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Extracellular vesicles derived from bone marrow mesenchymal stem cells ameliorate chronic liver damage via microRNA-136-5p Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-04-23 Xiaodan Jiang, Zhejun Liu, Hongjie You, Zuoqing Tang, Yun Ma, Ruifang Nie, Zheng Yang, Niancong Che, Wenlan Liu
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Ang-1 and VEGF: central regulators of angiogenesis Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-04-23 Yuanqin Zhao, Bo Yu, Yanxia Wang, Shiming Tan, Qian Xu, Zhaoyue Wang, Kun Zhou, Huiting Liu, Zhong Ren, Zhisheng Jiang
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From stem cells to pancreatic β-cells: strategies, applications, and potential treatments for diabetes Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-04-20 Xingrong Feng, Hongmei Zhang, Shanshan Yang, Daxin Cui, Yanting Wu, Xiaocun Qi, Zhiguang Su
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Current advances in human-induced pluripotent stem cell-based models and therapeutic approaches for congenital heart disease Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-04-18 Meiling Cao, Yanshan Liu, Ying Sun, Ruiyi Han, Hongkun Jiang
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Valproate decreases transgenerationally blood pressure by affecting thyrotropin-releasing hormone promoter DNA methylation and gene expression in spontaneously hypertensive rat Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-04-17 María S. Landa, Mariano L. Schuman, Maia Aisicovich, Ludmila S. Peres Diaz, Mariela M. Gironacci, Silvia I. García, Carlos J. Pirola
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A crazy trio in Parkinson's disease: metabolism alteration, α-synuclein aggregation, and oxidative stress Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-04-16 Sheng Li, Yanbing Liu, Sen Lu, Jiayi Xu, Xiaokun Liu, Di Yang, Yuxuan Yang, Lin Hou, Ning Li
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The mechanisms of exercise improving cardiovascular function by stimulating Piezo1 and TRP ion channels: a systemic review Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-04-16 Xinyan Duan, Renhan Liu, Yue Xi, Zhenjun Tian
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STAT3 mediates ECM stiffness-dependent progression in ovarian cancer Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-04-16 Sun Chenchen, Qian Xueqian, Lu Yahui, Yuan Yi, Zhang Hui, Bai Lanning, Cheng Min, Han Yangyang
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Crosstalk between lipid metabolism and EMT: emerging mechanisms and cancer therapy Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-04-15 Zaheer Ud Din, Bai Cui, Cenxin Wang, Xiaoyu Zhang, Arshad Mehmood, Fei Peng, Quentin Liu
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Autosis: a new form of cell death in myocardial ischemia–reperfusion injury Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-04-09 Xiaoting Yang, Hui Wu, Gang Zhou, Dong Zhang, Qingzhuo Yang, Yanfang Liu, Yi Li
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STING agonist, SMA-2, inhibits clear cell renal cell carcinoma through improving tumor microenvironment Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-04-09 Wei Wang, Fengqing Zhang, Yan Hu, Guangming Liu
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NCAPH serves as a prognostic factor and promotes the tumor progression in glioma through PI3K/AKT signaling pathway Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-04-08 Jianshen Liang, Debo Yun, Wenzhe Jin, Jikang Fan, Xuya Wang, Xisen Wang, Yiming Li, Shengping Yu, Chen Zhang, Tao Li, Xuejun Yang
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Irisin alters d-galactose-induced apoptosis by increasing caveolin-1 expression in C2C12 myoblasts and skeletal muscle fibroblasts Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-04-06 Yaoxuan Wu, Yongxin Wu, Jing Yu, Yingxiao Zhang, Xin Dai, Jinliang Chen, Yue Sun, Yongxue Yang, Kexiang Zhao, Qian Xiao
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Emerging concepts on the FGF23 regulation and activity Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-04-06 María Angélica Rivoira, María Elena Peralta López, Vanessa Areco, Gabriela Díaz de Barboza, María Paula Dionisi, Nori Tolosa de Talamoni
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Ursodeoxycholic and chenodeoxycholic bile acids attenuate systemic and liver inflammation induced by lipopolysaccharide in rats Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-04-05 T Milivojac, M Grabež, A Krivokuća, U Maličević, M Gajić Bojić, Đ Đukanović, S Uletilović, N Mandić-Kovačević, T Cvjetković, M Barudžija, N Vojinović, A Šmitran, Lj Amidžić, MP Stojiljković, M Čolić, M Mikov, R Škrbić
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Flavonoids and Alzheimer’s disease: reviewing the evidence for neuroprotective potential Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-04-03 Md. Al Amin, Zerrouki Dehbia, Mohamed H. Nafady, Mehrukh Zehravi, Kusuma Pravin Kumar, M. Akiful Haque, Mirza Shahed Baig, Azmath Farhana, Sharuk L. Khan, Tahmina Afroz, Doukani Koula, Marco Tutone, Firzan Nainu, Irfan Ahmad, Talha Bin Emran
Neurodegeneration, which manifests as several chronic and incurable diseases, is an age-related condition that affects the central nervous system (CNS) and poses a significant threat to the public’s health for the elderly. Recent decades have experienced an alarming increase in the incidence of neurodegenerative disorders (NDDs), a severe public health issue due to the ongoing development of people
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ACSL4 accelerates osteosarcoma progression via modulating TGF-β/Smad2 signaling pathway Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-04-02 Xiaofeng Li, Qianfen Chen, Duo Zhao, Jianshi Tan, Rongbo Liao, Yurong Gu, Jinwei Zhu, Huying Zhang, Jian Xie, Lu Chen
Osteosarcoma (OS) is a malignant bone sarcoma arising from mesenchymal stem cells. The biological role of Acyl-CoA synthetase long-chain family member 4 (ACSL4), recently identified as an oncogene in numerous tumor types, remains largely unclear in OS. In this study, we investigated the expression of ACSL4 in OS tissues using immunohistochemistry staining (IHC) staining of a human tissue microarray
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Protein kinase D2-Aurora kinase A-ERK1/2 signalling axis drives neuroendocrine differentiation of epithelial ovarian cancer Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-04-01 Abha Sachdeva, Adhiraj Roy, Supratim Mandal
Epithelial ovarian cancer (EOC) is deadliest gynecological malignancy with poor prognosis and patient survival. Despite development of several therapeutic interventions such as poly-ADP ribose polymerase (PARP) inhibitors, EOC remains unmanageable and discovery of novel early detection biomarkers and treatment targets are highly warranted. Although neuroendocrine differentiation (NED) is implicated
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Ferroptosis in organ ischemia–reperfusion injuries: recent advancements and strategies Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-03-31 Xiaoyu Luan, Peng Chen, Longyu Miao, Xinying Yuan, Chaoqun Yu, Guohu Di
Ferroptosis is a newly discovered type of regulated cell death participated in multiple diseases. Different from other classical cell death programs such as necrosis and apoptosis, ferroptosis involving iron-catalyzed lipid peroxidation is characterized by Fe2+ accumulation and mitochondria alterations. The phenomenon of oxidative stress following organ ischemia–reperfusion (I/R) has recently garnered
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PCSK5 downregulation promotes the inhibitory effect of andrographolide on glioblastoma through regulating STAT3 Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-03-29
Abstract Proprotein convertase subtilisin/kexin type 5 (PCSK5) is a member of the proprotein convertase (PC) family, which processes immature proteins into functional proteins and plays an important role in the process of cell migration and transformation. Andrographolide is a non-peptide compound with PC inhibition and antitumor activity. Our research aimed to investigate the functional role of PCSK5
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Folate induces stemness and increases oxygen consumption under glucose deprivation by notch-1 pathway activation in colorectal cancer cell Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-03-27 Juan Rodríguez Silva, Matías Monsalves-Álvarez, Carlos Sepúlveda, Camila Donoso-Barraza, Rodrigo Troncoso, Sandra Hirsch
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Intermittent fasting shifts the diurnal transcriptome atlas of transcription factors Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-03-25 Min Fu, Siyu Lu, Lijun Gong, Yiming Zhou, Fang Wei, Zhigui Duan, Rong Xiang, Frank J. Gonzalez, Guolin Li
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Mechanisms and therapeutic prospect of the JAK-STAT signaling pathway in liver cancer Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-03-22 JunJun Jia, Xuelian Zhou, Qingfei Chu
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Identification and validation of cuproptosis-related genes for diagnosis and therapy in nonalcoholic fatty liver disease Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-03-21 Jinquan Li, Yi Zhang, Xiaohan Ma, Ruiqi Liu, Cuicui Xu, Qin He, Ming Dong
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STK32C modulates doxorubicin resistance in triple-negative breast cancer cells via glycolysis regulation Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-03-20 Huawei Xiao, Lei Liu, Shaoyan Huang
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Combinational delivery of TLR4 and TLR7/8 agonist enhanced the therapeutic efficacy of immune checkpoint inhibitors to colon tumor Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-03-20
Abstract Immunotherapy is regarded as a potent cancer treatment, with DC vaccines playing a crucial role. Although clinical trials have demonstrated the safety and efficacy of DC vaccines, loading antigens in vitro is challenging, and their therapeutic effects remain unpredictable. Moreover, the diverse subtypes and maturity states of DCs in the body could induce both immune responses and immune tolerance
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NEK2 affects the ferroptosis sensitivity of gastric cancer cells by regulating the expression of HMOX1 through Keap1/Nrf2 Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-03-19 Jianyong Wu, Desheng Luo, Laizhen Tou, Hongtao Xu, Chuan Jiang, Dan Wu, Haifeng Que, Jingjing Zheng
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Investigation of homocysteine, D-dimer and platelet count levels as potential predictors of thrombosis risk in COVID-19 patients Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-03-19 Zahra Eslamifar, Mahin Behzadifard, Ehsan Zare
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Disturbances in mitochondrial bioenergetics and control quality and unbalanced redox homeostasis in the liver of a mouse model of mucopolysaccharidosis type II Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-03-18 Camila Vieira Pinheiro, Rafael Teixeira Ribeiro, Ana Cristina Roginski, Morgana Brondani, Ângela Beatris Zemniaçak, Chrístofer Ian Hernandez Hoffmann, Alexandre Umpierrez Amaral, Moacir Wajner, Guilherme Baldo, Guilhian Leipnitz
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Abnormal upregulation of NUBP2 contributes to cancer progression in colorectal cancer Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-03-16 Danfeng Lan, Junyu Wang, Guishun Sun, Lixia Jiang, Qiyun Chen, Sha Li, Haiyan Qu, Yibo Wang, Bian Wu
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Untargeted metabolomics identifies indole-3-propionic acid to relieve Ang II-induced endothelial dysfunction in aortic dissection Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-03-14 Qi Wang, Hui Lv, Mierxiati Ainiwan, Gulinazi Yesitayi, Asiya Abudesimu, Dilixiati Siti, Aliya Aizitiaili, Xiang Ma
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miR-575/RIPK4 axis modulates cell cycle progression and proliferation by inactivating the Wnt/β-catenin signaling pathway through inhibiting RUNX1 in colon cancer Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-03-14
Abstract Receptor interacting protein serine/threonine kinase 4 (RIPK4) is widely involved in human cancer development. Nevertheless, its role in colon cancer (COAD) has not been elucidated till now. Our research aimed at exploring the function and underlying molecular mechanism of RIPK4 in COAD progression. Through bioinformatic analyses and RT-qPCR, RIPK4 was discovered to be increased in COAD cells
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Walnut supplementation increases levels of UCP1 and CD36 in brown adipose tissue independently of diet type Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-03-13
Abstract Dietary interventions that modulate the brown adipose tissue (BAT) thermogenic activity could represent a promising therapy for metabolic disorders. In order to examine if dietary walnuts intake regulates the expression of BAT thermogenic markers levels in healthy and metabolically challenged (fructose fed) animals, rats were initially divided into the control and fructose-fed groups. After
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ATG4B as a novel biomarker for abdominal aortic aneurysm: integrated evaluation through experimental and bioinformatics analyses Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-03-13 Jingjing Jing, Qiuyan Sun, Rongqi Zhang, Chao Yang, Jun Yang, Chunyan Ma, Tan Li
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LncRNA MCM3AP-AS1 promotes chemoresistance in triple-negative breast cancer through the miR-524-5p/RBM39 axis Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-03-12 Yueping Wang, Xuedong Wang, Haiyi Sun, Ziyun Zhang, Juan Gu
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Lycorine hydrochloride interferes with energy metabolism to inhibit chemoresistant glioblastoma multiforme cell growth through suppressing PDK3 Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-03-11 Qingsheng Dong, Wanxiang Niu, Maolin Mu, Chengkun Ye, Pengfei Wu, Shanshan Hu, Chaoshi Niu
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Nicaraven attenuates the acquired radioresistance of established tumors in mouse models via PARP inhibition Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-03-11 Kai Huang, Chen Yan, Lina Abdelghany, Xu Zhang, Keiichi Jingu, Tao-Sheng Li
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A specific inflammatory suppression fibroblast subpopulation characterized by MHCII expression in human dilated cardiomyopathy Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-03-10
Abstract Dilated cardiomyopathy (DCM) is a significant cause of heart failure that requires heart transplantation. Fibroblasts play a central role in the fibro-inflammatory microenvironment of DCM. However, their cellular heterogeneity and interaction with immune cells have not been well identified. An integrative analysis was conducted on single-cell RNA sequencing (ScRNA-Seq) data from human left
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Exosomes derived from human umbilical cord mesenchymal stem cells decrease neuroinflammation and facilitate the restoration of nerve function in rats suffering from intracerebral hemorrhage Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-03-08 Chengrui Nan, Yan Zhang, Aobo Zhang, Yunpeng Shi, Dongdong Yan, Zhimin Sun, Qianxu Jin, Haoran Huo, Yayu Zhuo, Zongmao Zhao
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IL-33 aggravates extranodal NK/T cell lymphoma aggressiveness and angiogenesis by activating the Wnt/β-catenin signaling pathway Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-03-05
Abstract Extranodal NK/T cell lymphoma (ENKTCL) is an extremely aggressive form of lymphoma and lacks of specific diagnostic markers. The study intended to unearth the role of interleukin-33 (IL-33) in ENKTCL. RT-qPCR was conducted to assess mRNA levels of ENKTCL tissues and cells, while western blot assay was performed for evaluating protein levels. Plate cloning experiment and transwell assay were
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Protective effect of SERCA2a-SUMOylation by SUMO-1 on diabetes-induced atherosclerosis and aortic vascular injury Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-03-05 Jinlin Liu, Shifang Xu, Bin Gao, Meng Yuan, Li Zhong, Rui Guo
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Long-term intake of sulforaphene alleviates d-galactose-induced skin senescence by activating AMPK-Sirt 1 pathway Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-03-05 Bo Zhang, Pengtao Liu, Huakang Sheng, Yongzhi Han, Qipeng Yuan
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New insights of DsbA-L in the pathogenesis of metabolic diseases Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-03-02
Abstract Metabolic diseases, such as obesity, diabetes mellitus, and non-alcoholic fatty liver disease (NAFLD), are abnormal conditions that result from disturbances of metabolism. With the improvement of living conditions, the morbidity and mortality rates of metabolic diseases are steadily rising, posing a significant threat to human health worldwide. Therefore, identifying novel effective targets
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P21-activated kinase-1 signaling is required to preserve adipose tissue homeostasis and cardiac function Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-03-02 Marcos Munoz, Christopher Solis, Maximilian McCann, Jooman Park, Koreena Rafael-Clyke, Shamim A. K. Chowdhury, Yuwei Jiang, Paola C. Rosas
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Erythronecroptosis: an overview of necroptosis or programmed necrosis in red blood cells Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-03-01
Abstract Necroptosis is considered a programmed necrosis that requires receptor-interacting protein kinase 1 (RIPK1), receptor-interacting protein kinase 3 (RIPK3), and pore-forming mixed lineage kinase domain-like protein (MLKL) to trigger a regulated cell membrane lysis. Membrane rupture in necroptosis has been shown to fuel innate immune response due to release of damage-associated molecular patterns
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YAP/TEAD involvement in resistance to paclitaxel chemotherapy in lung cancer Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-03-01 S. Brosseau, P. Abreu, C. Bouchez, L. Charon, Y. Kieffer, G. Gentric, V. Picant, I. Veith, J. Camonis, S. Descroix, F. Mechta-Grigoriou, M. C. Parrini, G. Zalcman
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The pharmaco-epigenetics of hypertension: a focus on microRNA Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-02-29 Serge Yaacoub, Ammar Boudaka, Ali AlKhatib, Gianfranco Pintus, Amirhossein Sahebkar, Firas Kobeissy, Ali H. Eid
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Long non-coding RNAs in cancer: multifaceted roles and potential targets for immunotherapy Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-02-28
Abstract Cancer remains a major global health concern with high mortality rates mainly due to late diagnosis and poor prognosis. Long non-coding RNAs (lncRNAs) are emerging as key regulators of gene expression in human cancer, functioning through various mechanisms including as competing endogenous RNAs (ceRNAs) and indirectly regulating miRNA expression. LncRNAs have been found to have both oncogenic
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KIF4A promotes epithelial–mesenchymal transition by activating the TGF-β/SMAD signaling pathway in glioma cells Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-02-27 Yao Xu, Guangren Xue, Lei Zhou, Gaotian Wu, Lingji Hu, Shuchen Ma, Jian Zhang, Xiangdong Li
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CircHAT1 regulates the proliferation and phenotype switch of vascular smooth muscle cells in lower extremity arteriosclerosis obliterans through targeting SFRS1 Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-02-26 Xian-ying Huang, Fang-yong Fu, Kai Qian, Qiao-li Feng, Sai Cao, Wei-yu Wu, Yuan-lin Luo, Wei-jie Chen, Zhi Zhang, Shui-chuan Huang
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Neutrophil extracellular traps: a catalyst for atherosclerosis Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-02-24 Yinyu Wang, Cuiping Wang, Jiayan Li
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MYC-dependent MiR-7-5p regulated apoptosis and autophagy in diffuse large B cell lymphoma by targeting AMBRA1 Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-02-23 Cuifen Zhang, Ke Wang, Jiahao Tao, Chuangjie Zheng, Linzhu Zhai
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Aerobic exercise mitigates high-fat diet-induced cardiac dysfunction, pyroptosis, and inflammation by inhibiting STING-NLRP3 signaling pathway Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-02-22 Zujie Xu, Zheying Ma, Xiaoqin Zhao, Bing Zhang
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Role of AMP deaminase in diabetic cardiomyopathy Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-02-22
Abstract Diabetes mellitus is one of the major causes of ischemic and nonischemic heart failure. While hypertension and coronary artery disease are frequent comorbidities in patients with diabetes, cardiac contractile dysfunction and remodeling occur in diabetic patients even without comorbidities, which is referred to as diabetic cardiomyopathy. Investigations in recent decades have demonstrated that
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METTL3-mediated m6A modification of NORAD inhibits the ferroptosis of vascular smooth muscle cells to attenuate the aortic dissection progression in an YTHDF2-dependent manner Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-02-22 Mingfang Liao, Sili Zou, Jianjin Wu, Jun Bai, Yandong Liu, Kangkang Zhi, Lefeng Qu
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Identification of key genes of diabetic cardiomyopathy in hiPSCs-CMs based on bioinformatics analysis Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-02-21 Shuo An, Hongchen Bi, Xiaoli Luo, Caiying Zhu, Min Wang, Aiming Pang, Yujie Cui
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Coronary microthrombi in the failing human heart: the role of von Willebrand factor and PECAM-1 Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-02-21 Sawa Kostin, Theodoros Giannakopoulos, Manfred Richter, Florian Krizanic, Benjamin Sasko, Oliver Ritter, Nikolaos Pagonas
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Circ_0004872 deficiency attenuates ox-LDL-induced vascular smooth muscle cell dysfunction by miR-424-5p-dependent regulation of FRS2 Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-02-20 Peng Qian, Xuanchao Cao, Qian Zhang, Meihua Gao, Xin Liu, Lijie Yan
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Molecular mechanisms of ferroptosis in cardiovascular disease Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-02-19 Qun Zeng, Tingting Jiang
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Tripartite-motif 3 represses ovarian cancer progression by downregulating lactate dehydrogenase A and inhibiting AKT signaling Mol. Cell. Biochem. (IF 4.3) Pub Date : 2024-02-17 Yu Cong, Xin Cui, Yaqian Shi, Xinxing Pan, Ke Huang, Zhe Geng, Pengfei Xu, Lili Ge, Jin Zhu, Juan Xu, Xuemei Jia