-
Erratum to: Viral Vectors in Gene Replacement Therapy Biochemistry Moscow (IF 2.8) Pub Date : 2024-04-08 Ekaterina Minskaia, Alima Galieva, Alexander D. Egorov, Roman Ivanov, Alexander Karabelsky
In this article the funding section was misprinted unintentionally. The funding statement should be corrected as follows: A.D.E. was supported by the Russian Science Foundation and Kuban Science Foundation (project no. 22-14-20046). E.M., A.G., A.K., and R.A.I. were supported by the internal projects GTH-RND-2011 and GTH-RND-2112.
-
The Mechanism of Inhibition of Mycobacterial (p)ppGpp Synthetases by a Synthetic Analog of Erogorgiaene Biochemistry Moscow (IF 2.8) Pub Date : 2024-04-08 Roman Y. Sidorov, Alexander G. Tkachenko
-
Association of Increased Homocysteine Levels with Impaired Folate Metabolism and Vitamin B Deficiency in Early-Onset Multiple Sclerosis Biochemistry Moscow (IF 2.8) Pub Date : 2024-04-08 Victoria I. Lioudyno, Evgenia A. Tsymbalova, Ekaterina A. Chernyavskaya, Elena Y. Scripchenko, Gennadij N. Bisaga, Alexander V. Dmitriev, Irina N. Abdurasulova
-
Structure- and Cation-Dependent Mechanism of Interaction of Tricyclic Antidepressants with NMDA Receptor According to Molecular Modeling Data Biochemistry Moscow (IF 2.8) Pub Date : 2024-04-08 Daria A. Belinskaia, Natalia N. Shestakova
-
Novel Gain-of-Function Mutation in the Kv11.1 Channel Found in the Patient with Brugada Syndrome and Mild QTc Shortening Biochemistry Moscow (IF 2.8) Pub Date : 2024-04-08 Denis Abramochkin, Bowen Li, Han Zhang, Ekaterina Kravchuk, Tatiana Nesterova, Grigory Glukhov, Anna Shestak, Elena Zaklyazminskaya, Olga S. Sokolova
-
Role of I182, R187, and K188 Amino Acid Residues in the Catalytic Domain of HIV-1 Integrase in the Processes of Reverse Transcription and Integration Biochemistry Moscow (IF 2.8) Pub Date : 2024-04-08 Tatiana F. Kikhai, Yulia Yu. Agapkina, Tatiana A. Prikazchikova, Maria V. Vdovina, Sofia P. Shekhtman, Sofia V. Fomicheva, Sergey P. Korolev, Marina B. Gottikh
-
Oxidative Stress-Induced Platelet Apoptosis/Activation: Alleviation by Purified Curcumin via ASK1-JNK/p-38 Pathway Biochemistry Moscow (IF 2.8) Pub Date : 2024-04-08 Kurnegala Manikanta, Manoj Paul, Vaddaragudisalu D. Sandesha, Shanmuga S. Mahalingam, Thimmasandra Narayan Ramesh, Krishnegowda Harishkumar, Shashank S. Koundinya, Shivanna Naveen, Kempaiah Kemparaju, Kesturu S. Girish
-
Human Blood Serum Counteracts EGFR/HER2-Targeted Drug Lapatinib Impact on Squamous Carcinoma SK-BR-3 Cell Growth and Gene Expression Biochemistry Moscow (IF 2.8) Pub Date : 2024-04-08 Nina Shaban, Mikhail Raevskiy, Galina Zakharova, Victoria Shipunova, Sergey Deyev, Maria Suntsova, Maksim Sorokin, Anton Buzdin, Dmitri Kamashev
-
Protective Activity of Inactivated Rabies Vaccine Using Flagellin-Based Adjuvant Biochemistry Moscow (IF 2.8) Pub Date : 2024-04-08 Olga O. Sokol, Nikolai A. Nikitin, Ekaterina A. Evtushenko, Olga V. Karpova, Irina N. Matveeva, Svetlana A. Gryn, Vera M. Popova, Igor V. Ivanov, Yuri N. Fedorov, Irina Y. Litenkova
-
Role of the Gut Microbiome and Bacterial Amyloids in the Development of Synucleinopathies Biochemistry Moscow (IF 2.8) Pub Date : 2024-04-08 Nina P. Trubitsina, Anton B. Matiiv, Tatyana M. Rogoza, Anna A. Zudilova, Mariya D. Bezgina, Galina A. Zhouravleva, Stanislav A. Bondarev
-
Effect of Focal Adhesion Kinase and Vinculin Expression on Migration Parameters of Normal and Tumor Epitheliocytes Biochemistry Moscow (IF 2.8) Pub Date : 2024-04-08 Evgenia S. Solomatina, Anastasia V. Kovaleva, Anna V. Tvorogova, Ivan A. Vorobjev, Aleena A. Saidova
-
Pro-Inflammatory Activation Suppresses TRAIL-induced Apoptosis of Acute Myeloid Leukemia Cells Biochemistry Moscow (IF 2.8) Pub Date : 2024-04-08 Margarita I. Kobyakova, Anatoly S. Senotov, Kirill S. Krasnov, Yana V. Lomovskaya, Irina V. Odinokova, Anastasia A. Kolotova, Artem M. Ermakov, Alena I. Zvyagina, Irina S. Fadeeva, Elena I. Fetisova, Vladimir S. Akatov, Roman S. Fadeev
-
The Impact of Long-Term Hypoxia on the Antioxidant Defense System in the Siberian Frog Rana amurensis Biochemistry Moscow (IF 2.8) Pub Date : 2024-04-08 Sergei V. Shekhovtsov, Yana L. Vorontsova, Irina A. Slepneva, Dmitry N. Smirnov, Ekaterina E. Khrameeva, Alexey Shatunov, Tatiana V. Poluboyarova, Nina A. Bulakhova, Ekaterina N. Meshcheryakova, Daniil I. Berman, Viktor V. Glupov
-
Overexpression of the limk1 Gene in Drosophila melanogaster Can Lead to Suppression of Courtship Memory in Males Biochemistry Moscow (IF 2.8) Pub Date : 2024-04-08 Aleksandr V. Zhuravlev, Oleg V. Vetrovoy, Ekaterina S. Zalomaeva, Ekaterina S. Egozova, Ekaterina A. Nikitina, Elena V. Savvateeva-Popova
-
Investigation of Potential Effects of Some Indole Compounds on the Glutathione S-Transferase Enzyme Biochemistry Moscow (IF 2.8) Pub Date : 2024-04-08 Muhammet Serhat Özaslan
-
The Imidazolium Ionic Liquids Toxicity is Due to Their Effect on the Plasma Membrane Biochemistry Moscow (IF 2.8) Pub Date : 2024-04-08 Svyatoslav S. Sokolov, Ekaterina A. Smirnova, Tatyana I. Rokitskaya, Fedor F. Severin
-
Two Types of Survival Curves of Different Lines of Progeric Mice Biochemistry Moscow (IF 2.8) Pub Date : 2024-03-20 Svyatoslav S. Sokolov, Fedor F. Severin
Abstract For most of their lifespan, the probability of death for many animal species increases with age. Gompertz law states that this increase is exponential. In this work, we have compared previously published data on the survival kinetics of different lines of progeric mice. Visual analysis showed that in six lines of these rapidly aging mutants, the probability of death did not strictly depend
-
Biological Clocks: Why We Need Them, Why We Cannot Trust Them, How They Might Be Improved Biochemistry Moscow (IF 2.8) Pub Date : 2024-03-20 Josh Mitteldorf
Abstract Late in life, the body is at war with itself. There is a program of self-destruction (phenoptosis) implemented via epigenetic and other changes. I refer to these as type (1) epigenetic changes. But the body retains a deep instinct for survival, and other epigenetic changes unfold in response to a perception of accumulated damage (type (2)). In the past decade, epigenetic clocks have promised
-
Safari with an Electron Gun: Visualization of Protein and Membrane Interactions in Mitochondria in Natural Environment Biochemistry Moscow (IF 2.8) Pub Date : 2024-03-20 Semen V. Nesterov, Konstantin S. Plokhikh, Yuriy M. Chesnokov, Denis A. Mustafin, Tatyana N. Goleva, Anton G. Rogov, Raif G. Vasilov, Lev S. Yaguzhinsky
-
Retinoprotective Effect of SkQ1, Visomitin Eye Drops, Is Associated with Suppression of P38 MAPK and ERK1/2 Signaling Pathways Activity Biochemistry Moscow (IF 2.8) Pub Date : 2024-03-20 Natalia A. Muraleva, Anna A. Zhdankina, Anzhella Zh. Fursova, Nataliya G. Kolosova
-
Relationship of Cytotoxic and Antimicrobial Effects of Triphenylphosphonium Conjugates with Various Quinone Derivatives Biochemistry Moscow (IF 2.8) Pub Date : 2024-03-20 Pavel A. Nazarov, Lyudmila A. Zinovkina, Anna A. Brezgunova, Konstantin G. Lyamzaev, Andrei V. Golovin, Marina V. Karakozova, Elena A. Kotova, Egor Yu. Plotnikov, Roman A. Zinovkin, Maxim V. Skulachev, Yuri N. Antonenko
-
Evolution of Longevity in Tetrapods: Safety Is More Important than Metabolism Level Biochemistry Moscow (IF 2.8) Pub Date : 2024-03-20 Gregory A. Shilovsky, Tatyana S. Putyatina, Alexander V. Markov
Abstract Various environmental morphological and behavioral factors can determine the longevity of representatives of various taxa. Long-lived species develop systems aimed at increasing organism stability, defense, and, ultimately, lifespan. Long-lived species to a different extent manifest the factors favoring longevity (gerontological success), such as body size, slow metabolism, activity of body’s
-
Enhanced ROS Production in Mitochondria from Prematurely Aging mtDNA Mutator Mice Biochemistry Moscow (IF 2.8) Pub Date : 2024-03-20 Irina G. Shabalina, Daniel Edgar, Natalia Gibanova, Anastasia V. Kalinovich, Natasa Petrovic, Mikhail Yu. Vyssokikh, Barbara Cannon, Jan Nedergaard
-
Mitocentricity Biochemistry Moscow (IF 2.8) Pub Date : 2024-03-20 Dmitry B. Zorov, Polina A. Abramicheva, Nadezda V. Andrianova, Valentina A. Babenko, Ljubava D. Zorova, Savva D. Zorov, Irina B. Pevzner, Vasily A. Popkov, Dmitry S. Semenovich, Elmira I. Yakupova, Denis N. Silachev, Egor Y. Plotnikov, Gennady T. Sukhikh
Abstract Worldwide, interest in mitochondria is constantly growing, as evidenced by scientific statistics, and studies of the functioning of these organelles are becoming more prevalent than studies of other cellular structures. In this analytical review, mitochondria are conditionally placed in a certain cellular center, which is responsible for both energy production and other non-energetic functions
-
Developing Peripheral Biochemical Biomarkers of Brain Disorders: Insights from Zebrafish Models Biochemistry Moscow (IF 2.8) Pub Date : 2024-03-20 Nikita P. Ilyin, Elena V. Petersen, Tatyana O. Kolesnikova, Konstantin A. Demin, Sergey L. Khatsko, Kirill V. Apuhtin, Allan V. Kalueff
Abstract High prevalence of human brain disorders necessitates development of the reliable peripheral biomarkers as diagnostic and disease-monitoring tools. In addition to clinical studies, animal models markedly advance studying of non-brain abnormalities associated with brain pathogenesis. The zebrafish (Danio rerio) is becoming increasingly popular as an animal model organism in translational neuroscience
-
Exploring Patterns of Human Mortality and Aging: A Reliability Theory Viewpoint Biochemistry Moscow (IF 2.8) Pub Date : 2024-03-20 Leonid A. Gavrilov, Natalia S. Gavrilova
-
Age-Dependent Changes in the Production of Mitochondrial Reactive Oxygen Species in Human Skeletal Muscle Biochemistry Moscow (IF 2.8) Pub Date : 2024-03-20 Mikhail Yu. Vyssokikh, Maksim A. Vigovskiy, Vladislav V. Philippov, Yakov R. Boroday, Mariya V. Marey, Olga A. Grigorieva, Tatiana F. Vepkhvadze, Nadezhda S. Kurochkina, Ludmila A. Manukhova, Anastasiya Yu. Efimenko, Daniil V. Popov, Vladimir P. Skulachev
-
A Redox-Regulated, Heterodimeric NADH:cinnamate Reductase in Vibrio ruber Biochemistry Moscow (IF 2.8) Pub Date : 2024-03-20 Yulia V. Bertsova, Marina V. Serebryakova, Victor A. Anashkin, Alexander A. Baykov, Alexander V. Bogachev
-
Organ Frame Elements or Free Intercellular Gel-Like Matrix as Necessary Conditions for Building Organ Structures during Regeneration Biochemistry Moscow (IF 2.8) Pub Date : 2024-03-20 Vasily N. Manskikh
-
Reactive Halogen Species: Role in Living Systems and Current Research Approaches Biochemistry Moscow (IF 2.8) Pub Date : 2024-03-08 Yuliya V. Khramova, Veronika A. Katrukha, Victoria V. Chebanenko, Alexander I. Kostyuk, Nikolay P. Gorbunov, Oleg M. Panasenko, Alexey V. Sokolov, Dmitry S. Bilan
Abstract Reactive halogen species (RHS) are highly reactive compounds that are normally required for regulation of immune response, inflammatory reactions, enzyme function, etc. At the same time, hyperproduction of highly reactive compounds leads to the development of various socially significant diseases – asthma, pulmonary hypertension, oncological and neurodegenerative diseases, retinopathy, and
-
Post-Translational Oxidative Modifications of Hemostasis Proteins: Structure, Function, and Regulation Biochemistry Moscow (IF 2.8) Pub Date : 2024-03-08 Mark A. Rosenfeld, Lyubov V. Yurina, Elizaveta S. Gavrilina, Alexandra D. Vasilyeva
-
Multicomponent DNAzyme Nanomachines: Structure, Applications, and Prospects Biochemistry Moscow (IF 2.8) Pub Date : 2024-03-08 Daria D. Nedorezova, Maria S. Rubel, Aleksandr A. Rubel
-
Formation of Supplementary Metal-Binding Centers in Proteins under Stress Conditions Biochemistry Moscow (IF 2.8) Pub Date : 2024-03-08 Olga V. Kosmachevskaya, Natalia N. Novikova, Sergey N. Yakunin, Alexey F. Topunov
-
Fenton Reaction in vivo and in vitro. Possibilities and Limitations Biochemistry Moscow (IF 2.8) Pub Date : 2024-03-08 Konstantin O. Muranov
-
Animal Models of FUS-Proteinopathy: A Systematic Review Biochemistry Moscow (IF 2.8) Pub Date : 2024-03-08 Alexander Rezvykh, Daniil Shteinberg, Evgeny Bronovitsky, Aleksey Ustyugov, Sergei Funikov
-
G-Quadruplexes as Sensors of Intracellular Na+/K+ Ratio: Potential Role in Regulation of Transcription and Translation Biochemistry Moscow (IF 2.8) Pub Date : 2024-03-08 Olga D. Lopina, Svetlana V. Sidorenko, Dmitry A. Fedorov, Elizaveta A. Klimanova
-
Biomolecular Condensates: Structure, Functions, Methods of Research Biochemistry Moscow (IF 2.8) Pub Date : 2024-03-08 Natalia A. Gorsheneva, Julia V. Sopova, Vladimir V. Azarov, Anastasia V. Grizel, Aleksandr A. Rubel
-
The Role of Vitamin K in the Development of Neurodegenerative Diseases Biochemistry Moscow (IF 2.8) Pub Date : 2024-03-08 Anna I. Diachenko, Igor A. Rodin, Tatiana N. Krasnova, Oleg I. Klychnikov, Lidia N. Nefedova
-
Synthetic Biology Approaches to Posttranslational Regulation in Plants Biochemistry Moscow (IF 2.8) Pub Date : 2024-03-08 Inna A. Abdeeva, Yulia S. Panina, Liliya G. Maloshenok
-
Electroanalysis in Pharmacogenomic Studies: Mechanisms of Drug Interaction with DNA Biochemistry Moscow (IF 2.8) Pub Date : 2024-03-08 Victoria V. Shumyantseva, Veronica V. Pronina, Tatiana V. Bulko, Lyubov E. Agafonova
-
Free Radical Lipid Peroxidation Induced by Reactive Halogen Species Biochemistry Moscow (IF 2.8) Pub Date : 2024-03-08 Oleg M. Panasenko, Yury A. Vladimirov, Valery I. Sergienko
-
Impairment of Assembly of the Vimentin Intermediate Filaments Leads to Suppression of Formation and Maturation of Focal Contacts and Alteration of the Type of Cellular Protrusions Biochemistry Moscow (IF 2.8) Pub Date : 2024-02-14 Anna O. Zholudeva, Nikolay S. Potapov, Ekaterina A. Kozlova, Maria E. Lomakina, Antonina Y. Alexandrova
-
Serum Glycome as a Diagnostic and Prognostic Factor in Gestational Diabetes Mellitus Biochemistry Moscow (IF 2.8) Pub Date : 2024-02-14 Ognjen Radojičić, Lucia Pažitná, Zorana Dobrijević, Paras Kundalia, Kristina Kianičková, Jaroslav Katrlík, Vesna Mandić Marković, Željko Miković, Olgica Nedić, Dragana Robajac
-
Natural Activators of Autophagy Biochemistry Moscow (IF 2.8) Pub Date : 2024-02-14 Julia A. Pavlova, Ekaterina A. Guseva, Olga A. Dontsova, Petr V. Sergiev
-
Synthetic Activators of Autophagy Biochemistry Moscow (IF 2.8) Pub Date : 2024-02-14 Ekaterina A. Guseva, Julia A. Pavlova, Olga A. Dontsova, Petr V. Sergiev
-
The Functions of N6-Methyladenosine in Nuclear RNAs Biochemistry Moscow (IF 2.8) Pub Date : 2024-02-14 Nadezhda A. Zhigalova, Katerina Yu. Oleynikova, Alexey S. Ruzov, Alexander S. Ermakov
-
N-Terminal Fragment of Cardiac Myosin Binding Protein C Modulates Cooperative Mechanisms of Thin Filament Activation in Atria and Ventricles Biochemistry Moscow (IF 2.8) Pub Date : 2024-02-14 Anastasia M. Kochurova, Evgenia A. Beldiia, Victoria V. Nefedova, Natalia S. Ryabkova, Daria S. Yampolskaya, Alexander M. Matyushenko, Sergey Y. Bershitsky, Galina V. Kopylova, Daniil V. Shchepkin
-
Influence of Nucleotide Context on Non-Specific Amplification of DNA with Bst exo– DNA Polymerase Biochemistry Moscow (IF 2.8) Pub Date : 2024-02-14 Ravil R. Garafutdinov, Olga Yu. Kupova, Assol R. Sakhabutdinova
-
Synthesis and Biological Properties of Polyphenol-Containing Linear and Dendrimeric Cationic Peptides Biochemistry Moscow (IF 2.8) Pub Date : 2024-02-14 Artem A. Shatilov, Sergey M. Andreev, Anastasiya V. Shatilova, Evgeny A. Turetskiy, Renata A. Kurmasheva, Marina O. Babikhina, Larisa V. Saprygina, Nadezhda N. Shershakova, Dar’ya K. Bolyakina, Valeriy V. Smirnov, Igor P. Shilovsky, Musa R. Khaitov
-
Pathogenetic Significance of Long Non-Coding RNAs in the Development of Thoracic and Abdominal Aortic Aneurysms Biochemistry Moscow (IF 2.8) Pub Date : 2024-02-14 Aksana N. Kucher, Iuliia A. Koroleva, Maria S. Nazarenko
Abstract Aortic aneurysm (AA) is a life-threatening condition with a high prevalence and risk of severe complications. The aim of this review was to summarize the data on the role of long non-coding RNAs (lncRNAs) in the development of AAs of various location. Within less than a decade of studies on the role of lncRNAs in AA, using experimental and bioinformatic approaches, scientists have obtained
-
Immunology of SARS-CoV-2 Infection Biochemistry Moscow (IF 2.8) Pub Date : 2024-02-14 Aida G. Gabdoulkhakova, Rimma N. Mingaleeva, Albina M. Romozanova, Aisylu R. Sagdeeva, Yulia V. Filina, Albert A. Rizvanov, Regina R. Miftakhova
-
Calculating Aging: Analysis of Survival Curves in the Norm and Pathology, Fluctuations in Mortality Dynamics, Characteristics of Lifespan Distribution, and Indicators of Lifespan Variation Biochemistry Moscow (IF 2.8) Pub Date : 2024-02-01
Abstract The article describes the history of studies of survival data carried out at the Research Institute of Physico-Chemical Biology under the leadership of Academician V. P. Skulachev from 1970s until present, with special emphasis on the last decade. The use of accelerated failure time (AFT) model and analysis of coefficient of variation of lifespan (CVLS) in addition to the Gompertz methods
-
AgeMeta: Quantitative Gene Expression Database of Mammalian Aging Biochemistry Moscow (IF 2.8) Pub Date : 2024-02-01
Abstract AgeMeta is a database that provides systemic and quantitative description of mammalian aging at the level of gene expression. It encompasses transcriptomic changes with age across various tissues of humans, mice, and rats, based on a comprehensive meta-analysis of 122 publicly available gene expression datasets from 26 studies. AgeMeta provides an intuitive visual interface for quantification
-
Direct Determination of the Structure of Single Biopolymer Molecules Using Nanopore Sequencing Biochemistry Moscow (IF 2.8) Pub Date : 2024-01-01
Abstract This review highlights operational principles, features, and modern aspects of the development of third-generation sequencing technology of biopolymers focusing on the nucleic acids analysis, namely the nanopore sequencing system. Basics of the method and technical solutions used for its realization are considered, from the first works showing the possibility of creation of these systems to
-
Tumor Organoids: The Era of Personalized Medicine Biochemistry Moscow (IF 2.8) Pub Date : 2024-01-01
Abstract The strategies of future medicine are aimed to modernize and integrate quality approaches including early molecular-genetic profiling, identification of new therapeutic targets and adapting design for clinical trials, personalized drug screening (PDS) to help predict and individualize patient treatment regimens. In the past decade, organoid models have emerged as an innovative in vitro platform
-
Leaf Extract from European Olive (Olea europaea L.) Post-Transcriptionally Suppresses the Epithelial-Mesenchymal Transition and Sensitizes Gastric Cancer Cells to Chemotherapy Biochemistry Moscow (IF 2.8) Pub Date : 2024-01-01
Abstract The overall survival of patients with the advanced and recurrent gastric cancer (GC) remains unfavorable. In particular, this is due to cancer spreading and resistance to chemotherapy associated with the epithelial-mesenchymal transition (EMT) of tumor cells. EMT can be identified by the transcriptome profiling of GC for EMT markers. Indeed, analysis of the TCGA and GTEx databases (n = 408)
-
Genomic Imprinting and Random Monoallelic Expression Biochemistry Moscow (IF 2.8) Pub Date : 2024-01-01
Abstract The review discusses the mechanisms of monoallelic expression, such as genomic imprinting, in which gene transcription depends on the parental origin of the allele, and random monoallelic transcription. Data on the regulation of gene activity in the imprinted regions are summarized with a particular focus on the areas controlling imprinting and factors influencing the variability of the imprintome
-
Phenoptosis and the Various Types of Natural Selection Biochemistry Moscow (IF 2.8) Pub Date : 2023-12-27 Giacinto Libertini
-
Opposite Effects of CRABP1 and CRABP2 Homologs on Proliferation of Breast Cancer Cells and Their Sensitivity to Retinoic Acid Biochemistry Moscow (IF 2.8) Pub Date : 2023-12-27 Adel D. Enikeev, Pavel M. Abramov, Danila S. Elkin, Andrey V. Komelkov, Anastasiya A. Beliaeva, Darya M. Silantieva, Elena M. Tchevkina
-
Serotonin Receptors as a Potential Target in the Treatment of Alzheimer’s Disease Biochemistry Moscow (IF 2.8) Pub Date : 2023-12-27 Dmitrii V. Eremin, Elena M. Kondaurova, Aleksander Ya. Rodnyy, Camilla A. Molobekova, Dmitrii A. Kudlay, Vladimir S. Naumenko