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Autosomal recessive non-syndromic hearing loss genes in Pakistan during the previous three decades J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-27 Madiha Shadab, Ansar Ahmed Abbasi, Ahsan Ejaz, Afif Ben-Mahmoud, Vijay Gupta, Hyung-Goo Kim, Barbara Vona
Hearing loss is a clinically and genetically heterogeneous disorder, with over 148 genes and 170 loci associated with its pathogenesis. The spectrum and frequency of causal variants vary across different genetic ancestries and are more prevalent in populations that practice consanguineous marriages. Pakistan has a rich history of autosomal recessive gene discovery related to non-syndromic hearing loss
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Mitochondrial respiration in peripheral arterial disease depends on stage severity J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-27 Fiona Speichinger, Alexandra Gratl, Ben Raude, Larissa Schawe, Jan Carstens, Nina A. Hering, Andreas Greiner, Dominik Pesta, Jan Paul Frese
Peripheral arterial disease (PAD) is an increasing cause of morbidity and its severity is graded based on clinical manifestation. To investigate the influence of the different stages on myopathy of ischemic muscle we analysed severity-dependent effects of mitochondrial respiration in PAD. Eighteen patients with severe PAD, defined as chronic limb-threatening ischemia, 47 patients with intermittent
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Hepatoprotective activity of Lactéol® forte and quercetin dihydrate against thioacetamide-induced hepatic cirrhosis in male albino rats J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-27 Hebatallah M. Saad, Samah S. Oda, Athanasios Alexiou, Marios Papadakis, Mohamed H. Mahmoud, Gaber El-Saber Batiha, Eman Khalifa
Liver cirrhosis is a silent disease in humans and is experimentally induced by many drugs and toxins as thioacetamide (TAA) in particular, which is the typical model for experimental induction of hepatic fibrosis. Thus, the objective of the present study was to elucidate the possible protective effects of lactéol® forte (LF) and quercetin dihydrate (QD) against TAA-induced hepatic damage in male albino
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A novel mitochondria-related core gene signature to predict the prognosis and evaluate tumour microenvironment in CESC single-cell validation J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-27 Lingxiao Ying, Lin Kong, Xiaoxiao Qiu, Aihua Cheng, Qijun Wang, Limeng Xiu, Jinmei Shi, Yanfei Tao, Zhihong Chai
Mitochondria and their related genes (MTRGs) are pivotal in the tumour microenvironment (TME) of cervical cancer, influencing prognosis and treatment response. This study developed a prognostic model using MTRGs to predict overall survival (OS) in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), aiming for personalized therapy. Analysing 14 MTRGs like ISCU and NDUFA11 through
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Integration of single-cell and RNA-seq data to explore the role of focal adhesion-related genes in osteoporosis J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-27 Xiaojian Shi, Qiang Fu, Jianyu Mao, Jiajie Yang, Ye Chen, Jiajia Lu, Aimin Chen, Nan Lu
Integrin-based focal adhesion is one of the major mechanosensory in osteocytes. The aim of this study was to mine the hub genes associated with focal adhesion and investigate their roles in osteoporosis based on the data of single-cell RNA sequencing and RNA-sequencing. Two hub genes (FAM129A and RNF24) with the same expression trend and AUC values greater than 0.7 in both GSE56815 and GSE56116 cohorts
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Depletion of CPNE7 sensitizes colorectal cancer to 5‐fluorouracil by downregulating ATG9B expression J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-25 Weile Xu, Yujie Tang, Yang Yang, Changjing Wang, Chen Liu, Jianqing Zhang, Lianmei Zhao, Guiying Wang
We aimed to explore the biological function of CPNE7 and determine the impact of CPNE7 on chemotherapy resistance in colorectal cancer (CRC) patients. According to the Gene Expression Profiling Interactive Analysis database and previously published data, CPNE7 was identified as a potential oncogene in CRC. RT‐qPCR and Western blotting were performed to verify the expression of CPNE7. Chi‐square test
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The KIR2DL family serves as prognostic biomarkers and correlates with immune infiltrates in acute myeloid leukaemia J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-25 Wenling Liu, Mingming Zhu, Ganggang Li, Yaming Xi
Acute myeloid leukaemia (AML) is a prevalent haematological malignancy in which various immune and stromal cells in the bone marrow microenvironment have instrumental roles and substantially influence its progression. KIR2DL is a member of the immunoglobulin‐like receptor family and a natural killer (NK) cell surface‐specific receptor. However, its impact on immune infiltration regarding AML has not
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Causal effect of gut microbiota on pancreatic cancer: A Mendelian randomization and colocalization study J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-25 Xin Li, Zhihai Liang
The causal relationship between gut microbiota (GM) and pancreatic cancer (PC) remains unclear. This study aimed to investigate the potential genes underlying this mechanism. GM Genome‐wide association study (GWAS) summary data were from the MiBioGen consortium. PC GWAS data were from the National Human Genome Research Institute‐European Bioinformatics Institute (NHGRI‐EBI) GWAS Catalogue. To detect
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Huayu Qutan Recipe promotes lipophagy and cholesterol efflux through the mTORC1/TFEB/ABCA1‐SCARB1 signal axis J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-25 Yue Li, Jiaxiang Pan, J. J. Jiajia Yu, Xize Wu, Guanlin Yang, Xue Pan, Guoyuan Sui, Mingyang Wang, Meijia Cheng, Shu Zhu, He Tai, Honghe Xiao, Lili Xu, Jin Wu, Yongju Yang, Jing Tang, Lihong Gong, Lianqun Jia, Dongyu Min
This study aims to investigate the mechanism of the anti‐atherosclerosis effect of Huayu Qutan Recipe (HYQT) on the inhibition of foam cell formation. In vivo, the mice were randomly divided into three groups: CTRL group, MOD group and HYQT group. The HYQT group received HYQT oral administration twice a day (20.54 g/kg/d), and the plaque formation in ApoE−/− mice was observed using haematoxylin–eosin
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NEDD4L is a promoter for angiogenesis and cell proliferation in human umbilical vein endothelial cells J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-25 Binghong Liu, Fei Song, Xiaoxia Zhou, Chan Wu, Huizhu Huang, Weiyin Wu, Gang Li, Yan Wang
Dysregulated angiogenesis leads to neovascularization, which can promote or exacerbate various diseases. Previous studies have proved that NEDD4L plays an important role in hypertension and atherosclerosis. Hence, we hypothesized that NEDD4L may be a critical regulator of endothelial cell (EC) function. This study aimed to define the role of NEDD4L in regulating EC angiogenesis and elucidate their
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Identification of important genes related to anoikis in acute myocardial infarction J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-25 Puwei Song, Yasen Yakufujiang, Jianghui Zhou, Shaorui Gu, Wenli Wang, Zhengyuan Huo
Acute myocardial infarction (AMI) increasingly precipitates severe heart failure, with diagnoses now extending to progressively younger demographics. The focus of this study was to pinpoint critical genes linked to both AMI and anoikis, thereby unveiling potential novel biomarkers for AMI detection and intervention. Differential analysis was performed to identify significant differences in expression
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Hepatocyte‐derived exosomes deliver the lncRNA CYTOR to hepatic stellate cells and promote liver fibrosis J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-23 Wenqiang Xu, Wenhui Mo, Dengyu Han, Weiqi Dai, Xiaorong Xu, Jingjing Li, Xuanfu Xu
Liver fibrosis is characterized by the activation and transformation of hepatic stellate cells (HSCs) induced by various injury factors. The degree of liver fibrosis can be significantly improved, but persistent injury factors present a significant therapeutic challenge. Hepatocytes are the most important parenchymal cell type in the liver. In this study, we explored the molecular mechanisms by which
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Targeting HOXA11‐AS to mitigate prostate cancer via the glycolytic metabolism: In vitro and in vivo J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-23 Jiankang Zhang, Sailian Li, Mengyu Zhang, Zhenting Wang, Zengshu Xing
As oncogenes or oncogene suppressors, long‐stranded non‐coding RNAs are essential for the formation and progression of human tumours. However, the mechanisms behind the regulatory role of RNA HOXA11‐AS in prostate cancer (PCa) are unclear. PCa is a common malignant tumour worldwide, and an increasing number of studies have focused on its metabolic profile. Studies have shown that the long non‐coding
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MAOB expression correlates with a favourable prognosis in prostate cancer, and its genetic variants are associated with the metastasis of the disease J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-23 Hsiang‐Ching Huang, Yi‐Hsien Hsieh, Chi‐Hao Hsiao, Chia‐Yen Lin, Shian‐Shiang Wang, Kuo‐Hao Ho, Lun‐Ching Chang, Huei‐Mei Huang, Shun‐Fa Yang, Ming‐Hsien Chien
Monoamine oxidase B (MAOB), a neurotransmitter‐degrading enzyme, was reported to reveal conflicting roles in various cancers. However, the functional role of MAOB and impacts of its genetic variants on prostate cancer (PCa) is unknown. Herein, we genotyped four loci of MAOB single‐nucleotide polymorphisms (SNPs), including rs1799836 (A/G), rs3027452 (G/A), rs6651806 (A/C) and rs6324 (G/A) in 702 PCa
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Geniposidic acid alleviates osteoarthritis progression through inhibiting inflammation and chondrocytes ferroptosis J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-23 Jiayang Sun, Xianji Song, Cuijie Wang, Qing Ruan
Osteoarthritis is one of the common diseases that seriously affects the quality of life of middle‐aged and elderly people worldwide. Geniposidic acid (GPA) is extracted from Eucommia ulmoides that exhibits various pharmacological effects. This study investigated the function of GPA on osteoarthritis (OA) in IL‐1β‐stimulated mouse chondrocytes and mouse OA model. Mouse OA model was established by destabilization
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Transcriptomics analysis of LINC02202/XBP1 axis in melanoma: Implications for drug targeting and PD‐1 monoclonal antibody efficacy J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-23 Yuanyuan Shang, Haiqian Yang, Jian Cui, Lipeng Wang, Le Wang, Yuan Wang, Miao‐Miao Zhao, Pei‐Yao Yu, Hui Qiao, Wen‐Jun Yang
Malignant melanoma (MM) is a highly aggressive and deadly form of skin cancer, primarily caused by recurrence and metastasis. Therefore, it is crucial to investigate the regulatory mechanisms underlying melanoma recurrence and metastasis. Our study has identified a potential targeted regulatory relationship between LINC02202, miR‐526b‐3p and XBP1 in malignant melanoma. Through the regulation of the
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Prognostic and immunotherapeutic potential of regulatory T cell‐associated signature in ovarian cancer J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-23 Yinglei Liu, Feng Shan, Ying Sun, Haili Kai, Yang Cao, Menghui Huang, Jinhui Liu, Pengpeng Zhang, Yanli Zheng
Tumour‐induced immunosuppressive microenvironments facilitate oncogenesis, with regulatory T cells (Tregs) serving as a crucial component. The significance of Treg‐associated genes within the context of ovarian cancer (OC) remains elucidated insufficiently. Utilizing single‐cell RNA sequencing (scRNA‐Seq) for the identification of Treg‐specific biomarkers, this investigation employed single‐sample
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Histone modification‐linked prognostic model for ovarian cancer reveals LBX2 as a novel growth promoter J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-23 Jian Xiong, Hongyuan Liang, Xiang Sun, Kefei Gao
Ovarian cancer (OC) is a deadly disease with limited treatment options and poor overall survival rates. This study aimed to investigate the role of histone modification‐related genes in predicting the prognosis of OC patients. Transcriptome data from multiple cohorts, including bulk RNA‐Seq data and single‐cell scRNA‐Seq data, were collected. Gene set enrichment analysis was used to identify enriched
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Exosomal circSTRBP from cancer cells facilitates gastric cancer progression via regulating miR‐1294/miR‐593‐3p/E2F2 axis J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-23 Yin Wang, Rong Zou, Deke Li, Xiankui Gao, Xingjun Lu
CircRNAs represent a new class of non‐coding RNAs which show aberrant expression in diverse cancers, such as gastric cancer (GC). circSTRBP, for instance, is suggested to be overexpressed in GC cells and tissues. However, the biological role of circSTRBP in the progression of GC and the potential mechanisms have not been investigated. circSTRBP levels within GC cells and tissues were measured by RT‐qPCR
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TRIM52 knockdown inhibits proliferation, inflammatory responses and oxidative stress in IL‐1β‐induced synovial fibroblasts to alleviate temporomandibular joint osteoarthritis J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-23 Tie Ma, Chuan‐bin Wu, Qing‐xia Shen, Qiang Wang, Qing Zhou
To explore the mechanism of tripartite motif 52 (TRIM52) in the progression of temporomandibular joint osteoarthritis (TMJOA). Gene and protein expression were tested by quantitative real‐time polymerase chain reaction and western blot, respectively. The levels of pro‐inflammatory cytokines and oxidative stress factors were evaluated using enzyme‐linked immunosorbent assay and biochemical kit, respectively
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Intracerebroventricular BDNF infusion may reduce cerebral ischemia/reperfusion injury by promoting autophagy and suppressing apoptosis J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-23 Umit Yilmaz, Kevser Tanbek, Semir Gul, Ahmet Koc, Mehmet Gul, Suleyman Sandal
Here, it was aimed to investigate the effects of intracerebroventricular (ICV) Brain Derived Neurotrophic Factor (BDNF) infusion for 7 days following cerebral ischemia (CI) on autophagy in neurons in the penumbra. Focal CI was created by the occlusion of the right middle cerebral artery. A total of 60 rats were used and divided into 4 groups as Control, Sham CI, CI and CI + BDNF. During the 7‐day reperfusion
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Construction of a prognostic model with CAFs for predicting the prognosis and immunotherapeutic response of lung squamous cell carcinoma J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-23 Xiang Zhang, Qingqing Xiao, Cong Zhang, Qinghua Zhou, Tao Xu
Lung squamous cell carcinoma (LUSC) is one of the subtypes of lung cancer (LC) that contributes to approximately 25%–30% of its prevalence. Cancer‐associated fibroblasts (CAFs) are key cellular components of the TME, and the large number of CAFs in tumour tissues creates a favourable environment for tumour development. However, the function of CAFs in the LUSC is complex and uncertain. First, we processed
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SBFI26 induces triple‐negative breast cancer cells ferroptosis via lipid peroxidation J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-22 Gang He, Yiyuan Zhang, Yanjiao Feng, Tangcong Chen, Mei Liu, Yue Zeng, Xiaojing Yin, Shaokui Qu, Lifen Huang, Youqiang Ke, Li Liang, Jun Yan, Wei Liu
SBFI26, an inhibitor of FABP5, has been shown to suppress the proliferation and metastasis of tumour cells. However, the underlying mechanism by which SBFI26 induces ferroptosis in breast cancer cells remains largely unknown. Three breast cancer cell lines were treated with SBFI26 and CCK‐8 assessed cytotoxicity. Transcriptome was performed on the Illumina platform and verified by qPCR. Western blot
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Induced pluripotent stem cell‐based assays recapture multiple properties of human astrocytes J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-21 Hideki Nonaka, Takayuki Kondo, Mika Suga, Ryu Yamanaka, Yukako Sagara, Kayoko Tsukita, Naoko Mitsutomi, Kengo Homma, Ryuta Saito, Fumihiko Miyoshi, Hiromitsu Ohzeki, Masahiro Okuyama, Haruhisa Inoue
The majority of the population of glial cells in the central nervous system consists of astrocytes, and impairment of astrocytes causes various disorders. It is useful to assess the multiple astrocytic properties in order to understand their complex roles in the pathophysiology. Although we can differentiate human astrocytes from induced pluripotent stem cells (iPSCs), it remains unknown how we can
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Catalpol promotes articular cartilage repair by enhancing the recruitment of endogenous mesenchymal stem cells J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-21 Congzi Wu, Zhenyu Shi, Qinwen Ge, HuiHui Xu, Zhen Wu, Peijian Tong, Hongting Jin
Articular cartilage defect is challenged by insufficient regenerative ability of cartilage. Catalpol (CA), the primary active component of Rehmanniae Radix, could exert protective effects against various diseases. However, the impact of CA on the treatment of articular cartilage injuries is still unclear. In this study, full‐thickness articular cartilage defect was induced in a mouse model via surgery
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Randomized clinical trial of continuous transversus thoracis muscle plane block for patients undergoing open heart valve replacement surgery J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-21 Yanping Zhan, Lei Li, Shibiao Chen, Yongbao Peng, Yang Zhang
The optimal analgesia regimen after open cardiac surgery is unclear. The aim of this study was to investigate the beneficial effects of continuous transversus thoracis muscle plane (TTMP) blocks initiated before surgery on open cardiac surgery outcomes. A group of 110 patients were randomly allocated to either receive bilateral continuous TTMP blocks (TTP group) or no nerve block (SAL group). The primary
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NPS‐2143 inhibit glioma progression by suppressing autophagy through mediating AKT–mTOR pathway J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-21 Jia‐Li Nie, Qi Li, Hai‐Tang Yin, Ji‐Hong Yang, Ming Li, Qin Li, Xing‐Hua Fan, Qing‐Qing Zhao, Zhi‐Peng Wen
Gliomas are the most common tumours in the central nervous system. In the present study, we aimed to find a promising anti‐glioma compound and investigate the underlying molecular mechanism. Glioma cells were subjected to the 50 candidate compounds at a final concentration of 10 μM for 72 h, and CCK‐8 was used to evaluate their cytotoxicity. NPS‐2143, an antagonist of calcium‐sensing receptor (CASR)
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Retraction: Increased Six1 expression in macrophages promotes hepatocellular carcinoma growth and invasion by regulating MMP‐9 J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-21
Yongyu Zhang, Shiji Wang, Zhongmin Liu, Lewei Yang, Jian Liu, Ming Xiu. Increased Six1 expression in macrophages promotes hepatocellular carcinoma growth and invasion by regulating MMP‐9. J Cell Mol Med. 2019; 23: 4523–4533. https://doi.org/10.1111/jcmm.14342.The above article, published online on 02 May 2019 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between
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CCDC157 is essential for sperm differentiation and shows oligoasthenoteratozoospermia‐related mutations in men J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-21 Huimei Zheng, Chenjia Gong, Jingping Li, Jiaru Hou, Xinhan Gong, Xinhai Zhu, Huan Deng, Haoyue Wu, Fengbin Zhang, Qinghua Shi, Jianteng Zhou, Baolu Shi, Xiaohang Yang, Yongmei Xi
Oligoasthenoteratospermia (OAT), characterized by abnormally low sperm count, poor sperm motility, and abnormally high number of deformed spermatozoa, is an important cause of male infertility. Its genetic basis in many affected individuals remains unknown. Here, we found that CCDC157 variants are associated with OAT. In two cohorts, a 21‐bp (g.30768132_30768152del21) and/or 24‐bp (g.30772543_30772566del24)
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ICA/SDF‐1α/PBMSCs loaded onto alginate and gelatin cross‐linked scaffolds promote damaged cartilage repair J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-21 Pengzhen Wang, Pingping Zhu, Wenhui Yin, Jian Wu, Shaoheng Zhang
A three‐dimensional alginate‐coated scaffold (GAIS) was constructed in the present study to showcase the multidifferentiation potential of peripheral blood mesenchymal stem cells (PBMSCs) and to investigate the role and mechanism by which Icariin (ICA)/stromal cell‐derived factor (SDF‐1α)/PBMSCs promote damaged articular repair. In addition, the ability of ICA, in combination with SDF‐1α, to promote
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Deficiency of heme oxygenase 1a causes detrimental effects on cardiac function J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-21 Hong Wang, Juuso Siren, Sanni Perttunen, Katariina Immonen, Yu‐Chia Chen, Suneeta Narumanchi, Riikka Kosonen, Jere Paavola, Mika Laine, Ilkka Tikkanen, Päivi Lakkisto
Humans lacking heme oxygenase 1 (HMOX1) display growth retardation, haemolytic anaemia, and vulnerability to stress; however, cardiac function remains unclear. We aimed to explore the cardiac function of zebrafish lacking hmox1a at baseline and in response to stress. We generated zebrafish hmox1a mutants using CRISPR/Cas9 genome editing technology. Deletion of hmox1a increases cardiac output and further
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HBI‐8000 improves heart failure with preserved ejection fraction via the TGF‐β1/MAPK signalling pathway J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-21 Jing Tian, Wenjing Li, Lu Zeng, Yang Li, Jiamin Du, Ying Li, Bin Li, Guohai Su
Heart failure with preserved ejection fraction (HFpEF) accounts for approximately 50% of total heart failure patients and is characterized by peripheral circulation, cardiac remodelling and comorbidities (such as advanced age, obesity, hypertension and diabetes) with limited treatment options. Chidamide (HBI‐8000) is a domestically produced benzamide‐based histone deacetylase isoform‐selective inhibitor
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Immune patterns of cuproptosis in ischemic heart failure: A transcriptome analysis J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-21 Zhebin Chen, Yunhui Zhu, Songzan Chen, Zhengwei Li, Guosheng Fu, Yao Wang
Cuproptosis is a recently discovered programmed cell death pattern that affects the tricarboxylic acid (TCA) cycle by disrupting the lipoylation of pyruvate dehydrogenase (PDH) complex components. However, the role of cuproptosis in the progression of ischemic heart failure (IHF) has not been investigated. In this study, we investigated the expression of 10 cuproptosis‐related genes in samples from
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Electroacupuncture suppresses neuronal ferroptosis to relieve chronic neuropathic pain J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-21 Chunchun Xue, Wenyun Kui, Aiping Huang, Yanan Li, Lingxing Li, Zhen Gu, Lei Xie, Shuyi Kong, Jun Yu, Hongfeng Ruan, Kaiqiang Wang
Growing evidence supports the analgesic efficacy of electroacupuncture (EA) in managing chronic neuropathic pain (NP) in both patients and NP models induced by peripheral nerve injury. However, the underlying mechanisms remain incompletely understood. Ferroptosis, a novel form of programmed cell death, has been found to be activated during NP development, while EA has shown potential in promoting neurological
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FLRT3 and TGF‐β/SMAD4 signalling: Impacts on apoptosis, autophagy and ion channels in supraventricular tachycardia J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-21 Yang Pang, Ye Xu, Qingxing Chen, Kuan Cheng, Yunlong Ling, Jun Jang, Junbo Ge, Wenqing Zhu
To explore the underlying molecular mechanisms of supraventricular tachycardia (SVT), this study aimed to analyse the complex relationship between FLRT3 and TGF‐β/SMAD4 signalling pathway, which affects Na+ and K+ channels in cardiomyocytes. Bioinformatics analysis was performed on 85 SVT samples and 15 healthy controls to screen overlapping genes from the key module and differentially expressed genes
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Necroptosis pathway emerged as potential diagnosis markers in spinal cord injury J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-21 Jingcheng Liu, Jiang Cao, Xiao Yu, Jie Chang, Tao Sui, Xiaojian Cao
The present research focused on identifying necroptosis‐related differentially expressed genes (NRDEGs) in spinal cord injury (SCI) to highlight potential therapeutic and prognostic target genes in clinical SCI. Three SCI‐related datasets were downloaded, including GSE151371, GSE5296 and GSE47681. MSigDB and KEGG datasets were searched for necroptosis‐related genes (NRGs). Differentially expressed
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NGCN: Drug‐target interaction prediction by integrating information and feature learning from heterogeneous network J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-21 Junyue Cao, Qingfeng Chen, Junlai Qiu, Yiming Wang, Wei Lan, Xiaojing Du, Kai Tan
Drug‐target interaction (DTI) prediction is essential for new drug design and development. Constructing heterogeneous network based on diverse information about drugs, proteins and diseases provides new opportunities for DTI prediction. However, the inherent complexity, high dimensionality and noise of such a network prevent us from taking full advantage of these network characteristics. This article
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Understanding formation processes of calcareous nephrolithiasis in renal interstitium and tubule lumen J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-21 Caitao Dong, Jiawei Zhou, Xiaozhe Su, Ziqi He, Qianlin Song, Chao Song, Hu Ke, Chuan Wang, Wenbiao Liao, Sixing Yang
Kidney stone, one of the oldest known diseases, has plagued humans for centuries, consistently imposing a heavy burden on patients and healthcare systems worldwide due to their high incidence and recurrence rates. Advancements in endoscopy, imaging, genetics, molecular biology and bioinformatics have led to a deeper and more comprehensive understanding of the mechanism behind nephrolithiasis. Kidney
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Neuroendocrine and cellular mechanisms in stress resilience: From hormonal influence in the CNS to mitochondrial dysfunction and oxidative stress J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-21 Arghya Bhattacharya, Manas Chakraborty, Ananya Chanda, Taha Alqahtani, Ajoy Kumer, Bikram Dhara, Moitreyee Chattopadhyay
Recent advancements in neuroendocrinology challenge the long‐held belief that hormonal effects are confined to perivascular tissues and do not extend to the central nervous system (CNS). This paradigm shift, propelled by groundbreaking research, reveals that synthetic hormones, notably in anti‐inflammatory medications, significantly influence steroid psychosis, behavioural, and cognitive impairments
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Hedan tablet ameliorated non‐alcoholic steatohepatitis by moderating NF‐κB and lipid metabolism‐related pathways via regulating hepatic metabolites J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-20 Liying Guo, Jinyan Lei, Peng Li, Yuming Wang, Jing Wang, Taotao Song, Bo Zhu, Jianwei Jia, Jing Miao, Huantian Cui
Non‐alcoholic steatohepatitis (NASH) is a severe form of fatty liver disease. If not treated, it can lead to liver damage, cirrhosis and even liver cancer. However, advances in treatment have remained relatively slow, and there is thus an urgent need to develop appropriate treatments. Hedan tablet (HDP) is used to treat metabolic syndrome. However, scientific understanding of the therapeutic effect
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MRPS16 promotes lung adenocarcinoma growth via the PI3K/AKT/Frataxin signalling axis J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-20 Zaixing Cheng, Kaming Xue, Cui Xiong, Zhikun Zheng, Jinsong Li, Xinwei Qiao
Although MRPS16 is involved in cancer development, its mechanisms in developing LAUD remain unclear. Herein, qRT‐PCR, WB and IHC were utilized for evaluating MRPS16 expression levels, while functional assays besides animal experiments were performed to measure MRPS16 effect on LAUD progression. Using WB, the MRPS16 effect on PI3K/AKT/Frataxin signalling pathway was tested. According to our study, MRPS16
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Correction to ‘Retraction’ J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-20
Retraction. J Cell Mol Med, 26: 956-956. https://doi.org/10.1111/jcmm.17181. Retraction: ‘Long noncoding RNA MALAT1 enhances the docetaxel resistance of prostate cancer cells via miR-145-5p-mediated regulation of AKAP12’” Xue, D., Lu, H., Xu, H-Y., Zhou, C-X., He, X-Z. J Cell Mol Med. 2018; 22: 3223–3237. https://doi.org/10.1111/jcmm.13604. The above article, published online on 06 April 2018 on Wiley
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Retraction: Long non‐coding RNA LINC00607 silencing exerts antioncogenic effects on thyroid cancer through the CASP9 promoter methylation J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-20
Lanzhen Li, Zhongcheng Gao, Lei Zhao, Peiyou Ren, Hongyan Shen. Long non-coding RNA LINC00607 silencing exerts antioncogenic effects on thyroid cancer through the CASP9 Promoter methylation. J Cell Mol Med. 2021; 25: 7608–7620. https://doi.org/10.1111/jcmm.16265. The above article, published online on 07 July 2021 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between
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ApoE4 dysregulation incites depressive symptoms and mitochondrial impairments in mice J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-20 Weifen Li, Tahir Ali, Kaiwu He, Chengyou Zheng, Ningning Li, Zhi‐Jian Yu, Shupeng Li
Apolipoprotein E4 (ApoE4) is involved in the stress‐response processes and is hypothesized to be a risk factor for depression by means of mitochondrial dysfunction. However, their exact roles and underlying mechanisms are largely unknown. ApoE4 transgenic mice (B6. Cg‐ApoEtm1UncCdh18Tg(GFAP−APOE i4)1Hol/J) were subjected to stress (lipopolysaccharides, LPS) to elucidate the aetiology of ApoE4‐induced
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Steroid receptor coactivator 1 promotes human hepatocellular carcinoma invasiveness through enhancing MMP‐9 J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-20 Zhangwei Tong, Yong Zhang, Peng Guo, Wei Wang, Qiang Chen, Jing Jin, Shixiao Liu, Chundong Yu, Pingli Mo, Lei Zhang, Junli Huang
SRC‐1 functions as a transcriptional coactivator for steroid receptors and various transcriptional factors. Notably, SRC‐1 has been implicated in oncogenic roles in multiple cancers, including breast cancer and prostate cancer. Previous investigations from our laboratory have established the high expression of SRC‐1 in human HCC specimens, where it accelerates HCC progression by enhancing Wnt/beta‐catenin
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Competitive endogenous RNA networks: Decoding the role of long non‐coding RNAs and circular RNAs in colorectal cancer chemoresistance J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-20 Ali Khalafizadeh, Seyedeh Donya Hashemizadegan, Fatemeh Shokri, Babak Bakhshinejad, Keyvan Jabbari, Mahsa Motavaf, Sadegh Babashah
Colorectal cancer (CRC) is recognized as one of the most common gastrointestinal malignancies across the globe. Despite significant progress in designing novel treatments for CRC, there is a pressing need for more effective therapeutic approaches. Unfortunately, many patients undergoing chemotherapy develop drug resistance, posing a significant challenge for cancer treatment. Non‐coding RNAs (ncRNAs)
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Long noncoding RNA Glis2 regulates podocyte mitochondrial dysfunction and apoptosis in diabetic nephropathy via sponging miR‐328‐5p J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-20 Ting Wang, Yanxia Chen, Zhihong Liu, Jing Zhou, Na Li, Yue Shan, Yinxi He
Podocyte apoptosis exerts a crucial role in the pathogenesis of DN. Recently, long noncoding RNAs (lncRNAs) have been gradually identified to be functional in a variety of different mechanisms associated with podocyte apoptosis. This study aimed to investigate whether lncRNA Glis2 could regulate podocyte apoptosis in DN and uncover the underlying mechanism. The apoptosis rate was detected by flow cytometry
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Identification of circRNA‐disease associations via multi‐model fusion and ensemble learning J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-20 Jing Yang, Xiujuan Lei, Fa Zhang
Circular RNA (circRNA) is a common non‐coding RNA and plays an important role in the diagnosis and therapy of human diseases, circRNA‐disease associations prediction based on computational methods can provide a new way for better clinical diagnosis. In this article, we proposed a novel method for circRNA‐disease associations prediction based on ensemble learning, named ELCDA. First, the association
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Association between sex hormones and bone age in boys aged 9–18 years from China J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-20 Wen Shu, Wenquan Niu, Yaqin Zhang, Hui Li
This study aimed to analyse the association between sex hormones and bone age (BA) in boys aged 9–18 years, both individually and interactively, and further to explore whether nutritional status may influence this association. A retrospective analysis was performed among 1382 Chinese boys with physical measurements, sexual characteristics, BA radiographs and sex hormone indicators from February 2015
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Research progress on the regulatory mechanism of integrin‐mediated mechanical stress in cells involved in bone metabolism J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-20 Li Yang, Hong Chen, Chanchan Yang, Zhengqi Hu, Zhiliang Jiang, Shengzi Meng, Rong Liu, Lan Huang, Kun Yang
Mechanical stress is an internal force between various parts of an object that resists external factors and effects that cause an object to deform, and mechanical stress is essential for various tissues that are constantly subjected to mechanical loads to function normally. Integrins are a class of transmembrane heterodimeric glycoprotein receptors that are important target proteins for the action
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Glutamine metabolism prognostic index predicts tumour microenvironment characteristics and therapeutic efficacy in ovarian cancer J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-20 Lingling Gao, Zheng Wei, Feiquan Ying, Lin Huang, Jingni Zhang, Si Sun, Zehua Wang, Jing Cai, Yuan Zhang
Mounting evidence has highlighted the multifunctional characteristics of glutamine metabolism (GM) in cancer initiation, progression and therapeutic regimens. However, the overall role of GM in the tumour microenvironment (TME), clinical stratification and therapeutic efficacy in patients with ovarian cancer (OC) has not been fully elucidated. Here, three distinct GM clusters were identified and exhibited
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Mendelian randomization analysis reveals a causal effect of Streptococcus salivarius on diabetic retinopathy through regulating host fasting glucose J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-20 Jingjing Li, Gongwei Zheng, Dingping Jiang, Chunyu Deng, Yaru Zhang, Yunlong Ma, Jianzhong Su
Diabetic retinopathy (DR) is one of leading causes of vision loss in adults with increasing prevalence worldwide. Increasing evidence has emphasized the importance of gut microbiome in the aetiology and development of DR. However, the causal relationship between gut microbes and DR remains largely unknown. To investigate the causal associations of DR with gut microbes and DR risk factors, we employed
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Retinoic acid induced specific changes in the phosphoproteome of C17.2 neural stem cells J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-20 Cheng Zhang, Lite Ge, Huali Xie, Xiaoqian Liu, Chengfeng Xun, Yan Chen, Haiyan Chen, Ming Lu, Ping Chen
Retinoic acid (RA), a vitamin A derivative, is an effective cell differentiating factor which plays critical roles in neuronal differentiation induction and the production of neurotransmitters in neurons. However, the specific changes in phosphorylation levels and downstream signalling pathways associated with RA remain unclear. This study employed qualitative and quantitative phosphoproteomics approaches
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Unveiling the role of YARS1 in bladder cancer: A prognostic biomarker and therapeutic target J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-20 YaXuan Wang, Jinfeng Wang, Lu Zhang, JiaXing He, Bo Ji, JianShe Wang, BeiChen Ding, MingHua Ren
YARS is responsible for catalysing the binding of tyrosine to its cognate tRNA and plays a crucial role in basic biosynthesis. However, its biological functions in bladder cancer remains to be proven. We analysed variations in YARS1 expression and survival in bladder cancer using multiple data sets, including TCGA‐BLCA, GSE13507 and bladder cancer‐specific tissue microarrays. Furthermore, we explored
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4‐octyl itaconate alleviates cisplatin‐induced ferroptosis possibly via activating the NRF2/HO‐1 signalling pathway J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-20 Li Zhang, Wenao Song, Hua Li, Xiaolin Cui, Jingyu Ma, Rongrong Wang, Yue Xu, Ming Li, Xiaohui Bai, Dawei Wang, Haihui Sun, Zhiming Lu
Ferroptosis, characterized by iron‐dependent lipid reactive oxygen species (ROS) accumulation, plays a pivotal role in cisplatin‐induced ototoxicity. Existing research has suggested that in cisplatin‐mediated damage to auditory cells and hearing loss, ferroptosis is partially implicated. 4‐Octyl itaconate (4‐OI), derived from itaconic acid, effectively permeates cell membranes, showcasing potent anti‐inflammatory
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Identification and characterization of extrachromosomal circular DNA in large‐artery atherosclerotic stroke J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-20 Kejie Chen, Yanqi Chi, Hang Cheng, Min Yang, Quandan Tan, Junli Hao, Yapeng Lin, Fengkai Mao, Song He, Jie Yang
Extrachromosomal circular DNA (eccDNA) is a new biomarker and regulator of diseases. However, the role of eccDNAs in large‐artery atherosclerotic (LAA) stroke remains unclear. Through high‐throughput circle‐sequencing technique, the length distribution, genomic characteristic and motifs feature of plasma eccDNA from healthy controls (CON) and patients with LAA stroke were analysed. Then, the potential
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Retraction: IL‐17A‐producing T cells exacerbate fine particulate matter‐induced lung inflammation and fibrosis by inhibiting PI3K/Akt/mTOR‐mediated autophagy J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-20
Lu-Hong Cong, Tao Li, Hui Wang, Yi-Na Wu, Shu-Peng Wang, Yu-Yue Zhao, Guo-Qiang Zhang and Jun Duan. IL-17A-producing T cells exacerbate fine particulate matter-induced lung inflammation and fibrosis by inhibiting PI3K/Akt/mTOR-mediated autophagy. J Cell Mol Med. 2020; 24: 8532–8544. https://doi.org/10.1111/jcmm.15475. The above article, published online on 9 July 2020 in Wiley Online Library (wileyonlinelibrary
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CircRNA LOC729852 promotes bladder cancer progression by regulating macrophage polarization and recruitment via the miR‐769‐5p/IL‐10 axis J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-20 Changming Dong, Pengyu Hui, Zhengqi Wu, Jianfeng Li, Xiaojun Man
Circular RNAs (circRNAs) function as tumour promoters or suppressors in bladder cancer (BLCA) by regulating genes involved in macrophage recruitment and polarization. However, the underlying mechanisms are largely unknown. The aim of this study was to determine the biological role of circLOC729852 in BLCA. CircLOC729852 was upregulated in BLCA tissues and correlated with increased proliferation, migration
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Indoxyl sulphate‐initiated activation of cardiac fibroblasts is modulated by aryl hydrocarbon receptor and nuclear factor‐erythroid‐2‐related factor 2 J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-20 Chiara Barisione, Daniela Verzola, Silvano Garibaldi, Paola Altieri, Anna Lisa Furfaro, Mariapaola Nitti, Giovanni Pratesi, Domenico Palombo, Pietro Ameri
In the last decade, extensive attention has been paid to the uremic toxin indoxyl sulphate (IS) as an inducer of cardiac fibroblast (cFib) activation and cardiac fibrosis in chronic kidney disease. At cellular level, IS engages aryl hydrocarbon receptor (AhR) and regulates many biological functions. We analysed how AhR inhibition by CH‐223191 (CH) and overexpression of non‐functional (dominant negative