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Mathematical model of aging in COVID-19. J. Med. Biochem. (IF 2.5) Pub Date : 2023-08-25 Olivera Jovanikić,G Stevanović,Boban Đorđevic,Milan Jovanović,Milan Lepić
Background The aim was examination of the intimamedia thickness of carotid arteries in COVID-19 infection. Methods In 50 patients, the thickness of the intimomedial complex (IMT) in the common carotid arteries was measured. The values were compared with the control group in 2006-9. The condition of the lungs was assessed by ultrasound score (It score) (0-42) as mild (0-14) or mediumsevere (15-28) Covid
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Prognostic values of baseline cortisol levels and neutrophil to lymphocyte ratio in COVID-19. J. Med. Biochem. (IF 2.5) Pub Date : 2023-08-25 Sengel Buket Erturk,Tigen Elif Tukenmez,Can Ilgin,Volkan Korten,Zekaver Odabasi
Background The prediction of disease severity in COVID19 could be a valuable tool for providing early treatment and reducing mortality. We aimed to evaluate the predictor value of baseline cortisol values on disease severity and assess the correlation between the neutrophil to lymphocyte ratio (NLR) and cortisol levels. Methods In this retrospective study, we compared the prognostic value of baseline
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Vitamin D deficiency in relation with the systemic and central inflammation during multiple sclerosis. J. Med. Biochem. (IF 2.5) Pub Date : 2023-08-25 Sawsan Feki,Manel Naifar,Mariem Dammak,Sabrina Majdoub,Salma Sakka,Ali Yesmine Ben,Hend Hachicha,Chokri Mhiri,Fatma Ayadi,Hatem Masmoudi
Background During the last decade, vitamin D (VitD) has become a topic of interest in immune regulation, especially in multiple sclerosis (MS) disease. Amongst the wide range of effects reported for this vitamin on the immune system, a regulatory role on cytokines production has been described. Our aim is to analyze the status of VitD and its correlation with the circulating inflammation and the intrathecal
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Principal component analysis of the oxidative stress, inflammation, and dyslipidemia influence in patients with different levels of glucoregulation. J. Med. Biochem. (IF 2.5) Pub Date : 2023-08-25 Maja Malenica,Aleksandra Klisić,Neven Meseldžić,Tanja Dujić,Tamer Bego,Jelena Kotur-Stevuljević
Background The aim of the study was to explore the mutual relationship between oxidative stress, inflammation and metabolic biomarkers in subjects with prediabetes (PRE), newly diagnosed type 2 diabetes patients (NT2D) and overt type 2 diabetes (T2D) using principal component analysis (PCA) as a thorough statistical approach. Methods Glycated hemoglobin, lipid parameters, inflammation (IL-6, CRP and
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Spexin level in acute myocardial infarction in the emergency department. J. Med. Biochem. (IF 2.5) Pub Date : 2023-08-25 Yahya Çiftçi,Mehtap Gurger,Evrim Gul,Mustafa Yilmaz,Selda Telo,Metin Atescelik,Goktekin Mehmet Cagri,Kobat Mehmet Ali
Background We aimed to determine the serum spexin level in patients with acute myocardial infarction (AMI) admitted to the emergency department. Methods A total of 100 patients with AMI (50 with ST-segment elevation myocardial infarction (STEMI) and 50 with non-ST-segment elevation myocardial infarction (NSTEMI)) and 50 control group patients with non-cardiac chest pain were included in the study.
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Investigation of the relationship between endothelial nitric oxide synthase T786C polymorphism and PSA, PSA derivatives, and prostate cancer in the Turkish population. J. Med. Biochem. (IF 2.5) Pub Date : 2023-08-25 Senay Balci,Serin Akbayir,Murat Bozlu,Lulufer Tamer
Background Prostate cancer is a slowly progressing cancer. However, it has remained a major medical problem for affected men. Risk factors of prostate cancer include age, race, and prostate cancer family history. Prostate cancer may occur at different frequencies between ethnic populations and countries. Currently, studies on genetic risk factors in prostate cancer aetiology have been increasing. Due
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Short-term outcome of plasma adsorption therapy in amyotrophic lateral sclerosis. J. Med. Biochem. (IF 2.5) Pub Date : 2023-08-25 Bin Li,Wei Zhang,Shaoxin Zhong,Jianyi Pan,Xiaohong Wang,Hequn Zou,Xianrui Dou
Background To observe the short-term outcome of plasma adsorption PA therapy in amyotrophic lateral sclerosis (ALS). Methods 28 cases of als patients were recruited in this study, of which 20 were male and 8 were female with a mean age of 53.21±9.07 years and the average course of 33±23.35 months. The clinical manifestations were limb weakness (N=27), muscular atrophy (N=27), muscular tremor (N=5)
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Correlation analysis of serum levels of H19 and CRP levels and ulcerative colitis. J. Med. Biochem. (IF 2.5) Pub Date : 2023-08-25 Aihua Wang,Yongkang Jiang
Background To elucidate clinical applications of detecting serum levels of H19 and CRP in predicting the severity of ulcerative colitis (UC). Methods Two hundred UC patients were recruited, and classified to mild/moderate group and severe group according to the Truelove-Witts grading system. Serum levels of H19 and CRP in UC patients were detected by turbidimetric inhibition immuno assay and qRT-PCR
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Association analysis of apoptosis-related gene caspase3, Integrin a subunit 1 and glutathione sulfur transferase M1 gene polymorphisms and susceptibility to gastric cardia carcinoma. J. Med. Biochem. (IF 2.5) Pub Date : 2023-08-25 Rui Wang,Zetian Zhang,Duo Li,Na Wu,Zhao Peng
Background To explore the association of polymorphisms of apoptosis-linked genes caspase3 (CASP3), integrin a subunit 1 (ITGA1), glutathione sulfur transferase M1 (GSTM1) with susceptibility to gastric cardia carcinoma (GCC). Methods From February 2016 to March 2018, selection of 113 GCC patients was as the gastric cancer (GC), and selection of 75 patients without gastric disease was as the control
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Investigation of the effect of vitamin K1 prophylaxis on newborn screenings tests in newborns. J. Med. Biochem. (IF 2.5) Pub Date : 2023-08-25 Murat Caglayan,Ataman Gonel,Cuneyt Tayman,Ufuk Cakir,Ismail Koyuncu,Ebru Temiz,Yasemin Sert
Background Routine screening for hereditary disorders in newborns includes screening for treatable metabolic and endocrine disorders, such as biotidinase deficiency, galactosemia, maple syrup urine disease, hypothyroidism, and cystic fibrosis. Incorrect test results may be encountered due to the use of vitamin K1. To investigate the interference effect of vitamin K1 on neonatal screening tests and
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Lncrna CASC11 aggravates diabetic nephropathy via targeting FoxO1. J. Med. Biochem. (IF 2.5) Pub Date : 2023-08-25 Yun Zhang,Shuhan Shi,Changda Lin,Lishuang Che,Yuangen Li,Quanzuan Zeng,Weiyuan Lin
Background To explore the biological effects of CASC11 on aggravating diabetic nephropathy (DN) by regulating FoxO1 (forkhead transcription factor O1). Methods Serum levels of CASC11 and FoxO1 in DN patients were detected. The possibility of CASC11 in predicting the onset of DN was analyzed by depicting ROC curves. Correlation between CASC11 and FoxO1 was evaluated by Pearson correlation test. After
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Effect of Ganglioside combined with pramexol in the treatment of Parkinson's disease and its effect on motor function. J. Med. Biochem. (IF 2.5) Pub Date : 2023-08-25 Xinna Li,Peihai Han,Mengjiao Liu,Xiaowen Li,Shuai Xue
Background This study was aimed to evaluate the efficacy of pramipexole combined with ganglioside for PD treatment and pramipexole monotherapy, so as to provide reference for clinical practice. Methods 61 PD patients selected from June 2019 to December 2020 at our hospital were divided into two groups. The control group (n=31) was given dopasizide oral treatment, and the treatment group (n=30) was
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Efficacy of single-and double-volume exchange transfusion for neonatal hyperbilirubinemia. J. Med. Biochem. (IF 2.5) Pub Date : 2023-08-25 Zhongzheng Xiong,Xianchuan Liu,Xiangzhu Li
Background To investigate the efficacy and safety of singleand double-volume exchange transfusion for neonatal hyperbilirubinemia (HB) and compare their effects on the internal environment of newborns. Methods The clinical data of 96 HB newborns admitted to and treated in our hospitals from January 2016 to October 2021 were retrospectively analyzed. Then, these newborns were divided into single volume
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Analysis of multiple organ function damage in patients with severe COVID-19 pneumonia. J. Med. Biochem. (IF 2.5) Pub Date : 2023-08-25 Shiyan Feng,Fengxin Wang,Weibo Wu,Yinfeng Li,Chuming Chen,Jianming Li,Mengli Cao,Ling Peng,Peiyan Zhang,Fuxiang Wang
Background This study aims to analyze the changes and significance of organ function indices in patients with severe Coronavirus Disease 2019 (COVID-19) pneumonia for prediction of major organ damages and guiding treatment schemes. Methods 63 patients with severe COVID-19 pneumonia were selected as the severe group and 73 patients with mild syndromes were selected as the mild group. SAS9.4 software
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Diagnosis of severe anaemia and positive antibody screening as consequences of pre-analytical error. J. Med. Biochem. (IF 2.5) Pub Date : 2023-08-25 Marta Krygowska-Okrój,Katarzyna Kurpierz,Agnieszka Ćwiklińska
The pre-analytical phase is the principal source of errors in laboratory medicine and continues to pose a challenge to laboratory professionals. We present the case of a 73-yearold female patient with a very low hemoglobin level (69 g/L) and positive indirect antiglobulin test result that indicates the key role of phlebotomy as an important error-prone process in which mistakes can have serious consequences
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The utility of serum amyloid A and other acute-phase reactants determination in ambulatory care COVID-19 patients. J. Med. Biochem. (IF 2.5) Pub Date : 2023-08-25 Boris Jegorović,Aleksandra Nikolić,Neda Milinković,Svetlana Ignjatović,Sandra Šipetić-Grujičić
Background The unpredictable course of Coronavirus Disease 19 (COVID-19) is making good severity assessment tools crucial. This study aimed to assess the usefulness of serum amyloid A (SAA) and other acute-phase reactants (APRs) in ambulatory care COVID-19 patients and identified relationships between these markers and disease outcomes. Methods From August to November 2020, patients seen in the outpatient
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Analysis of Interleukin-17, Interleukin-23, neopterin and Nesfatin-1 levels in the sera of Hashimoto patients. J. Med. Biochem. (IF 2.5) Pub Date : 2023-08-25 Nihayet Bayraktar,Mehmet Ali Eren,Mustafa Bayraktar,Ali Öztürk,Hamza Erdoğdu
Background Hashimoto's thyroiditis (HT) is an autoimmune disorder affecting the thyroid gland and may present as goiter or atrophic thyroiditis that may result in various metabolic and inflammatory disorders. The aim of this study is to determine the changes in serum levels of interleukin-17 (IL-17), IL-23, neopterin, and nesfatin-1 parameters in HT patients and to evaluate the possible relationship
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Evaluation of serum vitamin B12 levels in patients with COVID-19 infection: A case-control study. J. Med. Biochem. (IF 2.5) Pub Date : 2023-08-25 Yılmaz Sezgin
Background COVID-19 disease affects the respiratory and cardiovascular systems. Vitamin B12 has been associated with A1AT, one of the protective factors of lung tissue, and homocysteine among the cardiovascular risk factors. Therefore we suggest that low vitamin B12 levels are associated with a disposition to COVID-19 infection. This study aims to determine whether there is a relationship between COVID-19
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Physiological effect of iron status on patients with polycystic ovary syndrome in Basrah city. J. Med. Biochem. (IF 2.5) Pub Date : 2023-08-25 Dalal F Al-Akabi,Hanadi A Hafth
Polycystic ovary syndrome (PCOS) is one of the most common gynecological diseases that affect the fertility in women in Basra governorate. The current study was designed in order to assess iron aberrations in PCOS patients by measuring the related parameters and their relationship with sex hormones in patients with PCOS. Serum samples were collected from 45 PCOS patients and 45 controls from a private
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Salivary cortisol as a biomarker of stress in surgical patients. J. Med. Biochem. (IF 2.5) Pub Date : 2023-08-25 Sanja Vicković,Ranko Zdravković,Sanja Maričić-Prijić,Dragan Nikolić,Dragana Pap,Emina Čolak,Snežana Jovičić
Background Surgical stress and pain result in activation of hypothalamus-pituitary-adrenal axis. The aim of this study was to establish the effects of postoperative pain and various modalities of analgesic administration on salivary and serum cortisol levels, as well as to establish the validity of salivary cortisol as a stress indicator in surgical patients. Methods A randomized controlled trial involved
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The predictive role of biochemical markers on outcomes of severe COVID-19 patients admitted to intensive care unit. J. Med. Biochem. (IF 2.5) Pub Date : 2023-08-25 Bosa Mirjanić-Azarić,Ivana Pejić,Smiljana Mijić,Aleksandra Pejčić,Anita Đurđević-Svraka,Dragan Svraka,Darija Knežević,Tatjana Milivojac,Nataša Bogavac-Stanojević
Background The pandemic of severe acute respiratory syndrome by coronavirus 2 (SARS-CoV-2) is a multi-system disease caused by a diffuse systemic process involving a complex interaction of the inflammatory, immunological and coagulative cascades. This study aims to identify the most effective biomarkers to predict poor outcome in intensive care unit (ICU) patients with severe COVID-19 disease. Methods
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Leukocyte cell population data as potential markers of COVID-19 disease characterization. J. Med. Biochem. (IF 2.5) Pub Date : 2023-08-25 Giovanni Introcaso,Arianna Galotta,Laura Salvini,Elena Maria Faioni,Alice Bonomi,Emilio Assanelli,Maria Luisa Biondi
Background The usefulness of leukocyte cell population data (CPD) is currently being investigated. In COVID-19 pandemic several reports showed the clinical importance of hematological parameters. Our study aimed to assess CPDs in Sars CoV-2 patients as new disease markers. Methods From February to April 2020 (1st wave) 540 and from September to December 2020 (2nd wave) 2821 patients respectively were
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Effects of obesity on the serum BMP15, GDF9, and kisspeptin concentrations in women of reproductive age. J. Med. Biochem. (IF 2.5) Pub Date : 2023-08-25 Funda Bulut Arıkan,Nevin Sagsoz
Background As BMP15, GDF9, and kisspeptin all play critical roles in folliculogenesis and fertilization, investigating the possible relationship between obesity and these three factors could prove crucial in relation to understanding the role of obesity in infertility. Thus, the present study sought to determine the effects of obesity on the serum BMP15, GDF9, and kisspeptin concentrations in women
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Lidocaine clearance as pharmacokinetic parameter of metabolic hepatic activity in patients with impaired liver. J. Med. Biochem. (IF 2.5) Pub Date : 2023-03-15 Marija Jovanović,Milena Kovačević,Sandra Vezmar-Kovačević,Ivan Palibrk,Jasna Bjelanović,Branislava Miljković,Katarina Vučićević
Background The study aimed to estimate lidocaine (LID) pharmacokinetic parameter values in patients with impaired liver function, level of correlation between the pharmacokinetic parameters and Child-Pugh class and change in pharmacokinetic parameters after liver tumor resection compared to the preoperative value. Methods Patients with impaired liver function were subject to the LID test 1 day prior
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SCN1A polymorphisms influence the antiepileptic drugs responsiveness in Jordanian epileptic patients. J. Med. Biochem. (IF 2.5) Pub Date : 2023-03-15 Rami Abduljabbar,Tamimi Duaa Eid,Al-Motassem Yousef,Saeed Ramzi Mukred,Mohammed Zawiah
Background The aim of this study was to evaluate whether the voltage-gated sodium channel alpha subunit 1 (SCN1A) gene polymorphisms influence the responsiveness of Jordanian epileptic patients to antiepileptic drugs (AEDs). Methods A total of 72 AEDs-treated epileptics were polymerase chain reaction (PCR)-genotyped for six single nucleotide polymorphisms (SNPs), including SCN1A rs2298771, rs3812718
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Serum fetuin-A and RANKL levels in patients with early stage breast cancer. J. Med. Biochem. (IF 2.5) Pub Date : 2023-03-15 Cigdem Usul Afsar,Hale Aral,Orçun Can,Trabulus Didem Can,Didem Karacetin,Nazlı Mehmet Ali,Gursu Rıza Umar,Senem Karabulut
Background Breast cancer (BC) is the primary cause of mortality due to cancer in females around the world. Fetuin-A is known to increase metastases over signals and peroxisomes related with growing. Receptor activator of nuclear factor-kB ligand (RANKL) takes part in cell adhesion, and RANKL inhibition is used in the management of cancer. We aimed to examine the relationship between serum fetuin-A
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Diagnostic significance of hsa_circ_0000146 and hsa_circ_0000072 biomarkers for Diabetic Kidney Disease in patients with type 2 diabetes mellitus. J. Med. Biochem. (IF 2.5) Pub Date : 2023-03-15 Amul M Badr,Omayma Elkholy,Mona Said,Sally A Fahim,Mohamed El-Khatib,Dina Sabry,Radwa M Gaber
Background Diabetic Kidney Disease (DKD) is a significant challenge in healthcare. However, there are currently no reliable biomarkers for renal impairment diagnosis, prognosis, or staging in DKD patients. CircRNAs and microRNAs have emerged as noninvasive and efficient biomarkers. Methods We explored Cannabinoid receptor 1 (CNR1), C reactive protein (CRP), hsa_circ_ 0000146 and 0000072, and hsa-miR-21
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Antioxidative behavior of a2-macroglobulin in intervertebral disc degeneration. J. Med. Biochem. (IF 2.5) Pub Date : 2023-03-15 Yuhong Chen,Huaixiang Wei,Feng Xu
Background To clarify if a2-macroglobulin (α2M) has an antioxidative effect during the progression of the intervertebral disc degeneration (IVDD). Methods The content of α2M and reactive oxygen species (ROS) were measured to compare mildly and severely degenerated human nucleus pulposus (NP) tissue by immunohistochemistry, mass spectrometry, and enzyme-linked immunosorbent assay (ELISA). Additionally
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False negative effect of high triglycerides concentration on vitamin D levels: A big data study. J. Med. Biochem. (IF 2.5) Pub Date : 2023-03-15 Murat Çağlayan,Ataman Gonel,Tugba Songul Tat,Osman Celik,Fidanci Ali Aykut,Ayvali Mustafa Okan,Ulgu Mustafa Mahir,Naim Ata,Suayip Birinci
Background Inaccurate test results may be a reason why vitamin D deficiency is seen as a common problem worldwide. Interferences from the sample matrix during testing are the most important factors in measurement errors. In this study, the relationship between triglycerides and total cholesterol levels and vitamin D levels in Turkey was investigated. Methods The 25-hydroxyvitamin D test results and
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Low plateletcrit is associated with reduced progression: Free and overall survival in chronic lymphocytic leukemia. J. Med. Biochem. (IF 2.5) Pub Date : 2023-03-15 Demircan Ozbalci,Emine Guchan Alanoglu,Eda Findos,Hande Nur Eroglu
Background Alterations of plateletcrit and mean platelet volume (MPV) and pathogenesis of chronic lymphocytic leukaemia (CLL) have been linked to various inflammatory disorders. The prognostic impact of plateletcrit and MPV were evaluated. Methods MPV and plateletcrit levels of both CLL and control group were compared and then in CLL patients, additional diseases, leukocyte count, platelet count, lactate
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Evaluation of the validity of the pre-marriage mean corpuscular volume value as a predictive test for b-thalassemia carrier status. J. Med. Biochem. (IF 2.5) Pub Date : 2023-03-15 Ali A Almomani,Ala'a S Shraim,Ali M Atoom,Majeed Bayan A Abdel,Jehad F Alhmoud
Background The national mandatory premarital screening test is based on mean corpuscular volume (MCV) > 80 fL value for the detection of β-thalassemia to provide acceptance for marriage. The objective of this study is to assess the efficacy of MCV as a screening test for β-thalassemia trait in the present population. Methods This study was conducted on 418 blood samples collected from adult individuals
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LINC00467 induces melanoma deterioration by targeting miR-485-5p/p21 activated kinase 1. J. Med. Biochem. (IF 2.5) Pub Date : 2023-03-15 Zhoujing Ji,Jie Zhang,Lili Zhang,Shengju Yang,Yangcheng Li,Lixiong Gu
Background The purpose of the current research was to investigate the biological roles of LINC00467 in inducing melanoma deterioration. Methods Differential level of LINC00467 in melanoma tissues and its prognostic value were analyzed in GEPIA, which were further confirmed in clinical samples we collected. Regulatory effects of LINC00467 on proliferation, migration and invasion capacities of A375 and
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Lncrna FEZf1-as1 negatively regulates ETNK1 to promote malignant progression of renal cell carcinoma. J. Med. Biochem. (IF 2.5) Pub Date : 2023-03-15 Jiangyong Lou,Xiaoming Liu,Xiaodong Fan,Xiaoming Xu,Zhichao Wang,Liqun Wang
Background To explore the role of LncFEZF1-AS1 in renal cell carcinoma (RCC) tissues and cells, and the possible molecular mechanism. Methods Expressions of LncFEZF1-AS1 in RCC tissues and adjacent ones were detected. The association of LncFEZF1-AS1 level with clinical data of RCC patients was also analyzed. Besides, the differential expressions of LncFEZF1-AS1 in a variety of RCC cell lines were also
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Maternal serum preptin levels in the pathogenesis and diagnosis of Gestational diabetes mellitus. J. Med. Biochem. (IF 2.5) Pub Date : 2023-03-15 Utku Irem Kıraç,Esra Demır,Hanişe Ozkan,Berrak Sahtıyancı,Hafize Uzun,Iskender Ekıncı,Mitat Buyukkaba,Sinem Durmus,Murat Akarsu,Remise Gelisgen,Omur Tabak
Background Gestational diabetes mellitus (GDM) is a metabolic disorder that occurs during pregnancy that increases both maternal and fetal mortality and morbidity. It was investigated whether there is a change in circulating levels of preptin, a new peptide secreted from pancreatic beta cells, due to GDM in pregnant women. The relationship between serum preptin levels with insulin and other metabolic
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Clinical meaning of serum trimethylamine oxide, N-terminal-pro-brain natriuretic peptide, hypoxia-inducible factor-1a and left ventricular function and pregnancy outcome in patients with pregnancy-induced hypertension. J. Med. Biochem. (IF 2.5) Pub Date : 2023-03-15 Ying Wu,Yue Wu,Lihong Duan,Chunhui Xiao,Zeya Ren,Yuntai Liang
Background To figure out the clinical meaning of serum trimethylamine oxide (TMAO), N-terminal-pro-brain natriuretic peptide (NT-proBNP) and hypoxia-inducible factor-1a (HIF-1a) with left ventricular function and pregnancy outcome in patients with pregnancy-induced hypertension. Methods From January 2018 to October 2020, 117 patients with gestational hypertension were taken as the research objects
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Reference intervals for thyroid hormones for the elderly population and their influence on the diagnosis of subclinical hypothyroidism. J. Med. Biochem. (IF 2.5) Pub Date : 2023-03-15 Jingxuan Fu,Yidan Wang,Yunyi Liu,Qinfei Song,Jingrong Cao,Wang Peichang
Background This study aims to establish reference intervals (RIs) for thyroid hormones in the elderly population and analyze their influence on the prevalence of subclinical hypothyroidism. Methods Thyroid hormone records of subjects who underwent routine health checkup at our hospital between 2018 and 2020 were analyzed. Thyroid stimulating hormone (TSH), total triiodothyronine, total thyroxine, free
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Malondialdehyde as an independent predictor of body mass index in adolescent girls. J. Med. Biochem. (IF 2.5) Pub Date : 2023-03-15 Aleksandra Klisic,Maja Malenica,Jelena Kostadinovic,Gordana Kocic,Ana Ninic
Background Given the fact that the studies that examined oxidative stress in relation to obesity that included late adolescents are scarce and show inconclusive results we aimed to investigate a wide spectrum of nitro-oxidative stress biomarkers i.e., malondialdehyde (MDA), xanthine oxidase (XO), xanthine oxidoreductase (XOD), xanthine dehydrogenase (XDH), advanced oxidation protein products (AOPP)
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MiRNA-200b level in peripheral blood predicts renal interstitial injury in patients with diabetic nephropathy. J. Med. Biochem. (IF 2.5) Pub Date : 2023-03-15 Tingfang Chen,Zhenzhen Jiang,Haiying Zhang,Ruifeng Yang,Yan Wu,Yongping Guo
Background To uncover the diagnostic potential of peripheral blood microRNA-200b (miRNA-200b) in renal interstitial injury in diabetic nephropathy (DN) patients. Methods A total of 50 diabetes subjects, 50 mild DN subjects, 50 moderate-severe DN subjects and 50 healthy subjects were included. Peripheral blood level of miRNA-200b in every subject was detected by reverse transcriptase-polymerase chain
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Interactions of the eNOS and ACE genes and cigarette smoking in chronic obstructive pulmonary disease. J. Med. Biochem. (IF 2.5) Pub Date : 2023-01-20 Marija Stanković,Valentina Đorđević,Andrija Tomović,Ljudmila Nagorni-Obradović,Nataša Petrović-Stanojević,Mirjana Kovač,Dragica Radojković
Background Chronic obstructive pulmonary disease (COPD) is a complex disorder with unexplained heritability. Interactions of genetic and environmental factors are thought to be crucial in COPD. So, we aim to examine interactions of the endothelial nitric oxide synthase (eNOS) and angiotensin converting enzyme (ACE) genes and cigarette smoking in COPD. Methods The eNOS G 894T and ACE ID variants were
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Association of octacosanol supplementation with redox status in patients on chronic statin therapy. J. Med. Biochem. (IF 2.5) Pub Date : 2023-01-20 Milica Zrnić-Ćirić,Jelena Kotur-Stevuljević,Ivan Stanković,Brižita Đordjević,Ivana Baralić,Miodrag Ostojić
Background The uneven lipid-lowering statin effects and statin intolerance raise interest regarding the involvement of coadministration of statins and dietary supplements. This study aimed to evaluate the effects of octacosanol supplementation on markers of redox status in cardiovascular patients on chronic atorvastatin therapy. Methods A double-blind, randomized, placebo-controlled, single-centre
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Diagnostic performance of lactate dehydrogenase (LDH) isoenzymes levels for the severity of COVID-19. J. Med. Biochem. (IF 2.5) Pub Date : 2023-01-20 Ilkay Ergenc,Emre Capar,Sengel Buket Erturk,Gunel Bahramzade,Fatih Atalah,Derya Kocakaya,Sait Karakurt,Goncagul Haklar,Zekaver Odabasi
Background Lactate dehydrogenase (LDH) levels predict coronavirus disease 2019 (COVID-19) severity. We investigated LDH isoenzyme levels to identify the tissue responsible for serum LDH elevation in patients with COVID-19. Methods Hospitalised COVID-19 patients with serum LDH levels exceeding the upper reference limit included. LDH isoenzymes were detected quantitatively on agarose gels. The radiological
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Dyslipidaemia and inflammatory markers as the risk predictors for cardiovascular disease in newly diagnosed premenopausal hypothyroid women. J. Med. Biochem. (IF 2.5) Pub Date : 2023-01-20 Vaideki Balamurugan,Ravindra Maradi,Vivek Joshi,Belle Vijetha Shenoy,Manjunatha B K Goud
Background Hypothyroidism can predispose systolic and diastolic cardiac dysfunction, increased peripheral vascular resistance, endothelial dysfunction, altered coagulopathy, and dyslipidemia resulting in atherosclerosis. Thyroid hormones can influence homocysteine metabolism by regulating the methylenetetrahydrofolate reductase (M THR). So, this study aimed to compare the markers homocysteine, high
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The accuracy of serum osmolarity calculation in small children. J. Med. Biochem. (IF 2.5) Pub Date : 2023-01-20 Joanna Berska,Jolanta Bugajska,Krystyna Sztefko
Background Serum osmolality can be measured (Omeas) or calculated (Ocal). Many formulas for Ocal have been already published, but data regarding the most accurate equation in small babies is not available. Thus, we aim to compare Omeas and Ocal obtained by different formulas in newborns and small children. Methods The study included 280 serum samples taken from children, from the first day of life
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The assessment value of pathological condition of serum adiponectin and amylin in primary osteoporosis and its correlation analysis with bone metabolism indexes. J. Med. Biochem. (IF 2.5) Pub Date : 2023-01-20 Xiao Jie Wang,Xue Bai,Ying Miu,Pan Chen,Pi Jun Yan,Chun Xia Jiang
Background This paper explores the assessment value of pathological condition of serum adiponectin (APN) and amylin in primary osteoporosis (POP) and their correlation with bone metabolism indexes. Methods From January 2019 to June 2021, 79 cases of POP patients were selected as the research objects. A test of the patients' bone density was conducted, and clinical grading of POP was via T value (normal
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Biochemical and hematological findings and risk factors associated with kidney impairment in patients with COVID-19. J. Med. Biochem. (IF 2.5) Pub Date : 2023-01-20 Yosra Mohammed Yaghmour,Shraim Ala'a Said,Abbas Manal Ahmad
Background COVID-19 is a new pandemic that has infected millions of people worldwide and caused a high morbidity and mortality rate. COVID-19 may have a harmful effect on organs, especially the kidneys. Aims: The main aim of our research is to study the association between the severity of COVID-19 disease and biochemical parameters related to kidney function and to investigate certain risk factors
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Associations of serum high-sensitivity C-reactive protein and prealbumin with coronary vessels stenosis determined by coronary angiography and heart failure in patients with myocardial infarction. J. Med. Biochem. (IF 2.5) Pub Date : 2023-01-20 Yun Zhu,Zhen Yu,Ronggui Xu,Beibei Wang,Yiqun Lou,Na Zhang,Ziyin Chen
Background To explore the associations of serum high-sensitivity C-reactive protein (hs-CRP) and prealbumin (PAB) with the number of diseased coronary vessels, degree of stenosis and heart failure in patients with myocardial infarction (MI). Methods A total of 39 MI patients treated in the Cardiology were selected as the observation group, and another 41 patients with normal results of coronary angiography
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Comparison urine neutrophil gelatinase - associated lipocalin with standard parameters in monitoring activity Lupus nephritis: Class IV. J. Med. Biochem. (IF 2.5) Pub Date : 2023-01-20 Violeta Rabrenović,Milica Petrović,Milorad Rabrenović
Background Lupus nephritis (LN) is one of the most serious complications in the development of systemic lupus erythematosus, that can adversely affect the course and prognosis of this autoimmune disease. Therefore, monitoring the effect of applied therapy, achieving remission, or monitoring class IV LN activity is still a great challenge for nephrologists. This study aimed to compare the urinary neutrophile
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Prognosis and clinical features analysis of EMT-related signature and tumor Immune microenvironment in glioma. J. Med. Biochem. (IF 2.5) Pub Date : 2023-01-20 Zheng Xiao,Xiaoyan Liu,Yixiang Mo,Weibo Chen,Shizhong Zhang,Yingwei Yu,Huiwen Weng
Background As the most common primary malignant intracranial tumor, glioblastoma has a poor prognosis with limited treatment options. It has a high propensity for recurrence, invasion, and poor immune prognosis due to the complex tumor microenvironment. Methods Six groups of samples from four datasets were included in this study. We used consensus ClusterPlus to establish two subgroups by the EMT-related
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EPS8L3 promotes pancreatic cancer proliferation and metastasis by activating GSK3B. J. Med. Biochem. (IF 2.5) Pub Date : 2023-01-20 Zun Fan,Ming Li,Yinjie Xu,Chenxing Ge,Jianfeng Gu
Background We intended to investigate the role and regulatory mechanism of EPS8L3 in increase the development of pancreatic cancer (PC). Methods In order to analyze the relationship between EPS8L3 level and clinicopathological indicators of PC patients, qRT-PCR was used to detect the expression of EPS8L3 in tumor specimens of 40 PC patients. EPS8L3 knockdown models were then constructed in PC cell
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Pregnancy outcomes and newborn characteristics in women with follicular fluid thyroid autoantibodies undergoing assisted reproduction. J. Med. Biochem. (IF 2.5) Pub Date : 2023-01-20 Sanja Medenica,Eliana Garalejić,Džihan Abazović,Zoran Bukumirić,Stavroula A Paschou,Biljana Arsić,Snežana Vujošević,Biljana Međo,Miloš Žarković
Background Higher levels of thyroid autoantibodies in follicular fluid (FF) of thyroid autoimmunity (TAI) positive women are strongly correlated with serum levels and may have effect on the post-implantation embryo development. Literature highlights that levothyroxine (LT4) treatment may attenuate the risk of adverse pregnancy outcomes. The aim of the study was to estimate the pregnancy and newborn
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Impact of the seventh day nucleated red blood cell count on mortality in COVID-19 intensive care unit patients: A retrospective case-control study. J. Med. Biochem. (IF 2.5) Pub Date : 2023-01-20 Muhammed Emin Düz,Mustafa Arslan,Elif E Menek,Burak Yasin Avci
Background COVID-19 covers a broad clinical spectrum, threatening global health. Although several studies have investigated various prognostic biochemical and hematological parameters, they generally lack specificity and are insufficient for decision-making. Beyond the neonatal period, NRBCs (nucleated red blood cells) in peripheral blood is rare and often associated with malignant neoplasms, bone
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Assessing whether serum ceruloplasmin promotes non-alcoholic steatohepatitis via regulating iron metabolism. J. Med. Biochem. (IF 2.5) Pub Date : 2023-01-20 Ziqiang Xia,Mei Hu,Liang Zheng,Endian Zheng,Min Deng,Jinming Wu,Xiong Sheng
Background Non-alcoholic steatohepatitis (NASH) is a progressive form of non-alcoholic fatty liver disease (NAFLD). The diagnostic gold standard for detecting NASH still relies upon an invasive pathological biopsy. There is, therefore, a need to identify non-invasive diagnostic markers. Oxidative stress mediates fatty liver progression to NASH. Imbalanced iron metabolism produces many reactive oxygen
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Oxidative stress-related risk of the multiple sclerosis development. J. Med. Biochem. (IF 2.5) Pub Date : 2023-01-20 Marija Vasić,Aleksandra Topić,Bojan Marković,Neda Milinković,Evica Dinčić
Background Multiple sclerosis (MS) is characterized by inflammation, demyelination and axonal degeneration. Oxidative stress (OS) plays a significant role in the pathogenesis of the disease. The aim of the study was to examine the association between OS and smoking on the MS development. Methods The study included 175 patients with relapsing-remitting multiple sclerosis (RRMS) (76 males, 99 females)
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Association between serum irisin concentration and ischemic stroke: From etiology to clinic. J. Med. Biochem. (IF 2.5) Pub Date : 2022-10-15 Mustafa Çalık,Yildizhan Sengul,Gurkan Zahide Mail,Deniz Hintoglu,Mısırlıoglu Naile Fevziye,Hafize Uzun
Background To investigate the relationship between irisin levels in serum and classification of subtype of acute ischemic stroke, National Institutes of Health Stroke Scale (NIHSS) and Modified Rankin Score (mRS) at the time of discharge from the hospital in Turkish patients who had their first acute ischemic stroke (AIS). Methods Serum irisin levels were measured using enzyme linked immunosorbent
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Effects of ultrasound-guided lumbar-sciatic nerve block and epidural anesthesia on the levels of IL-6, IL-8, TNF-α and coagulation factors in peripheral blood of elderly patients after hip arthroplasty. J. Med. Biochem. (IF 2.5) Pub Date : 2022-10-15 Zhi Huang,Yan Cai,Yunfei Yang,Jin Shi,Xuya Zhao,Haise Mo,Qingfan Zeng
Background To investigate the effects of ultrasound-guided lumbar-sciatic nerve block and epidural anesthesia on the levels of inflammatory factors such as Interleukin-6 (IL6), Interleukin-8 (IL-8), Tumor necrosis factor-a (TNF-α) and coagulation factors in peripheral blood of elderly patients after hip arthroplasty to provides reference value for the choice of intraoperative anesthesia. Methods 96
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Cathepsin a upregulation in glioma: A potential therapeutic target associated with immune infiltration. J. Med. Biochem. (IF 2.5) Pub Date : 2022-10-15 Ming Zhang,Jun Huang,Yunfei Wang,Qingbin Nie,Xinye Zhang,Yufeng Yang,Gengsheng Mao
Background Glioma is the result of malignant transformation of glial cells in the white matter of the brain or spinal cord and accounts for approximately 80% of all intracranial malignancies. Cathepsin A (CTSA) is highly expressed in a variety of tumor tissues, but its role in glioma is poorly studied. This study analyses the relationship between CTSA, and glioma based on The Cancer Genome Atlas (TCGA)
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25-hydroxyvitamin D (25-OHD) levels in Turkish geriatric population: A nationwide study. J. Med. Biochem. (IF 2.5) Pub Date : 2022-10-15 Murat Çağlayan,Cigdem Sonmez,Mehmet Senes,Ataman Gonel,Ozlem Gulbahar,Nurbanu Bursa,Derun Taner,Osman Celik,Fidanci Ali Aykut,Ulgu Mustafa Mahir,Abdulvahit Sozuer,Naim Ata,Suayip Birinci
Background Across the world, 25-hydroxyvitamin D (25-OHD) deficiency is a major health problem associated with many chronic diseases in the geriatric population. Prior to this study, there were no data regarding 25-OHD levels among individuals over the age of 65 in Turkey. The aim of this study was to assess 25-OHD levels and seasonal variations in these values among people over the age of 65 in Turkey
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Association of increased oncostatin M with adverse left ventricular remodeling in patients with myocardial infarction. J. Med. Biochem. (IF 2.5) Pub Date : 2022-10-15 Anna M Gusakova,Tatiana E Suslova,Maria A Kercheva,Irina V Kologrivova,Tamara R Ryabova,Vyacheslav V Ryabov
Background The study of laboratory biomarkers that reflect the development of adverse cardiovascular events in the postinfarction period is of current relevance. The aim of the present study was evaluation of oncostatin M (OSM) concentration changes in the early and late stages of myocardial infarction and evaluation of the possibility of its use in prediction of adverse left ventricular (LV) remodeling
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Evaluation of amino acid profile in serum of patients with Covid-19 for providing a new treatment strategy. J. Med. Biochem. (IF 2.5) Pub Date : 2022-10-15 Ali Ozturk,Nihayet Bayraktar,Mustafa Bayraktar,Bashar Ibrahim,Taylan Bozok,Ceylan Mehmet Resat
Background Amino acids have an important role in metabolism and may affect COVID-19-related outcomes. In our study, the amino acid serum level of hospitalized COVID19 patients was evaluated to determine a new treatment strategy. Methods The amino acid profile covering 43 amino acids in 68 subjects, comprising 30 (14 men and 16 women) controls and 38 (16 men and 22 women) COVID-19 patients, were examined
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Critical literature review and pooled analysis of diagnostic accuracy of Ortho VITROS SARS-CoV-2 antigen test for diagnosing acute SARS-CoV-2 infections. J. Med. Biochem. (IF 2.5) Pub Date : 2022-10-15 Giuseppe Lippi,Riccardo Nocini,Henry M Brandon
Background The present study is aimed at reviewing and meta-analyzing the currently published data on the diagnostic accuracy of Ortho VITROS SARS-CoV-2 antigen test for diagnosing acute SARS-CoV-2 infections. Methods An electronic search was conducted in Scopus and Medline with the keywords "VITROS" AND "antigen" AND "COVID-19" OR "SARS-CoV-2" AND "immunoassay" within the search fields "TITLE" AND