng Li
Litchi pericarp is rich in polyphenols, and demonstrates significant biological activity. This study assessed the therapeutic effects of litchi pericarp extract (LPE) on type 2 diabetes mellitus in db/db mice. The results showed that LPE ameliorated symptoms of glucose metabolism disorder, oxidative stress, inflammatory response, and insulin resistance in db/db mice. The mechanistic studies indicated
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An AlphaFold Structure Analysis of COQ2 as Key a Component of the Coenzyme Q Synthesis Complex Antioxidants (IF 7.0) Pub Date : 2024-04-21 María de los Ángeles Vargas-Pérez, Damien Paul Devos, Guillermo López-Lluch
Coenzyme Q (CoQ) is a lipidic compound that is widely distributed in nature, with crucial functions in metabolism, protection against oxidative damage and ferroptosis and other processes. CoQ biosynthesis is a conserved and complex pathway involving several proteins. COQ2 is a member of the UbiA family of transmembrane prenyltransferases that catalyzes the condensation of the head and tail precursors
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Protective and Regenerative Effects of Reconstituted HDL on Human Rotator Cuff Fibroblasts under Hypoxia: An In Vitro Study Antioxidants (IF 7.0) Pub Date : 2024-04-22 Ra Jeong Kim, Hyung Bin Park
Hypoxia and hypo-high-density lipoproteinemia (hypo-HDLemia) are proposed risk factors for rotator cuff tear. HDL is recognized for its potential benefits in ischemia-driven angiogenesis and wound healing. Nevertheless, research on the potential benefits of reconstituted HDL (rHDL) on human rotator cuff fibroblasts (RCFs) under hypoxia is limited. This study investigates the cytoprotective and regenerative
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The Reducing Agent Dithiothreitol Modulates the Ventilatory Responses That Occur in Freely Moving Rats during and following a Hypoxic–Hypercapnic Challenge Antioxidants (IF 7.0) Pub Date : 2024-04-22 Paulina M. Getsy, Gregory A. Coffee, Walter J. May, Santhosh M. Baby, James N. Bates, Stephen J. Lewis
The present study examined the hypothesis that changes in the oxidation–reduction state of thiol residues in functional proteins play a major role in the expression of the ventilatory responses in conscious rats that occur during a hypoxic–hypercapnic (HH) gas challenge and upon return to room air. A HH gas challenge in vehicle-treated rats elicited robust and sustained increases in minute volume (via
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Redox Regulation of LAT Enhances T Cell-Mediated Inflammation Antioxidants (IF 7.0) Pub Date : 2024-04-22 Jaime James, Ana Coelho, Gonzalo Fernandez Lahore, Clara M. Hernandez, Florian Forster, Bernard Malissen, Rikard Holmdahl
The positional cloning of single nucleotide polymorphisms (SNPs) of the neutrophil cytosolic factor 1 (Ncf1) gene, advocating that a low oxidative burst drives autoimmune disease, demands an understanding of the underlying molecular causes. A cellular target could be T cells, which have been shown to be regulated by reactive oxygen species (ROS). However, the pathways by which ROS mediate T cell signaling
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The Role of NOX2-Derived Reactive Oxygen Species in the Induction of Endothelin-Converting Enzyme-1 by Angiotensin II Antioxidants (IF 7.0) Pub Date : 2024-04-22 Michael Adu-Gyamfi, Claudia Goettsch, Julian Kamhieh-Milz, Lei Chen, Anna Maria Pfefferkorn, Anja Hofmann, Coy Brunssen, Gregor Müller, Thomas Walther, Muhammad Imtiaz Ashraf, Henning Morawietz, Janusz Witowski, Rusan Catar
Endothelin-1 is a key regulator of vascular tone and blood pressure in health and disease. We have recently found that ET-1 production in human microvascular endothelial cells (HMECs) can be promoted by angiotensin II (Ang II) through a novel mechanism involving octamer-binding transcription factor-1 (Oct-1), NADPH oxidase-2 (NOX2), and superoxide anions. As the formation of bioactive ET-1 also depends
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Selenium-Enriched E. coli Bacteria Mitigate the Age-Associated Degeneration of Cholinergic Neurons in C. elegans Antioxidants (IF 7.0) Pub Date : 2024-04-20 Palina Zytner, Anne Kutschbach, Weiye Gong, Verena Alexia Ohse, Laura Taudte, Anna Patricia Kipp, Lars-Oliver Klotz, Josephine Priebs, Holger Steinbrenner
Selenium (Se) is an essential trace element for humans and animals, but high-dose supplementation with Se compounds, most notably selenite, may exert cytotoxic and other adverse effects. On the other hand, bacteria, including Escherichia coli (E. coli), are capable of reducing selenite to red elemental Se that may serve as a safer Se source. Here, we examined how a diet of Se-enriched E. coli bacteria
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Uncovering the Cardioprotective Potential of Diacerein in Doxorubicin Cardiotoxicity: Mitigating Ferritinophagy-Mediated Ferroptosis via Upregulating NRF2/SLC7A11/GPX4 Axis Antioxidants (IF 7.0) Pub Date : 2024-04-20 Rehab M. El-Gohary, Asmaa H. Okasha, Alaa H. Abd El-Azeem, Muhammad T. Abdel Ghafar, Sarah Ibrahim, Islam I. Hegab, Eman E. Farghal, Soha Abdel Fattah Shalaby, Ola A. Elshora, Aisha E. ElMehy, Amany Nagy Barakat, Basma Saed Amer, Fatma G. Sobeeh, Gehan H. AboEl-Magd, Asmaa A. Ghalwash
Doxorubicin (DOX)-induced cardiotoxicity (DIC) is a life-threatening clinical issue with limited preventive approaches, posing a substantial challenge to cancer survivors. The anthraquinone diacerein (DCN) exhibits significant anti-inflammatory, anti-proliferative, and antioxidant actions. Its beneficial effects on DIC have yet to be clarified. Therefore, this study investigated DCN’s cardioprotective
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Cord Blood Adductomics Reveals Oxidative Stress Exposure Pathways of Bronchopulmonary Dysplasia Antioxidants (IF 7.0) Pub Date : 2024-04-20 Erika T. Lin, Yeunook Bae, Robert Birkett, Abhineet M. Sharma, Runze Zhang, Kathleen M. Fisch, William Funk, Karen K. Mestan
Fetal and neonatal exposures to perinatal oxidative stress (OS) are key mediators of bronchopulmonary dysplasia (BPD). To characterize these exposures, adductomics is an exposure science approach that captures electrophilic addition products (adducts) in blood protein. Adducts are bound to the nucleophilic cysteine loci of human serum albumin (HSA), which has a prolonged half-life. We conducted targeted
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Single-Cell Profiling Reveals Immune-Based Mechanisms Underlying Tumor Radiosensitization by a Novel Mn Porphyrin Clinical Candidate, MnTnBuOE-2-PyP5+ (BMX-001) Antioxidants (IF 7.0) Pub Date : 2024-04-17 Sun Up Noh, Jinyeong Lim, Sung-Won Shin, Yeeun Kim, Woong-Yang Park, Ines Batinic-Haberle, Changhoon Choi, Won Park
Manganese porphyrins reportedly exhibit synergic effects when combined with irradiation. However, an in-depth understanding of intratumoral heterogeneity and immune pathways, as affected by Mn porphyrins, remains limited. Here, we explored the mechanisms underlying immunomodulation of a clinical candidate, MnTnBuOE-2-PyP5+ (BMX-001, MnBuOE), using single-cell analysis in a murine carcinoma model. Mice
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Effects of Dietary Inosine 5′-Monophosphate Supplementation on the Growth Performance and Salinity and Oxidative Stress Resistance of Gibel Carp (Carassius auratus gibelio) Antioxidants (IF 7.0) Pub Date : 2024-04-19 Luohai Hua, Peiyu Zhang, Haokun Liu, Mingze Xin, Zhiwei Zhang, Dong Han, Zhimin Zhang, Xiaoming Zhu, Junyan Jin, Yunxia Yang, Shouqi Xie
An 88-day feeding trial was conducted to evaluate the effects of dietary inosine 5′-monophosphate (5′-IMP) on the growth performance and salinity and oxidative stress resistance in the juvenile gibel carp CAS III (Carassius auratus gibelio; initial body weight: 7.48 g). Four isonitrogenous and isoenergetic diets containing exogenous 5′-IMP were formulated. P1, P2, P3 and P4 were diets containing 5′-IMP
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Clove Essential Oil: Chemical Profile, Biological Activities, Encapsulation Strategies, and Food Applications Antioxidants (IF 7.0) Pub Date : 2024-04-19 Rafael Liñán-Atero, Fatemeh Aghababaei, Samuel Rodríguez García, Zahra Hasiri, Dimitrios Ziogkas, Andres Moreno, Milad Hadidi
Plants have proven to be important sources for discovering new compounds that are useful in the treatment of various diseases due to their phytoconstituents. Clove (Syzygium aromaticum L.), an aromatic plant widely cultivated around the world, has been traditionally used for food preservation and medicinal purposes. In particular, clove essential oil (CEO) has attracted attention for containing various
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Specific NOX4 Inhibition Preserves Mitochondrial Function and Dampens Kidney Dysfunction Following Ischemia–Reperfusion-Induced Kidney Injury Antioxidants (IF 7.0) Pub Date : 2024-04-19 Tomas A. Schiffer, Lucas Rannier Ribeiro Antonino Carvalho, Drielle Guimaraes, Ariela Boeder, Per Wikström, Mattias Carlström
Background: Acute kidney injury (AKI) is a sudden episode of kidney failure which is frequently observed at intensive care units and related to high morbidity/mortality. Although AKI can have many different causes, ischemia–reperfusion (IR) injury is the main cause of AKI. Mechanistically, NADPH oxidases (NOXs) are involved in the pathophysiology contributing to oxidative stress following IR. Previous
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Targeted Metabolomics Highlights Dramatic Antioxidant Depletion, Increased Oxidative/Nitrosative Stress and Altered Purine and Pyrimidine Concentrations in Serum of Primary Myelofibrosis Patients Antioxidants (IF 7.0) Pub Date : 2024-04-19 Renata Mangione, Cesarina Giallongo, Andrea Duminuco, Enrico La Spina, Lucia Longhitano, Sebastiano Giallongo, Daniele Tibullo, Giuseppe Lazzarino, Miriam Wissam Saab, Arianna Sbriglione, Giuseppe A. Palumbo, Andrea Graziani, Amer M. Alanazi, Valentina Di Pietro, Barbara Tavazzi, Angela Maria Amorini, Giacomo Lazzarino
To date, little is known concerning the circulating levels of biochemically relevant metabolites (antioxidants, oxidative/nitrosative stress biomarkers, purines, and pyrimidines) in patients with primary myelofibrosis (PMF), a rare form of myeloproliferative tumor causing a dramatic decrease in erythropoiesis and angiogenesis. In this study, using a targeted metabolomic approach, serum samples of 22
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Corilagin Inhibits Neutrophil Extracellular Trap Formation and Protects against Hydrochloric Acid/Lipopolysaccharide-Induced Acute Lung Injury in Mice by Suppressing the STAT3 and NOX2 Signaling Pathways Antioxidants (IF 7.0) Pub Date : 2024-04-19 Fu-Chao Liu, Huang-Ping Yu, Chia-Chih Liao, An-Hsun Chou, Hung-Chen Lee
Acute lung injury (ALI) and its severe manifestation, acute respiratory distress syndrome (ARDS), are characterized by uncontrolled inflammatory responses, neutrophil activation and infiltration, damage to the alveolar capillary membrane, and diffuse alveolar injury. Neutrophil extracellular traps (NETs), formed by activated neutrophils, contribute significantly to various inflammatory disorders and
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Antioxidant Activity and Mechanism of Action of Amwaprin: A Protein in Honeybee (Apis mellifera) Venom Antioxidants (IF 7.0) Pub Date : 2024-04-17 Bo-Yeon Kim, Kwang-Sik Lee, Byung-Rae Jin
Bee venom contains several bioactive components, including enzymatic and non-enzymatic proteins. There is increasing interest in the bioactive components of bee venom since they have exhibited various pharmacological effects. Recently, Apis mellifera waprin (Amwaprin) was identified as a novel protein in Apis mellifera (honeybee) venom and characterized as an antimicrobial agent. Herein, the novel
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Tricarboxylic Acid Cycle Regulation of Metabolic Program, Redox System, and Epigenetic Remodeling for Bone Health and Disease Antioxidants (IF 7.0) Pub Date : 2024-04-17 Wei-Shiung Lian, Re-Wen Wu, Yu-Han Lin, Yu-Shan Chen, Holger Jahr, Feng-Sheng Wang
Imbalanced osteogenic cell-mediated bone gain and osteoclastic remodeling accelerates the development of osteoporosis, which is the leading risk factor of disability in the elderly. Harmonizing the metabolic actions of bone-making cells and bone resorbing cells to the mineralized matrix network is required to maintain bone mass homeostasis. The tricarboxylic acid (TCA) cycle in mitochondria is a crucial
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Tributyrin Supplementation Rescues Chronic–Binge Ethanol-Induced Oxidative Stress in the Gut–Lung Axis in Mice Antioxidants (IF 7.0) Pub Date : 2024-04-17 Anthony Santilli, David Shapiro, Yingchun Han, Naseer Sangwan, Gail A. M. Cresci
Excessive alcohol consumption increases the severity and worsens outcomes of pulmonary infections, often due to oxidative stress and tissue damage. While the mechanism behind this relationship is multifaceted, recent evidence suggests ethanol-induced changes to the gut microbiome impact the gut–lung axis. To assess this, a chronic–binge ethanol feeding mouse model was used to determine how ethanol
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Redox Regulation of Phosphatase and Tensin Homolog by Bicarbonate and Hydrogen Peroxide: Implication of Peroxymonocarbonate in Cell Signaling Antioxidants (IF 7.0) Pub Date : 2024-04-17 Vu Hoang Trinh, Jin-Myung Choi, Thang Nguyen Huu, Dhiraj Kumar Sah, Hyun-Joong Yoon, Sang-Chul Park, Yu-Seok Jung, Young-Keun Ahn, Kun-Ho Lee, Seung-Rock Lee
Phosphatase and tensin homolog (PTEN) is a negative regulator of the phosphoinositide 3-kinases/protein kinase B (PI3K/AKT) signaling pathway. Notably, its active site contains a cysteine residue that is susceptible to oxidation by hydrogen peroxide (H2O2). This oxidation inhibits the phosphatase function of PTEN, critically contributing to the activation of the PI3K/AKT pathway. Upon the stimulation
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Correction: Abbas et al. Bioactive Compounds, Antioxidant, Anti-Inflammatory, Anti-Cancer, and Toxicity Assessment of Tribulus terrestris—In Vitro and In Vivo Studies. Antioxidants 2022, 11, 1160 Antioxidants (IF 7.0) Pub Date : 2024-04-17 Malik Waseem Abbas, Mazhar Hussain, Saeed Akhtar, Tariq Ismail, Muhammad Qamar, Zahid Shafiq, Tuba Esatbeyoglu
In the original publication [...]
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S-Allylmercapto-N-Acetylcysteine (ASSNAC) Attenuates Osteoporosis in Ovariectomized (OVX) Mice Antioxidants (IF 7.0) Pub Date : 2024-04-17 Itay Bleichman, Sahar Hiram-Bab, Yankel Gabet, Naphtali Savion
Osteoporosis is a bone-debilitating disease, demonstrating a higher prevalence in post-menopausal women due to estrogen deprivation. One of the main mechanisms underlying menopause-related bone loss is oxidative stress. S-allylmercapto-N-acetylcysteine (ASSNAC) is a nuclear factor erythroid 2-related factor 2 (Nrf2) activator and cysteine supplier, previously shown to have anti-oxidation protective
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Potential New Therapies “ROS-Based” in CLL: An Innovative Paradigm in the Induction of Tumor Cell Apoptosis Antioxidants (IF 7.0) Pub Date : 2024-04-17 Raffaele Sciaccotta, Sebastiano Gangemi, Giuseppa Penna, Laura Giordano, Giovanni Pioggia, Alessandro Allegra
Chronic lymphocytic leukemia, in spite of recent advancements, is still an incurable disease; the majority of patients eventually acquire resistance to treatment through relapses. In all subtypes of chronic lymphocytic leukemia, the disruption of normal B-cell homeostasis is thought to be mostly caused by the absence of apoptosis. Consequently, apoptosis induction is crucial to the management of this
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Porcine Brain Enzyme Hydrolysate Enhances Immune Function and Antioxidant Defense via Modulation of Gut Microbiota in a Cyclophosphamide-Induced Immunodeficiency Model Antioxidants (IF 7.0) Pub Date : 2024-04-17 Yu Yue, Hye Jeong Yang, Ting Zhang, Chen Li, Min Jung Kim, Keun-Nam Kim, Sunmin Park
This study examined how consuming porcine brain enzyme hydrolysate (PBEH) affects the immune function and composition of the gut microbiota in an immunodeficient animal model. Male Wistar rats aged 6 weeks were fed casein (control), 100 mg/kg body weight (BW), red ginseng extract (positive-control), and 6, 13, and 26 mg PBEH per kg BW (PBEH-L, PBEH-M, and PBEH-H, respectively) daily for 4 weeks. At
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Bipiperidinyl Derivatives of Cannabidiol Enhance Its Antiproliferative Effects in Melanoma Cells Antioxidants (IF 7.0) Pub Date : 2024-04-17 Peihong Lyu, Huifang Li, Junzhao Wan, Ying Chen, Zhen Zhang, Panpan Wu, Yinsheng Wan, Navindra P. Seeram, Jean Christopher Chamcheu, Chang Liu, Hang Ma
Cannabis and its major cannabinoid cannabidiol (CBD) are reported to exhibit anticancer activity against skin tumors. However, the cytotoxic effects of other minor cannabinoids and synthetic CBD derivatives in melanoma are not fully elucidated. Herein, the antiproliferative activity of a panel of phytocannabinoids was screened against murine (B16F10) and human (A375) melanoma cells. CBD was the most
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Advances in Research on the Activity Evaluation, Mechanism and Structure-Activity Relationships of Natural Antioxidant Peptides Antioxidants (IF 7.0) Pub Date : 2024-04-17 Baoting Xu, Qin Dong, Changxia Yu, Hongyu Chen, Yan Zhao, Baosheng Zhang, Panling Yu, Mingjie Chen
Antioxidant peptides are a class of biologically active peptides with low molecular weights and stable antioxidant properties that are isolated from proteins. In this review, the progress in research on the activity evaluation, action mechanism, and structure-activity relationships of natural antioxidant peptides are summarized. The methods used to evaluate antioxidant activity are mainly classified
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Impact of Adherence to the Mediterranean Diet on Antioxidant Status and Metabolic Parameters in NAFLD Patients: A 24-Month Lifestyle Intervention Study Antioxidants (IF 7.0) Pub Date : 2024-04-17 Maria Magdalena Quetglas-Llabrés, Margalida Monserrat-Mesquida, Cristina Bouzas, Silvia García, Emma Argelich, Miguel Casares, Lucía Ugarriza, Isabel Llompart, Josep A. Tur, Antoni Sureda
Background: The Mediterranean Diet (MedDiet) is recognized as a healthy dietary pattern. Non-alcoholic fatty liver disease (NAFLD) is characterized by the excessive accumulation of fat in the liver. Objectives: To assess the antioxidant status in erythrocytes, plasma, and peripheral blood mononuclear cells (PBMCs) of NAFLD patients following a 24-month lifestyle intervention based on the MedDiet. Adult
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NLRX1 Inhibits LPS-Induced Microglial Death via Inducing p62-Dependent HO-1 Expression, Inhibiting MLKL and Activating PARP-1 Antioxidants (IF 7.0) Pub Date : 2024-04-17 Yu-Ling Huang, Duen-Yi Huang, Vladlen Klochkov, Chi-Ming Chan, Yuan-Shen Chen, Wan-Wan Lin
The activation of microglia and the production of cytokines are key factors contributing to progressive neurodegeneration. Despite the well-recognized neuronal programmed cell death regulated by microglial activation, the death of microglia themselves is less investigated. Nucleotide-binding oligomerization domain, leucine-rich repeat-containing X1 (NLRX1) functions as a scaffolding protein and is
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Chemical Characterization and Biological Properties of Leguminous Honey Antioxidants (IF 7.0) Pub Date : 2024-04-18 Florinda Fratianni, Giuseppe Amato, Maria Neve Ombra, Vincenzo De Feo, Filomena Nazzaro, Beatrice De Giulio
Honey can beneficially act against different human diseases, helping our body to improve its health. The aim of the present study was first to increase knowledge of some biochemical characteristics (amount and composition of polyphenols and volatile organic compounds, vitamin C content) of five Italian legume honeys (alfalfa, astragalus, carob, indigo, and sainfoin). Furthermore, we evaluated their
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Comparison of the Antioxidant Potency of Four Triterpenes of Centella asiatica against Oxidative Stress Antioxidants (IF 7.0) Pub Date : 2024-04-18 Jinyeong Lim, Hana Lee, Seonghwa Hong, Junsoo Lee, Younghwa Kim
We comparatively evaluated the antioxidant properties of key triterpenes from Centella asiatica, including asiatic acid (AA), asiaticoside, madecassic acid, and madecassoside, in several cell types, including skin fibroblasts, macrophages, hepatocytes, and endothelial cells, under conditions promoting oxidative stress. AA conferred the highest viability on Hs68 cells exposed to ultraviolet B (UVB)
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Hormetic Nutrition and Redox Regulation in Gut–Brain Axis Disorders Antioxidants (IF 7.0) Pub Date : 2024-04-18 Maria Scuto, Francesco Rampulla, Giuseppe Maria Reali, Sestina Maria Spanò, Angela Trovato Salinaro, Vittorio Calabrese
The antioxidant and anti-inflammatory effects of hormetic nutrition for enhancing stress resilience and overall human health have received much attention. Recently, the gut–brain axis has attracted prominent interest for preventing and therapeutically impacting neuropathologies and gastrointestinal diseases. Polyphenols and polyphenol-combined nanoparticles in synergy with probiotics have shown to
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Unlocking the Therapeutic Potential of Ellagic Acid for Non-Alcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis Antioxidants (IF 7.0) Pub Date : 2024-04-18 Tharani Senavirathna, Armaghan Shafaei, Ricky Lareu, Lois Balmer
Obesity is in epidemic proportions in many parts of the world, contributing to increasing rates of non-alcoholic fatty liver disease (NAFLD). NAFLD represents a range of conditions from the initial stage of fatty liver to non-alcoholic steatohepatitis (NASH), which can progress to severe fibrosis, through to hepatocellular carcinoma. There currently exists no treatment for the long-term management
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Potential of Natural Phenolic Compounds against Doxorubicin-Induced Chemobrain: Biological and Molecular Mechanisms Involved Antioxidants (IF 7.0) Pub Date : 2024-04-18 Simona Serini, Gabriella Calviello
Chemotherapy-induced cognitive impairment or “chemobrain” is a prevalent long-term complication of chemotherapy and one of the more devastating. Most of the studies performed so far to identify the cognitive dysfunctions induced by antineoplastic chemotherapies have been focused on treatment with anthracyclines, frequently administered to breast cancer patients, a population that, after treatment,
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Complexes of Soluble Dietary Fiber and Polyphenols from Lotus Root Regulate High-Fat Diet-Induced Hyperlipidemia in Mice Antioxidants (IF 7.0) Pub Date : 2024-04-16 Zhan Zheng, Weilan Gao, Zhenzhou Zhu, Shuyi Li, Xueling Chen, Giancarlo Cravotto, Yong Sui, Lei Zhou
In this paper, complexes of soluble dietary fiber (SDF) and polyphenols (PPs) isolated from lotus roots were prepared (SDF-PPs), as well as physical mixtures (SDF&PPs), which were given to high-fat-diet (HFD)-fed mice. The results demonstrated that SDF-PPs improve lipid levels and reverse liver injury in hyperlipidemic mice. Western blotting and real-time quantitative Polymerase Chain Reaction (RT-qPCR)
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Inflammatory Cytokines and Chemokines Are Synergistically Induced in a ROS-Dependent Manner by a Co-Culture of Corneal Epithelial Cells and Neutrophil-like Cells in the Presence of Particulate Matter Antioxidants (IF 7.0) Pub Date : 2024-04-16 Zirui Zeng, Yasuhiro Yoshida, Duo Wang, Yuri Fujii, Mengyue Shen, Tatsuya Mimura, Yoshiya Tanaka
Ocular exposure to particulate matter (PM) causes local inflammation; however, the influence of neutrophils on PM-induced ocular inflammation is still not fully understood. In this study, we constructed a system to investigate the role of PM in ocular inflammation using a co-culture of human corneal epithelial cells (HCE-T) and differentiation-induced neutrophils (dHL-60). To investigate whether HCE-T
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18Beta-Glycyrrhetinic Acid Attenuates H2O2-Induced Oxidative Damage and Apoptosis in Intestinal Epithelial Cells via Activating the PI3K/Akt Signaling Pathway Antioxidants (IF 7.0) Pub Date : 2024-04-16 Cui Ma, Fuxi Wang, Jiawei Zhu, Shiyi Wang, Yaqing Liu, Jianfang Xu, Qingyu Zhao, Yuchang Qin, Wei Si, Junmin Zhang
Oxidative stress causes gut dysfunction and is a contributing factor in several intestinal disorders. Intestinal epithelial cell survival is essential for maintaining human and animal health under oxidative stress. 18beta-Glycyrrhetinic acid (GA) is known to have multiple beneficial effects, including antioxidant activity; however, the underlying molecular mechanisms have not been well established
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Biochelates from Spent Coffee Grounds Increases Iron Levels in Dutch Cucumbers but Affects Their Antioxidant Capacity Antioxidants (IF 7.0) Pub Date : 2024-04-15 Beatriz Navajas-Porras, Ana Cervera-Mata, Alejandro Fernández-Arteaga, Adriana Delgado-Osorio, Miguel Navarro-Moreno, Daniel Hinojosa-Nogueira, Silvia Pastoriza, Gabriel Delgado, Miguel Navarro-Alarcón, José Ángel Rufián-Henares
Spent coffee grounds (SCG) are a type of food waste and are produced in abundance around the world. However, their utilization as a soil organic amendment is challenging due to their phytotoxic effect. In the present work, the impact of agronomic biofortification on Dutch cucumbers was investigated using different chemically modified SCG and analyzing their effects on iron contents, their capacity
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Profile of Bioactive Components and Antioxidant Activity of Aronia melanocarpa Fruits at Various Stages of Their Growth, Using Chemometric Methods Antioxidants (IF 7.0) Pub Date : 2024-04-14 Natalia Dobros, Agnieszka Zielińska, Paweł Siudem, Katarzyna Dorota Zawada, Katarzyna Paradowska
Aronia (chokeberry, Aronia melanocarpa) is a valuable fruit that combines the health benefits of green tea and red wine and is gaining popularity worldwide. Aronia has a unique chemical composition with strong antioxidant properties, including anthocyanins and chlorogenic acids (CGAs). However, it remains unclear which specific compounds or groups are primarily responsible for the antioxidant properties
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Multivariate Analysis of Biochemical Properties Reveals Diversity among Yardlong Beans of Different Origins Antioxidants (IF 7.0) Pub Date : 2024-04-14 Yu-Mi Choi, Hyemyeong Yoon, Myoung-Jae Shin, Sukyeung Lee, Jungyoon Yi, Young-ah Jeon, Xiaohan Wang, Kebede Taye Desta
This study analyzed the nutrient levels, secondary metabolite contents, and antioxidant activities of 35 yardlong bean accessions from China, Korea, Myanmar, and Thailand, along with their key agronomic traits. Significant variations were found in all the parameters analyzed (p < 0.05). The crude fiber (CFC), dietary fiber (DFC), total protein, and total fat contents varied from 4.10 to 6.51%, 16.71
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Antioxidant Systematic Alteration Was Responsible for Injuries Inflicted on the Marine Blue Mussel Mytilus edulis Following Strontium Exposure Antioxidants (IF 7.0) Pub Date : 2024-04-14 Zihua Cheng, Mengxue Xu, Qiyue Cao, Wendan Chi, Sai Cao, Zhongyuan Zhou, You Wang
The ionic properties of strontium (Sr), a significant artificial radionuclide in the marine environment, were estimated using a stable nuclide-substituting experimental system under controlled laboratory conditions. The bio-accumulation of Sr and its impacts, as well as any possible hidden mechanisms, were evaluated based on the physiological alterations of the sentinel blue mussel Mytilus edulis.
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Εleven Greek Legume Beans: Assessment of Genotypic Effect on Their Phytochemical Content and Antioxidant Properties Antioxidants (IF 7.0) Pub Date : 2024-04-13 Eleni D. Myrtsi, Dimitrios N. Vlachostergios, Christos Petsoulas, Sofia D. Koulocheri, Epameinondas Evergetis, Serkos A. Haroutounian
Legumes, one of the first crops of humanity, inherently constitute a staple nutritional source for mankind, attracting significant research attention that has been afforded to the development of numerous cultivars. The study herein concerns the exploitation of the nutritional and bio-functional content of beans harvested from eleven Greek cultivars belonging to five different species, namely Cicer
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The Neuroprotective Flavonoids Sterubin and Fisetin Maintain Mitochondrial Health under Oxytotic/Ferroptotic Stress and Improve Bioenergetic Efficiency in HT22 Neuronal Cells Antioxidants (IF 7.0) Pub Date : 2024-04-13 Marie Goujon, Zhibin Liang, David Soriano-Castell, Antonio Currais, Pamela Maher
The global increase in the aging population has led to a rise in many age-related diseases with continuing unmet therapeutic needs. Research into the molecular mechanisms underlying both aging and neurodegeneration has identified promising therapeutic targets, such as the oxytosis/ferroptosis cell death pathway, in which mitochondrial dysfunction plays a critical role. This study focused on sterubin
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Oxidative Stress and Chronic Myeloid Leukemia: A Balance between ROS-Mediated Pro- and Anti-Apoptotic Effects of Tyrosine Kinase Inhibitors Antioxidants (IF 7.0) Pub Date : 2024-04-13 Alessandro Allegra, Giuseppe Mirabile, Santino Caserta, Fabio Stagno, Sabina Russo, Giovanni Pioggia, Sebastiano Gangemi
The balanced reciprocal translocation t (9; 22) (q34; q11) and the BCR-ABL fusion gene, which produce p210 bcr-abl protein production with high tyrosine kinase activity, are characteristics of chronic myeloid leukemia, a myeloproliferative neoplasm. This aberrant protein affects several signaling pathways connected to both apoptosis and cell proliferation. It has been demonstrated that tyrosine kinase
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Nrf2 Plays a Key Role in Erythropoiesis during Aging Antioxidants (IF 7.0) Pub Date : 2024-04-12 Serge Cedrick Toya Mbiandjeu, Angela Siciliano, Alessandro Mattè, Enrica Federti, Massimiliano Perduca, Davide Melisi, Immacolata Andolfo, Angela Amoresano, Achille Iolascon, Maria Teresa Valenti, Francesco Turrini, Michele Bovi, Arianna Pisani, Antonio Recchiuti, Domenico Mattoscio, Veronica Riccardi, Luca Dalle Carbonare, Carlo Brugnara, Narla Mohandas, Lucia De Franceschi
Aging is characterized by increased oxidation and reduced efficiency of cytoprotective mechanisms. Nuclear factor erythroid-2-related factor (Nrf2) is a key transcription factor, controlling the expression of multiple antioxidant proteins. Here, we show that Nrf2−/− mice displayed an age-dependent anemia, due to the combined contributions of reduced red cell lifespan and ineffective erythropoiesis
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Oxidative Stress: A Culprit in the Progression of Diabetic Kidney Disease Antioxidants (IF 7.0) Pub Date : 2024-04-12 Na Wang, Chun Zhang
Diabetic kidney disease (DKD) is the principal culprit behind chronic kidney disease (CKD), ultimately developing end-stage renal disease (ESRD) and necessitating costly dialysis or kidney transplantation. The limited therapeutic efficiency among individuals with DKD is a result of our finite understanding of its pathogenesis. DKD is the result of complex interactions between various factors. Oxidative
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Unravelling the Influence of Chlorogenic Acid on the Antioxidant Phytochemistry of Avocado (Persea americana Mill) Fruit Peel Antioxidants (IF 7.0) Pub Date : 2024-04-12 Gloria O. Izu, Emmanuel Mfotie Njoya, Gaetan T. Tabakam, Jennifer Nambooze, Kgalaletso P. Otukile, Seiso E. Tsoeu, Victoria O. Fasiku, Ayodeji M. Adegoke, Ochuko L. Erukainure, Samson S. Mashele, Tshepiso J. Makhafola, Mamello P. Sekhoacha, Chika I. Chukwuma
Oxidative stress is pivotal in the pathology of many diseases. This study investigated the antioxidant phytochemistry of avocado (Persea americana Mill) peel. Different solvent extracts (dichloromethane, ethyl acetate, methanol, and water) of avocado peel were subjected to total phenol and flavonoid quantification, as well as in vitro radical scavenging and ferric reducing evaluation. The methanol
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Obesity Is Associated with Oxidative Stress Markers and Antioxidant Enzyme Activity in Mexican Children Antioxidants (IF 7.0) Pub Date : 2024-04-12 Ana Isabel Cota-Magaña, Miguel Vazquez-Moreno, Andrés Rocha-Aguado, Selene Ángeles-Mejía, Adán Valladares-Salgado, Margarita Díaz-Flores, Norma Edith López-Díazguerrero, Miguel Cruz
The relationship between metabolic disorders and oxidative stress is still controversial in the child population. The present cross-sectional study aimed to analyze the associations between obesity, cardiometabolic traits, serum level of carbonylated proteins (CPs), malondialdehyde (MDA), and the enzyme activity of catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) in children
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Effects of Phytosterol Ester Supplementation on Egg Characteristics, Eggshell Ultrastructure, Antioxidant Capacity, Liver Function and Hepatic Metabolites of Laying Hens during Peak Laying Period Antioxidants (IF 7.0) Pub Date : 2024-04-12 Wenzi Wu, Xin Ma, Rui Chen, Jinghui Fan, Wenxin Ye, Zhuo Chen, Qixin Huang, Lichun Qian
The aim of this experiment was to investigate the effects of dietary Phytosterol Ester (PSE) supplementation on egg characteristics, eggshell ultrastructure, antioxidant capacity, liver function, hepatic metabolites, and its mechanism of action in Hy-Line Brown laying hens during peak laying period. A total of 256 healthy Hy-Line Brown laying hens were randomly allocated into four groups. The hens
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Protective Effects of Isoliquiritigenin and Licochalcone B on the Immunotoxicity of BDE-47: Antioxidant Effects Based on the Activation of the Nrf2 Pathway and Inhibition of the NF-κB Pathway Antioxidants (IF 7.0) Pub Date : 2024-04-10 Minghui Dong, Ziying Yang, Qian Gao, Qingyuan Deng, Le Li, Hongmei Chen
2,2′,4,4′-Tetrabrominated biphenyl ether (BDE-47) is a polybrominated diphenyl ether (PBDE) homologue that is ubiquitous in biological samples and highly toxic to humans and other organisms. Prior research has confirmed that BDE-47 can induce oxidative damage in RAW264.7 cells, resulting in apoptosis and impaired immune function. The current study mainly focused on how Isoliquiritigenin (ISL) and Licochalcone