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Ivermectin increases striatal cholinergic activity to facilitate dopamine terminal function Cell Biosci. (IF 7.5) Pub Date : 2024-04-17 Hillary A. Wadsworth, Alicia M. P. Warnecke, Joshua C. Barlow, J. Kayden Robinson, Emma Steimle, Joakim W. Ronström, Pacen E. Williams, Christopher J. Galbraith, Jared Baldridge, Michael W. Jakowec, Daryl L. Davies, Jordan T. Yorgason
Ivermectin (IVM) is a commonly prescribed antiparasitic treatment with pharmacological effects on invertebrate glutamate ion channels resulting in paralysis and death of invertebrates. However, it can also act as a modulator of some vertebrate ion channels and has shown promise in facilitating L-DOPA treatment in preclinical models of Parkinson’s disease. The pharmacological effects of IVM on dopamine
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Microglia and macrophage metabolism: a regulator of cerebral gliomas Cell Biosci. (IF 7.5) Pub Date : 2024-04-17 Yue Deng, Qinyan Chen, Chao Wan, Yajie Sun, Fang Huang, Yan Hu, Kunyu Yang
Reciprocal interactions between the tumor microenvironment (TME) and cancer cells play important roles in tumorigenesis and progression of glioma. Glioma-associated macrophages (GAMs), either of peripheral origin or representing brain-intrinsic microglia, are the majority population of infiltrating immune cells in glioma. GAMs, usually classified into M1 and M2 phenotypes, have remarkable plasticity
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GLUT1-mediated microglial proinflammatory activation contributes to the development of stress-induced spatial learning and memory dysfunction in mice Cell Biosci. (IF 7.5) Pub Date : 2024-04-16 Xue Wang, Yuhan Wu, Yingrui Tian, Hui Hu, Yun Zhao, Binghua Xue, Zhaowei Sun, Aijun Wei, Fang Xie, Ling-Jia Qian
Stress is a recognized risk factor for cognitive decline, which triggers neuroinflammation involving microglial activation. However, the specific mechanism for microglial activation under stress and affects learning and memory remains unclear. The chronic stress mouse model was utilized to explore the relationship between microglial activation and spatial memory impairment. The effect of hippocampal
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Cerebral venous congestion alters CNS homeostatic plasticity, evoking tinnitus-like behavior Cell Biosci. (IF 7.5) Pub Date : 2024-04-09 Huimin Wei, Huimin Jiang, Yifan Zhou, Lu Liu, Wei Ma, Shanshan Ni, Chen Zhou, Xunming Ji
Brain function and neuronal activity depend on a constant supply of blood from the cerebral circulation. The cerebral venous system (CVS) contains approximately 70% of the total cerebral blood volume; similar to the cerebral arterial system, the CVS plays a prominent role in the maintenance of central nervous system (CNS) homeostasis. Impaired venous autoregulation, which can appear in forms such as
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Klotho exerts protection in chronic kidney disease associated with regulating inflammatory response and lipid metabolism Cell Biosci. (IF 7.5) Pub Date : 2024-04-07 Junhui Liu, Huaicheng Wang, Qinyu Liu, Shushu Long, Yanfang Wu, Nengying Wang, Wei Lin, Gang Chen, Miao Lin, Junping Wen
The anti-aging protein Klotho plays a protective role in kidney disease, but its potential as a biomarker for chronic kidney disease (CKD) is controversial. Additionally, the main pathways through which Klotho exerts its effects on CKD remain unclear. Therefore, we used bioinformatics and clinical data analysis to determine its role in CKD. We analyzed the transcriptomic and clinical data from the
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Cellular and molecular mechanisms of aspartoacylase and its role in Canavan disease Cell Biosci. (IF 7.5) Pub Date : 2024-04-06 Martin Grønbæk-Thygesen, Rasmus Hartmann-Petersen
Canavan disease is an autosomal recessive and lethal neurological disorder, characterized by the spongy degeneration of the white matter in the brain. The disease is caused by a deficiency of the cytosolic aspartoacylase (ASPA) enzyme, which catalyzes the hydrolysis of N-acetyl-aspartate (NAA), an abundant brain metabolite, into aspartate and acetate. On the physiological level, the mechanism of pathogenicity
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Crosstalk between m6A modification and autophagy in cancer Cell Biosci. (IF 7.5) Pub Date : 2024-04-04 Tao Chen, Liying Zheng, Peiyue Luo, Jun Zou, Wei Li, Qi Chen, Junrong Zou, Biao Qian
Autophagy is a cellular self-degradation process that plays a crucial role in maintaining metabolic functions in cells and organisms. Dysfunctional autophagy has been linked to various diseases, including cancer. In cancer, dysregulated autophagy is closely associated with the development of cancer and drug resistance, and it can have both oncogenic and oncostatic effects. Research evidence supports
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The role of goblet cells in Crohn’ s disease Cell Biosci. (IF 7.5) Pub Date : 2024-04-01 Zichen Wang, Jun Shen
The prevalence of Crohn’s disease (CD), a subtype of inflammatory bowel disease (IBD), is increasing worldwide. The pathogenesis of CD is hypothesized to be related to environmental, genetic, immunological, and bacterial factors. Current studies have indicated that intestinal epithelial cells, including columnar, Paneth, M, tuft, and goblet cells dysfunctions, are strongly associated with these pathogenic
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Complement C1q-mediated microglial synaptic elimination by enhancing desialylation underlies sevoflurane-induced developmental neurotoxicity Cell Biosci. (IF 7.5) Pub Date : 2024-04-01 Gang Wang, Hua-yue Liu, Xiao-wen Meng, Ying Chen, Wei-ming Zhao, Wen-ting Li, Han-bing Xu, Ke Peng, Fu-hai Ji
Repeated neonatal sevoflurane exposures led to neurocognitive disorders in young mice. We aimed to assess the role of microglia and complement C1q in sevoflurane-induced neurotoxicity and explore the underlying mechanisms. Neonatal mice were treated with sevoflurane on postnatal days 6, 8, and 10, and the Morris water maze was performed to assess cognitive functions. For mechanistic explorations, mice
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The multifaceted therapeutic value of targeting steroid receptor coactivator-1 in tumorigenesis Cell Biosci. (IF 7.5) Pub Date : 2024-03-29 Qiang Chen, Peng Guo, Yilin Hong, Pingli Mo, Chundong Yu
Steroid receptor coactivator-1 (SRC-1, also known as NCOA1) frequently functions as a transcriptional coactivator by directly binding to transcription factors and recruiting to the target gene promoters to promote gene transcription by increasing chromatin accessibility and promoting the formation of transcriptional complexes. In recent decades, various biological and pathological functions of SRC-1
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Unveiling the functional heterogeneity of cytokine-primed human umbilical cord mesenchymal stem cells through single-cell RNA sequencing Cell Biosci. (IF 7.5) Pub Date : 2024-03-26 Zhiwei Hu, Duanduan Li, Shiduo Wu, Ke Pei, Zeqin Fu, Yulin Yang, Yinfu Huang, Jian Yang, Chuntao Liu, Junyuan Hu, Cheguo Cai, Yan Liao
Mesenchymal stem cells (MSCs) hold immense promise for use in immunomodulation and regenerative medicine. However, their inherent heterogeneity makes it difficult to achieve optimal therapeutic outcomes for a specific clinical disease. Primed MSCs containing a certain cytokine can enhance their particular functions, thereby increasing their therapeutic potential for related diseases. Therefore, understanding
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The role of long noncoding RNAs in ocular angiogenesis and vascular oculopathy Cell Biosci. (IF 7.5) Pub Date : 2024-03-23 Pranali Gandhi, Yuzhi Wang, Guigang Li, Shusheng Wang
Long noncoding RNAs (lncRNAs) are RNA transcripts over 200 nucleotides in length that do not code for proteins. Initially considered a genomic mystery, an increasing number of lncRNAs have been shown to have vital roles in physiological and pathological conditions by regulating gene expression through diverse mechanisms depending on their subcellular localization. Dysregulated angiogenesis is responsible
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Enhanced bacterial cancer therapy delivering therapeutic RNA interference of c-Myc Cell Biosci. (IF 7.5) Pub Date : 2024-03-23 Jason S. Williams, Adam T. Higgins, Katie J. Stott, Carly Thomas, Lydia Farrell, Cleo S. Bonnet, Severina Peneva, Anna V. Derrick, Trevor Hay, Tianqi Wang, Claire Morgan, Sarah Dwyer, Joshua D’Ambrogio, Catherine Hogan, Matthew J. Smalley, Lee Parry, Paul Dyson
Bacterial cancer therapy was first trialled in patients at the end of the nineteenth century. More recently, tumour-targeting bacteria have been harnessed to deliver plasmid-expressed therapeutic interfering RNA to a range of solid tumours. A major limitation to clinical translation of this is the short-term nature of RNA interference in vivo due to plasmid instability. To overcome this, we sought
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Revealing the role of SPP1+ macrophages in glioma prognosis and therapeutic targeting by investigating tumor-associated macrophage landscape in grade 2 and 3 gliomas Cell Biosci. (IF 7.5) Pub Date : 2024-03-21 Wenshu Tang, Cario W. S. Lo, Wei Ma, Annie T. W. Chu, Amy H. Y. Tong, Brian H. Y. Chung
Glioma is a highly heterogeneous brain tumor categorized into World Health Organization (WHO) grades 1–4 based on its malignancy. The suppressive immune microenvironment of glioma contributes significantly to unfavourable patient outcomes. However, the cellular composition and their complex interplays within the glioma environment remain poorly understood, and reliable prognostic markers remain elusive
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Association of glucose-lowering drug target and risk of gastrointestinal cancer: a mendelian randomization study Cell Biosci. (IF 7.5) Pub Date : 2024-03-19 Yi Yang, Bo Chen, Chongming Zheng, Hao Zeng, Junxi Zhou, Yaqing Chen, Qing Su, Jingxian Wang, Juejin Wang, Yurong Wang, Hongli Wang, Ruxue Jin, Zhiyuan Bo, Gang Chen, Yi Wang
Glucose-lowering drug is associated with various cancers, but the causality with gastrointestinal cancer risk is rarely reported. We aimed to explore the causality between them in this Mendelian randomization (MR) study. Two-sample MR, summary-data-based (SMR), mediation MR, and colocalization analyses was employed. Ten glucose-lowering drug targets (PPARG, DPP4, GLP1R, INSR, SLC5A2, ABCC8, KCNJ11
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Deubiquitinase PSMD7 facilitates pancreatic cancer progression through activating Nocth1 pathway via modifying SOX2 degradation Cell Biosci. (IF 7.5) Pub Date : 2024-03-17 Chen Luo, Yi Yu, Jinfeng Zhu, Leifeng Chen, Dan Li, Xingyu Peng, Zitao Liu, Qing Li, Qing Cao, Kai Huang, Rongfa Yuan
Ubiquitination is a critical post-translational modification which can be reversed with an enzyme family known as deubiquitinating enzymes (DUBs). It has been reported that dysregulation of deubiquitination leads to carcinogenesis. As a member of the DUBs family, proteasome 26 S subunit non-ATPase 7 (PSMD7) serves as an underlying tumour-promoting factor in multiple cancers. However, the clinical significance
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RNA editing enzymes: structure, biological functions and applications Cell Biosci. (IF 7.5) Pub Date : 2024-03-16 Dejiu Zhang, Lei Zhu, Yanyan Gao, Yin Wang, Peifeng Li
With the advancement of sequencing technologies and bioinformatics, over than 170 different RNA modifications have been identified. However, only a few of these modifications can lead to base pair changes, which are called RNA editing. RNA editing is a ubiquitous modification in mammalian transcriptomes and is an important co/posttranscriptional modification that plays a crucial role in various cellular
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A gene signature linked to fibroblast differentiation for prognostic prediction of mesothelioma Cell Biosci. (IF 7.5) Pub Date : 2024-03-10 Jun Liu, Yuwei Lu, Yifan Liu, Wei Zhang, Shuyuan Xian, Siqiao Wang, Zixuan Zheng, Ruoyi Lin, Minghao Jin, Mengyi Zhang, Weijin Qian, Jieling Tang, Bingnan Lu, Yiting Yang, Zichang Liu, Mingyu Qu, Haonan Ma, Xinru Wu, Zhengyan Chang, Jie Zhang, Yuan Zhang
Malignant mesothelioma is a type of infrequent tumor that is substantially related to asbestos exposure and has a terrible prognosis. We tried to produce a fibroblast differentiation-related gene set for creating a novel classification and prognostic prediction model of MESO. Three databases, including NCBI-GEO, TCGA, and MET-500, separately provide single-cell RNA sequencing data, bulk RNA sequencing
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Membrane-associated RING-CH 7 inhibits stem-like capacities of bladder cancer cells by interacting with nucleotide-binding oligomerization domain containing 1 Cell Biosci. (IF 7.5) Pub Date : 2024-03-10 Junlong Zhuang, Lingli Zhang, Siyuan Zhang, Zhongqing Zhang, Tianlei Xie, Wei Zhao, Yantao Liu
Cancer stem-like capacities are major factors contributing to unfavorable prognosis. However, the associated molecular mechanisms underlying cancer stem-like cells (CSCs) maintain remain unclear. This study aimed to investigate the role of the ubiquitin E3 ligase membrane-associated RING-CH 7 (MARCH7) in bladder cancer cell CSCs. Male BALB/c nude mice aged 4–5 weeks were utilized to generate bladder
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Single-cell transcriptome reveals a novel mechanism of C-Kit+-liver sinusoidal endothelial cells in NASH Cell Biosci. (IF 7.5) Pub Date : 2024-03-09 Hui-Yi Li, Yu-Xuan Gao, Jun-Cheng Wu, Jing-Ze Li, Seng-Wang Fu, Ming-Yi Xu
To understand how liver sinusoidal endothelial cells (LSECs) respond to nonalcoholic steatohepatitis (NASH). We profiled single-LSEC from livers of control and MCD-fed mice. The functions of C-Kit+-LSECs were determined using coculture and bone marrow transplantation (BMT) methods. Three special clusters of single-LSEC were differentiated. C-Kit+-LSECs of cluster 0, Msr1+-LSECs of cluster 1 and Bmp4+Selp+-VECs
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Cardiac progenitor cell therapy: mechanisms of action Cell Biosci. (IF 7.5) Pub Date : 2024-03-05 Rut Bryl, Magdalena Kulus, Artur Bryja, Dominika Domagała, Paul Mozdziak, Paweł Antosik, Dorota Bukowska, Maciej Zabel, Piotr Dzięgiel, Bartosz Kempisty
Heart failure (HF) is an end-stage of many cardiac diseases and one of the main causes of death worldwide. The current management of this disease remains suboptimal. The adult mammalian heart was considered a post-mitotic organ. However, several reports suggest that it may possess modest regenerative potential. Adult cardiac progenitor cells (CPCs), the main players in the cardiac regeneration, constitute
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Transcriptome-wide association studies associated with Crohn’s disease: challenges and perspectives Cell Biosci. (IF 7.5) Pub Date : 2024-02-25 Keyu Jia, Jun Shen
Crohn’s disease (CD) is regarded as a lifelong progressive disease affecting all segments of the intestinal tract and multiple organs. Based on genome-wide association studies (GWAS) and gene expression data, transcriptome-wide association studies (TWAS) can help identify susceptibility genes associated with pathogenesis and disease behavior. In this review, we overview seven reported TWASs of CD,
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Synergistic enhancement of the mouse Pramex1 and Pramel1 in repressing retinoic acid (RA) signaling during gametogenesis Cell Biosci. (IF 7.5) Pub Date : 2024-02-23 Mingyao Yang, Francisco Diaz, Ana Rita T. Krause, Yuguo Lei, Wan-Sheng Liu
PRAME constitutes one of the largest multi-copy gene families in Eutherians, encoding cancer-testis antigens (CTAs) with leucine-rich repeats (LRR) domains, highly expressed in cancer cells and gametogenic germ cells. This study aims to elucidate genetic interactions between two members, Pramex1 and Pramel1, in the mouse Prame family during gametogenesis using a gene knockout approach. Single-gene
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XBP1-mediated transcriptional regulation of SLC5A1 in human epithelial cells in disease conditions Cell Biosci. (IF 7.5) Pub Date : 2024-02-22 Yifei Sun, Yihan Zhang, Jifeng Zhang, Y. Eugene Chen, Jian-Ping Jin, Kezhong Zhang, Hongmei Mou, Xiubin Liang, Jie Xu
Sodium-Glucose cotransporter 1 and 2 (SGLT1/2) belong to the family of glucose transporters, encoded by SLC5A1 and SLC5A2, respectively. SGLT2 is almost exclusively expressed in the renal proximal convoluted tubule cells. SGLT1 is expressed in the kidneys but also in other organs throughout the body. Many SGLT inhibitor drugs have been developed based on the mechanism of blocking glucose (re)absorption
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Synthetic β-sheets mimicking fibrillar and oligomeric structures for evaluation of spectral X-ray scattering technique for biomarker quantification Cell Biosci. (IF 7.5) Pub Date : 2024-02-19 Karthika Suresh, Eshan Dahal, Aldo Badano
Archetypical cross-β spines sharpen the boundary between functional and pathological proteins including β-amyloid, tau, α-synuclein and transthyretin are linked to many debilitating human neurodegenerative and non-neurodegenerative amyloidoses. An increased focus on development of pathogenic β-sheet specific fluid and imaging structural biomarkers and conformation-specific monoclonal antibodies in
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Single nuclear RNA sequencing of terminal ileum in patients with cirrhosis demonstrates multi-faceted alterations in the intestinal barrier Cell Biosci. (IF 7.5) Pub Date : 2024-02-19 Xixian Jiang, Ying Xu, Andrew Fagan, Bhaumik Patel, Huiping Zhou, Jasmohan S. Bajaj
Patients with cirrhosis have intestinal barrier dysfunction but the role of the individual cell types in human small intestine is unclear. We performed single-nuclear RNA sequencing (snRNAseq) in the pinch biopsies of terminal ileum of four age-matched men [56 years, healthy control, compensated, early (ascites and lactulose use) and advanced decompensated cirrhosis (ascites and rifaximin use)]. Cell
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Exploiting bacterial-origin immunostimulants for improved vaccination and immunotherapy: current insights and future directions Cell Biosci. (IF 7.5) Pub Date : 2024-02-17 Guangyu Wang, Yongkang Wang, Fang Ma
Vaccination is a valid strategy to prevent and control newly emerging and reemerging infectious diseases in humans and animals. However, synthetic and recombinant antigens are poor immunogenic to stimulate efficient and protective host immune response. Immunostimulants are indispensable factors of vaccines, which can promote to trigger fast, robust, and long-lasting immune responses. Importantly, immunotherapy
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Interferon-stimulated gene PVRL4 broadly suppresses viral entry by inhibiting viral-cellular membrane fusion Cell Biosci. (IF 7.5) Pub Date : 2024-02-17 Qiaomei Cai, Nina Sun, Yurui Zhang, Jingfeng Wang, Chaohu Pan, Yu Chen, Lili Li, Xiaorong Li, Wancheng Liu, Saba R. Aliyari, Heng Yang, Genhong Cheng
Viral infection elicits the type I interferon (IFN-I) response in host cells and subsequently inhibits viral infection through inducing hundreds of IFN-stimulated genes (ISGs) that counteract many steps in the virus life cycle. However, most of ISGs have unclear functions and mechanisms in viral infection. Thus, more work is required to elucidate the role and mechanisms of individual ISGs against different
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Abnormal protein post-translational modifications induces aggregation and abnormal deposition of protein, mediating neurodegenerative diseases Cell Biosci. (IF 7.5) Pub Date : 2024-02-12 Wei Li, Hong-Lian Li, Jian-Zhi Wang, Rong Liu, Xiaochuan Wang
Protein post-translational modifications (PPTMs) refer to a series of chemical modifications that occur after the synthesis of protein. Proteins undergo different modifications such as phosphorylation, acetylation, ubiquitination, and so on. These modifications can alter the protein’s structure, function, and interaction, thereby regulating its biological activity. In neurodegenerative diseases, several
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PFKFB3 in neovascular eye disease: unraveling mechanisms and exploring therapeutic strategies Cell Biosci. (IF 7.5) Pub Date : 2024-02-10 Peiyu Liu, Dandan Sun, Shuchang Zhang, Shimei Chen, Xiaoqian Wang, Huiming Li, Fang Wei
Neovascular eye disease is characterized by pathological neovascularization, with clinical manifestations such as intraocular exudation, bleeding, and scar formation, ultimately leading to blindness in millions of individuals worldwide. Pathologic ocular angiogenesis often occurs in common fundus diseases including proliferative diabetic retinopathy (PDR), age-related macular degeneration (AMD), and
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Co-Packaged PARP inhibitor and photosensitizer for targeted photo-chemotherapy of 3D ovarian cancer spheroids Cell Biosci. (IF 7.5) Pub Date : 2024-02-06 Aaron Sorrin, Anika Dasgupta, Kathryn McNaughton, Carla Arnau Del Valle, Keri Zhou, Cindy Liu, Dana M. Roque, Huang Chiao Huang
Within the last decade, poly(ADP-ribose) polymerase inhibitors (PARPi) have emerged in the clinic as an effective treatment for numerous malignancies. Preclinical data have demonstrated powerful combination effects of PARPi paired with photodynamic therapy (PDT), which involves light-activation of specialized dyes (photosensitizers) to stimulate cancer cell death through reactive oxygen species generation
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Tunable PhenoCycler imaging of the murine pre-clinical tumour microenvironments Cell Biosci. (IF 7.5) Pub Date : 2024-02-04 Madelyn J. Abraham, Christophe Goncalves, Paige McCallum, Vrinda Gupta, Samuel E. J. Preston, Fan Huang, Hsiang Chou, Natascha Gagnon, Nathalie A. Johnson, Wilson H. Miller, Koren K. Mann, Sonia V. del Rincon
The tumour microenvironment (TME) consists of tumour-supportive immune cells, endothelial cells, and fibroblasts. PhenoCycler, a high-plex single cell spatial biology imaging platform, is used to characterize the complexity of the TME. Researchers worldwide harvest and bank tissues from mouse models which are employed to model a plethora of human disease. With the explosion of interest in spatial biology
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Aldo-keto reductase family 1 member A1 (AKR1A1) exerts a protective function in alcohol-associated liver disease by reducing 4-HNE accumulation and p53 activation Cell Biosci. (IF 7.5) Pub Date : 2024-02-03 Ying-Wei Lan, Wan-Ru Chen, Gary Ro-Lin Chang, Ying-Cheng Chen, Kowit-Yu Chong, Kai-Cheng Chuang, Yung-Tsung Kao, Ming-Shan Chen, Chuan-Mu Chen
The development of alcohol-associated liver disease (ALD) is influenced by the amount and duration of alcohol consumption. The resulting liver damage can range from reversible stages, such as steatosis, steatohepatitis and alcoholic fibrosis, to the advanced and irreversible stage of cirrhosis. Aldo-keto reductase family 1 member A1 (AKR1A1) is a member of the aldo-keto reductase family that catalyzes
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Macrophage heterogeneity and its interactions with stromal cells in tumour microenvironment Cell Biosci. (IF 7.5) Pub Date : 2024-02-01 Liren Cao, Xiaoyan Meng, Zhiyuan Zhang, Zhonglong Liu, Yue He
Macrophages and tumour stroma cells account for the main cellular components in the tumour microenvironment (TME). Current advancements in single-cell analysis have revolutionized our understanding of macrophage diversity and macrophage–stroma interactions. Accordingly, this review describes new insight into tumour-associated macrophage (TAM) heterogeneity in terms of tumour type, phenotype, metabolism
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CRISPR/Cas9 mediated Y-chromosome elimination affects human cells transcriptome Cell Biosci. (IF 7.5) Pub Date : 2024-01-30 Ludovica Celli, Patrizia Gasparini, Ginevra Biino, Laura Zannini, Miriana Cardano
Sexual dimorphism represents a key concept in the comprehension of molecular processes guiding several sex-specific physiological and pathological mechanisms. It has been reported that genes involved in many disorders show a sex-dependent expression pattern. Moreover, the loss of Y chromosome (LOY), found to be a physiological age-driven phenomenon, has been linked to many neurodegenerative and autoimmune
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Therapeutic potential of berberine in attenuating cholestatic liver injury: insights from a PSC mouse model Cell Biosci. (IF 7.5) Pub Date : 2024-01-25 Yanyan Wang, Derrick Zhao, Lianyong Su, Yun-Ling Tai, Grayson W. Way, Jing Zeng, Qianhua Yan, Ying Xu, Xuan Wang, Emily C. Gurley, Xi-Qiao Zhou, Jinze Liu, Jinpeng Liu, Weidong Chen, Phillip B. Hylemon, Huiping Zhou
Primary sclerosing cholangitis (PSC) is a chronic liver disease characterized by progressive biliary inflammation and bile duct injury. Berberine (BBR) is a bioactive isoquinoline alkaloid found in various herbs and has multiple beneficial effects on metabolic and inflammatory diseases, including liver diseases. This study aimed to examine the therapeutic effect of BBR on cholestatic liver injury in
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Rasal1 regulates calcium dependent neuronal maturation by modifying microtubule dynamics Cell Biosci. (IF 7.5) Pub Date : 2024-01-21 M. H. S. Deurloo, S. Eide, E. Turlova, Q. Li, S. Spijker, H.-S. Sun, A. J. A. Groffen, Z.-P. Feng
Rasal1 is a Ras GTPase-activating protein which contains C2 domains necessary for dynamic membrane association following intracellular calcium elevation. Membrane-bound Rasal1 inactivates Ras signaling through its RasGAP activity, and through such mechanisms has been implicated in regulating various cellular functions in the context of tumors. Although highly expressed in the brain, the contribution
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MIIP downregulation drives colorectal cancer progression through inducing peri-cancerous adipose tissue browning Cell Biosci. (IF 7.5) Pub Date : 2024-01-20 Qinhao Wang, Yuanyuan Su, Ruiqi Sun, Xin Xiong, Kai Guo, Mengying Wei, Guodong Yang, Yi Ru, Zhengxiang Zhang, Jing Li, Jing Zhang, Qing Qiao, Xia Li
The enrichment of peri-cancerous adipose tissue is a distinctive feature of colorectal cancer (CRC), accelerating disease progression and worsening prognosis. The communication between tumor cells and adjacent adipocytes plays a crucial role in CRC advancement. However, the precise regulatory mechanisms are largely unknown. This study aims to explore the mechanism of migration and invasion inhibitory
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NF-κB RelA is a cell-intrinsic metabolic checkpoint restricting glycolysis Cell Biosci. (IF 7.5) Pub Date : 2024-01-20 Liwen Li, Lei Han, Zhaoxia Qu
An intrinsic link between metabolism and function in immune cells, and in particular macrophages, has been well established recently. However, the molecular mechanisms controlling the metabolic switch in these sentinel cells for their integral roles in host defense, inflammation, homeostasis, and pathogenesis remain largely unknown. Here, we identify the master transcription factor NF-κB RelA as a
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WRN loss accelerates abnormal adipocyte metabolism in Werner syndrome Cell Biosci. (IF 7.5) Pub Date : 2024-01-06 Yuyao Tian, Sofie Lautrup, Patrick Wai Nok Law, Ngoc-Duy Dinh, Evandro Fei Fang, Wai-Yee Chan
Metabolic dysfunction is one of the main symptoms of Werner syndrome (WS); however, the underlying mechanisms remain unclear. Here, we report that loss of WRN accelerates adipogenesis at an early stage both in vitro (stem cells) and in vivo (zebrafish). Moreover, WRN depletion causes a transient upregulation of late-stage of adipocyte-specific genes at an early stage. In an in vivo study, we generated
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Autophagy induces hair follicle stem cell activation and hair follicle regeneration by regulating glycolysis Cell Biosci. (IF 7.5) Pub Date : 2024-01-05 Pingping Sun, Zhan Wang, Sixiao Li, Jiajing Yin, Yuyang Gan, Shizhao Liu, Zhen Lin, Hailin Wang, Zhexiang Fan, Qian Qu, Zhiqi Hu, Kaitao Li, Yong Miao
Hair follicle stem cells (HFSCs) typically remain quiescent and are activated only during the transition from telogen to anagen to ensure that the hair follicle enters a new cycle. The metabolic behavior of stem cells in tissues is regulated by macroautophagy/autophagy, and changes in HFSC metabolism directly affect their activation and maintenance. However, the role of autophagy in the regulation
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Müller glial cells located in the peripheral retina are more susceptible to high pressure: implications for glaucoma Cell Biosci. (IF 7.5) Pub Date : 2024-01-05 Xandra Pereiro, Noelia Ruzafa, Mikel Azkargorta, Félix Elortza, Arantxa Acera, António Francisco Ambrósio, Ana Raquel Santiago, Elena Vecino
Glaucoma, a progressive neurodegenerative disease, is a leading cause of irreversible vision loss worldwide. This study aims to elucidate the critical role of Müller glia (MG) in the context of retinal ganglion cell (RGC) death, particularly focusing on the influence of peripheral MG sensitivity to high pressure (HP). Co-cultures of porcine RGCs with MG were isolated from both the central and peripheral
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Cas13b-mediated RNA targeted therapy alleviates genetic dilated cardiomyopathy in mice Cell Biosci. (IF 7.5) Pub Date : 2024-01-04 Jiacheng Li, He Xuan, Xin Kuang, Yahuan Li, Hong Lian, Nie Yu
Recent advances in gene editing technology have opened up new avenues for in vivo gene therapy, which holds great promise as a potential treatment method for dilated cardiomyopathy (DCM). The CRISPR-Cas13 system has been shown to be an effective tool for knocking down RNA expression in mammalian cells. PspCas13b, a type VI-B effector that can be packed into adeno-associated viruses and improve RNA
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COUP-TFII regulates early bipotential gonad signaling and commitment to ovarian progenitors Cell Biosci. (IF 7.5) Pub Date : 2024-01-04 Lucas G. A. Ferreira, Marina M. L. Kizys, Gabriel A. C. Gama, Svenja Pachernegg, Gorjana Robevska, Andrew H. Sinclair, Katie L. Ayers, Magnus R. Dias-da-Silva
The absence of expression of the Y-chromosome linked testis-determining gene SRY in early supporting gonadal cells (ESGC) leads bipotential gonads into ovarian development. However, genetic variants in NR2F2, encoding three isoforms of the transcription factor COUP-TFII, represent a novel cause of SRY-negative 46,XX testicular/ovotesticular differences of sex development (T/OT-DSD). Thus, we hypothesized
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Acute exposure of microwave impairs attention process by activating microglial inflammation Cell Biosci. (IF 7.5) Pub Date : 2024-01-04 Shaofei Jiang, Yingping Ma, Yuan Shi, Yong Zou, Zhenqi Yang, Weijia Zhi, Zhe Zhao, Wei Shen, Liping Chen, Yan Wu, Lifeng Wang, Xiangjun Hu, Haitao Wu
Attention provides the foundation for cognitions, which was shown to be affected by microwave (MW) radiation. With the ubiquitous of microwaves, public concerns regarding the impact of MW radiation on attention has hence been increased. Our study aims to investigate the potential effect and mechanism of acute microwave exposure on attention. We identified obvious impairment of attention in mice by
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Knocking out Fkbp51 decreases CCl4-induced liver injury through enhancement of mitochondrial function and Parkin activity Cell Biosci. (IF 7.5) Pub Date : 2024-01-02 Bin Qiu, Zhaohui Zhong, Longyu Dou, Yuxue Xu, Yi Zou, Korri Weldon, Jun Wang, Lingling Zhang, Ming Liu, Kent E. Williams, John Paul Spence, Richard L. Bell, Zhao Lai, Weidong Yong, Tiebing Liang
Previously, we found that FK506 binding protein 51 (Fkbp51) knockout (KO) mice resist high fat diet-induced fatty liver and alcohol-induced liver injury. The aim of this research is to identify the mechanism of Fkbp51 in liver injury. Carbon tetrachloride (CCl4)-induced liver injury was compared between Fkbp51 KO and wild type (WT) mice. Step-wise and in-depth analyses were applied, including liver
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NUAK1 coordinates growth factor-dependent activation of mTORC2 and Akt signaling Cell Biosci. (IF 7.5) Pub Date : 2023-12-22 Mario Palma, Elizabeth Riffo, Alejandro Farias, Viviana Coliboro-Dannich, Luis Espinoza-Francine, Emilia Escalona, Roberto Amigo, José L. Gutiérrez, Roxana Pincheira, Ariel F. Castro
mTORC2 is a critical regulator of cytoskeleton organization, cell proliferation, and cancer cell survival. Activated mTORC2 induces maximal activation of Akt by phosphorylation of Ser-473, but regulation of Akt activity and signaling crosstalk upon growth factor stimulation are still unclear. We identified that NUAK1 regulates growth factor-dependent activation of Akt by two mechanisms. NUAK1 interacts
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Precision nephrotoxicity testing using 3D in vitro models Cell Biosci. (IF 7.5) Pub Date : 2023-12-21 Pengfei Yu, Hainan Zhu, Carol Christine Bosholm, Daniella Beiner, Zhongping Duan, Avinash K. Shetty, Steve S. Mou, Philip Adam Kramer, Luis F. Barroso, Hongbing Liu, Kun Cheng, Michael Ihnat, Matthew A. Gorris, Joseph A. Aloi, Jobira A. Woldemichael, Anthony Bleyer, Yuanyuan Zhang
Nephrotoxicity is a significant concern during the development of new drugs or when assessing the safety of chemicals in consumer products. Traditional methods for testing nephrotoxicity involve animal models or 2D in vitro cell cultures, the latter of which lack the complexity and functionality of the human kidney. 3D in vitro models are created by culturing human primary kidney cells derived from
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The crucial regulatory role of type I interferon in inflammatory diseases Cell Biosci. (IF 7.5) Pub Date : 2023-12-20 Ling Ji, Tianle Li, Huimin Chen, Yanqi Yang, Eryi Lu, Jieying Liu, Wei Qiao, Hui Chen
Type I interferon (IFN-I) plays crucial roles in the regulation of inflammation and it is associated with various inflammatory diseases including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and periodontitis, impacting people's health and quality of life. It is well-established that IFN-Is affect immune responses and inflammatory factors by regulating some signaling. However, currently
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Incidence, distribution, disease spectrum, and genetic deficits of congenital heart defects in China: implementation of prenatal ultrasound screening identified 18,171 affected fetuses from 2,452,249 pregnancies Cell Biosci. (IF 7.5) Pub Date : 2023-12-19 Xinlin Chen, Sheng Zhao, Xiaoyan Dong, Juntao Liu, Yulin Guo, Weina Ju, Peiwen Chen, Yanduo Gao, Qian Feng, Xia Zhu, Hui Huang, Xiaojun Lu, Xiaohong Yang, Fan Yang, Chen Cheng, Xishun Luo, Longxian Cheng, Nanbert Zhong
Congenital heart defects (CHDs) are the most common birth defects. Assessment of the incidence, distribution, disease spectrum, and genetic deficits of fetal CHDs in China is urgently needed. A national echocardiography screening program for fetal CHDs was implemented in 92 prenatal screening–diagnostic centers in China. A total of 18,171 fetal CHD cases were identified from 2,452,249 pregnancies,
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Regulation of telomerase towards tumor therapy Cell Biosci. (IF 7.5) Pub Date : 2023-12-18 Siyu Yan, Song Lin, Hongxin Qiu, Xining Wang, Yijun He, Chuanle Wang, Yan Huang
Cancer is an aging-related disease, while aging plays an important role in the development process of tumor, thus the two are inextricably associated. Telomere attrition is one of the recognized hallmark events of senescence. Hence, targeting telomerase which could extends telomere sequences to treat tumors is widely favored. Cancer cells rely on high activity of telomerase to maintain a strong proliferative
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Ferroptosis in cardiovascular diseases: role and mechanism Cell Biosci. (IF 7.5) Pub Date : 2023-12-15 Qi Zhang, Yuhao Luo, Lin Peng, Xi Rong, Yingxue Liu, Jiafu Li, Jing Luo
In multicellular organisms, regulatory cell death is a crucial aspect of growth and development. Ferroptosis, which was postulated roughly ten years ago, is a mode of cell death that differs from apoptosis, autophagy, and pyrodeath. This distinct pattern of cell death is triggered by an imbalance between oxidants and antioxidants and strongly associated with the metabolism of iron, lipids, amino acids
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Neural EGFL-like 1, a craniosynostosis-related osteochondrogenic molecule, strikingly associates with neurodevelopmental pathologies Cell Biosci. (IF 7.5) Pub Date : 2023-12-15 Chenshuang Li, Zhong Zheng, Pin Ha, Wenlu Jiang, Chia Soo, Kang Ting
Various craniofacial syndromes cause skeletal malformations and are accompanied by neurological abnormalities at different levels, leading to tremendous biomedical, financial, social, and psychological burdens. Accumulating evidence highlights the importance of identifying and characterizing the genetic basis that synchronously modulates musculoskeletal and neurobehavioral development and function
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Role of the P2 × 7 receptor in neurodegenerative diseases and its pharmacological properties Cell Biosci. (IF 7.5) Pub Date : 2023-12-13 Ziyan Hu, Yifan Luo, Jinxi Zhu, Danling Jiang, Zhenzhong Luo, Lidong Wu, Jin Li, Shengliang Peng, Jialing Hu
Neurodegenerative diseases seriously affect patients’ physical and mental health, reduce their quality of life, and impose a heavy burden on society. However, their treatment remains challenging. Therefore, exploring factors potentially related to the pathogenesis of neurodegenerative diseases and improving their diagnosis and treatment are urgently needed. Recent studies have shown that P2 × 7R plays
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Predictive and prognostic biomarkers of bone metastasis in breast cancer: current status and future directions Cell Biosci. (IF 7.5) Pub Date : 2023-12-01 Shenkangle Wang, Wenxin Wu, Xixi Lin, Kevin Matthew Zhang, QingLiang Wu, Mingpeng Luo, Jichun Zhou
The most common site of metastasis in breast cancer is the bone, where the balance between osteoclast-mediated bone resorption and osteoblast-mediated bone formation is disrupted. This imbalance causes osteolytic bone metastasis in breast cancer, which leads to bone pain, pathological fractures, spinal cord compression, and other skeletal-related events (SREs). These complications reduce patients'
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Uncoupling p38α nuclear and cytoplasmic functions and identification of two p38α phosphorylation sites on β-catenin: implications for the Wnt signaling pathway in CRC models Cell Biosci. (IF 7.5) Pub Date : 2023-12-01 Martina Lepore Signorile, Candida Fasano, Giovanna Forte, Katia De Marco, Paola Sanese, Vittoria Disciglio, Elisabetta Di Nicola, Antonino Pantaleo, Cristiano Simone, Valentina Grossi
Activation of the Wnt pathway has been linked to colorectal cancer (CRC). Previous reports suggest that Wnt3a can activate p38. Besides, p38α feeds into the canonical Wnt/β-catenin pathway by inhibiting GSK3β through phosphorylation. Recently, we identified p38α as a new druggable member of β-catenin chromatin-associated kinase complexes in CRC. The functional relationship between p38α and β-catenin
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A rapid and stable spontaneous reprogramming system of Spermatogonial stem cells to Pluripotent State Cell Biosci. (IF 7.5) Pub Date : 2023-12-01 Rui Wei, Xiaoyu Zhang, Xiaoxiao Li, Jian Wen, Hongyang Liu, Jiqiang Fu, Li Li, Wenyi Zhang, Zhen Liu, Yang Yang, Kang Zou
The scarcity of pluripotent stem cells poses a major challenge to the clinical application, given ethical and biosafety considerations. While germline stem cells commit to gamete differentiation throughout life, studies demonstrated the spontaneous acquisition of pluripotency by spermatogonial stem cells (SSCs) from neonatal testes at a low frequency (1 in 1.5 × 107). Notably, this process occurs without
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Differential interactome mapping of aggregation prone/prion-like proteins under stress: novel links to stress granule biology Cell Biosci. (IF 7.5) Pub Date : 2023-12-01 Neelam Younas, Saima Zafar, Tayyaba Saleem, Leticia Camila Fernandez Flores, Abrar Younas, Matthias Schmitz, Inga Zerr
Aberrant stress granules (SGs) are emerging as prime suspects in the nucleation of toxic protein aggregates. Understanding the molecular networks linked with aggregation-prone proteins (prion protein, synuclein, and tau) under stressful environments is crucial to understand pathophysiological cascades associated with these proteins. We characterized and validated oxidative stress-induced molecular
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GSTM2 alleviates heart failure by inhibiting DNA damage in cardiomyocytes Cell Biosci. (IF 7.5) Pub Date : 2023-11-30 Hongfei Xu, Zhen Wang, Yalin Wang, Shaobo Pan, Wenting Zhao, Miao Chen, Xiaofan Chen, Tingting Tao, Liang Ma, Yiming Ni, Weidong Li
Heart failure (HF) seriously threatens human health worldwide. However, the pathological mechanisms underlying HF are still not fully clear. In this study, we performed proteomics and transcriptomics analyses on samples from human HF patients and healthy donors to obtain an overview of the detailed changes in protein and mRNA expression that occur during HF. We found substantial differences in protein
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mTOR hypoactivity leads to trophectoderm cell failure by enhancing lysosomal activation and disrupting the cytoskeleton in preimplantation embryo Cell Biosci. (IF 7.5) Pub Date : 2023-11-30 Chiyuan Ma, Qin Li, Yuxin Yang, Lei Ge, Jiaxuan Cai, Juan Wang, Maoxian Zhu, Yue Xiong, Wenya Zhang, Jingtong Xie, Yujing Cao, Huashan Zhao, Qing Wei, Chen Huang, Junchao Shi, Jian V. Zhang, Enkui Duan, Xiaohua Lei
Metabolic homeostasis is closely related to early impairment of cell fate determination and embryo development. The protein kinase mechanistic target of rapamycin (mTOR) is a key regulator of cellular metabolism in the body. Inhibition of mTOR signaling in early embryo causes postimplantation development failure, yet the mechanisms are still poorly understood. Pregnancy mice and preimplantation mouse