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Recombinant human IL-37 attenuates acute cardiac allograft rejection in mice Cytokine (IF 3.8) Pub Date : 2024-04-08 Bo Shao, Jing-yi Zhang, Shao-hua Ren, Ya-fei Qin, Hong-da Wang, Yong-chang Gao, De-jun Kong, Yong-hao Hu, Hong Qin, Guang-ming Li, Hao Wang
Allograft rejection remains a major obstacle to long-term graft survival. Although previous studies have demonstrated that IL-37 exhibited significant immunomodulatory effects in various diseases, research on its role in solid organ transplantation has not been fully elucidated. In this study, the therapeutic effect of recombinant human IL-37 (rhIL-37) was evaluated in a mouse cardiac allotransplantation
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Diagnostic, monitoring, and prognostic value of combined detection of cerebrospinal fluid heparin-binding protein, interleukin-6, interleukin-10, and procalcitonin for post-neurosurgical intracranial infection Cytokine (IF 3.8) Pub Date : 2024-04-06 Xinfang Pan, Dina Haishaer, Mei Liu, Shaobo Zhou, Heya Na, Hongmei Zhao
Intracranial infection is a common complication after neurosurgery and can increase the length of hospital stay, affect patient prognosis, and increase mortality. We aimed to investigate the value of the combined detection of cerebrospinal fluid (CSF) heparin-binding protein (HBP), interleukin-6 (IL-6), interleukin-10 (IL-10), and procalcitonin (PCT) for post-neurosurgical intracranial infection. This
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Low expression of interleukin-1 receptor antagonist correlates with poor prognosis via promoting proliferation and migration and inhibiting apoptosis in oral squamous cell carcinoma Cytokine (IF 3.8) Pub Date : 2024-04-05 Yujie Ding, Jie Yi, Yufei Shan, Jiaqi Gu, Zhida Sun, Jie Lin
Biomarkers are biochemical indicators that can identify changes in the structure or function of systems, organs, or cells and can be used to monitor a wide range of biological processes, including cancer. Interleukin-1 receptor antagonist (IL1RA) is an important inflammatory suppressor gene and tumor biomarker. The goal of this study was to investigate the expression of IL1RA, its probable carcinogenic
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Establishment of reference intervals for plasma IL-2, IL-4, IL-5, and IL-17A in healthy adults from the Jiangsu region of eastern China using flow cytometry: A single-center study Cytokine (IF 3.8) Pub Date : 2024-04-05 Qian Liu, Zhengping Xia, Tingting Huang, Fang Yang, Xizhen Wang, Fumeng Yang
Cytokines are of utmost importance in both the physiological and pathological immune responses of the human body. This study utilized flow cytometry to measure the levels of plasma interleukin-2 (IL-2), interleukin-4 (IL-4), interleukin-5 (IL-5) and interleukin-17A (IL-17A) and established their reference intervals, aiming to provide data support for the diagnosis and treatment of clinical diseases
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Expression and function of cytokine interleukin-22 gene in the tumor microenvironment of triple negative breast cancer Cytokine (IF 3.8) Pub Date : 2024-04-05 Yibin Xiao, Xia Zhao, Yihui Guo, Yanping Li
The tumor microenvironment (TME) and interleukin-22 (IL-22) in cytokines have recently attracted much attention due to their potential impact on tumor biology. However, the role of IL-22 in triple negative breast cancer (TNBC) TME is still poorly understood. This article investigated the gene expression and function of IL-22 in TNBC TME. Tumor samples from TNBC patients were collected, and adjacent
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LncRNAs involvement in pathogenesis of immune-related disease via regulation of T regulatory cells, an updated review Cytokine (IF 3.8) Pub Date : 2024-04-04 Shayan Khalilollah, Sina Kalantari Soltanieh, Raed Obaid Saleh, Abdullah Ali Alzahrani, Hatem Ghaleb Maabreh, Mais Mazin Al-Hamdani, Mahmoud Dehghani-Ghorbi, Metanat Shafiei Khonachaei, Reza Akhavan-Sigari
The pathophysiology of several illnesses, including cancer and autoimmune diseasesdepends on human regulatory T cells (Tregs), and abnormalities in these cells may function as triggers for these conditions. Cancer and autoimmune, and gynecological diseases are associated with the differentiation of the proinflammatory T cell subset TH17 and its balance with the production of Treg. Recently, long non-coding
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Diverse pro-inflammatory ability of mutated spike protein derived from variant strains of SARS-CoV-2 Cytokine (IF 3.8) Pub Date : 2024-04-03 Daisuke Kawata, Hideyuki Iwai, Seiya Oba, Yoji Komiya, Ryuji Koike, Sho Miyamoto, Takayuki Kanno, Akira Ainai, Tadaki Suzuki, Tadashi Hosoya, Shinsuke Yasuda
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Cytokine and chemokine profiles in women with endometriosis, polycystic ovary syndrome, and unexplained infertility Cytokine (IF 3.8) Pub Date : 2024-03-30 Alireza Omidvar-Mehrabadi, Fateme Ebrahimi, Mehdi Shahbazi, Mousa Mohammadnia-Afrouzi
Numerous factors (including immunological, congenital, hormonal, and morphological disorders) can lead to infertility. In this regard, 3 specific diseases associated with infertility are discussed in this review study (i.e., polycystic ovary syndrome [PCOS], endometriosis [EMS], and unexplained infertility [UI]). PCOS is a common endocrine disorder characterized by chronic low-grade inflammation, and
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Correlation of circulating fibroblast growth factor 21 levels with inflammatory factors and the degree of coronary artery stenosis in patients with acute myocardial infarction Cytokine (IF 3.8) Pub Date : 2024-03-29 Xu Liu, Mengying Dong, Tianyi Li, Junnan Wang
Fibroblast growth factor 21 (FGF21) is a secreted protein that plays an important role in atherosclerosis and pathological cardiac remodeling. However, the correlation between FGF21 and the degree of coronary artery stenosis and its potential role in acute myocardial infarction (AMI) remain unclear. We examined whether changes in FGF21 levels in AMI correlate with the degree of coronary artery stenosis
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Serum VEGF-A levels on admission in COVID-19 patients correlate with SP-D and neutrophils, reflecting disease severity: A prospective study Cytokine (IF 3.8) Pub Date : 2024-03-29 Mayoko Tsuji, Mitsuko Kondo, Yasuto Sato, Azusa Miyoshi, Fumi Kobayashi, Ken Arimura, Kaoru Yamashita, Satoshi Morimoto, Naoko Yanagisawa, Atsuhiro Ichihara, Etsuko Tagaya
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in significant global morbidity and mortality. This study aimed to investigate the clinical significance of serum vascular endothelial growth factor A (VEGF-A) in COVID-19 patients and its association with disease severity and pulmonary injury. We prospectively collected
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FOXP3 (in)stability and cancer immunotherapy Cytokine (IF 3.8) Pub Date : 2024-03-27 Keywan Mortezaee
Dysregulation of regulatory T cells (Tregs) is described in the context of inflammatory and autoimmune diseases, and cancer. Forkhead box P3 (FOXP3) is a transcription factor that its activity is an indicator of Treg identity. FOXP3 induces metabolic versatility in intra-tumoral Tregs, so that its deficiency mediates Treg instability or even gives rise to the acquisition of effector T cell phenotype
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Atypical chemoattractants and their receptors: A potential gateway to novel therapeutic strategies Cytokine (IF 3.8) Pub Date : 2024-03-26 James Edward Pease, Silvano Sozzani
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Dual blockade of interleukin-17A and interleukin-17F as a therapeutic strategy for liver fibrosis: Investigating the potential effect and mechanism of brodalumab Cytokine (IF 3.8) Pub Date : 2024-03-25 Kazuki M. Matsuda, Hirohito Kotani, Teruyoshi Hisamoto, Ai Kuzumi, Takemichi Fukasawa, Asako Yoshizaki-Ogawa, Shinichi Sato, Ayumi Yoshizaki
Liver fibrosis is a terminal manifestation of various chronic liver diseases. There are no drugs that can reverse the condition. Recently, the importance of interleukin-17 (IL17) in the pathophysiology has been revealed and has attracted attention as a therapeutic target. We aimed to reveal the roles of IL17A and IL17F in liver fibrosis, and to validate the potential of their dual blockade as therapeutic
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Understanding long COVID myocarditis: A comprehensive review Cytokine (IF 3.8) Pub Date : 2024-03-19 Arti Srivastava, Shankar Nalroad Sundararaj, Jagriti Bhatia, Dharamvir Singh Arya
Infectious diseases are a cause of major concern in this twenty-first century. There have been reports of various outbreaks like severe acute respiratory syndrome (SARS) in 2003, swine flu in 2009, Zika virus disease in 2015, and Middle East Respiratory Syndrome (MERS) in 2012, since the start of this millennium. In addition to these outbreaks, the latest infectious disease to result in an outbreak
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Platelet-derived sTLT-1 is associated with platelet-mediated inflammation in coronary artery disease patients Cytokine (IF 3.8) Pub Date : 2024-03-19 Amir Ali, Nadella Mounika, Bishamber Nath, Ebin Johny, Indra Kuladhipati, Rajesh Das, Monowar Hussain, Arun Bandyopadhyay, Ramu Adela
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Serum cytokine profiles during engraftment syndrome and acute graft-versus-host disease in adult patients after hematopoietic stem cell transplantation Cytokine (IF 3.8) Pub Date : 2024-03-16 Beiying Wu, Cen Jiang, Lilan Jin, Xiayidan Azadan, Jiafei Lin, Lin Lin, Xiaomeng Nie, Gang Cai
The underlying biology of engraftment syndrome (ES) following allogeneic hematopoietic stem cell transplantation (HSCT) is not fully elucidated, and the extent of its overlap with acute graft-versus-host disease (aGvHD) remains unclear. In order to establish potential indicator to distinguish ES more accurately, we conducted a retrospective analysis of cytokine levels during HSCT. A total of 121 consecutive
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Association of adiponectin and its receptor gene polymorphisms with the risk of coronary heart disease in northern Guangxi Cytokine (IF 3.8) Pub Date : 2024-03-14 Xiaohua Xiang, Di Wang, Jun Leng, Ning Li, Chuandong Wei
To investigate the association of circulating adiponectin (APN) level and single nucleotide polymorphisms (rs1501299 and rs266729) of the APN gene in the coronary heart disease (CHD) population of Northern Guangxi Province. Two hundred and sixty-three CHD patients and 235 healthy controls from our hospital from August 2018 to October 2020 were included in this study. ELISA was used to determine the
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Corrigendum to “The relationship between serum cytokine profile and vitamin D in calves with neonatal diarrhea” [Cytokine 165 (2023) 156173] Cytokine (IF 3.8) Pub Date : 2024-03-13 Mehmet Çalışkan, Murat Dabak, Kenan Çağrı Tümer
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Synthesis, characterization, and anti-inflammatory activity of tetrahydropiperine, piperic acid, and tetrahydropiperic acid via down regulation of NF-κB pathway Cytokine (IF 3.8) Pub Date : 2024-03-13 Diljeet Kumar, Aminur Rahman Sarkar, Nusrit Iqbal Andrabi, Syed Assim Haq, Manzoor Ahmed, Sanket Kumar Shukla, Zabeer Ahmed, Rajkishor Rai
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Genetic liability to elevated circulating IP-10, IFNγ and SCGFβ levels in relation to thoracic aortic aneurysm: A mendelian randomization study Cytokine (IF 3.8) Pub Date : 2024-03-13 Qianxi Ye, Miao Chen, Liang Ma
Inflammation is associated with thoracic aortic aneurysm (TAA) but the effects of each circulating inflammatory factor on TAA remain unclear. In this study, we explored the relationship between circulating inflammatory factors and TAA risk using Mendelian randomization (MR) approach based on summary statistics from the latest genome-wide association study (GWAS) of 41 circulating inflammatory factors
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Comprehensive analysis of multiple cytokines to stratify uropathogenic Escherichia coli pathogenesis in mouse model of urinary tract infection Cytokine (IF 3.8) Pub Date : 2024-03-12 Snehashis Koley, Mandira Mukherjee
Urinary tract infection (UTI) is one of the most common human bacterial infections primarily caused by uropathogenic (UPEC). Empiric treatment in UTI cause emergence of multidrug resistance and limit treatment options. Understanding UTI at the molecular level with respect to the causative pathogen as well as subsequent host response pose an absolute necessity towards appropriate clinical management
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IL-4 regulates neutrophilic pulmonary inflammation in a mouse model of bronchial asthma Cytokine (IF 3.8) Pub Date : 2024-03-12 I.P. Shilovskiy, A.A. Nikolskii, E.D. Timotievich, V.I. Kovchina, L.I. Vishnyakova, K.V. Yumashev, K.V. Vinogradova, M.M. Kaganova, V.E. Brylina, V.V. Tyulyubaev, T.E. Rusak, M.E. Dyneva, O.M. Kurbacheva, D.A. Kudlay, M.R. Khaitov
Neutrophilic pulmonary inflammation in asthmatics substantially exacerbates the severity of the disease leading to resistance to conventional corticosteroid therapy. Many studies established the involvement of Th1- and Th17-cells and cytokines produced by them (IFNg, IL-17A, IL-17F etc.) in neutrophilic pulmonary inflammation. Recent studies revealed that IL-4 – a Th2-cytokine regulates neutrophil
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Expression of monocyte chemokine receptors in diabetes after non-surgical periodontal treatment: A pilot study Cytokine (IF 3.8) Pub Date : 2024-03-11 Danielle Borges Germano, Ana Luíza Pereira Assunção Silveira, Yeon Jung Kim, Jônatas Bussador do Amaral, Marina Tiemi Shio, Luiz Henrique da Silva Nali, Carlos Eduardo dos Santos Ferreira, Alexandre Miyahira, Francisco Antonio Helfenstein Fonseca, André Luis Lacerda Bachi, Débora Pallos, Carolina Nunes França
The aim of this study was to evaluate the effect of non-surgical periodontal treatment in the expression of chemokine receptors, in individuals with Periodontitis, associated or not with Diabetes. Pilot study, which included patients (n = 45) with Periodontitis, associated (n = 25) or not (n = 20) with Diabetes, submitted to the non-surgical periodontal treatment for one month. The expression of chemokine
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Pepsin-mediated inflammation in laryngopharyngeal reflux via the ROS/NLRP3/IL-1β signaling pathway Cytokine (IF 3.8) Pub Date : 2024-03-11 Jia-Jie Tan, Yuan-Feng Dai, Fan Wang, Ze-Hong Lv, Li-Jun Huang, Ling-Yi Peng, Xiang-Ping Li
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CD4+ Foxp3+ Regulatory T-cells in Modulating Inflammatory Microenvironment in Chronic Rhinosinusitis with Nasal Polyps: Progress and Future Prospect Cytokine (IF 3.8) Pub Date : 2024-03-07 Nur Najwa Farahin M Yusoff, Suhana Ahmad, Wan Faiziah Wan Abdul Rahman, Rohimah Mohamud, Jennifer C.Boer, Magdalena Plebanski, Baharudin Abdullah, Xin Chen, Tengku Ahmad Damitri Al-Astani Tengku Din
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a subtype of chronic rhinosinusitis (CRS) characterized by the presence of nasal polyps (NP) in the paranasal mucosa. Despite the complex etiology, NP is believed to result from chronic inflammation. The long-term aftermath of the type 2 response is responsible for symptoms seen in NP patients, i.e. rhinorrhea, hyposmia, and nasal obstruction. Immune
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Cytokine storm in human monkeypox: A possible involvement of purinergic signaling Cytokine (IF 3.8) Pub Date : 2024-03-05 Gilnei Bruno da Silva, Geórgia de Carvalho Braga, Júlia Leão Batista Simões, Aniela Pinto Kempka, Margarete Dulce Bagatini
Some evidence has indicated that monkeypox can induce a cytokine storm. Purinergic signaling is a cell pathway related to the cytokine storm. However, the precise mechanisms that lead to cytokine storms in monkeypox infections and the possible involvement of purinergic signaling in the immune response to this virus remain unknown. In this review article, we aimed to highlight a body of scientific evidence
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Plasmatic profiles of cytokines/chemokines, glial fibrillary acidic protein (GFAP) and MRI brain damage in neonates with hypoxic ischemic encephalopathy (HIE) Cytokine (IF 3.8) Pub Date : 2024-03-04 Cinzia Auriti, Vito Mondì, Fiammetta Piersigilli, Laura Timelli, Tamara del Pinto, Giusi Prencipe, Giulia Lucignani, Daniela Longo, Iliana Bersani
Perinatal hypoxia triggers the release of cytokines and chemokines by neurons, astrocytes and microglia. In response to hypoxia–ischemia resting/ramified microglia proliferate and undergo activation, producing proinflammatory molecules. The brain damage extension seems to be related to both the severity of hypoxia and the balance between pro and anti-inflammatory response and can be explored with neuroimaging
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Cancer energy reprogramming and the immune responses Cytokine (IF 3.8) Pub Date : 2024-03-02 Xingxing Yuan, Serge Yannick Ouedraogo, Muhammed Trawally, Yurong Tan, Ousman Bajinka
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Investigation of IL-6 serum level in COVID-19 patients with positive COVID-19 IgG/IgM antibody titers to check inflammation and disease progression Cytokine (IF 3.8) Pub Date : 2024-03-02 Samaneh mollazadeh, Mahmoud Mahmoudi, Mojgan Mohammadi, Ramiar Kamal Kheder, Hussein Nasiri Mahallati, Salime Sarbaz Haghighi, Elnaz Masoumi, Zahra Javanmardi, Seyed-Alireza Esmaeili
The SARS-CoV-2, the cause of coronavirus disease 2019 (COVID-19), leads to severe pathogenicity and high mortality among different communities around the world. Therefore, it is important to understand the mechanisms of virus pathogenesis and the immune system's response to prevent the further spread of this virus. This study was aimed to evaluate the relationship between the serum level of interleukin
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Th2-predominant immune response underlies the pathogenesis of Dengue Cytokine (IF 3.8) Pub Date : 2024-03-01 Dipesh Kale, Ashish Kumar Vyas, Girish Chandra Bhatt, Ashvini Kumar Yadav, Anirudh K. Singh, Shashwati Nema, Debasis Biswas
Dengue is a rapidly emerging pandemic-prone disease, whose manifestations range from asymptomatic infection to life-threatening complications like Dengue Hemorrhagic Fever and Dengue Shock Syndrome. This study investigates and compares the immune response in clinically defined cohorts of Dengue with and without warning signs, with the aim of identifying immunological correlates of clinical disease
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Expression of Siglec-9 in peripheral blood neutrophils was increased and associated with disease severity in patients with AECOPD Cytokine (IF 3.8) Pub Date : 2024-02-27 Linyang Ge, Nan Wang, Zi Chen, Shuanglan Xu, Linfu Zhou
The pathogenesis and treatment strategies for chronic obstructive pulmonary disease (COPD) require further exploration. Abnormal neutrophil inflammation and the overexpression of neutrophil extracellular traps (NETs) are closely associated with acute exacerbations of COPD (AECOPD). Siglec-9, a specific receptor expressed on neutrophils that inhibits their function, prompted us to investigate its relationship
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Hookworm infection as a model for deepen knowledge of iron metabolism and erythropoiesis in anemia Cytokine (IF 3.8) Pub Date : 2024-02-27 Luis Fernando Viana Furtado, William Pereira Alves, Vivian Jordania da Silva, Élida Mara Leite Rabelo
Over the years, there has been progress in understanding the molecular aspects of iron metabolism and erythropoiesis. However, despite research conducted both in laboratories and living organisms, there are still unanswered questions due to the complex nature of these fields. In this study we investigated the effects of hookworm infection on iron metabolism and how the hosts response to anemia is affected
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Modulation of macrophages by a phillyrin-loaded thermosensitive hydrogel promotes skin wound healing in mice Cytokine (IF 3.8) Pub Date : 2024-02-27 Chenggang Huang, Jiajia Teng, Wei Liu, Junzhe Wang, An Liu
Impaired wound healing in traumatic skin injuries remains a severe clinical challenge due to impaired re-vascularization, harmful bacteria infection, and inflammation dysregulation. Macrophages are recognized as prominent immune cells in tissue regeneration and wound healing. Consequently, the modulation of macrophages provides a promising therapeutic target for wound healing disorders. Here, we aimed
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Joost Oppenheim: A pioneer of cytokine research Cytokine (IF 3.8) Pub Date : 2024-02-24 Dhan V. Kalvakolanu, Howard A. Young, Scott Durum
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Causal relationships between circulating inflammatory cytokines and diabetic neuropathy: A Mendelian Randomization study Cytokine (IF 3.8) Pub Date : 2024-02-23 Zhaoxiang Wang, Li Zhang, Bing Lu, Heping Sun, Shao Zhong
Emerging evidence suggests systemic inflammation as a critical mechanism underlying diabetic neuropathy. This study aimed to investigate the causal relationship between 41 circulating inflammatory cytokines and diabetic neuropathy. Summary statistics from previous Genome-Wide Association studies (GWAS) included pooled data on 41 inflammatory cytokines and diabetic neuropathy. A two-sample Mendelian
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Interferon-α induces differentiation of cancer stem cells and immunosuppression in hepatocellular carcinoma by upregulating CXCL8 secretion Cytokine (IF 3.8) Pub Date : 2024-02-22 Yu-Ting Ma, Lu Zheng, Cheng-Wen Zhao, Yue Zhang, Xin-Wei Xu, Xin-Yu Wang, Guo-Ping Niu, Zhong-Song Man, Feng Gu, Yong-Qiang Chen
Interferon-alpha (IFN-α) is widely used in the clinical treatment of patients with chronic hepatitis B and hepatocellular carcinoma (HCC). However, high levels of CXCL8 are associated with resistance to IFN-α therapy and poorer prognosis in advanced cancers. In this study, we investigated whether IFN-α could directly induce the production of CXCL8 in HCC cells and whether CXCL8 could antagonize the
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Inflammatory cytokines and risk of allergic rhinitis: A Mendelian randomization study Cytokine (IF 3.8) Pub Date : 2024-02-18 Xu Zhang, Peng Wang, Qiuling Dang, Xueqin Huang, Yingjie Xiao, Bing Guan
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New synthetic molecules incorporated into polymeric micelles used for treatment against visceral leishmaniasis Cytokine (IF 3.8) Pub Date : 2024-02-18 Camila S. Freitas, Isabela A.G. Pereira, Daniela P. Lage, Danniele L. Vale, Breno L. Pimenta, Nícia P. Soares, Samira S. Santiago, Vívian T. Martins, Raquel S.B. Câmara, Marcelo M. Jesus, Grasiele S.V. Tavares, Fernanda F. Ramos, Fernanda Ludolf, Lícia N.D. Magalhães, Fabrício M. Oliveira, Mariana C. Duarte, Miguel A. Chávez-Fumagalli, Adilson V. Costa, Bruno M. Roatt, Róbson R. Teixeira, Eduardo A
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TNFα-308G>A Polymorphism and Susceptibility to Immune Thrombocytopenia Purpura (ITP): Evidence From a Systematic Review and Meta-analysis Cytokine (IF 3.8) Pub Date : 2024-02-17 Seyyede Fatemeh Shams, Hassan Mehrad-Majd
Relation between the emergence of ITP and the presence of TNFα 308G/A polymorphism in the involved individuals has been studied by previous researchers in different ethnicity, but a definite result was not gained. So, this meta-analysis was performed to find an absolute answer to the question whether TNF-α-308G/A polymorphism is a susceptibility factor for ITP or not? Electronic databases including
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Hepatic expression of tumor necrosis factor-α and evaluation of MAPK-p38 and NFκB signaling pathways in autoimmune hepatitis Cytokine (IF 3.8) Pub Date : 2024-02-17 Márcia Maria Medeiros de Ataides Bezerra, Isabela Cristina de Farias Andrade, Júlio Cesar Dias de Melo Silva, Ana Clara Santos Costa, Raldney Ricardo Costa da Silva, Luydson Richardison Silva Vasconcelos, Maria de Fátima Cavalcanti Toscano Barreto, Leila Maria Moreira Beltrão Pereira, Sura Wanessa Santos Rocha
Autoimmune hepatitis (AIH) is a necroinflammatory disease that occurs when genetically susceptible individuals are exposed to an environmental trigger. It is a rare disease, and its epidemiological aspects are nearly unknown in Northeast Brazil. In the literature, the activation of components of the inflammatory cascade pathways, including interleukins such as TNF-α and signaling factors like MAPK-p38
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Effect of SARS-CoV-2 and Toxoplasma gondii co-infection on IFN-γ and TNF-α expression and its impact on disease severity Cytokine (IF 3.8) Pub Date : 2024-02-17 Magda S.A. Abdeltawab, Mohamed Fateen, Shimaa Saad El-Din, Riem M. Elmessiery, Osama Mohammady Mohamed, Khaled Marzouk Sadek, Engy Medhat, Alshaimaa M.R. Hamed
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The redox status and inflammatory cytokine landscape: Potential therapeutic targets in the modulation of inflammation Cytokine (IF 3.8) Pub Date : 2024-02-15 Ellora Sen
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The ever-expanding role of cytokine receptor DR3 in T cells Cytokine (IF 3.8) Pub Date : 2024-02-15 Nurcin Liman, Dominic Lanasa, Françoise Meylan, Jung-Hyun Park
Death Receptor 3 (DR3) is a cytokine receptor of the Tumor Necrosis Factor receptor superfamily that plays a multifaceted role in both innate and adaptive immunity. Based on the death domain motif in its cytosolic tail, DR3 had been proposed and functionally affirmed as a trigger of apoptosis. Further studies, however, also revealed roles of DR3 in other cellular pathways, including inflammation, survival
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Circulating TNF-RII, IP-10 and HGF are associated with severity of COVID-19 in oncologic patients Cytokine (IF 3.8) Pub Date : 2024-02-15 Jaime Carrillo-García, Serena Lacerenza, Nadia Hindi, David S. Moura, Gloria Marquina, Daniel Parra Corral, Jennifer Olalla, Juana María Cano Cano, Sergio Hoyos, Marta Renshaw, Jose L Mondaza-Hernández, Davide Di Lernia, Antonio Casado, Arantxa Manzano, Antonio Gutierrez, Javier Martin-Broto
The COVID-19 patients showed hyperinflammatory response depending on the severity of the disease but little have been reported about this response in oncologic patients that also were infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Sixty-five circulating cytokines/chemokines were quantified in 15 oncologic patients, just after SARS-CoV-2 infection and fourteen days later
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Cytokine responses to major human Cytomegalovirus antigens in mouse model Cytokine (IF 3.8) Pub Date : 2024-02-14 Sahar Essa, Hussain A Safar, Raj Raghupathy
Human cytomegalovirus (CMV) continues to be a source of severe complications in immunologically immature and immunocompromised hosts. Effective CMV vaccines that help diminish CMV disease in transplant patients and avoid congenital infection are essential. Though the exact roles of defense mechanisms are unidentified, virus-specific antibodies and cytokine responses are known to be involved in controlling
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Th17/IL-17A axis is critical for pulmonary arterial hypertension (PAH) in systemic sclerosis (SSc): SSc patients with high levels of serum IL-17A exhibit reduced lung functions and increased prevalence of PAH Cytokine (IF 3.8) Pub Date : 2024-02-13 Noriyasu Seki, Hideto Tsujimoto, Shuhei Tanemura, Sho Ishigaki, Hiroshi Takei, Kunio Sugahara, Keiko Yoshimoto, Mitsuhiro Akiyama, Yuko Kaneko, Kenji Chiba, Tsutomu Takeuchi
It is thought that systemic sclerosis (SSc) might be a T helper 17 (Th17) cell-driven autoimmune disease. Noticeably, pulmonary arterial hypertension (PAH) is a leading cause of death in patients with SSc. Here, we investigated the association between serum Th17-related cytokines and prevalence of PAH in SSc patients. This study included 72 SSc patients and 51 healthy controls (HC). We determined clinical
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Macrophage inhibitory factor alters the functionality of macrophages and their involvement in disease pathogenesis of active generalized vitiligo patients Cytokine (IF 3.8) Pub Date : 2024-02-09 Nikita Sain, Vishakha Hooda, Ashu Singh, Somesh Gupta, Sudheer Arava, Alpana Sharma
In autoimmune dermatitis patients, a macrophage migration inhibitory factor (MIF) is widely used to determine the severity of the diseases with other clinical parameters. Moreover, in vitiligo, MIF has shown significant positive correlation with the VASI (Vitiligo Area Scoring Index) score of both generalized and localized vitiligo patients. MIF function as pro-inflammatory cytokine and inhibited random
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A novel therapeutic approach to modulate the inflammatory cascade: A timely exogenous local inflammatory response attenuates the sepsis-induced cytokine storm Cytokine (IF 3.8) Pub Date : 2024-02-09 Meng Gong, Shiyi Qi, Zhiting Wu, Ying Huang, Lihua Wu, Xiangbin Wang, Lingling He, Lili Lin, Dong Lin
The emergence of severe sepsis is contingent upon the occurrence of a cytokine storm (CS), a multifaceted process intricately entwined with the temporal dimension, thereby rendering the infection response remarkably intricate. Consequently, it becomes imperative to discern and accurately identify the optimal timing for interventions, predicated upon the dynamic timeline of inflammatory changes. Moreover
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Antiviral treatment significantly reduces the levels of CXCL9, CXCL10 and CXCL11 in chronic hepatitis C Cytokine (IF 3.8) Pub Date : 2024-02-08 Leona Radmanić, Petra Šimičić, Kristian Bodulić, Adriana Vince, Snjezana Zidovec-Lepej
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sPD-L1 and sPD-L2 in plasma of patients with lung cancer and their clinical significance Cytokine (IF 3.8) Pub Date : 2024-02-07 Shiyang Han, Yan Zhang, Jingzhi Yuan, Yi Wu, Yun Zhou, Yan Zhou, Xiaowei Li, Shuru Zhou
Lung cancer is the leading cause of cancer death worldwide. We aim here to determine the soluble programmed death ligand-1 (sPD-L1) and soluble programmed death ligand-2 (sPD-L2) levels in the plasma of patients with lung cancer and evaluate the clinical significance. Plasma samples from 95 lung cancer patients and 55 healthy donors were collected, and the sPD-L1 and sPD-L2 levels were measured using
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Inhibition of HMGB1 improves experimental mice colitis by mediating NETs and macrophage polarization Cytokine (IF 3.8) Pub Date : 2024-02-06 Xiaohong Chen, SaChuLa Bao, Meng Liu, Zheng Han, Jie Tan, Qingxi Zhu, Xiaodong Huang, Xia Tian
Inflammatory bowel disease (IBD) is listed by the World Health Organization as one of the modern intractable diseases. High mobility histone box 1 (HMGB1), originally described as a non-histone nucleoprotein involved in transcriptional regulation, was later identified as a pro-inflammatory cytokine that may contribute to the pathogenesis of inflammatory diseases such as IBD. Neutrophil extracellular
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Delayed CCL23 response is associated with poor outcomes after cardiac arrest Cytokine (IF 3.8) Pub Date : 2024-02-06 Joanne T. deKay, Elena Chepurko, Vadim Chepurko, Lacey Knudsen, Christine Lord, Meghan Searight, Sergey Tsibulnikov, Michael P. Robich, Douglas B. Sawyer, David J. Gagnon, Teresa May, Richard Riker, David B. Seder, Sergey Ryzhov
Late chemokine response is associated with poor outcomes in patients after cardiac arrest.
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A gain of function mutation in AKT1 increases hexokinase 2 and diminishes oxidative stress in meningioma Cytokine (IF 3.8) Pub Date : 2024-02-06 Swati Singh, Kirti Lathoria, Sonia B. Umdor, Jyotsna Singh, Vaishali Suri, Ellora Sen
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Expression of concern “The role of the CD95, CD38 and TGFβ1 during active human cytomegalovirus infection in liver transplantation” [Cytokine 35(3-4) (2006) 193–199] Cytokine (IF 3.8) Pub Date : 2024-02-05 Yuliang Wang, Yawu Liu, Yanyan Zhang, Lin Peng, Jun Ma, Zhiqin Tang, Wei Gao, Zhijun Zhu, Zhi Yao
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Expression of concern “Expression of fibroblast growth factor 21 in patients with biliary atresia” [Cytokine 83 (2016) 13–18] Cytokine (IF 3.8) Pub Date : 2024-02-03 Dawei Li, Tianfei Lu, Conghuan Shen, Yuan Liu, Jiang Zhang, Yuhua Shan, Yi Luo, Zhifeng Xi, Bijun Qiu, Qimin Chen, Jianjun Zhang, Qiang Xia
Abstract not available
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Long non-coding RNA Linc00657 up-regulates Skp2 to promote the progression of cervical cancer through lipid reprogramming and regulation of immune microenvironment Cytokine (IF 3.8) Pub Date : 2024-02-03 Yuting Li, Gulikezi Maimaitirexiati, Jing Wang, Jin Zhang, Ping Tian, Changhui Zhou, Jingqin Ren, Lingjie Wang, Jiaqi Zhao, Hengyu Wang, Zhen Chen, Xue Li, Qi Yan, Nazila Saitiniyazi, Chengqing Liu, Jiabo Wang, Nan Yang, Xiaoya Xu, Lu Ding, Cailing Ma, Rong Li
More and more evidence shows that long non-coding RNA (lncRNA) plays an important role in the biological behavior of many kinds of malignant tumors, but the specific function of lncRNA in cervical cancer is still unknown. The purpose of this study is to explore the effect of on the malignant progression of cervical cancer and its potential mechanism. In two kinds of cervical cancer cell lines and normal
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Early changes in serum interleukin-6 levels in extremely premature newborns for detecting fetal inflammation Cytokine (IF 3.8) Pub Date : 2024-02-02 Sota Iwatani, Takao Kobayashi, Toshihiko Ikuta, Makiko Yoshida, Seiji Yoshimoto
Fetal inflammatory response syndrome (FIRS) is defined by elevated levels of inflammatory cytokines circulating in fetal blood, which may result in preterm morbidities. Serum interleukin-6 (IL-6) level has been reported to be a good indicator of FIRS; however, changes in IL-6 levels after birth remain to be elucidated. Herein, we characterized early changes in serum IL-6 levels in extremely premature
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Natural variability of TRAIL, IP-10, and CRP in healthy adults – The “HERACLES” study Cytokine (IF 3.8) Pub Date : 2024-02-02 Annefleur C. Langedijk, Katrien Oude Rengerink, Eline Harding, Annemarie Wensing, Rianne van Slooten, Yael Israeli, Michal Rosenberg, Tanya Gottlieb, Eran Eden, Louis J. Bont
A novel host-protein score (called MMBV) helps to distinguish bacterial from viral infection by combining the blood concentrations of three biomarkers: tumour necrosis factor related apoptosis inducing ligand (TRAIL), interferon gamma induced protein 10 (IP-10), and C-reactive protein (CRP). These host biomarkers are differentially expressed in response to bacterial versus viral acute infection. We
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Increased tissue expression of IL-31 in patients with psoriasis Cytokine (IF 3.8) Pub Date : 2024-02-01 Rachot Wongjirattikarn, Nipon Chaisuriya, Suteeraporn Chaowattanapanit, Piti Ungarreevittaya, Pirawan Poosekeaw, Kengkart Winaikosol, Charoen Choonhakarn, Narachai Julanon, Eakkapol Utchariyaprasit, Kittisak Sawanyawisuth
Psoriasis is a chronic inflammatory skin disease, and its pathogenesis remains unclear. Although many studies have demonstrated the role of serum interleukin-31 (IL-31) in psoriasis, only one study has examined histopathological expression in lesional skin. This study aimed to investigate the expression of IL-31 in skin biopsy specimens of psoriasis patients compared to healthy subjects and identify