样式: 排序: IF: - GO 导出 标记为已读
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ASAPA: a bioinformatic pipeline based on Iso-Seq that identifies the links among alternative splicing, alternative transcription initiation and alternative polyadenylation Funct. Integr. Genomics (IF 2.9) Pub Date : 2024-03-26 Fei Wang, Zhongxin Jin, Shengnan Wang, Longcheng Yang, Zongbao Fan, Yuxin Yao
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Exploring transient global transcriptional changes induced by ascorbic acid revealed via atKAS-seq profiling Funct. Integr. Genomics (IF 2.9) Pub Date : 2024-03-25 Xiangyue Liu, Weizhi He, Lulu Hu
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Comparative and phylogenetic analysis of the complete chloroplast genomes of ten Pittosporum species from East Asia Funct. Integr. Genomics (IF 2.9) Pub Date : 2024-03-22 Shu-Dong Zhang, Li-Zhen Ling, Qi-Hui Zhang
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TRIM5 as a promising diagnostic biomarker of hepatocellular carcinoma: integrated analysis and experimental validation Funct. Integr. Genomics (IF 2.9) Pub Date : 2024-03-22 Huanxiang Liu, Yuhong Tang, Jiahao Zhang, Gefeng Wu, Qing Peng, Chen Chen, Jun Cao, Rui Peng, Bingbing Su, Daoyuan Tu, Guoqing Jiang, Qian Wang, Renjie Liu, Aoqing Wang, Shengjie Jin, Chi Zhang, Dousheng Bai
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Knockout of lws1 in zebrafish (Danio rerio) reveals its role in regulating feeding and vision-guided behavior Funct. Integr. Genomics (IF 2.9) Pub Date : 2024-03-22 Di-Mei Xu, Fa-Rui Chai, Xu-Fang Liang, Ke Lu
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CRISPR du-HITI an attractive approach to targeting Long Noncoding RNA HCP5 as inhibitory factor for proliferation of ovarian cancer cell Funct. Integr. Genomics (IF 2.9) Pub Date : 2024-03-20 Zeinab Moradi, Mandana Kazemi, Roya Jamshidi-Khalifelou, Vahid Bahramnia, Fatemeh Esfandmaz, Reza Rahnavard, Behnoush Moradgholi, Tohid Piri-Gharaghie
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Comprehensive pan-cancer analysis reveals SIRT5 is a predictive biomarker for prognosis and immunotherapy response Funct. Integr. Genomics (IF 2.9) Pub Date : 2024-03-19
Abstract Background Sirtuin 5 (SIRT5) is a promising therapeutic target involved in regulating multiple metabolic pathways in cells and organisms. The role of SIRT5 in cancer is currently unclear, and a comprehensive systematic pan-cancer analysis is required to explore its value in diagnosis, prognosis, and immune function. Methods We investigated the role of SIRT5 in tumorigenesis, diagnosis, prognosis
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Effect of gibberellin on crown root development in the mutant of the rice plasmodesmal Germin-like protein OsGER4 Funct. Integr. Genomics (IF 2.9) Pub Date : 2024-03-18 Trang Thi Nguyen, Thanh Chi Nguyen, Phat Tien Do, Huong Thi Mai To
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Nuclear protein NOP2 serves as a poor-prognosis predictor of LUAD and aggravates the malignancy of lung adenocarcinoma cells Funct. Integr. Genomics (IF 2.9) Pub Date : 2024-03-15 Weizhuo Qin, Gaoqiang Fei, Qian Zhou, Zhijie Li, Wei Li, Pingmin Wei
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CRISPR/Cas9-mediated mutagenesis of phytoene desaturase in pigeonpea and groundnut Funct. Integr. Genomics (IF 2.9) Pub Date : 2024-03-13 Kalyani Prasad, Harika Gadeela, Pradeep Reddy Bommineni, Palakolanu Sudhakar Reddy, Wricha Tyagi, Kalenahalli Yogendra
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Identification of RNA methylation-related lncRNAs for prognostic assessment and immunotherapy in bladder cancer—based on single cell/Bulk RNA sequencing data Funct. Integr. Genomics (IF 2.9) Pub Date : 2024-03-13 LianMing Fan, Jie Wang, Zhiya Zhang, Zili Zuo, Yunfei Liu, Fangdie Ye, Baoluo Ma, Zhou Sun
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MiR-29a-3p mediates phosphatase and tensin homolog and inhibits osteoarthritis progression Funct. Integr. Genomics (IF 2.9) Pub Date : 2024-03-12 Kai Zhu, Yan Zhang, DongDong Li, MingZhong Xie, HuaCai Jiang, KaiQuan Zhang, Yang Lei, GuangYou Chen
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Huang Qin decoction increases SLC6A4 expression and blocks the NFκB-mediated NLRP3/Caspase1/GSDMD pathway to disrupt colitis-associated carcinogenesis Funct. Integr. Genomics (IF 2.9) Pub Date : 2024-03-12 Yili Tao, Lai Wang, Xiaofeng Ye, Xin Qian, Danye Pan, Xiaoyu Dong, Qian Jiang, Po Hu
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ZNF692 drives malignant development of hepatocellular carcinoma cells by promoting ALDOA-dependent glycolysis Funct. Integr. Genomics (IF 2.9) Pub Date : 2024-03-08 Weiwei Meng, Xiaojuan Lu, Guanglei Wang, Qingyu Xiao, Jing Gao
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Long non-coding RNA CCAT1 acts as an oncogene to promote radiation resistance in lung adenocarcinoma: an epigenomics-based investigation Funct. Integr. Genomics (IF 2.9) Pub Date : 2024-03-07 Jian Li, Shengnan Guo, Tianhao Li, Songliu Hu, Jianyu Xu, Xiangying Xu
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Exploring the potential biological function of GRK2 in colorectal cancer Funct. Integr. Genomics (IF 2.9) Pub Date : 2024-03-06 Meng Gao, Xinyi Liang, Mengqi Fan, Yutong Wu, Ming-you Dong, Run-Lei Du
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LINC02086 inhibits ferroptosis and promotes malignant phenotypes of pancreatic cancer via miR-342-3p/CA9 axis Funct. Integr. Genomics (IF 2.9) Pub Date : 2024-03-05
Abstract Long noncoding RNAs (lncRNAs) play important roles in modulating the tumorigenesis and progression of malignant tumors. LINC02086 is a newly identified oncogene associated with tumorigenesis, but its role in pancreatic cancer (PC) has not been fully elucidated. In this study we examined the expression levels of LINC02086, miR-342-3p, and CA9 in PC. The relationship of ferroptosis with these
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CRISPR/Cas genome editing in plants: mechanisms, applications, and overcoming bottlenecks Funct. Integr. Genomics (IF 2.9) Pub Date : 2024-03-05
Abstract The CRISPR/Cas systems have emerged as transformative tools for precisely manipulating plant genomes and enhancement. It has provided unparalleled applications from modifying the plant genomes to resistant enhancement. This review manuscript summarises the mechanism, application, and current challenges in the CRISPR/Cas genome editing technology. It addresses the molecular mechanisms of different
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Downregulation of lncRNA CDKN2B-AS1 attenuates inflammatory response in mice with allergic rhinitis by regulating miR-98-5p/SOCS1 axis Funct. Integr. Genomics (IF 2.9) Pub Date : 2024-03-04 Bangyu Deng, Yunxia zhao, Jisheng Liu
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Draft genome of novel cyanobacteria Sphaerothrix Gracilis isolated from coastal microplastics reveal insights to chemical ecology, bloom and plastic-utilization potential Funct. Integr. Genomics (IF 2.9) Pub Date : 2024-03-02 Emily Curren, Victor S. Kuwahara, Teruaki Yoshida, Sandric Chee Yew Leong
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Genome-wide identification and comparative analysis of the Amino Acid Transporter (AAT) gene family and their roles during Phaseolus vulgaris symbioses Funct. Integr. Genomics (IF 2.9) Pub Date : 2024-03-02 Kalpana Nanjareddy, María Fernanda Guerrero-Carrillo, Miguel Lara, Manoj-Kumar Arthikala
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Codon usage bias and phylogenetic analysis of chloroplast genome in 36 gracilariaceae species Funct. Integr. Genomics (IF 2.9) Pub Date : 2024-03-01 Tingting Li, Zheng Ma, Tiemei Ding, Yanxin Yang, Fei Wang, Xinjing Wan, Fangyun Liang, Xi Chen, Huipeng Yao
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Harnessing the potential of mutation breeding, CRISPR genome editing, and beyond for sustainable agriculture Funct. Integr. Genomics (IF 2.9) Pub Date : 2024-02-29 Nelissa Maisara Nor A’azizam, Sakshi Chopra, Praveen Guleria, Vineet Kumar, Muhamad Hafiz Abd Rahim, Jamilah Syafawati Yaacob
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De novo transcriptome assembly and global analysis of differential gene expression of aphid tolerant wild mustard Rorippa indica (L.) Hiern infested by mustard aphid Lipaphis Erysimi (L.) Kaltenbach Funct. Integr. Genomics (IF 2.9) Pub Date : 2024-02-29 Lekha Bandopadhyay, Debabrata Basu, Samir Ranjan Sikdar
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Comparative plastome analysis and taxonomic classification of snow lotus species (Saussurea, Asteraceae) in Central Asia and Southern Siberia Funct. Integr. Genomics (IF 2.9) Pub Date : 2024-02-23 Nudkhuu Nyamgerel, Shukherdorj Baasanmunkh, Batlai Oyuntsetseg, Zagarjav Tsegmed, Gun-Aajav Bayarmaa, Georgy Lazkov, Elizaveta Pyak, Hee-Young Gil, Inkyu Park, Hyeok Jae Choi
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Fusarium wilt pandemic: current understanding and molecular perspectives Funct. Integr. Genomics (IF 2.9) Pub Date : 2024-02-22 Dalpat Lal, Devanshu Dev, Sarita Kumari, Saurabh Pandey, Aparna, Nilesh Sharma, Sudha Nandni, Ratnesh Kumar Jha, Ashutosh Singh
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SENP3 mediates the activation of the Wnt/β-catenin signaling pathway to accelerate the growth and metastasis of oesophagal squamous cell carcinoma in mice Funct. Integr. Genomics (IF 2.9) Pub Date : 2024-02-22 Pengzeng Wang, Linan Yang, Yin Guo, Shuliang Qi, Jia Liang, Guo Tian, Ziqiang Tian
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OsCSN2 orchestrates Oryza sativa L. growth and development through modulation of the GA and BR pathways Funct. Integr. Genomics (IF 2.9) Pub Date : 2024-02-21
Abstract The COP9 signalosome (CSN) is a conserved protein complex found in higher eukaryotes, consisting of eight subunits, and it plays a crucial role in regulating various processes of plant growth and development. Among these subunits, CSN2 is one of the most conserved components within the COP9 signalosome complex. Despite its prior identification in other species, its specific function in Oryza
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miR-34c-5p inhibited fibroblast proliferation, differentiation and epithelial-mesenchymal transition in benign airway stenosis via MDMX/p53 pathway Funct. Integr. Genomics (IF 2.9) Pub Date : 2024-02-20
Abstract Benign airway stenosis (BAS) means airway stenosis or obstruction that results from a variety of non-malignant factors, including tuberculosis, trauma, benign tumors, etc. In consideration of the currently limited research on microRNAs in BAS, this study aimed to explore the role and mechanism of miR-34c-5p in BAS. The expression of miR-34c-5p in BAS granulation tissues showed a significant
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GSCIT: smart Hash Table-based mapping equipped genome sequence coverage inspection Funct. Integr. Genomics (IF 2.9) Pub Date : 2024-02-20 Samarth Godara, Shbana Begam, Ramcharan Bhattacharya, Hukam C. Rawal, Anil Kumar Singh, Vijay Jangir, Sudeep Marwaha, Rajender Parsad
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DKC1 aggravates gastric cancer cell migration and invasion through up-regulating the expression of TNFAIP6 Funct. Integr. Genomics (IF 2.9) Pub Date : 2024-02-20 Huihua Chen, Yibo Wu, Yancheng Jiang, Zixuan Chen, Tingjin Zheng
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PCDH8 is a novel prognostic biomarker in thyroid cancer and promotes cell proliferation and viability Funct. Integr. Genomics (IF 2.9) Pub Date : 2024-02-17 Ruida Yang, Nan Yang, Pan Yin, Zihan Xue, Feidi Sun, Ruihan Fan, JiaFu Liang, Xinru Lv, Shaobo Wu, Liankang Sun
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Unveiling the protective effects of BMSCs/anti-miR-124-3p exosomes on LPS-induced endometrial injury Funct. Integr. Genomics (IF 2.9) Pub Date : 2024-02-16 Yihong Chen, Shan Zheng, Xiumei Zhao, Yi Zhang, Suchai Yu, Juanbing Wei
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Genetic biofortification: advancing crop nutrition to tackle hidden hunger Funct. Integr. Genomics (IF 2.9) Pub Date : 2024-02-16 Usman Zulfiqar, Amman Khokhar, Muhammad Faisal Maqsood, Muhammad Shahbaz, Nargis Naz, Maheen Sara, Sana Maqsood, Sajila Sahar, Saddam Hussain, Muhammad Ahmad
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The novel miR-873-5p-YWHAE-PI3K/AKT axis is involved in non-small cell lung cancer progression and chemoresistance by mediating autophagy Funct. Integr. Genomics (IF 2.9) Pub Date : 2024-02-16 Zhifeng Li, Jinglei Liu, Ping Wang, Boyu Zhang, Guanghui He, Liwei Yang
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VEGFR affects miR-3200-3p-mediated regulatory T cell senescence in tumour-derived exosomes in non-small cell lung cancer Funct. Integr. Genomics (IF 2.9) Pub Date : 2024-02-16 Kaiyuan Hui, Changhong Dong, Chenxi Hu, Jiawen Li, Dongyue Yan, Xiaodong Jiang
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A prognostic marker LTBP1 is associated with epithelial mesenchymal transition and can promote the progression of gastric cancer Funct. Integr. Genomics (IF 2.9) Pub Date : 2024-02-15 Xinju Jiang, Shengjie Yin, Xin Yin, Yufei Wang, Tianyi Fang, Shuo Yang, Xiulan Bian, Guoli Li, Yingwei Xue, Lei Zhang
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LINC00942 inhibits ferroptosis and induces the immunosuppression of regulatory T cells by recruiting IGF2BP3/SLC7A11 in hepatocellular carcinoma Funct. Integr. Genomics (IF 2.9) Pub Date : 2024-02-14 Dong Jin, Yongfeng Hui, Di Liu, Nan Li, Junzhi Leng, Genwang Wang, Qi Wang, Zhenhui Lu
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Ubiquitination-specific protease 7 enhances stemness of hepatocellular carcinoma by stabilizing basic transcription factor 3 Funct. Integr. Genomics (IF 2.9) Pub Date : 2024-02-10
Abstract This study aims to explore the molecular regulation mechanism of ubiquitination-specific protease 7 (USP7) in facilitating the stemness properties of hepatocellular carcinoma (HCC). Gain-of-function and loss-of-function assays were conducted in SK-Hep1 and HepG2 cells transfected with USP7 overexpression/knockdown plasmids and USP7 inhibitor P22077. The proliferation, migration, invasion,
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Knockdown of circZMIZ1 enhances the anti-tumor activity of CD8+ T cells to alleviate hepatocellular carcinoma Funct. Integr. Genomics (IF 2.9) Pub Date : 2024-02-09
Abstract ZMIZ1 acts as an oncogene in hepatocellular carcinoma (HCC). circZMIZ1 (hsa_circ_0018964) derives from ZMIZ1; its underlying mechanism in HCC has not been reported. Peripheral blood and peripheral blood mononuclear cells (PBMCs) were obtained from HCC patients and healthy volunteers. CD8+ T cells were sorted from PBMCs of HCC patients. Applying flow cytometry, cell apoptosis and the proportion
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Genetics and metabolic responses of Artemisia annua L to the lake of phosphorus under the sparingly soluble phosphorus fertilizer: evidence from transcriptomics analysis Funct. Integr. Genomics (IF 2.9) Pub Date : 2024-02-08 Lingyun Wan, Juan Huo, Qiulan Huang, Xiaowen Ji, Lisha Song, Zhanjiang Zhang, Limei Pan, Jine Fu, Mohamed A. Abd Elhamid, Salma A. Soaud, Rania M. Y. Heakel, Jihai Gao, Shugen Wei, Ahmed H. El- Sappah
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Low FHL1 expression indicates a good prognosis and drug sensitivity in ovarian cancer Funct. Integr. Genomics (IF 2.9) Pub Date : 2024-02-07
Abstract Chemotherapy resistance is the main reason for the poor prognosis of ovarian cancer (OC). FHL1 is an important tumour regulator, but its relationship with the prognosis, drug resistance, and tumour microenvironment of OC is unknown. Immunohistochemistry was used to determine FHL1 expression in OC. Kaplan‒Meier plotter was used for survival analysis. The value of gene expression in predicting
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Mechanism of miR-7 mediating TLR4/TRAF6/NF-κB inflammatory pathway in colorectal cancer Funct. Integr. Genomics (IF 2.9) Pub Date : 2024-02-05 Jianfeng Ren, Bing Han, Ping Feng, Gang Shao, Yunli Chang
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Optimised stacked machine learning algorithms for genomics and genetics disorder detection in the healthcare industry Funct. Integr. Genomics (IF 2.9) Pub Date : 2024-02-02 Amjad Rehman, Muhammad Mujahid, Tanzila Saba, Gwanggil Jeon
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MHY1485 promotes adriamycin sensitivity in HepG2 cells by inhibiting autophagy Funct. Integr. Genomics (IF 2.9) Pub Date : 2024-02-02
Abstract MHY1485 is an mTOR activator that inhibits the autophagy process by inhibiting the fusion between autophagosomes and lysosomes. This study aimed to explore the role and mechanism of MHY1485 in hepatocellular carcinoma (HCC) and to provide an in-depth understanding of the mechanisms of autophagy regulation in relation to adriamycin (ADM) resistance, as well as the development of a molecularly
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Activation of CHPF by transcription factor NFIC promotes NLRP3 activation during the progression of colorectal cancer Funct. Integr. Genomics (IF 2.9) Pub Date : 2024-01-24 Jiamei Wu, Miao Wang, Yuechuan Zhang, Guohong Liu, Yutong Xing
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Integrating bulk-RNA sequencing and single-cell sequencing analyses to characterize adenosine-enriched tumor microenvironment landscape and develop an adenosine-related prognostic signature predicting immunotherapy in lung adenocarcinoma Funct. Integr. Genomics (IF 2.9) Pub Date : 2024-01-24 Tao Han, Jing Wu, Yafeng Liu, Jiawei Zhou, Rui Miao, Jianqiang Guo, Zhi Xu, Yingru Xing, Ying Bai, Dong Hu
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Single-cell RNA sequencing reveals the transcriptional heterogeneity of Tbx18-positive cardiac cells during heart development Funct. Integr. Genomics (IF 2.9) Pub Date : 2024-01-24 Xianglin Long, Jiangjun Wei, Qinghua Fang, Xin Yuan, Jianlin Du
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Ultrasensitive and fast detection of SARS-CoV-2 using RT-LAMP without pH-dependent dye Funct. Integr. Genomics (IF 2.9) Pub Date : 2024-01-20 Moneerah Alsaeed, Galyah Alhamid, Huseyin Tombuloglu, Juma H Kabanja, Aysel Karagoz, Guzin Tombuloglu, Ali A. Rabaan, Ebtesam Al-Suhaimi, Turgay Unver
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MyeloDB: a multi-omics resource for multiple myeloma Funct. Integr. Genomics (IF 2.9) Pub Date : 2024-01-20 Ambuj Kumar, Keerthana Vinod Kumar, Kavita Kundal, Avik Sengupta, Simran Sharma, Kunjulakshmi R, Rahul Kumar
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Small nucleolar RNA Snora73 promotes psoriasis progression by sponging miR-3074-5p and regulating PBX1 expression Funct. Integr. Genomics (IF 2.9) Pub Date : 2024-01-19
Abstract Chronic psoriasis is a kind of immune-mediated skin illness and the underlying molecular mechanisms of pathogenesis remain incompletely understood. Here, we used small RNA microarray assays to scan the differential expressed RNAs in psoriasis patient samples. The downstream miRNAs and its targets were predicted using bioinformatics analysis from online bases and confirmed using fluorescence
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Complete chloroplast genome of the Malus baccata var. gracilis provides insights into the evolution and phylogeny of Malus species Funct. Integr. Genomics (IF 2.9) Pub Date : 2024-01-18 Xin Qin, Qiang Hao, Xun Wang, Yangbo Liu, Chen Yang, Mengyi Sui, Yawen Zhang, Yanli Hu, Xuesen Chen, Zhiquan Mao, Yunfei Mao, Xiang Shen
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Overexpression of cucumber CYP82D47 enhances resistance to powdery mildew and Fusarium oxysporum f. sp. cucumerinum Funct. Integr. Genomics (IF 2.9) Pub Date : 2024-01-18 Hong-yu Wang, Peng-fei Li, Yu Wang, Chun-yu Chi, Xiao-xia Jin, Guo-hua Ding
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DNMT1/DNMT3a-mediated promoter hypermethylation and transcription activation of ICAM5 augments thyroid carcinoma progression Funct. Integr. Genomics (IF 2.9) Pub Date : 2024-01-17 Zanbin Li, Yong Ying, Xiangtai Zeng, Jiafeng Liu, Yang Xie, Zefu Deng, Zhiqiang Hu, Junjie Yang
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Identification of TIMPs signatures in Randall plaque from single-cell RNA sequencing (scRNA-Seq) analysis Funct. Integr. Genomics (IF 2.9) Pub Date : 2024-01-16 Muhammad Sarfaraz Iqbal, Xiaolu Duan, Habib Ali, Peng Kaoqing, Zezehun Liu, Nimra Sardar, Roua A. Alsubki, Kotb A. Attia, Asmaa M. Abushady, Di Gu, Guohua Zeng
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A novel tRNA-derived fragment tRF-3023b suppresses inflammation in RAW264.7 cells by targeting Cul4a through NF-κB signaling Funct. Integr. Genomics (IF 2.9) Pub Date : 2024-01-15 Ying Zhang, Hua Zhou, Xu Chen, Ningning Wang, Yunfei Zhan, Ziyi Huang, Kaiyi Ruan, Qiulan Qi, Min Deng, Yuxin Jiang
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CMTM 6 promotes the development of thyroid cancer by inhibiting NIS activity through activating the MAPK signaling pathway Funct. Integr. Genomics (IF 2.9) Pub Date : 2024-01-15 Xin Chen, Hao Shen, Huifang Liu, Liling Tan, Nuobei Zhang
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ETV7 promotes colorectal cancer progression through upregulation of IFIT3 Funct. Integr. Genomics (IF 2.9) Pub Date : 2024-01-10 Bao Chai, Yanjun Li, Yarong Guo, Zhuowei Zhang, Kai Jia, Xinhao Chai, Yuhong Suo
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Inhibition of FoxO1 alleviates polycystic ovarian syndrome by reducing inflammation and the immune response Funct. Integr. Genomics (IF 2.9) Pub Date : 2024-01-08 Xiaolan Huang, Xiangmin Luo, Suzhen Huang, Xiaoqing Chen, Lingling Qiu
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Unscheduled excessive R-loops in immune response Funct. Integr. Genomics (IF 2.9) Pub Date : 2024-01-08 Jiah D. Lee, Woori Bae