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Exploring the Diagnostic and Prognostic Predictive Values of Ferroptosis- Related Markers in Lung Adenocarcinoma Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-03-25 Guoliang Mao, Wuqin Xu, Muhammad Jamil, Wei Zhang, Nanlin Jiao, Yinhua Liu
Background: Lung Adenocarcinoma (LUAD), a common and aggressive form of lung cancer, poses significant treatment challenges due to its low survival rates. Aim: To better understand the role of ferroptosis driver genes in LUAD, this study aimed to explore their diagnostic and prognostic significance, as well as their impact on treatment approaches and tumor immune function in LUAD. Method: To accomplish
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Biofilm Formation in Mycobacterial Genus; Mechanism of Biofilm Formation and Anti-Mycobacterial Biofilm Agents Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-03-15 Sina Nasrollahian, Hassan Pourmoshtagh, Sahar Sabour, Nahal Hadi, Taher Azimi, Saeed Soleiman-Meigooni
: Mycobacterium tuberculosis, Mycobacterium leprae, and non-tuberculous mycobacteria (NTM) are among the most significant human pathogens within the Mycobacterium genus. These pathogens can infect people who come into contact with biomaterials or have chronic illnesses. A characteristic pathogenic trait of mycobacteria is the development of biofilms, which involves several molecules, such as the GroEL1
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Intestinal Epithelial Cell-specific Knockout of METTL3 Aggravates Intestinal Inflammation in CLP Mice by Weakening the Intestinal Barrier Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-03-14 Hongzhou Shi, Jiahui Sun, Yaya Sun, Junjie Wu, Guangqing Jiang, Zhaiyue Xu, Xin Shi, Miao Fang
Background:: Many studies have demonstrated that the expression of methyltransferase- like 3 (METTL3) is altered in various inflammatory diseases. Its specific mechanistic role in the intestinal inflammatory response during sepsis remains limited and requires further investigation. Objectives:: Explore the potential mechanism of METTL3 in the intestinal inflammatory response during sepsis. Materials
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Unlocking the Potential of RNA Nanoparticles: A Breakthrough Approach to Overcoming Challenges in Colon Cancer Treatment Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-03-14 Dipanjan Karati, Swarupananda Mukherjee, Biswajit Basu, KevinKumar Garala, Ayon Dutta, Bhupendra G. Prajapati, Sankha Bhattacharya
: Globally, one of the leading causes of cancer-related deaths is colon cancer. As this form of cancer has a tremendous potential to metastasize, effective treatment is complicated and sometimes impossible. Despite the improvement of conventional chemotherapy and the advent of targeted therapies, overcoming multi-drug resistance (MDR) and side effects remain significant challenges. As a therapeutic
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Nano-delivery of Silibinin Potentiate the Induction of Immunogenic Cell Death (ICD) in Melanoma Cells Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-03-14 Mina Amiri, Sevda Jafari, Afsaneh Lavasanifar, Ommoleila Molavi, Soheila Montazersaheb
Background: Induction of immunogenic cell death (ICD) in tumors can enhance antitumor immunity and modulate immunosuppression in the tumor microenvironment (TME). Objective: In the current study, we investigated the effect of silibinin, a natural compound with anticancer activity, and its polymer-based nanoformulations on the induction of apoptosis and ICD in cancer cells. Methods: Free and nanoparticulate
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TP508 Promotes Bone Regeneration on Distraction Osteogenesis via the Activation of Wnt/β-catenin Signaling Pathway Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-03-12 Kehan Li, Linan Liu, Jingyi Zhang, Chenyu Liao, Jian Hu, Jian Song
Introduction:: TP508 is a thrombin peptide that participates in the inflammatory response and wound healing. Its role in the molecular mechanism of distraction osteogenesis remains unclear. This study established a tibia distraction osteogenesis (DO) model in rats and investigated the role and mechanism of TP508 in bone regeneration during DO. Method:: Micro-computed tomography (Micro-CT) and hematoxylin-eosin
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Marine Microalgae Schizochytrium sp. S31: Potential Source for New Antimicrobial and Antibiofilm Agent Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-03-11 Doaa Abdullah Hammadi Al-Ogaidi, Sevinç Karaçam, Rafig Gurbanov, Nurcan Vardar-Yel
Background: The rise of antibiotic-resistant bacteria necessitates the discovery of new, safe, and bioactive antimicrobial compounds. The antibacterial and antibiofilm activity of microalgae makes them a potential candidate for developing natural antibiotics to limit microbial infection in various fields. Objective: This study aimed to analyze the antibacterial effect of the methanolic extract of Schizochytrium
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The Emerging Roles of Circpvt1 in Cancer Progression Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-03-08 Shijie Wu, Yan Hu, Xiaoyong Lei, Xiaoyan Yang
CircRNA is stable due to its ring structure and is abundant in humans, which not only exists in various tissues and biofluids steadily but also plays a significant role in the physiology and pathology of human beings. CircPVT1, an endogenous circRNA, has recently been identified from the PVT1 gene located in the cancer risk region 8q24. CircPVT1 is reported to be highly expressed in many different
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Application of Nanotechnology to Develop Carrageenan-based Films and Coatings as Carriers for Essential Oils Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-03-05 Leila Nikravan, Setayesh Zamanpour, Mohammad Hashemi, Sayed Mahdi Hossaeini Marashi Marashi, Seyyed Mohammad Ali Noori
: This review highlights the effect of combining bioactive agents, especially nanoparticles, in carrageenan coating to increase the quality and stability of foods. This study is designed based on a review of previous studies. Biopolymer coatings and films are suitable for food and non-food packaging due to their degradability, renewable and edible nature. Edible coatings and films are based on polysaccharides
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Nanotheranostics: A Cutting-Edge Technology for Cancer Management Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-03-05 Shwetapadma Dash, Shasank Sekhar Swain, Auromira Khuntia, Sneha Dutta, Sanjeeb Kumar Sahoo
: Cancer is the second-leading cause of death in the 21st century, where early detection and appropriate therapeutic interventions are two components essential for effective cancer management. Despite the availability of several conventional diagnostics and therapeutic agents, cancer mortality rates are rising due to an increase in the frequency of recurrence and metastasis in cancer patients. Therefore
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In Rheumatoid Arthritis, A Review of ncRNAs Related to NF-κB Signaling Pathways Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-03-01 Chun-Xia Wang, Hsiang-Hung Cheng, Mei Luo, Jing-Rong Jiang
: Rheumatoid arthritis (RA) is an autoimmune disease with no known cure that results in joint deformities and dysfunction, significantly impacting the quality of life of patients. The abnormal NF-KB signaling pathway in RA has emerged as a crucial research area for the development of RA therapies, with non-coding RNAs (ncRNAs) serving as a potentially meaningful avenue to regulate it. Thus, understanding
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The Hepatoprotective Effects of Ginsenoside from Ginseng: A Review of Molecular Mechanisms and Therapeutic Potentials Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-03-01 Seyed Reza Taha, Andarz Fazlollahpour-Naghibi, Mahdieh Shariat Zadeh, Kimia Bagheri, Hamed Rahmani Youshanlouei, Reza Mosaddeghi-Heris, Seyyed Sina Hejazian, Amirreza Khalaji, Seyedeh Shaghayegh Alavi, Payam Fattahi, Saba Mehrtabar
: Treatment of hepatic diseases presents a significant challenge due to their diverse nature. Ginsenosides, bioactive compounds derived from the root of Panax ginseng and widely used in traditional Chinese medicine, offer multifaceted protection to various organs in the body. Their versatile effects, including antioxidant, anti-inflammatory, anti-apoptotic and more, make them a promising approach for
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Quassinoids from Eurycoma longifolia as Potential Dihydrofolate Reductase Inhibitors: A Computational Study Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-03-01 Nurhanan Murni Yunos, Mohammad Gasem Al-Thiabat, Nor Jannah Sallehudin, Habibah A Wahab
Background:: Quassinoids are degraded triterpene compounds that can be obtained from various species of the Simaroubaceae plant family, including Eurycoma longifolia. Quassinoids are the major compounds in E. longifolia, and they are known to have various medicinal potentials, such as anticancer and antimalarial properties. Dihydrofolate reductase (DHFR) was reported to be one of the important targets
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Non-Receptor Type PTPases and their Role in Controlling Pathways Related to Diabetes and Liver Cancer Signalling Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-03-01 Nidhee Chaudhary, Bellam Kiranmayee
: The role of non-receptor type Protein Tyrosine Phosphatase (PTPases) in controlling pathways related to diabetes and Hepatocellular Carcinoma (HCC) is significant. The insulin signal transduction pathway is regulated by the steady-state phosphorylation of tyrosyl residues of the insulin receptor and post-receptor substrates. PTPase has been shown to have a physiological role in the regulation of
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MFAP5 Strengthened the Stem Cell Features of Non-small Cell Lung Cancer Cells by Regulating the FBW/Sox9 Axis Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-02-28 Chun Du, Zijuan Qi, Wei Zhang
Introduction: Non-small cell lung cancer (NSCLC) is a type of malignant tumor with high morbidity as well as mortality. The process of lung cancer may be driven by cancer stem cells. It was known that MFAP5 enhanced the occurrence of diverse types of cancer. Also, MFAP5 has the potential to induce the degradation of FBW7 which is a tumor suppressor. Lower levels of FBW7 enhance the stability of Sox9
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An Updated Review on Nanoemulsion: Factory for Food and Drug Delivery Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-02-28 Virender Kumar, Vandana Garg, Nakul Saini, Navidha Aggarwal, Harsh Kumar, Davinder Kumar, Hitesh Chopra, Mohammad Amjad Kamal, Harish Dureja
Background: A nanoemulsion is a colloidal system of small droplets dispersed in another liquid. It has attracted considerable attention due to its unique properties and various applications. Throughout this review, we provide an overview of nanoemulsions and how they can be applied to various applications such as drug delivery, food applications, and pesticide formulations. Objective: This updated
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Recent Developments in Nanotechnology and Immunotherapy for the Diagnosis and Treatment of Pancreatic Cancer Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-02-28 Komal Sindhi, Abhishek Kanugo
: Pancreatic cancer kills millions of people worldwide each year and is one of the most prevalent causes of mortality that requires prompt therapy. A large number of people who have pancreatic cancer are detected at an advanced stage, with incurable and drug-resistant tumors. Hence the overall survival rate of pancreatic cancer is less. The advance phase of this cancer is generated because of the expression
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Diagnosis of Canine Visceral Leishmaniasis by Flow Cytometry Serology using the rMELEISH Multiepitope Antigen Coupled in a Functional Bead Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-02-27 Henrique Bonifácio Moura, Henrique Gama Ker, Luana S. Ramos, Lais M. Nogueira, Juliana M. Machado, Daniel S. Dias, Rita Alaíde Leandro Rodrigues, Mariana Campos da Paz, Rafael Gonçalves Teixeira-Neto, Alexandre Barbosa Reis, Alexsandro S. Galdino, Eduardo S. Silva
Background:: Visceral leishmaniasis (VL) is a zoonotic disease, with dogs being the main reservoir of the Leishmania infantum parasite. Objective:: To develop a new flow cytometry test to diagnosis canine VL (CVL) diagnosis. Methods:: The current study addresses a new flow cytometry test using beads coupled to the multiepitope antigen rMELEISH. Results:: In the study set of samples a sensitivity (87
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Role of Protein Ubiquitination and HIF Signaling in the Evolution of Hypoxic Breast Cancer Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-02-27 Suman Kumar Ray, Sukhes Mukherjee
: Alternations in protein ubiquitination along with hypoxia-inducible factor (HIF) signaling contribute to tumorigenesis and breast tumor advancement. Ubiquitination is an impulsive process, which is coordinately governed by E3 ligases and deubiquitinases (DUBs), that have come out as charismatic therapeutic targets. HIF expression, as well as the transcriptional process in malignancies, are frequently
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Anti-seizure Effects and Mechanisms of Berberine: A Systematic Review Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-02-22 Nahid Jivad, Saeid Heidari-Soureshjani, Hesamaldin Bagheri, Catherine MT Sherwin, Sahar Rostamian
Background:: Epilepsy is one of the most common in all age groups and disabling neurologic disorders around the world. Objectives:: This systematic review was to explore whether berberine (BBR) has any anti-seizure or anti-epileptic effects and also reviewed this possible mechanism. Methods:: The EMBASE, Scopus, Cochrane Library, PubMed, and Web of Science databases were searched before Sep 2023. All
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Icariin Attenuates Human Renal Tubular Epithelial Cell Senescence by Targeting PAK2 via miR-23b-3p Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-02-20 Suqin Zhang, Yanbin Li, Qiuyue Wang
Background: Renal tubular epithelial cells (RTECs) senescence is crucial in kidney diseases. Icariin is shown to have protective effects against renal fibrosis, acute kidney injury, and proteinuria. We aimed to explore the role of icariin in protecting RTECs from senescence and the underlying mechanism involved. Methods: An in vitro model of RTEC senescence was established by incubating HK-2 cells
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Unconventional Remedies for Squamous Cell Carcinoma: A Journey into Alternative Treatments Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-02-16 Elen Deng, Amor Kachemoune
: Squamous cell carcinoma (SCC) is the second most common form of skin cancer and is typically found on sun-exposed skin. Risk factors include ultraviolet radiation exposure, older age, fairer complexion, smoking, and immunosuppression. SCC is a slow-growing tumor with the possibility of metastasis if not treated. The clinical presentation can range from a dry, scaly erythematous patch or plaque to
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The Use of Lipid-Based Nanocarriers to Improve Ovarian Cancer Treatment: An Overview of Recent Developments Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-02-15 Junaid Tantray, Akhilesh Patel, Bhupendra G. Prajapati, Sourabh Kosey, Sankha Bhattacharya
: Ovarian cancer poses a formidable health challenge for women globally, necessitating innovative therapeutic approaches. This review provides a succinct summary of the current research status on lipid-based nanocarriers in the context of ovarian cancer treatment. Lipid-based nanocarriers, including liposomes, solid lipid nanoparticles (SLNs), and nanostructured lipid carriers (NLCs), offer a promising
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The Role of NAD+ in Myocardial Ischemia-induced Heart Failure in Sprague-Dawley Rats and Beagles Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-02-15 Zuowei Pei, Chenguang Yang, Ying Guo, Min Dong, Fang Wang
Introduction: Nicotinamide adenine dinucleotide (NAD+) participates in various processes that are dysregulated in cardiovascular diseases. Supplementation with NAD+ may be cardioprotective. However, whether the protective effect exerted by NAD+ in heart failure (HF) is more effective before acute myocardial infarction (MI) or after remains unclear. The left anterior descending arteries of male Sprague
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Determination of Ideal Factors for Early Adoption and Standardization of Metagenomic Next-Generation Sequencing for Respiratory System Infections Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-02-14 Lei Zhao, Cole R. Formslag, Qing Zhang, Braydon C. Cowan, Trenton G. Mayberry, Aaron R. Barnhill, Yongsheng Wang, Yujiang Fang
Background: Metagenomic next-generation sequencing (mNGS) demonstrates great promise as a diagnostic tool for determining the cause of pathogenic infections. The standard diagnostic procedures (SDP) include smears and cultures and are typically viewed as less sensitive and more time-consuming when compared to mNGS. There are concerns about the logistics and ease of transition from SDP to mNGS. mNGS
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Implementation of Silver Nanoparticles Green Synthesized with Leaf Extract of Coccinia grandis as Antimicrobial Agents Against Head and Neck Infection MDR Pathogens Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-02-14 Smarita Lenka, Debasmita Dubey, Santosh Kumar Swain, Goutam Rath, Ajit Mishra, Ajit Kumar Bishoyi, Gopal Krishna Purohit
Background: Head and neck infections (HNI) associated with multidrug resistance (MDR) offer several health issues on a global scale due to inaccurate diagnosis. background: Head and neck infections (HNI) associated with multidrug resistance (MDR) offer several health issues on a global scale due to inaccurate diagnosis. Objectives: This study aimed to identify the bacteria and Candidal isolates and
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Traditional Chinese Medicine-based Treatment in Cardiovascular Disease: Potential Mechanisms of Action Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-02-13 Lanlan Li, Yutong Ran, Jiao Wen, Yirui Lu, Shunmei Liu, Hong Li, Min Cheng
: Cardiovascular Disease (CVD) is the leading cause of morbidity and death worldwide and has become a global public health problem. Traditional Chinese medicine (TCM) has been used in China to treat CVD and achieved promising results. Therefore, TCM has aroused significant interest among pharmacologists and medical practitioners. Previous research showed that TCM can regulate the occurrence and development
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Naringenin Nanoformulations for Neurodegenerative Diseases Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-02-13 Liza Sahoo, Nigam Sekhar Tripathy, Fahima Dilnawaz
: Glioblastoma (GBM) is a grade-IV astrocytoma, which is the most common and aggressive type of brain tumor, spreads rapidly and has a life-threatening catastrophic effect. GBM mostly occurs in adults with an average survival time of 15 to 18 months, and the overall mortality rate is 5%. Significant invasion and drug resistance activity cause the poor diagnosis of GBM. Naringenin (NRG) is a plant secondary
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RNA-Based Therapeutics: Past, Present and Future Prospects, Challenges in Cancer Treatment Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-02-13 Anjana Goel, Amisha Rastogi, Mansi Jain, Kinjal Niveriya
abstract: It is becoming more and harder in today's climate to disregard the impact of cancer on social health. Even though a significant amount of money is spent annually on cancer research, it still ranks as the second leading cause of death worldwide. Additionally, only about half of the patients suffering from complex forms of cancer survive a year after receiving traditional cancer therapies.
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Long Non-coding RNA DLEU1 Promotes Progression of Osteoarthritis via miR-492/TLR8 Axis Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-02-07 Chenzhe Ni, Wanglin Zhang, Sai Qiu, Hao Cheng, Chunhui Ma
Background: Long non-coding RNAs (LncRNAs) are generally reported to participate in the development of Osteoarthritis (OA) by acting as competing endogenous RNAs (ceRNAs). However, the molecular mechanism is largely unknown. This study aimed to investigate the possible mechanisms contributing to osteoarthritis (OA). Methods: Four gene expression profiles from patients with OA were downloaded from a
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Biodistribution and Tumor Targeted Accumulation of Anti-CEA-loaded Iron Nanoparticles Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-02-07 Thais Silva Correa, William Gustavo Lima, Aline Beatriz do Couto Campos, Alexsandro Sobreira Galdino, Emilia Celma de Oliveira Lima, Valbert Nascimento Cardoso, Simone Odília Antunes Fernandes, Mariana Campos-da-Paz
Introduction: Active targeting of tumors by nanomaterials favors early diagnosis and the reduction of harsh side effects of chemotherapeuticals Method: We synthesized magnetic nanoparticles (64 nm; -40 mV) suspended in a magnetic fluid (MF) and decorated them with anti-carcinoembryonic antigen (MFCEA; 144 nm; -39 mV). MF and MFCEA nanoparticles were successfully radiolabeled with technetium–99m (99mTc)
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Deciphering Immune-Related Gene Signatures in Diabetic Retinopathy: Insights from In Silico Analysis and In vitro Experiment Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-02-04 Nan Xia, Qingsong Zhao, Jinmei Xu, Zhifeng Cheng
Background: Diabetes retinopathy (DR) is one of the most common microvascular consequences of diabetes, and the economic burden is increasing. Our aim is to decipher the relevant mechanisms of immune-related gene features in DR and explore biomarkers targeting DR. Provide a basis for the treatment and prevention of DR. background: Diabetic retinopathy (DR) is one of the most prevalent microvascular
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An Update to Novel Therapeutic Options for Combating Tuberculosis: Challenges and Future Prospectives Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-02-04 Swathi Suresh, Rukaiah Fatma Begum, Ankul Singh S., Chitra Vellapandian
: Drug repurposing is an ongoing and clever strategy that is being developed to eradicate tuberculosis amid challenges, of which one of the major challenges is the resistance developed towards antibiotics used in standard directly observed treatment, short-course regimen. Surpassing the challenges in developing anti-tuberculous drugs, some novel host-directed therapies, repurposed drugs, and drugs
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Harnessing Chimeric Antigen Receptor-engineered Invariant Natural Killer T Cells: Therapeutic Strategies for Cancer and the Tumor Microenvironment Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-02-04 Yiqing Wang, Yan-Ruide Li
: Chimeric antigen receptor (CAR)-engineered T (CAR-T) cell therapy has emerged as a revolutionary approach for cancer treatment, especially for hematologic cancers. However, CAR-T therapy has some limitations, including cytokine release syndrome (CRS), immune cellassociated neurologic syndrome (ICANS), and difficulty in targeting solid tumors and delivering allogeneic cell therapy due to graft-versus-host
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Recent Insight into Herbal Bioactives-Based Novel Approaches for Chronic Intestinal Inflammatory Disorders Therapy Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-02-04 Ranjit K. Harwansh, Sonia Chauhan, Rohitas Deshmukh, Rupa Mazumder
: Inflammatory bowel disease (IBD) is a life-threatening complex disease. It causes chronic intestinal inflammation in GIT. IBD significantly affects people’s lifestyles and carries a high risk of colon cancer. IBD involves the rectum, ileum, and colon, with clinical manifestations of bloody stools, weight loss, diarrhea, and abdominal pain. The prevalence of inflammatory disease is increasing dramatically
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Single Nucleotide Polymorphisms [SNPs] in the Shadows: Uncovering their Function in Non-Coding Region of Esophageal Cancer Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-02-04 Surovi Saikia, Humzah Postwala, Vishnu Prabhu Athilingam, Aparna A, V. Vijaya Padma, Partha P. Kalita, Mehul Chorawala, Bhupendra Prajapati
: Esophageal cancer is a complex disease influenced by genetic and environmental factors. Single nucleotide polymorphisms [SNPs] in non-coding regions of the genome have emerged as crucial contributors to esophageal cancer susceptibility. This review provides a comprehensive overview of the role of SNPs in non-coding regions and their association with esophageal cancer. The accumulation of SNPs in
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Effects and Mechanisms of Fisetin against Ischemia-reperfusion Injuries: A Systematic Review Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-02-04 Omid-Ali Adeli, Saeid Heidari-Soureshjani, Sahar Rostamian, Zahra Azadegan-Dehkordi, Armin Khaghani
Background: Ischemia-reperfusion injury (IRI) is a well-known ailment that can disturb organ function. Objectives: This systematic review study investigated fisetin's effects and possible mechanisms in attenuating myocardial, cerebral, renal, and hepatic IRIs. Methods: This systematic review included studies earlier than Sep 2023 by following the PRISMA statement 2020. After determining inclusion and
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Iron(III) Monoglycerolate as a New Biocompatible Precursor in the Synthesis of Bioactive Nanocomposite Glycerohydrogels Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-02-04 Tat'yana Grigorievna Khonina, Denis Sergeevich Tishin, Leonid Petrovich Larionov, Artur Vasilevich Osipenko, Maria Nikolaevna Dobrinskaya, Ekaterina Anatolievna Bogdanova, Maxim Sergeevich Karabanalov, Maria Alekseevna Bulatova, Elena Vladimirovna Shadrina, Oleg Nikolaevich Chupakhin
Background: Nanocomposite glycerohydrogels based on biocompatible elementcontaining glycerolates are of practicular interest for biomedical applications. Objective: Using two biocompatible precursors, silicon and iron glycerolates, a new bioactive nanocomposite silicon‒iron glycerolates hydrogel was obtained by sol-gel method. Methods: The composition and structural features of the hydrogel were studied
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Role of Nutraceuticals in Treating Erectile Dysfunction via Inhibition of Phosphodiesterase-5 Enzyme: A Mini Review Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-02-04 Rashi Kulshrestha, Neelam Singla, Obaid Afzal, Ahsas Goyal, Mahendra Saini, Abdulmalik Saleh Alfawaz Altamimi, Waleed Hassan almalki, Imran Kazmi, Fahad Al-Abbasi, Sami I. Alzarea, Gaurav Gupta
: Drug repurposing is an ongoing and clever strategy that is being developed to eradicate tuberculosis amid challenges, of which one of the major challenges is the resistance developed towards antibiotics used in standard directly observed treatment, short-course regimen. Surpassing the challenges in developing anti-tuberculous drugs, some novel host-directed therapies, repurposed drugs, and drugs
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Essential Oils of Some Potential Medicinal Plants and Their Wound Healing Activities Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-02-04 Shiv Bahadur, Sana Fatima
: The wound has been recognised as a deep cut or tearing of the epidermis, which is also referred to as trauma and harm to the body tissues. Healing of wounds requires a coordinated series of cellular processes, including cell attraction, proliferation, differentiation, and angiogenesis. These processes involve interactions between various cells, such as macrophages, endothelial cells, keratinocytes
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Emerging Therapeutic Approaches Targeting Ferroptosis in Cancer: Focus on Immunotherapy and Nanotechnology Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-01-29 Zongchao Yu, Zhongcheng Mo, Yuan Qiu, Hengzhe Lu, Biao Zheng, Longfei Liu
: Ferroptosis is a newly discovered form of programmed cell death characterized by iron overload, ROS accumulation, and lipid peroxidation. It is distinguished by unique morphological, biochemical, and genetic features and stands apart from other known regulated cell death mechanisms. Studies have demonstrated a close association between ferroptosis and various cancers, including liver cancer, lung
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The Gut Microbiota and Major Depressive Disorder: Current Understanding and Novel Therapeutic Strategies Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-01-29 Mohaddeseh Bahmani, Saba Mehrtabar, Ali Jafarizadeh, Sevda Zoghi, Fatemah Sadeghpour Heravi, Amin Abbasi, Sarvin Sanaie, Sama Rahnemayan, Hamed Ebrahimzadeh Leylabadlo
: Major depressive disorder (MDD) is a common neuropsychiatric challenge that primarily targets young females. MDD as a global disorder has a multifactorial etiology related to the environment and genetic background. A balanced gut microbiota is one of the most important environmental factors involved in human physiological health. The interaction of gut microbiota components and metabolic products
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Hydrogel Breakthroughs in Biomedicine: Recent Advances and Implications Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-01-29 Ravi K Mittal, Raghav Mishra, Rehan Uddin, Vikram Sharma
: The objective of this review is to present a succinct summary of the latest advancements in the utilization of hydrogels for diverse biomedical applications, with a particular focus on their revolutionary impact in augmenting the delivery of drugs, tissue engineering, along with diagnostic methodologies. Using a meticulous examination of current literary works, this review systematically scrutinizes
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Overcoming Low Adherence to Chronic Medications by Improving their Effectiveness Using a Personalized Second-generation Digital System Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-01-29 Areej Bayatra, Rima Nasserat, Yaron Ilan
Introduction: Low adherence to chronic treatment regimens is a significant barrier to improving clinical outcomes in patients with chronic diseases. Low adherence is a result of multiple factors. Methods: We review the relevant studies on the prevalence of low adherence and present some potential solutions. Results: This review presents studies on the current measures taken to overcome low adherence
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Extrusion and Co-extrusion: A Technology in Probiotic Encapsulation with Alternative Materials Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-01-25 Aziz Homayouni-Rad, Amir M. Mortazavian, Hadi Pourjafar, Saba kamalledin Moghadam
: Encapsulation, in particular extrusion and co-extrusion, is a common practice to protect probiotics from the harsh conditions of the digestive tract as well as processing. Hydrocolloids, including proteins and carbohydrates, natural or modified, are a group of ingredients used as the wall material in extrusion. Hydrocolloids, due to their specific properties, can significantly improve the probiotic
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Recent Approaches on Molecular Markers, Treatment and Novel Drug Delivery System Used for the Management of Colorectal Cancer: A Comprehensive Review Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-01-25 Sonia Chauhan, Sakshi Sharma
: Colorectal cancer affects 1 in 25 females and 1 in 24 males, making it the third most frequent cancer with over 6,08,030 deaths worldwide, despite advancements in detection and treatments, including surgery, chemotherapeutics, radiotherapy, and immune therapeutics. Novel potential agents have increased survival in acute and chronic disease conditions, with a higher risk of side effects and cost.
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The Astonishing Accomplishment of Biological Drug Delivery using Lipid Nanoparticles: An Ubiquitous Review Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-01-24 Devesh Kapoor, Shirisha C. Chilkapalli, Bhupendra G. Prajapati, Paul Rodriques, Ravish Patel, Sudarshan Singh, Sankha Bhattacharya
: Biotech drugs, including proteins, hormones, enzymes, DNA/RNA therapies, and cell-based treatments, are gaining popularity due to their effectiveness. However, effective delivery systems are needed to overcome administration challenges. Lipid nanoparticles (LNPs) have emerged as promising carriers for various therapies. LNPs are biocompatible, less likely to cause adverse reactions, and can stabilize
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The Impact of miR-122 on Cancer Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-01-23 Shijie Wu, Yiwen Wu, Sijun Deng, Xiaoyong Lei, Xiaoyan Yang
: MiRNAs are confirmed to be a kind of short and eminently conserved noncoding RNAs, which regulate gene expression at the post-transcriptional level via binding to the 3'- untranslated region (3’-UTR) of targeting multiple target messenger RNAs. Recently, growing evidence stresses the point that they play a crucial role in a variety of pathological processes, including human cancers. Dysregulated
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Obesity and its Relationship with Covid-19: A Review of the Main Pharmaceutical Aspects Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-01-23 Katharine Hodel, Ananda Fonseca, Islania Barbosa, Caio Medina, Brenda Alves, Carine Maciel, Daniel Nascimento, Gessualdo Oliveira-Junior, Lorena Pedreira, Monielly de Souza, Ana Leonor Godoy
: Important physiological changes are observed in patients with obesity, such as intestinal permeability, gastric emptying, cardiac output, and hepatic and renal function. These differences can determine variations in the pharmacokinetics of different drugs and can generate different concentrations at the site of action, which can lead to sub therapeutic or toxic concentrations. Understanding the physiological
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Industrial and Pharmaceutical Applications of Microbial Diversity of Hypersaline Ecology from Lonar Soda Crater Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-01-23 Pradip Bawane, Shirish Deshpande, Santosh Yele
: The unidentified geochemical and physiochemical characteristics of Soda Lakes across the globe make it a novel reservoir and bring attention to scientific civic for its conceivable industrial and pharmaceutical applications. In India, in the Maharashtra state, Lonar Lake is a naturally created Soda Lake by a meteorite impact. Phylogenetic data from this lake explored a diverse array of microorganisms
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Systematic Review on Herbal Preparations for Controlling Visceral Hypersensitivity in Functional Gastrointestinal Disorders Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-01-23 Naser-Aldin Lashgari, Nazanin Momeni Roudsari, Saeideh Momtaz, Faezeh Niazi Shahraki, Nadia Zandi, Benyamin Pazoki, Mohammad Hosein Farzaei, Mehdi Ghasemi, Mohammad Abdollahi, Amir Hossein Abdolghaffari
Background:: Visceral hypersensitivity (VH) is an overreaction of the gastrointestinal (GI) tract to various stimuli and is characterized by hyperalgesia and/or allodynia. VH contributes to the etiology of many GI dysfunctions, particularly irritable bowel syndrome (IBS). Although the exact mechanisms underlying VH are yet to be found, inflammation and oxidative stress, psychosocial factors, and sensorimotor
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Advances in Aerogels Formulations for Pulmonary Targeted Delivery of Therapeutic Agents: Safety, Efficacy and Regulatory Aspects Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-01-22 Shristy Verma, Pramod Sharma, Rishabha Malviya, Sanjita Das
: Aerogels are the 3D network of organic, inorganic, composite, layered, or hybrid-type materials that are used to increase the solubility of Class 1 (low solubility and high permeability) and Class 4 (poor solubility and low permeability) molecules. This approach improves systemic drug absorption due to the alveoli's broad surface area, thin epithelial layer, and high vascularization. Local therapies
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Synergistic Effect of Silver Nanoparticles with Antibiotics for Eradication of Pathogenic Biofilms Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-01-17 Majed M. Masadeh, Zeinab Al-Tal, Mai S. Khanfar, Karem H. Alzoubi, Salsabeel H. Sabi, Majd M. Massadeh
Background: The increase in nosocomial multidrug resistance and biofilm-forming bacterial infections led to the search for new alternative antimicrobial strategies other than traditional antibiotics. Silver nanoparticles [AgNP] could be a viable treatment due to their wide range of functions, rapid lethality, and minimal resistance potential. The primary aim of this study is to prepare silver nanoparticles
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Simultaneous Determination of Levo-tetrahydropalmatine and Naltrexone in Rat Plasma by LC-MS/MS and its Application in a Pharmacokinetic Study Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-01-12 Kun feng, Sherwin K. B. Sy, Mingming Yu, Zhihua Lv, Meixing Yan
Background: Levo-tetrahydropalmatine and low-dose naltrexone are used in association with reducing cocaine-related cravings, but there are no analytical methods for the quantitative simultaneous analysis of this drug combination. Objective: A highly selective and sensitive LC-MS/MS assay was developed and validated to simultaneously quantify l-THP and naltrexone. The analytical method for l-THP offers
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Preparation, Swelling, and Drug Release Studies of Chitosan-based Hydrogels for Controlled Delivery of Buspirone Hydrochloride Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-01-11 Muhammad Suhail, Chih-Wun Fang, I-Hui Chiu, Hamid Ullah, I-Ling Lin, Ming-Jun Tsai, Pao-Chu Wu
Background: Buspirone is used for the management of depression and anxiety disorders. Due to its short half-life and low bioavailability, it requires multiple daily doses and is associated with some side effects. background: Buspirone is used for depression and anxiety disorders treatment. Due to its short half-life and low bioavailability, it requires multiple daily doses and is associated with some
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Immunohistochemical Expression of the SERPINA3 Protein in Uterine Fibroids Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-01-11 Mateusz de Mezer, Anna Markowska, Janina Markowska, Monika Krzyżaniak, Beniamin Grabarek, Filip Pokusa, Jakub Żurawski
Background: SERPINA3 (α-1-antichymotrypsin, AACT, ACT) is produced by the liver and released into plasma in an anti-inflammatory response and plays a role as a modulator of extracellular matrix (ECM) by inhibiting serine proteases. Numerous studies proved an increased level of SERPINA3 in many types of cancer, which could be linked to SERPINA3’s anti-apoptotic function. Aim: In the context of progressive
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Recent Advances in the Preparation of Protein/peptide Microspheres by Solvent Evaporation Method Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-01-05 Huayan Sun, Weiwei Luo, Xiaowu Huang
Protein/peptide drugs are extensively used to treat various chronic and serious diseases. The short half-life in vivo of protein and peptide as therapeutics drug limit the realization of complete effects. Encapsulating drugs in microspheres can slow the speed of drug release and prolong the efficacy of drugs. The solvent evaporation method is widely used to prepare protein/peptide microspheres because
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Micrornas in Anticancer Drugs Hepatotoxicity: From Pathogenic Mechanism and Early Diagnosis to Therapeutic Targeting by Natural Products Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-01-05 Hebatallah Husseini Atteia
: Patients receiving cancer therapies experience severe adverse effects, including hepatotoxicity, even at therapeutic doses. Consequently, monitoring patients on cancer therapy for hepatic functioning is necessary to avoid permanent liver damage. Several pathways of anticancer drug-induced hepatotoxicity involve microRNAs (miRNAs) via targeting mRNAs. These short and non-coding RNAs undergo rapid
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Pharmacological Action and Research Progress of Taraxasterol Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-01-05 Yu Zhang, Ramizu Bin Shaari, Mohamad Arif Bin Awang Nawi, Akram Bin Hassan, Caiyun Cui
: Primarily sourced from Asteraceae family herbs such as the Dandelion, Taraxasterol is a pentacyclic triterpenoid lauded for its extensive biological functionalities. Its therapeutic potency is demonstrated in various disease models, encompassing enteritis, arthritis, acute hepatic injury, and pneumonia. Scientific literature underscores its anti-inflammatory, antioxidant, and antineoplastic attributes
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Quercetin Promotes the Repair of Mitochondrial Function in H9c2 Cells Through the miR-92a-3p/Mfn1 Axis Curr. Pharm. Biotechnol. (IF 2.8) Pub Date : 2024-01-04 Fen Li, Dongsheng Li, Xisheng Yan, Fen Zhu, Shifan Tang, Jianguang Liu, Jie Yan, Haifeng Chen
Objective:: Cardiocerebrovascular disease is a severe threat to human health. Quercetin has a wide range of pharmacological effects such as antitumor and antioxidant. In this study, we aimed to determine how quercetin regulates mitochondrial function in H9c2 cells. Methods:: An H9c2 cell oxygen glucose deprivation/reoxygenation (OGD/R) model was constructed. The expression of miR-92a-3p and mitofusin