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Oncogenic circ-SLC16A1 promotes progression of non-small cell lung cancer via regulation of the miR-1287-5p/profilin 2 axis Cell. Mol. Biol. Lett. (IF 8.3) Pub Date : 2024-03-27 Mingming Jin, Tailei Yuan, Kaisai Tian, Jingjing Li, Qingqing Huang, Yongbin Chi, Gang Huang
Circular RNAs (circRNAs) are single-stranded RNAs with covalently closed structures that have been implicated in cancer progression. However, the regulatory mechanisms remain largely unclear. So, the aim of this study was to reveal the role and regulatory mechanisms of circ-SLC16A1. In this study, next-generation sequencing was used to identify abnormally expressed circRNAs between cancerous and para-carcinoma
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Decoding epitranscriptomic regulation of viral infection: mapping of RNA N6-methyladenosine by advanced sequencing technologies Cell. Mol. Biol. Lett. (IF 8.3) Pub Date : 2024-03-27 Xiangdong Fan, Yitong Zhang, Ruiying Guo, Kuo Yue, Guy Smagghe, Yongyue Lu, Luoluo Wang
Elucidating the intricate interactions between viral pathogens and host cellular machinery during infection is paramount for understanding pathogenic mechanisms and identifying potential therapeutic targets. The RNA modification N6-methyladenosine (m6A) has emerged as a significant factor influencing the trajectory of viral infections. Hence, the precise and quantitative mapping of m6A modifications
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Emerging roles of prominin-1 (CD133) in the dynamics of plasma membrane architecture and cell signaling pathways in health and disease Cell. Mol. Biol. Lett. (IF 8.3) Pub Date : 2024-03-26 Petr Pleskač, Christine A. Fargeas, Renata Veselska, Denis Corbeil, Jan Skoda
Prominin-1 (CD133) is a cholesterol-binding membrane glycoprotein selectively associated with highly curved and prominent membrane structures. It is widely recognized as an antigenic marker of stem cells and cancer stem cells and is frequently used to isolate them from biological and clinical samples. Recent progress in understanding various aspects of CD133 biology in different cell types has revealed
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Role of ferroptosis and ferroptosis-related long non'coding RNA in breast cancer Cell. Mol. Biol. Lett. (IF 8.3) Pub Date : 2024-03-26 Shasha Xiang, Wen Yan, Xing Ren, Jianbo Feng, Xuyu Zu
Ferroptosis, a therapeutic strategy for tumours, is a regulated cell death characterised by the increased accumulation of iron-dependent lipid peroxides (LPO). Tumour-associated long non-coding RNAs (lncRNAs), when combined with traditional anti-cancer medicines or radiotherapy, can improve efficacy and decrease mortality in cancer. Investigating the role of ferroptosis-related lncRNAs may help strategise
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IGF2BP3 prevent HMGB1 mRNA decay in bladder cancer and development Cell. Mol. Biol. Lett. (IF 8.3) Pub Date : 2024-03-19 Lei Lv, Qinqin Wei, Jianxiao Zhang, Yitong Dong, Zhenglei Shan, Na Chang, Ye Zhao, Po Bian, Qiyi Yi
IGF2BP3 functions as an RNA-binding protein (RBP) and plays a role in the posttranscriptional control of mRNA localization, stability, and translation. Its dysregulation is frequently associated with tumorigenesis across various cancer types. Nonetheless, our understanding of how the expression of the IGF2BP3 gene is regulated remains limited. The specific functions and underlying mechanisms of IGF2BP3
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Uremic toxins mediate kidney diseases: the role of aryl hydrocarbon receptor Cell. Mol. Biol. Lett. (IF 8.3) Pub Date : 2024-03-15 Hongyan Xie, Ninghao Yang, Chen Yu, Limin Lu
Aryl hydrocarbon receptor (AhR) was originally identified as an environmental sensor that responds to pollutants. Subsequent research has revealed that AhR recognizes multiple exogenous and endogenous molecules, including uremic toxins retained in the body due to the decline in renal function. Therefore, AhR is also considered to be a uremic toxin receptor. As a ligand-activated transcriptional factor
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MRE11A: a novel negative regulator of human DNA mismatch repair Cell. Mol. Biol. Lett. (IF 8.3) Pub Date : 2024-03-14 Demin Du, Yueyan Yang, Yuanyuan Zhang, Guanxiong Wang, Liying Chen, Xiaowei Guan, Lene Juel Rasmussen, Dekang Liu
DNA mismatch repair (MMR) is a highly conserved pathway that corrects DNA replication errors, the loss of which is attributed to the development of various types of cancers. Although well characterized, MMR factors remain to be identified. As a 3′–5′ exonuclease and endonuclease, meiotic recombination 11 homolog A (MRE11A) is implicated in multiple DNA repair pathways. However, the role of MRE11A in
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Obesity-induced downregulation of miR-192 exacerbates lipopolysaccharide-induced acute lung injury by promoting macrophage activation Cell. Mol. Biol. Lett. (IF 8.3) Pub Date : 2024-03-14 Siqi Wu, Wenjing Tang, Ling Liu, Ke Wei, Yin Tang, Jingyue Ma, Hongbin Li, Yichan Ao
Macrophage activation may play a crucial role in the increased susceptibility of obese individuals to acute lung injury (ALI). Dysregulation of miRNA, which is involved in various inflammatory diseases, is often observed in obesity. This study aimed to investigate the role of miR-192 in lipopolysaccharide (LPS)-induced ALI in obese mice and its mechanism of dysregulation in obesity. Human lung tissues
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The micro-743a-3p–GSTM1 pathway is an endogenous protective mechanism against alcohol-related liver disease in mice Cell. Mol. Biol. Lett. (IF 8.3) Pub Date : 2024-03-12 Tiantian Xu, Yan Pan, Qinchao Ding, Feiwei Cao, Kaixin Chang, Jiannan Qiu, Hui Zhuge, Liuyi Hao, Haibin Wei, Caijuan Si, Xiaobing Dou, Songtao Li
Epidemiological evidence suggests that the phenotype of glutathione S-transferase mu 1 (GSTM1), a hepatic high-expressed phase II detoxification enzyme, is closely associated with the incidence of alcohol-related liver disease (ALD). However, whether and how hepatic GSTM1 determines the development of ALD is largely unclear. This study was designed to elucidate the role and potential mechanism(s) of
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A multiplex RPA-CRISPR/Cas12a-based POCT technique and its application in human papillomavirus (HPV) typing assay Cell. Mol. Biol. Lett. (IF 8.3) Pub Date : 2024-03-08 Yan Liu, Zhujun Chao, Wei Ding, Tanfeng Fang, Xinxian Gu, Man Xue, Wei Wang, Rong Han, Wanping Sun
Persistent infection with high-risk human papillomavirus (HR-HPV) is the primary and initiating factor for cervical cancer. With over 200 identified HPV types, including 14 high-risk types that integrate into the host cervical epithelial cell DNA, early determination of HPV infection type is crucial for effective risk stratification and management. Presently, on-site immediate testing during the HPV
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Unlocking the secrets: exploring the influence of the aryl hydrocarbon receptor and microbiome on cancer development Cell. Mol. Biol. Lett. (IF 8.3) Pub Date : 2024-03-06 Menatallah Rayan, Tahseen S. Sayed, Ola J. Hussein, Lubna Therachiyil, Zaid H. Maayah, Cristina Maccalli, Shahab Uddin, Jochen H. M. Prehn, Hesham M. Korashy
Gut microbiota regulates various aspects of human physiology by producing metabolites, metabolizing enzymes, and toxins. Many studies have linked microbiota with human health and altered microbiome configurations with the occurrence of several diseases, including cancer. Accumulating evidence suggests that the microbiome can influence the initiation and progression of several cancers. Moreover, some
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Curriculum vitae of CUG binding protein 1 (CELF1) in homeostasis and diseases: a systematic review Cell. Mol. Biol. Lett. (IF 8.3) Pub Date : 2024-03-05 Wan‑Jia Qin, Jin-Jin Shi, Ru-Yi Chen, Chang-Yun Li, Yan-Jun Liu, Jian-Fei Lu, Guan-Jun Yang, Jia-Feng Cao, Jiong Chen
RNA-binding proteins (RBPs) are kinds of proteins with either singular or multiple RNA-binding domains (RBDs), and they can assembly into ribonucleic acid–protein complexes, which mediate transportation, editing, splicing, stabilization, translational efficiency, or epigenetic modifications of their binding RNA partners, and thereby modulate various physiological and pathological processes. CUG-BP
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Inhibition of Drp1- Fis1 interaction alleviates aberrant mitochondrial fragmentation and acute kidney injury Cell. Mol. Biol. Lett. (IF 8.3) Pub Date : 2024-03-04 Zhixia Song, Yao Xia, Lang Shi, Hongchu Zha, Jing Huang, Xiaohong Xiang, Huiming Li, Hua Huang, Ruchi Yue, Hongtao Wang, Jiefu Zhu
Acute kidney injury (AKI) is a common clinical disorder with complex etiology and poor prognosis, and currently lacks specific and effective treatment options. Mitochondrial dynamics dysfunction is a prominent feature in AKI, and modulation of mitochondrial morphology may serve as a potential therapeutic approach for AKI. We induced ischemia–reperfusion injury (IRI) in mice (bilateral) and Bama pigs
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Nrf2 activation: a key mechanism in stem cell exosomes-mediated therapies Cell. Mol. Biol. Lett. (IF 8.3) Pub Date : 2024-03-02 Zeinab Vahidinia, Abolfazl Azami Tameh, Shirin Barati, Melika Izadpanah, Elahe Seyed Hosseini
Exosomes are nano-sized membrane extracellular vesicles which can be released from various types of cells. Exosomes originating from inflammatory or injured cells can have detrimental effects on recipient cells, while exosomes derived from stem cells not only facilitate the repair and regeneration of damaged tissues but also inhibit inflammation and provide protective effects against various diseases
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Loss of miR-101-3p in melanoma stabilizes genomic integrity, leading to cell death prevention Cell. Mol. Biol. Lett. (IF 8.3) Pub Date : 2024-03-02 Lisa Lämmerhirt, Melanie Kappelmann-Fenzl, Stefan Fischer, Paula Meier, Sebastian Staebler, Silke Kuphal, Anja-Katrin Bosserhoff
Malignant melanoma remains the most lethal form of skin cancer, exhibiting poor prognosis after forming distant metastasis. Owing to their potential tumor-suppressive properties by regulating oncogenes and tumor suppressor genes, microRNAs are important player in melanoma development and progression. We defined the loss of miR-101-3p expression in melanoma cells compared with melanocytes and melanoblast-related
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N6-methyladenosine-modified circ_104797 sustains cisplatin resistance in bladder cancer through acting as RNA sponges Cell. Mol. Biol. Lett. (IF 8.3) Pub Date : 2024-02-23 Congjie Xu, Jiaquan Zhou, Xiaoting Zhang, Xinli Kang, Shuan Liu, Mi Song, Cheng Chang, Youtu Lin, Yang Wang
Bladder cancer (BCa) ranks among the predominant malignancies affecting the urinary system. Cisplatin (CDDP) remains a cornerstone therapeutic agent for BCa management. Recent insights suggest pivotal roles of circular RNA (circRNA) and N6-methyladenosine (m6A) in modulating CDDP resistance in BCa, emphasizing the importance of elucidating these pathways to optimize cisplatin-based treatments. Comprehensive
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The ancestral type of the R-RAS protein has oncogenic potential Cell. Mol. Biol. Lett. (IF 8.3) Pub Date : 2024-02-21 Antea Talajić, Kristina Dominko, Marija Lončarić, Andreja Ambriović-Ristov, Helena Ćetković
The R-RAS2 is a small GTPase highly similar to classical RAS proteins at the regulatory and signaling levels. The high evolutionary conservation of R-RAS2, its links to basic cellular processes and its role in cancer, make R-RAS2 an interesting research topic. To elucidate the evolutionary history of R-RAS proteins, we investigated and compared structural and functional properties of ancestral type
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High-content image screening to identify chemical modulators for peroxisome and ferroptosis Cell. Mol. Biol. Lett. (IF 8.3) Pub Date : 2024-02-17 Daheng Zheng, Fei Li, Shanshan Wang, Pu-Ste Liu, Xin Xie
The peroxisome is a dynamic organelle with variety in number, size, shape, and activity in different cell types and physiological states. Recent studies have implicated peroxisomal homeostasis in ferroptosis susceptibility. Here, we developed a U-2OS cell line with a fluorescent peroxisomal tag and screened a target-selective chemical library through high-content imaging analysis. U-2OS cells stably
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CircMAST1 inhibits cervical cancer progression by hindering the N4-acetylcytidine modification of YAP mRNA Cell. Mol. Biol. Lett. (IF 8.3) Pub Date : 2024-02-08 Chunyu Zhang, Li Yuan, Qiaojian Zou, Caixia Shao, Yan Jia, Jiaying Li, Yan Liao, Xueyuan Zhao, Weijia Wen, Xu Jing, Guofen Yang, Wei Wang, Hongye Jiang, Shuzhong Yao
Cervical cancer (CCa) is the fourth most common cancer among females, with high incidence and mortality rates. Circular RNAs (circRNAs) are key regulators of various biological processes in cancer. However, the biological role of circRNAs in cervical cancer (CCa) remains largely unknown. This study aimed to elucidate the role of circMAST1 in CCa. CircRNAs related to CCa progression were identified
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The direct binding of bioactive peptide Andersonin-W1 to TLR4 expedites the healing of diabetic skin wounds Cell. Mol. Biol. Lett. (IF 8.3) Pub Date : 2024-02-05 Chao Li, Yuxin Xiong, Zhe Fu, Yuxin Ji, Jiayi Yan, Yan Kong, Ying Peng, Zeqiong Ru, Yubing Huang, Yilin Li, Ying Yang, Li He, Jing Tang, Ying Wang, Xinwang Yang
Chronic nonhealing wounds remain a considerable challenge in clinical treatment due to excessive inflammation and impeded reepithelialization and angiogenesis. Therefore, the discovery of novel prohealing agents for chronic skin wounds are urgent and important. Amphibian-derived prohealing peptides, especially immunomodulatory peptides, provide a promising strategy for the treatment of chronic skin
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Ubiquitous protein lactylation in health and diseases Cell. Mol. Biol. Lett. (IF 8.3) Pub Date : 2024-02-05 Junyong Wang, Ziyi Wang, Qixu Wang, Xiao Li, Yaping Guo
For decades, lactate has been considered a byproduct of glycolysis. The lactate shuttle hypothesis shifted the lactate paradigm, demonstrating that lactate not only plays important roles in cellular metabolism but also cellular communications, which can transcend compartment barriers and can occur within and among different cells, tissues and organs. Recently, the discovery that lactate can induce
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IP3R1-mediated MAMs formation contributes to mechanical trauma-induced hepatic injury and the protective effect of melatonin Cell. Mol. Biol. Lett. (IF 8.3) Pub Date : 2024-02-02 Rui Shi, Zhenhua Liu, Huan Yue, Man Li, Simin Liu, Dema De, Runjing Li, Yunan Chen, Shuli Cheng, Xiaoming Gu, Min Jia, Jun Li, Juan Li, Shumiao Zhang, Na Feng, Rong Fan, Feng Fu, Yali Liu, Mingge Ding, Jianming Pei
There is a high morbidity and mortality rate in mechanical trauma (MT)-induced hepatic injury. Currently, the molecular mechanisms underlying liver MT are largely unclear. Exploring the underlying mechanisms and developing safe and effective medicines to alleviate MT-induced hepatic injury is an urgent requirement. The aim of this study was to reveal the role of mitochondria-associated ER membranes
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New insights into the role of mitochondrial metabolic dysregulation and immune infiltration in septic cardiomyopathy by integrated bioinformatics analysis and experimental validation Cell. Mol. Biol. Lett. (IF 8.3) Pub Date : 2024-01-30 Yukun Li, Jiachi Yu, Ruibing Li, Hao Zhou, Xing Chang
Septic cardiomyopathy (SCM), a common cardiovascular comorbidity of sepsis, has emerged among the leading causes of death in patients with sepsis. SCM’s pathogenesis is strongly affected by mitochondrial metabolic dysregulation and immune infiltration disorder. However, the specific mechanisms and their intricate interactions in SCM remain unclear. This study employed bioinformatics analysis and drug
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Role of microRNA-4739 in enhancing cisplatin chemosensitivity by negative regulation of RHBDD2 in human cervical cancer cells Cell. Mol. Biol. Lett. (IF 8.3) Pub Date : 2024-01-25 Yuling Li, Zhengtong Zhou, Jinfeng Qu, Peiling Gong, Yuyan Wei, Yaping Sun
Cisplatin (DDP) is a widely used chemotherapy drug for advanced cervical cancer (CC), but resistance poses a significant challenge. While miR-4739 has been implicated in tumor development, its specific role in regulating DDP resistance in CC remains unclear. We analyzed the expression levels of miR-4739 and RHBDD2 in DDP-resistant and DDP-sensitive CC tissues using quantitative real-time polymerase
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Regulation of tumor metastasis and CD8+ T cells infiltration by circRNF216/miR-576-5p/ZC3H12C axis in colorectal cancer Cell. Mol. Biol. Lett. (IF 8.3) Pub Date : 2024-01-24 Wenqi Du, Xin Quan, Chaoqun Wang, Qiuya Song, Jie Mou, Dongsheng Pei
The tumor immune microenvironment (TIME) is an important regulator of tumor progression, growth and metastasis. In addition, tumor metastasis is one of the principal obstacles to the treatment of colorectal cancer (CRC). Circular RNAs (circRNAs) have been recognized as important regulators in the development of malignancies. However, their specific roles and mechanisms in both CRC metastasis and TIME
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Pro-inflammatory cytokines stimulate CFTR-dependent anion secretion in pancreatic ductal epithelium Cell. Mol. Biol. Lett. (IF 8.3) Pub Date : 2024-01-23 Dora Angyal, Tessa A. Groeneweg, Anny Leung, Max Desain, Kalyan Dulla, Hugo R. de Jonge, Marcel J. C. Bijvelds
Loss of CFTR-dependent anion and fluid secretion in the ducts of the exocrine pancreas is thought to contribute to the development of pancreatitis, but little is known about the impact of inflammation on ductal CFTR function. Here we used adult stem cell-derived cell cultures (organoids) obtained from porcine pancreas to evaluate the effects of pro-inflammatory cytokines on CFTR function. Organoids
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FFAR4 activation inhibits lung adenocarcinoma via blocking respiratory chain complex assembly associated mitochondrial metabolism Cell. Mol. Biol. Lett. (IF 8.3) Pub Date : 2024-01-19 Zhe Wang, Jinyou Li, LongFei Wang, Yaowei Liu, Wei Wang, JiaYao Chen, HuiJun Liang, Y. Q. Chen, ShengLong Zhu
Despite notable advancements in the investigation and management of lung adenocarcinoma (LUAD), the mortality rate for individuals afflicted with LUAD remains elevated, and attaining an accurate prognosis is challenging. LUAD exhibits intricate genetic and environmental components, and it is plausible that free fatty acid receptors (FFARs) may bridge the genetic and dietary aspects. The objective of
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Correction: ALKBH5 in mouse testicular Sertoli cells regulates Cdh2 mRNA translation to maintain blood–testis barrier integrity Cell. Mol. Biol. Lett. (IF 8.3) Pub Date : 2024-01-18 Zhonglin Cai, Yao Zhang, Lin Yang, Chunhui Ma, Yi Fei, Jing Ding, Wei Song, Wei-Min Tong, Yamei Niu, Hongjun Li
Correction: Cellular & Molecular Biology Letters (2022) 27:101 https://doi.org/10.1186/s11658-022-00404-x Following publication of the original article [1], the authors corrected the Funding section. The incorrect Funding is: This work is supported by the Grant from National Natural Science Foundation of China (81871152, 82171588), National Key R&D Program of China (2019YFA080703), and Chinese Academy
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SUMOylation modulates eIF5A activities in both yeast and pancreatic ductal adenocarcinoma cells Cell. Mol. Biol. Lett. (IF 8.3) Pub Date : 2024-01-16 Rocío Seoane, Tomás Lama-Díaz, Antonia María Romero, Ahmed El Motiam, Arantxa Martínez-Férriz, Santiago Vidal, Yanis H. Bouzaher, María Blanquer, Rocío M. Tolosa, Juan Castillo Mewa, Manuel S. Rodríguez, Adolfo García-Sastre, Dimitris Xirodimas, James D. Sutherland, Rosa Barrio, Paula Alepuz, Miguel G. Blanco, Rosa Farràs, Carmen Rivas
The eukaryotic translation initiation protein eIF5A is a highly conserved and essential factor that plays a critical role in different physiological and pathological processes including stress response and cancer. Different proteomic studies suggest that eIF5A may be a small ubiquitin-like modifier (SUMO) substrate, but whether eIF5A is indeed SUMOylated and how relevant is this modification for eIF5A
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Mechanistic role of quercetin as inhibitor for adenosine deaminase enzyme in rheumatoid arthritis: systematic review Cell. Mol. Biol. Lett. (IF 8.3) Pub Date : 2024-01-16 Amira Atta, Maha M. Salem, Karim Samy El-Said, Tarek M. Mohamed
Rheumatoid arthritis (RA) is an autoimmune disease involving T and B lymphocytes. Autoantibodies contribute to joint deterioration and worsening symptoms. Adenosine deaminase (ADA), an enzyme in purine metabolism, influences adenosine levels and joint inflammation. Inhibiting ADA could impact RA progression. Intracellular ATP breakdown generates adenosine, which increases in hypoxic and inflammatory
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Multipronged regulation of autophagy and apoptosis: emerging role of TRIM proteins Cell. Mol. Biol. Lett. (IF 8.3) Pub Date : 2024-01-16 Nuzhat Ahsan, Mohd Shariq, Avadhesha Surolia, Reshmi Raj, Mohammad Firoz Khan, Pramod Kumar
TRIM proteins are characterized by their conserved N-terminal RING, B-box, and coiled-coil domains. These proteins are efficient regulators of autophagy, apoptosis, and innate immune responses and confer immunity against viruses and bacteria. TRIMs function as receptors or scaffold proteins that target substrates for autophagy-mediated degradation. Most TRIMs interact with the BECN1-ULK1 complex to
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Increased serum extrachromosomal circular DNA SORBS1circle level is associated with insulin resistance in patients with newly diagnosed type 2 diabetes mellitus Cell. Mol. Biol. Lett. (IF 8.3) Pub Date : 2024-01-12 Xiang Kong, Shu-jun Wan, Tian-bing Chen, Lan Jiang, Yu-jie Xing, Ya-ping Bai, Qiang Hua, Xin-ming Yao, Yong-li Zhao, Hong-mei Zhang, De-guo Wang, Qing Su, Kun Lv
Extrachromosomal circular DNAs (eccDNAs) exist in human blood and somatic cells, and are essential for oncogene plasticity and drug resistance. However, the presence and impact of eccDNAs in type 2 diabetes mellitus (T2DM) remains inadequately understood. We purified and sequenced the serum eccDNAs obtained from newly diagnosed T2DM patients and normal control (NC) subjects using Circle-sequencing
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Retraction Note: Inhibition of inflammation using diacerein markedly improved renal function in endotoxemic acute kidney injured mice Cell. Mol. Biol. Lett. (IF 8.3) Pub Date : 2024-01-08 Guangzhe Yu, Qian Liu, Xuening Dong, Kaihong Tang, Bohui Li, Chunmei Liu, Wenzheng Zhang, Yiduo Wang, Yingyu Jin
Retraction: Cellular & Molecular Biology Letters (2018) 23:38 https://doi.org/10.1186/s11658-018-0107-z The Editor-in-Chief has retracted this article due to concerns about several images, specifically: In Fig. 1C the LPS panel is similar to Fig. 6C WKY/BCL6 OE in a previously-published paper by different authors [1]. In Figs. 2A,B there are multiple overlaps with panels in Figs. 8 and 3A in two previously-published
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The efficacy of adipose-derived stem cells in burn injuries: a systematic review Cell. Mol. Biol. Lett. (IF 8.3) Pub Date : 2024-01-05 Michael Kohlhauser, Alexandru Tuca, Lars-Peter Kamolz
Burn injuries can be associated with prolonged healing, infection, a substantial inflammatory response, extensive scarring, and eventually death. In recent decades, both the mortality rates and long-term survival of severe burn victims have improved significantly, and burn care research has increasingly focused on a better quality of life post-trauma. However, delayed healing, infection, pain and extensive
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MYH1G-AS is a chromatin-associated lncRNA that regulates skeletal muscle development in chicken Cell. Mol. Biol. Lett. (IF 8.3) Pub Date : 2024-01-04 Bolin Cai, Manting Ma, Rongshuai Yuan, Zhen Zhou, Jing Zhang, Shaofen Kong, Duo Lin, Ling Lian, Juan Li, Xiquan Zhang, Qinghua Nie
Skeletal muscle development is pivotal for animal growth and health. Recently, long noncoding RNAs (lncRNAs) were found to interact with chromatin through diverse roles. However, little is known about how lncRNAs act as chromatin-associated RNAs to regulate skeletal muscle development. Here, we aim to investigate the regulation of chromatin-associated RNA (MYH1G-AS) during skeletal muscle development
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IDH1/MDH1 deacetylation promotes acute liver failure by regulating NETosis Cell. Mol. Biol. Lett. (IF 8.3) Pub Date : 2024-01-03 Yukun Wang, Chunxia Shi, Jin Guo, Danmei Zhang, Yanqiong Zhang, Long Zhang, Zuojiong Gong
Acute liver failure (ALF) is a life-threatening disease, but its pathogenesis is not fully understood. NETosis is a novel mode of cell death. Although the formation of neutrophil extracellular traps (NETs) has been found in various liver diseases, the specific mechanism by which NETosis regulates the development of ALF is unclear. In this article, we explore the role and mechanism of NETosis in the
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The pyroptosis mediated biomarker pattern: an emerging diagnostic approach for Parkinson’s disease Cell. Mol. Biol. Lett. (IF 8.3) Pub Date : 2024-01-03 Junhan Liang, Zhirong Wan, Cheng Qian, Madiha Rasheed, Changling Cao, Jingyan Sun, Xuezhe Wang, Zixuan Chen, Yulin Deng
Parkinson’s disease (PD) affects 1% of people over 60, and long-term levodopa treatment can cause side effects. Early diagnosis is of great significance in slowing down the pathological process of PD. Multiple pieces of evidence showed that non-coding RNAs (ncRNAs) could participate in the progression of PD pathology. Pyroptosis is known to be regulated by ncRNAs as a key pathological feature of PD
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Oncogenic activation of EEF1A2 expression: a journey from a putative to an established oncogene Cell. Mol. Biol. Lett. (IF 8.3) Pub Date : 2024-01-03 Saket Awadhesbhai Patel, Md. Khurshidul Hassan, Manjusha Dixit
Protein synthesis via translation is a central process involving several essential proteins called translation factors. Although traditionally described as cellular “housekeepers,” multiple studies have now supported that protein initiation and elongation factors regulate cell growth, apoptosis, and tumorigenesis. One such translation factor is eukaryotic elongation factor 1 alpha 2 (EEF1A2), a member
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MYCT1 inhibits hematopoiesis in diffuse large B-cell lymphoma by suppressing RUNX1 transcription Cell. Mol. Biol. Lett. (IF 8.3) Pub Date : 2024-01-03 Ying Liang, Xin Wei, Peng-Jie Yue, He-Cheng Zhang, Zhen-Ning Li, Xiao-Xue Wang, Yuan-Yuan Sun, Wei-Neng Fu
The abnormality of chromosomal karyotype is one factor causing poor prognosis of lymphoma. In the analysis of abnormal karyotype of lymphoma patients, three smallest overlap regions were found, in which MYCT1 was located. MYCT1 is the first tumor suppressor gene cloned by our research team, but its studies relating to the occurrence and development of lymphoma have not been reported. R banding analyses
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The regulatory relationship between transcription factor STAT3 and noncoding RNA Cell. Mol. Biol. Lett. (IF 8.3) Pub Date : 2024-01-03 Siyi Liu, Wentao Li, Lin Liang, Yanhong Zhou, Yanling Li
Signal transducer and activator of transcription 3 (STAT3), as a key node in numerous carcinogenic signaling pathways, is activated in various tumor tissues and plays important roles in tumor formation, metastasis, and drug resistance. STAT3 is considered a potential subtarget for tumor therapy. Noncoding RNA (ncRNA) is a special type of RNA transcript. Transforming from “junk” transcripts into key
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Circular RNA-circPan3 attenuates cardiac hypertrophy via miR-320-3p/HSP20 axis Cell. Mol. Biol. Lett. (IF 8.3) Pub Date : 2024-01-03 Xinyu Fang, Xiang Ao, Dandan Xiao, Yu Wang, Yi Jia, Peiyan Wang, Mengyang Li, Jianxun Wang
Circular RNAs are enriched in cardiac tissue and play important roles in the pathogenesis of heart diseases. In this study, we aimed to investigate the regulatory mechanism of a conserved heart-enriched circRNA, circPan3, in cardiac hypertrophy. Cardiac hypertrophy was induced by isoproterenol. The progression of cardiomyocyte hypertrophy was assessed by sarcomere organization staining, cell surface
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Transfer RNA-derived small RNA tRF-Glu-CTC attenuates neointimal formation via inhibition of fibromodulin Cell. Mol. Biol. Lett. (IF 8.3) Pub Date : 2024-01-03 Qi-Lan Jiang, Jia-Ying Xu, Qing-Ping Yao, Rui Jiang, Qin Xu, Bo-Tao Zhang, Tao Li, Jun Jiang
Neointimal hyperplasia is a pathological vascular remodeling caused by abnormal proliferation and migration of subintimal vascular smooth muscle cells (VSMCs) following intimal injury. There is increasing evidence that tRNA-derived small RNA (tsRNA) plays an important role in vascular remodeling. The purpose of this study is to search for tsRNAs signature of neointima formation and to explore their
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Correction: ClC-2 knockdown prevents cerebrovascular remodeling via inhibition of the Wnt/β-catenin signaling pathway Cell. Mol. Biol. Lett. (IF 8.3) Pub Date : 2024-01-03 Jingjing Lu, Feng Xu, Yingna Zhang, Hong Lu, Jiewen Zhang
Correction: Cellular & Molecular Biology Letters (2018) 23:29 https://doi.org/10.1186/s11658-018-0095-z Following publication of the original article [1], the authors informed us that there is in Fig. 3C. The pictures used in the AngII and AngII + Negative groups in Fig. 3C were repeated. Neither of these changes affects the results and conclusions of this study. The correct Fig. 3 is given below:
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CircZNF609 regulates pulmonary fibrosis via miR-145-5p/KLF4 axis and its translation function Cell. Mol. Biol. Lett. (IF 8.3) Pub Date : 2023-12-18 Wenqing Sun, Siyun Zhou, Lan Peng, Yi Liu, Demin Cheng, Yue Wang, Chunhui Ni
Pulmonary fibrosis is a growing clinical problem that develops as a result of abnormal wound healing, leading to breathlessness, pulmonary dysfunction and ultimately death. However, therapeutic options for pulmonary fibrosis are limited because the underlying pathogenesis remains incompletely understood. Circular RNAs, as key regulators in various diseases, remain poorly understood in pulmonary fibrosis
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Molecular mechanism and therapeutic potential of HDAC9 in intervertebral disc degeneration Cell. Mol. Biol. Lett. (IF 8.3) Pub Date : 2023-12-13 Ming Lei, Hui Lin, Deyao Shi, Pan Hong, Hui Song, Bomansaan Herman, Zhiwei Liao, Cao Yang
Intervertebral disc degeneration (IVDD) is the major cause of low-back pain. Histone deacetylase 9 (HDAC9) was dramatically decreased in the degenerative nucleus pulposus (NP) samples of patients with intervertebral disc degeneration (IVDD) according to bioinformatics analysis of Gene Expression Omnibus (GEO) GSE56081 dataset. This study aims to investigate the role of HDAC9 in IVDD progression. The
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Role of N6-methyladenosine methylation in glioma: recent insights and future directions Cell. Mol. Biol. Lett. (IF 8.3) Pub Date : 2023-12-11 Chunlin Li, Bowen Li, Hui Wang, Linglong Qu, Hui Liu, Chao Weng, Jinming Han, Yuan Li
Glioma is the most pervasive intracranial tumor in the central nervous system (CNS), with glioblastoma (GBM) being the most malignant type having a highly heterogeneous cancer cell population. There is a significantly high mortality rate in GBM patients. Molecular biomarkers related to GBM malignancy may have prognostic values in predicting survival outcomes and therapeutic responses, especially in
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Regulator of G protein signaling protein 6 alleviates acute lung injury by inhibiting inflammation and promoting cell self-renewal in mice Cell. Mol. Biol. Lett. (IF 8.3) Pub Date : 2023-12-08 Juan Song, Miao Li, Cuicui Chen, Jian Zhou, Linlin Wang, Yu Yan, Jun She, Lin Tong, Yuanlin Song
Acute respiratory distress syndrome (ARDS) is a disease with high mortality and morbidity. Regulator of G protein signaling protein 6 (RGS6), identified as a tumor suppressor gene, has received increasing attention owing to its close relationship with oxidative stress and inflammation. However, the association between ARDS and RGS6 has not been reported. Congruously regulated G protein-coupled receptor
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METTL3/YTHDC1-medicated m6A modification of circRNA3634 regulates the proliferation and differentiation of antler chondrocytes by miR-124486-5-MAPK1 axis Cell. Mol. Biol. Lett. (IF 8.3) Pub Date : 2023-12-07 Mengmeng Song, Haibo Yao, Zitong Sun, Danyang Chen, Xiwen Xu, Guohui Long, Lei Wu, Wei Hu
The deer antler, a remarkable mammalian appendage, has a growth rate surpassing that of any other known osseous organ. Emerging evidence indicates that circRNA and MAPK1 play critical roles in chondrocytes. Thus, exploration of their functions in antler chondrocytes will help us to understand the mechanism regulating the rapid antler growth. qRT-PCR, western blot, and immunohistochemistry were used
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Metabolite itaconate in host immunoregulation and defense Cell. Mol. Biol. Lett. (IF 8.3) Pub Date : 2023-12-02 Wenchang Yang, Yaxin Wang, Kaixiong Tao, Ruidong Li
Metabolic states greatly influence functioning and differentiation of immune cells. Regulating the metabolism of immune cells can effectively modulate the host immune response. Itaconate, an intermediate metabolite derived from the tricarboxylic acid (TCA) cycle of immune cells, is produced through the decarboxylation of cis-aconitate by cis-aconitate decarboxylase in the mitochondria. The gene encoding
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Global research trends in CRISPR-related technologies associated with extracellular vesicles from 2015 to 2022: a bibliometric, dynamic, and visualized study Cell. Mol. Biol. Lett. (IF 8.3) Pub Date : 2023-12-02 Jianjing Lin, Shicheng Jia, Zilu Jiao, Jiayou Chen, Wei Li, Fuyang Cao, Xintao Zhang
This study aims to explore the emerging trends, dynamic development, and research hotspots of clustered regularly interspaced short palindromic repeats (CRISPR) technology associated with extracellular vesicles during the past 7 years and demonstrate them by visualization. A total of 219 records related to CRISPR technology associated with extracellular vesicles from 2015 to 2022 in the Web of Science
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Potential use of iPSCs for disease modeling, drug screening, and cell-based therapy for Alzheimer’s disease Cell. Mol. Biol. Lett. (IF 8.3) Pub Date : 2023-11-30 Hany E. Marei, Muhammad Umar Aslam Khan, Anwarul Hasan
Alzheimer’s disease (AD) is a chronic illness marked by increasing cognitive decline and nervous system deterioration. At this time, there is no known medication that will stop the course of Alzheimer’s disease; instead, most symptoms are treated. Clinical trial failure rates for new drugs remain high, highlighting the urgent need for improved AD modeling for improving understanding of the underlying
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Knock-in mice expressing a humanized arachidonic acid 15-lipoxygenase (Alox15) carry a partly dysfunctional erythropoietic system Cell. Mol. Biol. Lett. (IF 8.3) Pub Date : 2023-11-29 Florian Reisch, Dagmar Heydeck, Marjann Schäfer, Michael Rothe, Jiaxing Yang, Sabine Stehling, Gerhard P. Püschel, Hartmut Kuhn
Arachidonic acid 15-lipoxygenases (ALOX15) play a role in mammalian erythropoiesis but they have also been implicated in inflammatory processes. Seven intact Alox genes have been detected in the mouse reference genome and the mouse Alox15 gene is structurally similar to the orthologous genes of other mammals. However, mouse and human ALOX15 orthologs have different functional characteristics. Human
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Synthetic CRISPR/dCas9-KRAB system driven by specific PSA promoter suppresses malignant biological behavior of prostate cancer cells through negative feedback inhibition of PSA expression Cell. Mol. Biol. Lett. (IF 8.3) Pub Date : 2023-11-28 Yi Yang, Hongbing Mei, Xiaohong Han, Xintao Zhang, Jianli Cheng, Zhongfu Zhang, Han Wang, Haixia Xu
PSA is a type of proto-oncogene that is specifically and highly expressed in embryonic and prostate cancer cells, but not expressed in normal prostate tissue cells. The specific expression of prostate-specific antigen (PSA) is found to be related with the conditional transcriptional regulation of its promoter. Clustered regularly interspaced short palindromic repeats (CRISPR)-dCas9-KRAB is a newly
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Astaxanthin alleviates PM2.5-induced cardiomyocyte injury via inhibiting ferroptosis Cell. Mol. Biol. Lett. (IF 8.3) Pub Date : 2023-11-25 Jingyi Ren, Bowen Yin, Zihao Guo, Xiaoya Sun, Huanting Pei, Rui Wen, Ziyi Wang, Siqi Zhu, Jinshi Zuo, Yadong Zhang, Yuxia Ma
Long-term exposure of humans to air pollution is associated with an increasing risk of cardiovascular diseases (CVDs). Astaxanthin (AST), a naturally occurring red carotenoid pigment, was proved to have multiple health benefits. However, whether or not AST also exerts a protective effect on fine particulate matter (PM2.5)-induced cardiomyocyte damage and its underlying mechanisms remain unclear. In
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Correction: Patterns of human and porcine gammaherpesvirus-encoded BILF1 receptor endocytosis Cell. Mol. Biol. Lett. (IF 8.3) Pub Date : 2023-11-24 Maša Mavri, Sanja Glišić, Milan Senćanski, Milka Vrecl, Mette M. Rosenkilde, Katja Spiess, Valentina Kubale
Correction : Cellular & Molecular Biology Letters (2023) 28:14 https://doi.org/10.1186/s11658-023-00427-y Following publication of the original article [1], the authors updated the Funding section. The original article has been corrected. Mavri M, Glišić S, Senćanski M, Vrecl M, Rosenkilde MM, Spiess K, Kubale V. Patterns of human and porcine gammaherpesvirus-encoded BILF1 receptor endocytosis. Cell
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Disrupted cardiac fibroblast BCAA catabolism contributes to diabetic cardiomyopathy via a periostin/NAP1L2/SIRT3 axis Cell. Mol. Biol. Lett. (IF 8.3) Pub Date : 2023-11-22 Qing-Bo Lu, Xiao Fu, Yao Liu, Zi-Chao Wang, Shi-Yi Liu, Yu-Chao Li, Hai-Jian Sun
Periostin is an extracellular matrix protein that plays a critical role in cell fate determination and tissue remodeling, but the underlying role and mechanism of periostin in diabetic cardiomyopathy (DCM) are far from clear. Thus, we aimed to clarify the mechanistic participation of periostin in DCM. The expression of periostin was examined in DCM patients, diabetic mice and high glucose (HG)-exposed
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Exosomal miR-155-5p drives widespread macrophage M1 polarization in hypervirulent Klebsiella pneumoniae-induced acute lung injury via the MSK1/p38-MAPK axis Cell. Mol. Biol. Lett. (IF 8.3) Pub Date : 2023-11-13 Yihan Xu, Chunying Zhang, Danni Cai, Rongping Zhu, Yingping Cao
Hypervirulent Klebsiella pneumoniae (hvKp) infection-induced sepsis-associated acute lung injury (ALI) has emerged as a significant clinical challenge. Increasing evidence suggests that activated inflammatory macrophages contribute to tissue damage in sepsis. However, the underlying causes of widespread macrophage activation remain unclear. BALB/c mice were intravenously injected with inactivated hvKp
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Irf7 regulates the expression of Srg3 and ferroptosis axis aggravated sepsis-induced acute lung injury Cell. Mol. Biol. Lett. (IF 8.3) Pub Date : 2023-11-09 Xinyu Ling, Shiyou Wei, Dandan Ling, Siqi Cao, Rui Chang, Qiuyun Wang, Zhize Yuan
To investigate the mechanism of action of Srg3 in acute lung injury caused by sepsis. First, a sepsis-induced acute lung injury rat model was established using cecal ligation and puncture (CLP). RNA sequencing (RNA-seq) was used to screen for highly expressed genes in sepsis-induced acute lung injury (ALI), and the results showed that Srg3 was significantly upregulated. Then, SWI3-related gene 3 (Srg3)
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GCN5L1 regulates pulmonary surfactant production by modulating lamellar body biogenesis and trafficking in mouse alveolar epithelial cells Cell. Mol. Biol. Lett. (IF 8.3) Pub Date : 2023-11-07 Wenqin Xu, Xiaocui Ma, Qing Wang, Jingjing Ye, Nengqian Wang, Zhenzhen Ye, Tianbing Chen
The pulmonary surfactant that lines the air–liquid surface within alveoli is a protein–lipid mixture essential for gas exchange. Surfactant lipids and proteins are synthesized and stored in the lamellar body (LB) before being secreted from alveolar type II (AT2) cells. The molecular and cellular mechanisms that regulate these processes are incompletely understood. We previously identified an essential
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N6-methyladenosine-modified oncofetal lncRNA MIR4435-2HG contributed to stemness features of hepatocellular carcinoma cells by regulating rRNA 2′-O methylation Cell. Mol. Biol. Lett. (IF 8.3) Pub Date : 2023-10-27 Yiqing Zhu, Bang Xiao, Meng Liu, Meiting Chen, Ningqi Xia, Haiyan Guo, Jinfeng Huang, Zhiyong Liu, Fang Wang
The unique expression pattern endows oncofetal genes with great value in cancer diagnosis and treatment. However, only a few oncofetal genes are available for clinical use and the underlying mechanisms that drives the fetal-like reprogramming of cancer cells remain largely unknown. Microarray assays and bioinformatic analyses were employed to screen for potential oncofetal long non-coding RNAs (lncRNAs)